BMP9 enhances osteogenic differentiation in rheumatoid arthritis. BMP9 is down-regulated in synovial tissue of RA patients. In arthritis mice model BMP9 enhances osteogenic differentiation of synovial cells. Han Zhang et al. J Transl Med 2025 Feb 28 tinyurl.com/y65xbekk

BMP9 regulates the endothelial secretome to drive pulmonary hypertension https://www.biorxiv.org/content/10.1101/2025.08.29.673113v1

Our preprint is out! We induced apoptosis in myeloma cells with BMP9 and did a whole genome KO screen to find regulators of apoptosis (and BMP-SMAD signaling). ID3 induced by SMAD activity inhibited TCF3 and induced apoptosis. This was the main work in Clara Andersson-Rusch's PhD. Have a look! 👇

Our new collection offers cell biologists practical, expert-driven guidance and best practices in the design, execution, and analysis of experiments, and the subsequent communication of their results to their peers. 👉 rupress.org/jcb/collecti... #Reproducibility

Excited to share our new manuscript, now published in Blood! BCMA #CART show impressive responses for #myeloma, but pts with high-risk cytogenetics relapse more quickly and are in urgent need of new therapies. Thread👇 (1/10) ashpublications.org/blood/articl...

SMAD7: riding on fibrosis-limiting routes and beyond www.embopress.org/doi/full/10....

Nice work! Temporal patterns of genomic evolution in multiple myeloma showing importance of timing of events for progression and prognosis. #myeloma #multiplemyeloma #hemesky www.nature.com/articles/s41...

GCK inhibition induces IKZF1 degradation through a CRBN-independent mechanism in MM. buff.ly/B79qqYd #hemesky

📣 Save the date 📣 The next FASEB Science Research Conference on TGF-β Family in Development and Disease will take place: July 26-30, 2026 in Porto, Portugal! @faseborg.bsky.social With Mythreye Karthikeyan @mythreye.bsky.social, Rosemary Akhurst and Andrew Hinck web.cvent.com/event/af5f6d...

Elskar når folk som ikkje anar noko om landbruk skal romantisere denne livsstilen, og så lage tv av at dei ikkje er førebudd på det betyr å vere bonde. Då blir det rør. Heggdal er god til å rydde opp.

Vi må ta kampen mot brøl-apene som maksimerer utnyttelsen av urimelige konflikter, gjennom sort-hull effektene på vår oppmerksomhet. Men hvordan? Her er iallefall bilde av rett person @froyasjursaether.bsky.social

Ever wondered what happens when therapeutic antibodies bind to cancer cells? In our latest study, we used multiplexed 3D-RESI to directly visualize how anti-CD20 antibodies interact with their receptors, revealing their precise arrangement at single-protein resolution. (1/6)

🧪Move over CUT&Tag, there’s a new #TranscriptionFactor mapping method in town. Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag. 🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41... 🧵Let’s break down what makes DynaTag so powerful (1/7)

This seems like a really important paper comparing chromosome tracing methods, demonstrating that classical denaturing DNA-FISH and chromosome tracing leads to substantial distortion of 3D genome structure, likely due to the high-temperatures involved (70-90C): www.nature.com/articles/s41...

Translational research is digging for gold. Basic research is learning where and what to dig. The more funding is diverted to translation, the more we deplete the research ecosystem, driving the supplies of "gold" - immediately translatable findings and innovations - to unsustainably low levels.

I still can’t believe that all NIH grants to my colleagues at Harvard and Harvard Medical School have been nullified. And that, as a nation, we’re somehow okay with this illegal, arbitrary, and petty act. Just think of the consequences: scientists, students, and patients will all suffer.

A big day for preventing mitochondrial diseases from transmitting to the next generation www.nature.com/articles/d41... www.nejm.org/doi/full/10.... www.nejm.org/doi/full/10.... www.nejm.org/doi/full/10....

Cells size variation is often an important factor to consider when thinking about the biological scales & mechanisms. It's also also a relevant technical factor when analyzing omics data www.nature.com/articles/s41...

Today’s #Bluesky #bsky #kjerringøy #midnightsun

Now that we can assay thousands of plasma proteins in 1-2 ml of blood, there's discovery and validation of many new cancer biomarkers www.nature.com/articles/s41...

We are all somatic mutation mosaics. "There are trillions of cells in a human body and so the total number of somatic mutations acquired in a single individual may well exceed quadrillions, millions of times the size of the human genome." @nature.com nature.com/articles/s41...

Today’s magical Bluesky #bsky #midnightsun #kjerringøy

Today’s Bluesky #bsky Norwegian summer ⛅️

Even linkedin gets it

Our July issue is LIVE! 🌞🥵🏖️ It features articles on: - Targeted protein degradation for cancer therapy - Advances in therapeutic cancer vaccines - The TGFβ paradox in HPV-driven cancer - The paths to metastasis Happy reading! 👇 📖 https://www.nature.c...

