This week's issue of #ScienceTranslationalMedicine is out! Patient-specific inflammatory "entotypes" may predict outcomes in severe trauma, deep sequencing identifies a gene variant that may drive early obesity in young adults, and more. https://scim.ag/4kyuFm7

Mapping the metabolic effects of drugs helps define their mode of action go.nature.com/3CreANg rdcu.be/eUK7o

I am grateful to share that I have been appointed as the PhD Graduate Program Director for UMB Pharmaceutical Sciences at the University of Maryland School of Pharmacy. Our application deadline for PhD has been extended to Dec. 15. lnkd.in/eqhKuytA Apply today!

#Throwback 🧪 COMMENT | A brief guide to studying extracellular vesicle function in the context of metabolism C Crewe et al

The University of Maryland School of Pharmacy (UMSOP) in Baltimore is recruiting new students for PhD and MS programs. Come join us and apply today! www.pharmacy.umaryland.edu/academics/ps...

Myelin damage in multiple sclerosis can be detected up to seven years before symptoms, with early immune pathway activation and a 21-protein panel showing promise for presymptomatic diagnosis, according to a paper in Nature Medicine. go.nature.com/4qqq47L #medsky 🧪

RESEARCH | S Benhmammouch, L Yvan-Charvet et al. (Univ Côte d’Azur) Glutamine uptake and utilization regulates macrophage function in atherosclerosis 🧪

#Throwback 🧪 COMMENT | Metabolites are not genes — avoiding the misuse of pathway analysis in metabolomics KS Lee, X Su & T Huan

#Throwback 🧪 PERSPECTIVE | On the pathogenesis of obesity: causal models and missing pieces of the puzzle F Magkos, @kevinh-phd.bsky.social , @johnspeakman4.bsky.social , A Astrup et al ‪ www.nature.com/articles/s42...

A study in Nature Metabolism shows that the dietary fiber inulin modifies the gut #microbiome to better process fructose, helping prevent metabolic dysfunctions and emphasizing the role of dietary fiber. go.nature.com/4gKCvHe#microbiome🧪

Artificial intelligence-assisted academic writing: recommendations for ethical use advancesinsimulation.biomedcentral.com/articles/10....

#Throwback 🧪 REVIEW | Futile lipid cycling: from biochemistry to physiology C Wolfrum et al.

Extremely happy to see our work out in #ScienceImmunology. We show allergen-induced ECM remodelling occurs independently of IL-13 or IL-17 driven inflammation. Rather chitinase-like proteins drive airway ECM accumulation & inhibition of Ym1 can remarkably reverse it. www.science.org/doi/10.1126/...

The immune response

'Here, we identify the immunometabolic crosstalk that generates homocysitaconate, a metabolite formed by homocysteine & itaconate adduction catalyzed by S-adenosyl-L-homocysteine hydrolase. Homocysitaconate increases 152-fold during #inflammation and exhibits anti-inflammatory effects.' #Immunology

Join us for #IMES2025! 🚨 Abstract deadline for trainees and early career PI's is coming soon! Due: Aug. 15, 2025 Submit for a chance to present oral talks and for awards!💲 👉Learn more/submit: tinyurl.com/DIMES2025

We're recruiting a lab technician to assist with our ongoing liquid biopsy projects. Please encourage those with relevant experience to apply. Feel free to contact me with questions! tinyurl.com/prattlabtech

COMMENT | ‪🧪 @colbyvorland.bsky.social ‬, L Golzarri-Arroyo & DB Allison (Indiana Uni) This comment discusses how clustering and nesting (C&N) arise in #preclinical studies, as well as valid designs and analyses. www.nature.com/articles/s42...

RESEARCH | MH Tschöp, TD Müller et al @www.helmholtz-munich.de Part 2: This study and a co-pub delve into how both #GIPreceptor #agonists and #antagonists trigger weight loss through different mechanisms. 🧪 www.nature.com/articles/s42...

Excited to be co-chairing a fantastic Immuno Delivery session at the CRS this Wednesday alongside Helena Florindo! We have an outstanding lineup of speakers : ✨ Ayelet David ✨ Vincent J. Venditto ✨ Paul Sagoe ✨ Milan paul ✨ Ana Baião ✨ David Peeler ✨ Madhan Mohan Chandra Sekhar Jaggarapu

A paper in Nature Nanotechnology presents a method using arrays of silicon nanoneedles to generate molecular replicas of living tissue, enabling mapping for glioma characterization and classification. The method allows for the monitoring of the response of the tumours to chemotherapy. #medsky 🧪

#Fumarate update Gang of 3: How the Krebs cycle-linked metabolites itaconate, succinate, and fumarate regulate macrophages & inflammation Dual role in Inflammation Anti- KEAP1-NRF2 GSDMD NLRP3 IL-10 Pro- mtDNA mtRNA➡️IFNβ #CellMetab 2025 www.sciencedirect.com/science/arti...

