We analyzed changes in physiology relative to menopause using two large scale studies that include millions of lab tests. Rather than align by age, we used statistical inference to align tests to final menstrual period. (1/2) arunamed.com/the-menopaus...

Excited to share our new FinnGen single-nucleus multiome preprint! 🧬 We profiled ~10M PBMCs (snRNA-seq + snATAC-seq) from 1,108 Finnish donors to map how genetic variants drive complex disease through chromatin and gene regulation 🧵👇 🔗 Link: www.medrxiv.org/content/10.1...

Very excited to see this in its final form! Here's our in-depth exploration of the sequences, dynamics, and functions of grey seal milk oligosaccharides throughout their (brief) lactation period, from a wild colony in Scotland. Full of surprises! www.nature.com/articles/s41...

Congratulations @hilarycmartin.bsky.social from @sangerinstitute.bsky.social on being awarded the 2026 Balfour Lecture!

Interesting story in this preprint. A male infant was diagnosed with Fanconi anemia due to an X-linked frameshift mutation. Three years later, his hematopoiesis became normal (without intervention). How? www.medrxiv.org/content/10.1...

Online now! 📄Maternal age and genome-wide failure of meiotic recombination are associated with triploid conceptions in humans 🧑‍🤝‍🧑 @shaicarmi.bsky.social @eva-hoffmann.bsky.social & co

Open to connecting with potential candidates at #ASHG25 !

Another record month for bioRxiv - and further evidence the pandemic spike+dip was just that and growth continues. Thanks to all involved and that includes 🫵

Authors can now include a translation of their submitted manuscript’s abstract in their chosen language, which will be published directly following the English language abstract. We also enable the display of non-Western character author names. Read more: journals.biologists.com/dmm/pages/news

@jengreitz.bsky.social l & my lab want to co-hire a computational biologist/biostatistician with project management expertise to help map the regulatory code of the human genome and discover genetic mechanisms of disease. Details below careersearch.stanford.edu/jobs/computa... Plz RT

High impact, small size. With Short Reports, we welcome papers that might address findings from a single set of experiments, or that are substantial enough to stand alone in 1,500 words or fewer. Read the latest Short Reports: buff.ly/1T4094h

There are still important details lacking. 1) How to address the substantial differences in prediction calibration and uncertainty across different environmental contexts (see: Hou et al. 2024 pubmed.ncbi.nlm.nih.gov/38886587/), many of which are unknown for an embryo by definition?

It is depressing, but all too predictable, how swiftly we’ve gone from the Social Science Genetic Association Consortium offering reassurances about the uses of behavioural polygenic scores to one of their lead authors marketing embryo selection for IQ

www.nature.com/articles/s44... This is a message that cannot be emphasized enough!!

🧵 THREAD: Preprint from @chrisrayner.bsky.social reveals how to fix selection bias in the Norwegian #MoBa study using population-wide registry data! For the first time, we can quantify and adjust for selection bias in this major epidemiological resource. Spread the good news! osf.io/preprints/os...

Are you a US-based academic that has prior ties to Sweden? Are you also 7-12 years from your PhD? If so, the Foundation for Strategic Research is providing funds of up to $1.5 mil (15m SEK) to bring you back to Sweden! Application deadline Sep 23. strategiska.se/pressmeddela...

Pro tip: the second you post your preprint it's "accepted for publication"

Looking forward to attending #GeneForum2025 in Tartu, Estonia Sept 9-10 and learning more about @estbiobank.bsky.social. Thanks @kauralasoo.bsky.social for the invitation!

The ERC welcomes the offer of substantial additional budget from @ec.europa.eu for the development of a new ERC funding instrument offering larger, longer-term grants, as announced by President Ursula Von der Leyen at the Sorbonne this morning. 👉 europa.eu/!NTYTTV

Our vision for Precision Omics Initiative Sweden (PROMISE) is now published in Nature Medicine! By boosting data-driven precision omics in Sweden, we can not only empower research but also integrate it with healthcare in a new way, with an impact in 🇸🇪 and 🌎. 🧵: rdcu.be/egmXY

A really nice paper by @drghawkes.bsky.social et al. argues that rare and common genetic associations converge on the same genes. While this seems at odds with our recent work about how burden tests and GWAS prioritize different genes, our results agree (🧬🧪🧵 1/6) www.biorxiv.org/content/10.1...

Congrats to Natàlia Pujol Gualdo, Triin Laisk, and the Estonian Biobank Research team on this beautiful paper! We replicated their association between PRS for intrahepatic cholestasis of pregnancy and the outcome (OR 1.7 per SD increase in PRS) in the HUNT Study. www.nature.com/articles/s41...

Hey researchers, bloggers, everyone interested in fertility data! We recently added lots of new data at Our World in Data on fertility rates, ages at childbirth, twin birth rates, birth seasonality, and more. Here's a thread of what you can find on the site! 🧵

Big news: we are setting up a new non-profit organization to run bioRxiv and medRxiv. It's called openRxiv [no it's not a new preprint server; it's dedicated organization to oversee the servers] openrxiv.org 1/n

We are looking for postdocs in reproductive genetics in beautiful Gothenburg! 📢 Virtually free childcare, free school, free healthcare, free higher ed 📢 Gothenburg = vibrant city (Way Out West) + 100s activities (🌍's largest 1/2 marathon) + biotech companies (AstraZeneca) + Volvo

📢 We are recruiting postdocs to help me build my research group in #reproductive genetics in Sweden mosaic-wlab.github.io Comp bio background? Join us to work on the genetics of miscarriage! Apply below or contact me 😃 A unique opportunity to shape how we approach science Reposts appreciated🥳

PLOS has issued a statement on recent US Executive Orders and scientific integrity. We are determined to stand firmly behind our mission, our values and our principles, and against any attempt at censorship or undermining of the core principles of scientific inquiry. plos.io/3D4O8cH

Happy to share a new preprint, to which I provided a minor contribution. Using genetic data from ~100k human embryos, we found ~1k that were haploid or triploid. We describe a thorough characterization of these embryos, with many interesting findings 🧵 1/9 www.biorxiv.org/content/10.1...