Paracrine Action of Bone Morphogenetic Protein 3 in Pulmonary Arterial Hypertension https://www.biorxiv.org/content/10.1101/2025.06.13.659638v1

Wide-ranging, curiosity-driven research has led to enormous theoretical and practical benefits over the decades, ranging from anti-obesity drugs to the internet.

Problematic colormaps are common: "Over 67% of biology articles contain at least one colormap, of which 81% contain some form of misuse" www.biorxiv.org/content/10.1... Misuse is defined quite broadly though

Hurra! 🙌🏻 www.universitetsavisa.no/internasjona...

👋 Are you looking for a postdoc position? Do you think microtubules are fascinating? Then we might have the job for you! 2-year funded postdoc to join our lab! 👉 deadline 20/06 👇 check it out www.godinholab.com

... and a few minutes ago our Chart-Checklist came out in @natcellbio.nature.com 🥳🎉 Gift link for #TCTeAC: rdcu.be/eqPpi www.nature.com/articles/s41...

Vaccines are rigorously tested, they are effective, and they save lives. More than 150 million lives have been saved in the past 50 years thanks to vaccines! But you may be worried about what's in them? So, let’s break it down ⬇

Lovely new paper from @leedham-simon.bsky.social dissecting epithelium-microenvironment crosstalk through BMP & wnt signalling in the intestine. Inhibition of BMP antagonist GREM1 may forestall polyp formation in Hereditary Mixed Polyposis Syndrome (HMPS). www.nature.com/articles/s41...

We currently have a call for support that has gone out to European labs, to support FlyBase-UK. We are asking our colleagues from labs in the US and other countries to wait for a similar call to them that will go out in the near future, to support the US sites. We thank you for your patience.

New from the Steinberg lab #GDF15 drives anxiety like behaviors in mice and is linked to adipose tissue lipolysis.

GDF8 and activin A are the key negative regulators of muscle mass in postmenopausal females: a randomized phase I trial www.nature.com/articles/s41...

New #NatureComms paper: GDF8 and activin A blockade protects against GLP-1–induced muscle loss while enhancing fat loss in obese male mice and non-human primates. #Myoblue tinyurl.com/bdhb6ne9

Bimagrumab is Eli Lilly’s investigational monoclonal antibody that targets activin type II receptors (ActRIIA and ActRIIB) to shut down signalling by negative muscle-regulators such as myostatin and activin A.

On #WorldBlood#CancerDay, let’s remember those affected and raise awareness about these diseases. Explore the main types of blood cancer and how they impact the body 👇 🔗 https://bit.ly/4kkBfvA#WorldBlood#CancerDay, #HemeSky #MedSky #HemeOnc

The genomic features of precursor conditions of multiple myeloma provide multiple biological insights into disease origins and evolution, together with opportunities to identify those at highest risk of progression, according to a paper in Nature Genetics. go.nature.com/44LiHzA 🧪 🧬

What we heard this week 🧵 "Make no mistake about it, this is going to lead to overtreatment." -Christopher Lieu, MD, of @cucancercenter.bsky.social, discussing the potential approval of the 1st drug for smoldering myeloma during an FDA advisory committee meeting. www.medpagetoday.com/hematologyon...

28 of the most important drugs approved by the Food and Drug Administration (FDA) between 1985 and 2009. They found that 80 percent stemmed directly from basic discoveries made in the lab, often by scientists trying to understand a biological process or disease bit.ly/4jLCfbC

Get ready for the PROTACS, targeting proteins related to cancer and potentially other diseases a new feature @nature.com www.nature.com/articles/d41...

*Paid internship opportunity* @biologists.bsky.social is looking for a 3-month intern this summer to work across the Node, @prelights.bsky.social and @focalplane.bsky.social If you're interested in #SciCommm & #publishing, and have the right to work in the UK, apply by 5 June 👇

Due to great enthusiasm, we are extending the early bird registration deadline, at a reduced rate, until 25 May. After this date, the rate will increase by 1500NOK (approx. 135USD). We look forward to seeing you in Trondheim! www.endodnadamage.com

Cool project where we were happy to contribute with cell experiments. Have a look 👇🏻

A new era of cellular biology. Today, we’re launching CellScapes. The mission – to uncover the foundational principles of how cells behave collectively and change states in health and disease. #CellBio

A lipid nanoparticle–delivered base-editing therapy was custom designed for an infant with a ureacycle disorder. The affected infant was treated at approximately 7 and 8 months of age. Read the Brief Report: nej.md/42XF03F #ASGCT2025 #MedSky @asgct.bsky.social

Deubiquitinase-targeting chimeras for targeted protein stabilization The paper describes an approach to targeting proteins for stabilization, called DUBTACs - heterobifunctional molecules that consist of a protein-targeting ligand linked to a DUB recruiter www.nature.com/articles/s41...