The ITP therapeutic Avatrombopag alleviates OVX-osteoporosis in mice model by targeting NFATc1 signaling. Yangyang Hu et al. Eur J Pharmacol 2025 Nov 24 shorturl.at/TKsgz …therapeutic option for osteoclast-related bone loss and potentially for ITP patients with osteoporosis?

Parathyroid Hormone (1-34) Signaling for Bone Health in Breast Cancer Survivorship and Metastasis. Shinyoung Oh et al. J Cell Physiol 2025 Dec shorturl.at/X4GGC ...fine update

Beyond Structure: The Interplay of Bone and Brain During Alzheimer's Disease. A Pinnamaneni et al. Compr Physiol 2025 27 Nov 2025 shorturl.at/EiZys …fine update

Cortical Bone Loss and Fragility in a 2-Month Triple Transgenic Mouse Model of Alzheimer's Disease. G Storlino et al. Cells 2025 Nov 19 shorturl.at/IIVeg … increased number of empty osteocyte lacunae, reduced TRAP+ osteocytes, and an elevated number of osteoclasts

APOE4 induces multi-omic, cellular, and functional deregulation of female bone. CA Schurman et al. bioRxiv preprint Oct 16 2025 shorturl.at/VyVBO … APOE4 is a new molecular culprit capable of disrupting osteocyte maintenance that disproportionately affects females in mouse model

Sclerostin: A Potential Link between Osteoporosis and Alzheimer’s Disease. Ziyang Guo et al. Neurodegener Dis June 23 2025 shorturl.at/zMY3V …support concept bone-brain axis …could anti-sclerostin treatment be of use?

Romosozumab-induced ectopic epidural calcification in a hemodialysis patient with pre-existing spinal pathology. S Yoshikawa. Cureus 2025 Oct 23 shorturl.at/Gut3F

Low-frequency electrical stimulation, when combined with physical activity, can produce localized skeletal benefits in healthy premenopausal women; small controlled pilot study. AS Comtois et al. Clin Ther 2025 Nov 23 shorturl.at/L8EJx

Exercise-induced modulation of IGF-1 in healthy, obese, and cancer populations: syst. rev. and meta-analysis. YR Kwon et al. Annals Med 17 Nov 2025 shorturl.at/G309t ...complex endocrine response to exercise and support the therapeutic potential of tailored exercise prescriptions

Novel aspects of biochemical assessment of bone remodeling and mineralization. D Leszczy et al. Front Endocrinol 24 Nov 2025 shorturl.at/3mCUq … novel BTM cannot be viewed as substitutes for classical BTM but rather as complementary tools

Macrophages in osteoporotic fractures: from immunometabolic mechanisms to precision therapeutic approaches. J X Xing et al. Front Endocrinol 21 Nov2025 shorturl.at/6j2Vv …outlines the immunometabolic regulatory network of macrophages in OPF and its therapeutic relevance

Gαi1/3 Regulates Wnt/β-Catenin Signaling to Promote Osteogenesis and Bone Formation. J Bai et al. JBMR 22 Nov 2025 shorturl.at/61xOZ …first study to demonstrate that knockdown of Gαi1/3 significantly inhibits bone formation in mice

Differences and Similarities in Cortical Bone of the Femur between Donors with and without Type 2 Diabetes. E Berestesky et al. JBMR 21 Nov 2025 shorturl.at/owL5C …no differences in strength and toughness …fracture risk more dependent on diabetic comorbidities as chronic kidney disease?

Vitamin C as an Epigenetic Gatekeeper of Osteogenesis and Skeletal Health – a New Perspective on an Ancient Molecule. Roman Thaler. JBMR 21 Nov 2025 shorturl.at/ydDwm ...underappreciated determinant of bone health …very interesting

Impact of parathyroid Hormone’s dose, timing, and delivery mode on osteoclastogenesis and osteogenesis using a human periodontal ligament fibroblast model. WMI Talbi et al. Front Pharmacol 18 Nov 2025 shorturl.at/W335Y …intersting

What Is Osteoporosis? Rebecca Voelker JAMA 20 Nov 2025 shorturl.at/zWBKF …JAMA Patient Page …clear figure

😂 The White House POSTPONED the unveiling of Trump's healthcare plan on Monday 👇 Just a reminder of Trump’s 13 years of promising a NEW healthcare plan Trump has NO healthcare plan. BTW... Republicans have been PROMISING a new healthcare plan since 2009! youtube.com/shorts/o_x8D...

