An exciting PhD opportunity in a great collaboration between @noelresearchlab.bsky.social and my lab looking at heart infections in zebrafish. Details below. Deadline is the 4th December. www.findaphd.com/phds/project...

Have you heard of the Zebrafish Rock! Slack Pro tankspace? Sponsored by ZFIN, it acts as the premier source for questions and queries for the #zebrafish community and beyond! If you are keen to join, please fill out this Google form at our website: linktr.ee/zebrafishrock

Academic growth is best understood not as a linear or exponential curve, but as a process of dispersal—spreading ideas, people, and collaborations outward into new domains. #notetoself it’s dispersal, should be dispersal.

You know how sometimes situations hit different and suddenly it’s high time? If you know, you know! #academicnomad

Y-Maze in fish? Y not? :))

This summer, I’m mentoring three high school students, and they’re absolute rockstars! Three brilliant, budding minds who are eager to dive into STEM. The insightful questions they ask and how quickly they grow are simply astounding—it’s impossible not to be impressed.

Biological Age and Age Acceleration Predict Alzheimer's Disease Plasma Biomarker Levels https://www.medrxiv.org/content/10.1101/2025.05.22.25328181v1

Sex-Specific Genetic Drivers of Memory, Executive Functioning, and Language Performance in Older Adults https://www.medrxiv.org/content/10.1101/2025.05.26.25328369v1

Check our latest preprint out!

We identified unique molecular changes in various cell types that regulate the interaction between brain cells and blood vessels. An important cell type, #astrocytes, adopt a hyper-adhesive, mechanically rigid states at the #vascular interface with #APOE-ε4.

In no language I speak can I find the words to express my feelings! First “Yilmaz et al.” of my postdoctoral period is now out as preprint 🎉🥳 after all those sleepless nights and analysis even in my dreams (😅), we identified a conserved molecular signature in astrocytes. Details in repost 👇🏻

Some exciting news! NCBI has finished the annotation pipeline for our new #zebrafish reference sequence GRCz12tu: www.ncbi.nlm.nih.gov/refseq/annot... This is a big step up in data depth and quality and should be super helpful going forward.

I cannot be the only one who thinks zebrafish brain sections look like stormtroopers, right? #zebrafish #stormtrooper #maytheforcebewithyou

We are pleased to announce Beattie Award Submissions are now open! Postdocs & grad students entering their third year are invited to submit a nomination by May 19th, 2025. View detailed award information here:

Optimised genome editing for precise DNA insertion and substitution using Prime Editors in zebrafish https://www.biorxiv.org/content/10.1101/2025.04.23.650248v1

I think I am my own “reviewer 2” 😅 I don’t like watching my presentation recordings but I should admit that it’s very useful for the progress. I know what I can do and I can see how close I was, and how I can improve myself. I took my notes and looking forward to having my next conference talk 😊

I cannot share as “then and now” but I can share as “co-chair and presenter” as for the first time attandee of #adpd2025 does it count? 😅

A study in Nature suggests that parrots and humans may use similar brain mechanisms to produce complex sounds. The study uncovers a specialized brain region in budgerigars that works in a similar way to speech-related regions in the human brain. https://go.nature.com/43VkmC5 🧪

Women are twice as likely to develop Alzheimer’s disease as men. A feature in Nature Medicine reports how the changes to the female brain during menopause, along with social and cultural factors, might affect disease risk. #medsky #alzsky 🧪

#FluorescenceFriday: a simple pattern based on a revisit/re-design of the #zebrafish tbx6l promoter region as GFP reporter, originally uncovered by Szeto & Kimelman (2004) to label paraxial mesoderm. (pIGLET14a-harbored tbx6l:EGFP F1, pic and line by Amanda Garfield)

Four transgenic #zebrafish embryos with fluorescent blood vessels and blood cells. Credit to @pillaylab.bsky.social & @zebrafish007.bsky.social. #ZebrafishZunday 🧪

Mosaic of a #zebrafish embryo constructed using in situ hybridization images of #Drosophila embryos. Credit to @paveltomancak.bsky.social. #ZebrafishZunday 🧪

Check out the latest preprint from our lab, led by Aytac Kadir Mutlu, on the role of topographically organized dorsal raphe (DRN) activity in regulating forebrain function and adaptive behaviors! 🧵👇 www.biorxiv.org/content/10.1...

How does a brain with #Alzheimer look in the microscope? Neurons are dying, and I literally see holes in the tissue, like below. You can see microglia (🟡), brain immune cells, accumulating where the tissue disappears (hippocampus & entorhinal cortex). Additional markers: Astrocyte(🟣), pTau(🔵). 🧠🔬

As time getting closer to the #ADPD2025, I feel more and more excited that I’ll not only be giving an oral presentation but also co-moderate the session in #Vienna this April 1-5!

A versatile glycan binding dye (Rhobo6) for labeling the extracellular matrix in living tissues and organisms, from the Pedram lab. www.nature.com/articles/s41...

"Imagine a DAPI-like stain, but for the extracellular matrix." That's basically how this work was pitched to me by Kayvon and Antonio a year or so ago. Now the final product really delivers. Read about their versatile label for ECM in living tissues here: www.nature.com/articles/s41...

