No Significant Improvement in Osteoporosis Management of Post-fragility Fracture Patients From 2010 to 2019: A National Database Study. HD Smith et al. J Am Acad Orthop Surg Glob Res Rev 2025 Sep 22 shorturl.at/eeGPC …current system provides disappointing results

Research progress on sarcopenia in the musculoskeletal system. Xinning Mao et al. Bone Res 2025 Sep 23 shorturl.at/7uvBf … review current assessment methods for sarcopenia and its correlation with common musculoskeletal disorders, particularly age-related degenerative diseases

Impact of anti-osteoporotic treatments on hyperlipidemia risk in osteoporosis patients: evidence from a population-based retrospective cohort study. H-H Hsieh et al. Eur J Med Res 2025 Sep 23 shorturl.at/Z4MkQ …risk of hyperlipidemia was considerably↓ in patients with anti-osteoporosis treatment

Affective depolarization is a growing crucial problem in the US but also in Europe. Does it look bleak? …We must address the "elitist" behavior of members of both opposing camps and their institutions.

The mechanosensitive adhesion G protein-coupled receptor (GPR133/ADGRD1) enhances bone formation. J Lehmann et al. Signal Transduction and Targeted Therapy 30 June 2025 shorturl.at/83n30 …substance AP503 increase bone strength in both healthy and osteoporotic mice DIA

MMP9 deficiency protects against trauma-induced heterotopic ossification. V Smith et al. Poster ASBMR shorturl.at/3fWQt …data support potential benefit of MMP9 inhibition in non-hereditary heterotopic ossification …patients with spinal cord injury currently enrolled in clinical trial

Statins do not affect LS/FN BMD in retrosp. study in 104 pmp women treated with teriparatide (2 yrs). C Oliveri et al. JCEM 22 Sept 2025 shorturl.at/yvUfQ …Moreover, statins were associated with reduced bone resorption during the final six months of therapy …interesting

The impact of obesity on bone health: molecular pathways, metabolic interactions, and associated pathologies. A Bagherifard et al. Int J Obes 2025 Sep 19 shorturl.at/upPkJ …extensive fine and important review …relationship remains complex and not fully understood

Positive association of BMI and BMD in PMP women: syst. rev. & meta-analysis of 29 studies from 19 countries. Sijia Cai et al. Ann Med 18 Sep 2025 shorturl.at/qDmqd …trochanteric sites had the largest correlation, calcaneal sites had the lowest correlation, while other sites were moderate

Hi wimps where is your voice?

we in our still democratic Netherlands laughed a lot watching Lubach. I hope you also will

Clinically relevant association between the presence of sarcopenia and bone loss in the past 6 to 16 years in 907 community-dwelling older women. A Bellanger et al. Rehabilitacion 2025 Sep 19 shorturl.at/PWTr8 …BMD loss should alert clinicians to the possible coexistence of sarcopenia

Dasatinib and Quercetin alleviate bone loss and improved bone microstructure in type 2 diabetic osteoporosis mouse model by regulating serum metabolite and gut microbiome in mouse model. Junzheng Yang et al. Front Microbiol 2025 Sep 3 shorturl.at/lIUvW

Role of lactoferrin in osteopenia and osteoporosis. Deming Li et al. Front Nutr 2025 Sep 3 shorturl.at/DpRoh …potential application of Lf for OP …lack of clinical evidence remains the largest pain point for the application

Mitochondrial Transplantation: A Paradigm Shift in Osteoporosis Therapy. Jianlin Shen et al. Int J Nanomedicine 2025 Sep 12 shorturl.at/ucbtT …review positioning MT as a cornerstone of next-generation osteoporosis therapeutics

[18F]NaF PET/CT imaging provides valuable insights into bone healing potential, especially in non-unions, helping guide clinical decisions and reducing unnecessary surgeries. ND van Rijswijk et al. Eur J Nucl Med Mol Imaging 2025 Aug shorturl.at/OFju5

