📣 New preprint 📣 We present a detailed map of nascent and mature ribosomal RNAs in mouse hematopoiesis and AML (including absolute rRNA molecule numbers), and outline principles of rDNA regulation. Work by Eleanor Sams (@eleanor44.bsky.social) & Victoria Feist (@victoriafeist.bsky.social). (1/x)

NIH is allowing us to recruit postbacs and postdocs again. Please reach out if you are interested in working with us! Ad: genomeinformatics.github.io/jobs2025/

Our next guest speaker webinar is happening next Friday, May 9th at 14:00 GMT. Omer Bayraktar will give a talk on: "Mapping the rules of glioblastoma using single cell and spatial multiomics". To join please follow the link below: www.qmul.ac.uk/epigenetics/...

🧵1/ 🚨Check out our significantly updated preprint, now out on @biorxivpreprint.bsky.social. Together with Sasi Conte lab, we characterize a novel role for intrinsically disordered regions (IDRs) in promoting RNA-binding selectivity in RNA binding proteins (RBPs): www.biorxiv.org/content/10.1...

I am recruiting for a postdoc in my lab at @blizardinstitute.bsky.social @qmulepigenetics.bsky.social to work on explainable AI/ML and epigenetics with a focus on enhancers. 3-year BBSRC funded position. A collaboration with @a-radzisheuskaya.bsky.social qmul-jobs.tal.net/vx/mobile-0/.... Pls share.

Just wanted to remind folks of the upcoming abstract submission deadline for the 2025 Human Genetics and Genomics GRS on March 30! 🧬 Come join us in beautiful Portland, Maine from July 5-6! Check out this link for more details: www.grc.org/human-geneti...

We're excited to announce the official QMUL Centre for Epigenetics Launch Conference 2025! 🎉 To find out more and book your free ticket, please follow the link below: www.eventbrite.co.uk/e/qmul-centr... @qmul.ac.uk @bartscharity.bsky.social @qmulepigenetics.bsky.social

Members of the U.K. and international scientific community are invited to sign to show their support: docs.google.com/forms/d/e/1F...

Had the pleasure of hearing about this cool story from @rakyanlab.bsky.social and @franrodalg.bsky.social last summer, congrats to all involved.

Thrilled to share the lab's latest preprint on the phenotypic impact of SNVs and INDELs in human rDNA using UK Biobank data! www.biorxiv.org/content/10.1...

🚨Thanks to generous support from @cancerresearchuk.org, we have multiple postdoctoral positions available in our lab (www.mardakhehlab.info) @oxfordbiochemistry.bsky.social to study ribosomes synthesis in cancer. Get in touch if you’re interested + RT and spread the word! 📣 #cancer #RNA 🚨

QMUL Epigenetics Centre (www.qmul.ac.uk/epigenetics/) is looking to recruit a senior lecturer with expertise in Genomics/Epigenomics and/or cell-free DNA. This is an excellent opportunity to join a strong Epigenetics and genomics community. Pl share/apply here qmul-jobs.tal.net/vx/mobile-0/...

@blizardinstitute.bsky.social, @qmulepigenetics.bsky.social is looking to recruit a senior lecturer with strong expertise in genomics/epigenomics/cell-free nucleic acids. Supported by @bartscharity.bsky.social to develop genomic and epigenomic liquid biopsy analyses for diagnostics.

The world has been through anti-science cycles before, to disastrous results On a detour on my lit review, a mosey through the history of our familiar friend, the standard onion (Allium cepa) brought me right to one of botany's greatest cautionary tales of what happens when ideology overrides data

🚨New review paper alert!🚨 At the @rakyanlab.bsky.social , we have summarised what is currently known about genetic variation within the human ribosomal DNA and its potential consequences. Check it out if you are curious!!! Plenty of intriguing possibilities 😊 onlinelibrary.wiley.com/doi/10.1002/...

We are hiring! 3-year BBSRC-funded postdoc position available. TEs, epigenetics, pregnancy: if you love one or more of these keywords, apply through the link below. Please spread the word.

Delighted to share the below perspective on human rDNA genetic variation on BlueSky. It’s an exciting, young field with lots of new stuff to discover! Plus, it is a prelude to a cool preprint from the lab that will be up soon. #ribosome #rRNA #rDNA

🚨New review paper alert!🚨 At the @rakyanlab.bsky.social, we have summarised what is currently known about genetic variation within the human ribosomal DNA and its potential consequences. Check it out if you are curious!!! Plenty of intriguing possibilities 😊 onlinelibrary.wiley.com/doi/10.1002/...

So excited that our work on predicting gene expression from histone modifications using deep learning is out in NAR today. Brilliant to work with lead author @al-murphy.bsky.social and collaborators Aydan Askarova, @borislenhard.bsky.social and Nathan Skene 🧬⭐️🙏 academic.oup.com/nar/advance-...