I've been developing a semantic search tool that covers not just bioRxiv and medRxiv, but the entire PubMed database. This means you can search across a massive collection of biomedical research using keywords, questions, hypotheses, or even full abstracts. Try it out: mssearch.xyz

📢 We are recruiting postdocs to help me build my research group in #reproductive genetics in Sweden mosaic-wlab.github.io Comp bio background? Join us to work on the genetics of miscarriage! Apply below or contact me 😃 A unique opportunity to shape how we approach science Reposts appreciated🥳

E-Life special issue on reproductive health #ReproSky #MedSky 🧪 elifesciences.org/collections/...

So happy to see this published in NatComms! tinyurl.com/yc66amvu Rare variant assocs with birth weight identify 9 genes. Insights into links between earlygrowth & later metabolic health. Great collabs between teams Exe&Camb. Amazing resources of UKB & deCODE made it possible.

📢@naturegenet.bsky.social is looking to hire a new editor! Come join our team and help publish the most exciting research in genetics and genomics! Deadline is February 5th. springernature.wd3.myworkdayjobs.com/SpringerNatu...

@anusri.bsky.social first author & developer of ChromBPNet is looking for opportunities in industry in ML for bio/genomics. She is an excellent rigorous scientist (as u can see from the paper). Very strongly recommend her. Plz reach out to her if u have openings. Plz forward.

📢📢📢 open permanent position for a researcher interested in genetics of pregnancy traits! If you like trios (aka pedigrees) register data and genetics, apply!

We're hiring! Make a real difference in women's health at Hvidovre Hospital, Denmark. Use your data skills to analyze large datasets, collaborate with clinicians, and contribute to advancements in reproductive health. Apply now: www.regionh.dk/job/s%C3%B8g...

Authors of this paper on ageing and senescence massively improved their paper after just one revision, with evidence jumping from “incomplete” to “compelling”. You can openly view reviews and version histories alongside the final paper. #12DaysOfeLife https://buff.ly/4fTdI2A

Come join us on an exciting joint PhD project on ML for protein function with @kailalab.bsky.social -- We are looking for a strong quantitative candidate with prior experience in ML. The position is based in Gothenburg and is fully funded for 5 years. www.chalmers.se/en/about-cha...

🌟 Exciting news: The Leena Peltonen School of Human Genetics returns in 2025! We're excited to bring PhD students together with an all-star list of leaders in human genetics. 📅 July 27-31, 2025 📍 Wellcome Genome Campus, UK 📝 Apply by March 7 at www.lpshg.com

There is no "committee on science" that will impose a new order or set of incentives. No one is going to "fix" peer review or incentivize it differently in one fell swoop. We have to BE the change - the tools already exist for everyone at every level to make an impact and change the incentives

Aneuploidy is the leading cause of pregnancy loss. In our latest study (www.biorxiv.org/content/10.1...) led by undergrad Angela Yang, we used a simulation framework to infer rates of both meiotic (39-43%) and mitotic errors (1-3% per division) that best explain data from human IVF embryo biopsies.

Three must read papers for PhD students. #scisky #PhD #science #research #academicsky 2. How To Choose a Good Scientific Problem Open Access www.cell.com/molecular-ce...

This one I'm very proud of: we identified a common genetic variant 🧬 that protects 5-fold from neonatal jaundice (replicated in different ancestries) which increases UGT1A1 (main bilirubin enzyme) expression in the gut, but not in the liver! 🖥️🧪🧬 A lot more here: www.nature.com/articles/s41...

Organising the EMGM in Brest next year: emgm2025.sciencesconf.org

📣 Two ERC-funded positions are available in the lab! If you are interested in exploring the mechanisms underlying mutation, we’d love to hear from you. PhD: shorturl.at/Oc04N Postdoc: shorturl.at/1ShHB RPs and shares would be greatly appreciated! 🧪🧬🖥️ #ScienceJobs #PostdocJobs

🧬🧪🖥️ One week left to apply to our postdoc position (2 + 1 years) in reproductive genetics! Please, share with colleagues and potentially interested candidates (comp bio/ biostats). Happy to chat about the project, position and/ or Gothenburg (Sweden) to anyone interested! #NewPI 🧬🧪🖥️

This feed should populate with posts that have: biorxiv,arxiv, medrxiv or "new preprint" in them, but are not by one of the automated *rxiv bots. It will take a while to start working, the custom feed provider is crashing/lagging all the time because of load: bsky.app/profile/did:...

I feel I need to say that: I am not particularly creative myself (maybe non-conventional?), but hey, some of the best football coaches were frustrated players!

A surge of biologists here on 🦋! A conversation starter for PIs: ow do you encourage/force your students to read more papers, beyond Journal Clubs? I feel I keep failing in this, and the students don't meet the "know your sub-field's literature better than the PI" bar...

Preserve the Friday traditions