18F-NaF PET/CT for early detection and monitoring of osteoporosis in the lumbar spine: two case reports. S Patil et al. Am J Nucl Med Mol Imaging 30 Aug 2025 shorturl.at/pwNaz … a potential clinical application for early detection

Lactobacillus rhamnosus alleviates bone loss by suppressing NLRP3 inflammasome activation in OVX mouse model. K Xiong et al. Biochem Biophys Res Commun 2025 Sep 15 shorturl.at/TIpQc … new strategy for prevention and treatment of postmenopausal osteoporosis

Regeneron announces positive phase 3 Trial in adults with Fibrodysplasia Ossificans Progressiva (FOP), demonstrating that Garetosmab an ab against Act A prevents >99% of abnormal bone formation. Sept 17, 2025 investor.regeneron.com/node/31261/pdf

Periodontal Manifestations of Systemic Diseases. C Susin et al. J Periodontal Res 2025 Sep 16 shorturl.at/TZRx9 …excellent review

in Dutch parliament Esther Ouwehand was asked to change blouse….. x.com/abierkhatib/...

Endocrinological complications of Duchenne muscular dystrophy and their subjective burden: observational study evaluating growth, puberty, and bone health. M Rohlenova et al. J Endocrinol Invest 2025 Sep 16 shorturl.at/fxrRy

Capsaicin-activated autophagy protects the osteogenic differentiation of bone marrow stromal cells function under oxidative stress by inhibiting the PI3K/AKT/mTOR pathway. Y Chen et al. J Mol Endocrinol 2025 Sep 16 shorturl.at/wglBR …novel therapeutic approach for osteoporosis DIA

Exploring capsaicin as a multi-target agent for osteoporosis through computational insights. M Adhish et al. In Silico Pharmacol 2025 Aug 2 shorturl.at/VvREG … highlights the therapeutic potential of capsaicin in osteoporosis

Meta-analysis: Strength Training in older people with osteosarcopenia increases skeletal muscle mass, handgrip strength, and protein intake; but no effect on BMD, body fat percentage, gait speed and calcium intake. J Hernandez-Martinez et al. Nutrients 2025 Sep 2 shorturl.at/vnpBl

Impact of baseline PINP on the BMD increase with romosozumab, teriparatide, and denosumab in treatment-naïve primary osteoporosis. Y Etani et al. Bone 3 Sept 2025 shorturl.at/K5vnI … retrospective cohort study …PINP levels may help guide agent selection for osteoporosis treatment

Congrats Aris and your team! Milestone after almost ten year of research. Impressive efficacy results in adult FOP people treated wit Garetosmab. Curious how to deal with the safety issues of Garetosmab especially when starting trials in adolescents and children. www.linkedin.com/posts/aris-e...

Bone loss and impaired formation are associated with shared vascular changes in type 1 and type 2 diabetic mice with systemic microangiopathy. S Viallon et al. Bone 2025 Sep 13 shorturl.at/bpY3u

Men with prostate cancer had a bone microarchitecture and strength comparable to normative data at the time of ADT initiation. However, men with at least one prevalent VF had impaired microarchitecture at the tibia. MM van Oostwaard et al. Bone 11 Sept 2025 shorturl.at/haf9K

Clinical evidence linking osteoporosis and the gut microbiome in postmenopausal females: systematic review. Kyungjae Lee et al. Bone 13 Sept 2025 shorturl.at/VgMqE …targeting the gut microbiota presents a promising therapeutic strategy … popular item with so many reviews, but little hard evidence

Enhancing Wnt signaling lowers fracture incidence in a severe mouse model of Osteogenesis Imperfecta. Giulia Montagna et al. Bone 2025 Sep 11 shorturl.at/0OBlT …relevant to ongoing clinical trials testing the effectiveness of enhancing Wnt signaling in patients with OI

Osteoporosis Seminar. C Ye, P Ebeling, G Kline. Lancet 2025 Sep 11 shorturl.at/oWkIW ...interesting update and discussion