Congratulations to Dr Ines Hofer (co-sup Dr Matt Reeves) for passing her PhD viva yesterday (subject to minor corrections). Ines worked on how HCMV impacts hematopoiesis and found very interesting results. Many thanks to @louisakjames.bsky.social and Prof Joanna Parish for examining Ines.

Highlight on @alexdemendoza.bsky.social's latest fascinating work.

Bacteria are known to develop antibiotic resistance through mutations in DNA or their ability to actively pump and transport antibiotics out of the cell. Alterations to chemical modifications in ribosomal RNA could emerge as another mechanism. Full study here: www.nature.com/articles/s41...

E. coli modifies its ribosomes when exposed to widely used antibiotics, according to new research by @evamarianovoa.bsky.social. The subtle changes might be enough to alter the binding site of drug targets and constitute a possible new mechanism of antibiotic resistance.

SOX and POU are crucial Transcription Factors in animal development, believed to be innovations of this group. Here we find them in unicellular relatives of animals. And hold tight, you can use a choanoflagellate 🦠 SOX gene to make a full chimeric 🐁 ! Read more here 🧵: rdcu.be/d0dPN 1/6

🙌🙌🙌

Reminder to update the "social links" in your ORCiD profile with your Bluesky handle:

Warning to all: Dr. Peter Hotez is not on BSKY. This is a fake. (Repeating Dr. Hotez’ warning on Twitter).

If you are interested in #Epigenetics apply for a PhD with Jack Hardwick and Jonathan Hanley in Bristol, and our group in Exeter. Elucidating the role of DNA modifications in neurons Funded by #SWBio DTP Deadline: Dec 4 To apply: www.swbio.ac.uk/programme/ho...

This might be quite relevant for a few people around. @alexdemendoza.bsky.social, thoughts?

One part of our upgraded infrastructure may affect your profile. If you see your handle now says “Invalid handle,” please reverify it by navigating to Settings > Change my handle > Type in your current handle > Verify DNS Record > Update. (Basically, update to the same handle.)

At #GenomeInformatics24 to learn about the latest advances in bioinformatic methods and present our ongoing work at the @rakyanlab.bsky.social on rDNA variant calling at scale 🙌

Hello World! New here, and a little bit scared of having to rebuild the Twitter network, but here we go: I'm a group leader at UK DRI and @kingsioppn.bsky.social. My lab works on #epigenetics in neurodegenerative diseases, to understand non-coding genetic and environmental risk factors 🧬🧠

We are looking for a talented PhD candidate to join us on an exciting project on glioblastoma working on single cell, epigenetics and AI. supervised by me and Prof Silvia Marino www.findaphd.com/phds/project... @qmulepigenetics.bsky.social Pls RT.

Well... that's... unexpected 👀 www.nature.com/articles/s41...

New paper alert! The RNA ribosomal components are so essential that they appear as tons of back to back copies in the genome, which makes them really hard to analyse, so have been mostly ignored. But does it matter how many copies one has? A thread (1/9) www.cell.com/cell-genomic...

We have two new faculty opportunities at QMUL, part of a £3.2M investment by Barts Charity to develop genomic and epigenomic liquid biopsy analyses for diagnostics and research applications. More details here: qmulepigenetics.com/jobs Please RT abundantly

We are recruiting computational and wet-lab scientists and support international candidates. Please reach out if you are interested in working with us: Dark antigens, interferon responses, transposable elements, the HUSH complex, immuno-epigenetics and MORE....❤️

I know so many colleagues that suffer from the terrible ailment on the top-right of this snapshot...

Postdoc position in Rakyan Lab! The position will focus on the molecular basis of differences in translational output amongst different ancestries in humans, combining proteomics, genomics and computational approaches. Please do email me for further info! www.jobs.ac.uk/job/DFL087/p...

We'll be leveraging the expertise at @qmulepigenetics.bsky.social to develop liquid biopsy-based diagnostics to serve our ethnically diverse population. Co-led by Gabriella Ficz, Christopher Bell, Stamatina Iliodromoti and Ajay Sinha. Amazing support from Barts Charity.

At the Festival of Genomics and Biodata with a poster and a short talk tomorrow 15:35 at the Live Lounge. Would love to see you there if you're around!

I have several invite codes available, in case anyone needs some to bring acquaintances from the hellsite

will be hiring a research operations tech to help with lab maintenance. if you know anyone interested in, please send them my way! (ad will be posted soon)

Festival of Genomics (ExCeL, London), Jan 24/25. Free to attend! hubs.la/Q0263wyZ0

Like ribosomes? Like cytokines? Check out our new preprint! In it we show that the response to cytokines is mediated by a specific ribosome population. Brief rundown (Bluetorial? Skytorial?) of the paper below! www.biorxiv.org/content/10.1...

Dinner with Ryan Lister after his excellent talk at QM EpiHub.

The @rakyanlab.bsky.social is finally here! Vardhman and I are looking forward to updating you all on what we've been working on lately. Exciting things coming up soon (hopefully)!!! 🤞🤞🤞