Tiny plastic particles may accumulate at higher levels in the human brain than in the kidney and liver, with greater concentrations detected in postmortem samples from 2024 than in those from 2016, suggests a paper in Nature Medicine. https://go.nature.com/414lf9S #Medsky 🧪

The perfect histological section through a five-day-old zebrafish larva. Credit to Sara Coordes from Baumann Lab (prev. Uni Heidelberg). #ZebrafishZunday 🧪

An immunome in 550 older adults and young adult controls demonstrated age-related changes at high-resolution along with some unique immune signatures www.thelancet.com/journals/ebi...

Divide and conquer. Or don’t divide but still conquer. @kkukreja.bsky.social & co. looked into the role of cell division in forming all major cell types during early zebrafish 🐟development, and found something they didn't expect. Read the story behind the paper:

Lifetime risk of dementia after age 55 years estimated to be 42%, based on a community-based, prospective cohort study of 15,043. Policies that enhance healthy aging urgently needed 🧪 @natureportfolio.bsky.social www.nature.com/articles/s41...

Benzer bir cümleyi Canan Dağdeviren de Duygu Demirdağ ile yaptığı röportajda demişti. Sözün orijinali Hugh Hefner’a atfedilir.

Towing of lateral line axons in vivo in a transgenic zebrafish embryo. Great imaging at the EMBO #DevBiol course in Quintay, Chile, using a Zeiss Light Sheet microscope. Huge thanks to Universidad Mayor, Microxchile, Leo Valdivia, & LiSIUM_Chile for allowing the use of the microscope at the course

A paper in Nature demonstrates a new method to generate high resolution reconstructions of the genetic history of northern and central Europe from the Iron Age through to the later Viking Age. https://go.nature.com/4fL3Bfb 🧪 🏺

Scientists at the Wellcome Trust Sanger Institute set out to sequence the #zebrafish genome in 2001, completing it in 2013. This revealed zfish have more than 26k protein-coding genes (more than humans) and that around 70% of human genes have at least one similar gene in zfish. #ZebrafishFunFacts 🧪

A Quantitative Proteome Map of the Human Body . www.cell.com/cell/fulltex...

A reminder: for genotypes to produce phenotypes, they have to go through development

“Life is too short to be living somebody else's dream”! Every grad students should keep this quote in mind. And I hope, one way or another, everyone finds their own dreams to follow.

This has been a fun project to be involved in - interesting strategy to improve sensory neuropathy. Great 🧪work by the Raspopovic lab now out in @natureportfolio.bsky.social rdcu.be/d5ozg I recommend watching the short video (below).

Happy new year 🎉 I hope 2025 will bring health, happiness, success and new adventures, cherished memories, and dreams coming true in the year ahead 🎉🎉

I can tell them. She slept most of the nights with the papers, projects, ideas in her mind. She just worked hard!

I am very excited to talk about my #zebrafish shenanigans on December 10th as part of the Gulmohar Series If you would like to attend, please fill out this form and @insdb.bsky.social will share the link docs.google.com/forms/d/e/1F... 6 PM IST/ 13.30 Zurich / 7.30 NYC BE THERE OR BE SQUARE

This was a collaborative effort from teams at @karolinskainst.bsky.social and @columbiauniversity.bsky.social. Congratulations to all authors, including our own @elanuryilmaz.bsky.social and Prabesh Bhattarai! 🙌 Thanks for the generous support of our funding agencies 🙏

Why it matters: This research challenges the idea that the heart is just a simple relay, positioning the IcNS as a key player in rhythm generation. A leap toward new therapeutic strategies for arrhythmia and heart failure.

🔑Highlights: - Pacemaker-like neurons in the IcNS, generating rhythmic activity autonomously 🧠💓 - A complex diversity of neurotransmitter systems finely tuning heart rhythms 🔬 - Ex-vivo study of intact neural heart networks 🧪

🚨 Our new study out in @natureportfolio.bsky.social! 🌟 We identify the "little brain" of the heart: the intricate intracardiac nervous system (IcNS) of zebrafish! 🐟 More about how this changes what we know about heart functionality. #Zebrafish #Neuroscience #LittleBrain doi.org/10.1038/s414...

Can there be a “little brain” in the heart? This is one of the “out of the box” project that we performed as KizilLab and AmpatzisLab. Huge thanks to Andrea, Kostas and Caghan 🤘🏻 #zebrafish #heart #neuron Check this little brain of the heart: www.nature.com/articles/s41...

Looking to satisfy your fish fix? Begin with one of our Starter Packs covering the #zebrafish community: 🐟🧪 PIs/Group Leaders/Senior Scientists v1: go.bsky.app/2cHYybY PIs/Group Leaders/Senior Scientists v2: go.bsky.app/4zBuxAF Early-Career Researchers/Trainees: go.bsky.app/HwxuHey

105 cool microscopists in this starter pack, but I know there are more out there! I want to find more 45 to complete the list, can you help me? 🤓🔬 go.bsky.app/Aaf8sKT