Epigenetic Clocks as Biomarkers for Bone Aging: Evidence From a Twin Study. M Soerensen et al. Aging Cell 2025 Sep 14 shorturl.at/v9xUH …accelerated aging phenotype, as reflected in the epigenetic clocks, for individuals with fractures or osteoporosis phenotypes …strong study design

Inhibition of ferroptosis rescues BMP osteogenic differentiation impaired by iron overload in the osteoporotic microenvironment. Xun Tang et al. Cell Signal 2025 Sep 8 shorturl.at/TZlTG … melatonin holds promise as an effective adjunct therapy

Diminished healing capacity of proximal femur fracture in middle-aged mice that were 52 weeks old. T Schmid et al. J Orthop Res 2025 Sep 10 shorturl.at/w3VBm

Case documents a severe cutaneous reaction at the romosozumab application site, with an atypical presentation due to its extent and intensity leading to treatment discontinuation. LAR Arrieta et al. Eur J Case Rep Intern Med 2025 Aug 25 shorturl.at/wogZD

Calcitonin Gene-Related Peptide antagonist use and bilateral atypical femur fractures; case report. K Choy et al. JBJS Case Connect 2025 Jul 10 shorturl.at/d7g4R …possible association …bone markers not measure

of intermittent PTH treatment on bone remodeling and modeling in humans—a histomorphometry centered scoping review. L Koch Thomsen et al. Osteoporos Int 9 Sept 2025 shorturl.at/2Pbk5

Complex interaction between diabetes and osteoporosis: imbalance between inflammation and bone remodeling. Xiao Zhang et al. Osteoporos Int 8 Sept 2025 shorturl.at/61GXE …review exploring interactive mechanisms

Incidence, risk factors, prognosis of periprosthetic fractures post hip fracture: unveiling protective role of anti-osteoporotic medication. Shao-Wei Lo et al. Osteoporos Int 2025 Sep 8 shorturl.at/Is7Ct …retrospective study large Taiwanese cohort

Multiple large language AI models versus clinical guidelines for postmenopausal osteoporosis. Chun-Ru Lin et al. Arch Osteoporos 2025 Sep 8 shorturl.at/O7N4A …significant response accuracy variations across AI models …first study in comparison different models

One-year mortality rates of fragility fractures of the pelvis: syst.rev.&meta-analysis. DNAnh Tran et al. EFORT Open Rev 2025 Sep 4 shorturl.at/VWh4c …high mortality, especially in FFP III. Conservative treatment may be suitable for FFPI, while surgery might be better fo FFPIII

Wishing strength and courage to a deeply divided US without unifying, empathetic leadership

Hyponatremia and bone pathophysiology: an integrated preclinical and clinical perspective. E Varaldo & Potasso. Best Pract Res Clin Endocrinol Metab 2025 Aug 29 shorturl.at/gvvk5

Pathophysiology of femoral fractures in hypophosphatasia. FGA Tabegna et al. Curr Osteoporos Rep 2025 Sep 4 shorturl.at/KemB3 … new insights into the role of anatomical, molecular and biochemical bone abnormalities …key aspects pathophysiology of femoral fractures in adults with HPP

Two decades into the crosstalk between bone and energy metabolism. Patricia Ducy. Nat Rev Endocrinol 2025 Sep 4 shorturl.at/bdZcx …fine comment

The 2024 UK clinical guideline for the prevention and treatment of osteoporosis. CL Gregson et al. Arch Osteoporos 2025 Sep 8 shorturl.at/2d5D2 ...for specialists a fine minor update ...but, not practical and too easy top-down for non-specialized healthcare professionals and interested patients

Presence of Schmorl's nodes should raise clinical suspicion for underlying osteoporosis and vertebral fractures, particularly when imaging and clinical findings and DXA appear discordant. B Çulha et al. Geriatr Gerontol Int 2025 Sep 3 shorturl.at/UkR3l

Patients with prior oral bisphosphonate use had higher rates of receiving a second infusion of zoledronic acid. N Konstantelos et al. Osteoporos Int 4 Sept 2023 shorturl.at/Y15ZD