I'm thrilled to share that our lab has been awarded an R01 from NIH NIAID to continue our research to develop new nanoparticle-based immunotherapies for treating sepsis! news.pharmacy.umaryland.edu/umsop-facult...

Dr. Daniela Frasca et al highlight the interesting role of metabolism in #aging by comparing age and obesity in humans. They note that aging and obesity are conditions which can lead to dysregulated immune responses. Learn more: ow.ly/MeGI50W6fLn

A Tutorial in Nature Protocols provides guidelines for the use of machine learning models to mine genomes and proteomes for the discovery of antimicrobial peptides. 🔒

NEWS&VIEWS | Peter Arner ( ‪@ki.se‬ ) Under acute stress, adipose tissue lipolysis causes release of GDF15 from local macrophages, which binds to GFRAL in the brain, evoking anxiety.

I am excited to share that we are hiring for up to 3 postdoctoral fellow positions! Please see ad. (1) Translational Immunology Fellow (2) En Route Care Fellow (3) Polymer Chemistry and Drug Delivery Fellow Reach out if you have any questions. Application review will begin immediately.

We've learned a lot more about the principal drivers of age-related diseases in the past few weeks. And the leads to a unified model to put it all together. (open-access) erictopol.substack.com/p/the-driver...

Our latest review on macrophages Macrophages: sentinels, warriors, and healers url:https://academic.oup.com/hmg/article-abstract/doi/10.1093/hmg/ddaf087/8158008 academic.oup.com/hmg/advance-...

ACOD1 regulates microglial arginine metabolism and inflammatory responses https://www.biorxiv.org/content/10.1101/2025.06.01.657243v1

Why is the dual receptor agonist tirzepatide (Mounjaro, Zepbound) more potent than semaglutide (Ozempic, single receptor, GLP-1 agonist)? www.cell.com/cell-reports...

Injectable semaglutide reduces the risk of major adverse cardiovascular events in persons with type 2 diabetes and high cardiovascular risk. Research findings from the SOUL trial with oral semaglutide are summarized in a new Quick Take video. nej.md/3Ze59cr #MedSky #CardioSky

A way to improve a person's immune system response is through the diversity of their microbiome www.nature.com/articles/s41...

Ischaemic stroke remains a leading cause of disability. This article discusses the design of biomaterials that can engage and modulate pro-repair mechanisms in the brain to improve repair after ischaemic stroke:

🌿💥 New from our lab: Plant-derived lipid nanoparticles from Lepidium meyenii (maca) show potent protection against sepsis by forming a multimodal protein corona that soaks up inflammatory biomolecules, reducing organ damage and boosting survival. @cellpress.bsky.social Link: tinyurl.com/ucfjebtm

Our ability to accurately predict #Alzheimer's disease years in advance of any symptoms keeps getting better with plasma proteins and A.I. analytics @nataging.nature.com www.nature.com/articles/s43...

T cell memory alters pulmonary inflammatory responses to cecal ligation and puncture. https://www.biorxiv.org/content/10.1101/2025.05.15.654338v1

New paper online: Analysis of multi-drug cancer nanomedicine. Multi-drug #nanomedicine consistently outperforms single-drug therapy, multi-drug combination therapy, & single-drug nanotherapy across different experimental settings, strategies, and #cancer types. www.nature.com/articles/s41...

New paper online: Discovering nanoparticle corona ligands for liver macrophage capture. The study identifies receptor-ligand interactions that #macrophages use to capture circulating #nanoparticles and leverages them to engineer nanoparticles that escape uptake. www.nature.com/articles/s41...

A new #ScienceAdvances study identifies a neuroimmune pathway for treating sepsis, finding that dopamine inhibits expression of a critical regulator of immunometabolism. This suggests that pramipexole, a dopamine agonist, could effectively treat lethal infections. scim.ag/4kfAfrZ

#NatureMicroPicks Microbial integrons in focus 🦠🧬 Two studies showing microbial integrons encoding phage defense systems #MicroSky www.science.org/doi/10.1126/... www.science.org/doi/10.1126/...

Discovering a natural brake to inflammation! WanJun Chen & team reveal the Activin A/Smad3 axis protects mice from inflammation in models of sepsis and psoriasis and is active in humans: buff.ly/Gt8xW0v

A study in Nature Immunology explores soluble biomarkers, immune cell subsets, viral antibody responses and plasma proteomics to better define and understand long COVID in two independent cohorts. go.nature.com/3GVktnC #medsky 🧪

To restore the gut microbiome after antibiotics, the right diet (rich in carbohydrates, low in fat) was a better approach than fecal microbial transplants (in the experimental model) www.nature.com/articles/s41... www.nature.com/articles/d41...

Review how airway epithelial cells can serve as drivers of severe asthma pathogenesis: www.mucosalimmunology.org/article/S193...

On the dysregulation of the immune system after infection resulting in #LongCovid, 2 new studies @natimmunol.bsky.social www.nature.com/articles/s41...