The Potential Inverse Association between Dietary and Circulating Copper Levels and Osteoporosis: a Scoping Review. Ye Ju et al. Biol Trace Elem Res 2025 Nov 18 shorturl.at/OFctU …current evidence is insufficient to delineate a clear dose-response relationship

A recent retrospective analysis of US emergency department (ED) data from 2015-2024 revealed an estimated 38,720 injuries related to automatic doors; retrospective analysis. V Shapovalov et al. JEM shorturl.at/fzVRZ …older adults had higher odds of severe injury (OR 3.18; 1.33–7.56) vs adults

Management of skeletal‑related events and fracture prevention in systemic mastocytosis. EM Lunn et al. Osteoporos Int 20 Nov 2025 shorturl.at/0UC6B …fine review …although controlling the underlying disease is usually most effective, the benefits and risks should be balanced if needed

The prevalence of ENPP1 deficiency in humans with ossification of the posterior longitudinal ligament (OPLL) and the preclinical efficacy of ENPP1 enzyme therapy in OPLL mice. S Srivastava et al. JBMR 18 Nov 2025 shorturl.at/WNZYK …clear link between ↓PPi, ENPP1 deficiency and OPLL

The relationship between ossification of the posterior longitudinal ligament (OPLL) and metabolic disorders. J Wang et al. Bone Res 2025 Oct 24 shorturl.at/fy1C7 …review

Countering bone loss and marrow fat expansion in the race to Mars by artificial gravity via centrifuge. QA Meslier et al. JBMR 17 Nov 2025 shorturl.at/w8lvH …comment on paper of K. Culliton et al JBMR Aug 2025 shorturl.at/VPZow …promising countermeasure

long-term GLP-1 agonist therapy can significantly diminish spinal BMD as measured by CT-based Hounsfield units regardless of the amount of weight loss achieved. ML Martini et al. J Neurosurg Spine 21 Nov 2025 shorturl.at/edpzx

DXA-derived hip shape is associated with hip fracture: longitudinal study of 38,123 UK Biobank participants characterised by narrower FN, higher FN angle and reduced acetabular coverage. S Scott et al. JBMR 20 Nov 2025 shorturl.at/73FSm

Trajectories of Femoral neck aBMD significantly differ by patterning of FN-area and FN-BMC across the menopausal transition. AM Leis et al. JBMR 13 Nov 2025 shorturl.at/ROcXF … highly informative in identifying women at greatest risk for low aBMD and future risk for fracture

Roles of skeletal muscle-derived exosomes in osteoporosis. Y He et al. J Transl Med 18 Nov 2025 shorturl.at/0FkEx … theoretical foundation for novel therapeutic strategies

Testosterone and Cardiovascular Disease: The Enduring Myth. F Mauvais-Jarvis. JCEM 18 Nov 2025 shorturl.at/f6mvr …fine discussion regarding three recent trials

Low-dose androgenic anabolic-steroid therapy after hip fracture surgery increased BMD and improved patient function without significant safety concerns; syst.rev. and meta-analysis. MW Box et al. Osteoporos Int 17 Nov 2025 shorturl.at/BV3IU … limited by small and often unblinded trials

Sirtuin 5-mediated desuccinylation of Slc25a4 inhibits osteoporosis by enhancing mitochondrial respiration. J Chen & X Jiang. Bone Research 17 Nov 2025 shorturl.at/EhQu3 …fine promising experiment

Glucocorticoid-induced osteoporosis: novel concepts and clinical implications. LC Hofbauer et al. Lancet Diabetes Endocrinol 26 Sept 2025 shorturl.at/KQ09S …fine update and recommendations

Changes in bone metabolism dynamics in the trabecular bone of elastase-induced emphysema pulmonary emphysema mice model after unloading followed by reloading via bone histomorphometry. D Arakawa et al. J Bone Miner Metab 2025 Nov 17 shorturl.at/w2OIX ...mechanism unclear

Approach to the patient - Transitions in Osteoporosis Therapy. BL Langdahl et al. JCEM 17 Nov 2025 shorturl.at/mxroc …majority are safe except for transitioning from denosumab to a bone anabolic agent or discontinuation of denosumab without appropriate follow-up treatment

Facial skin aging is a potential osteoporosis‑associated marker. Observational data in this study shows association but not in genetic MR analysis. Zhi-Dan Yu et al. J Bone Miner Metab 2025 Nov 5 shorturl.at/iipg6 …derived from the UK Biobank database

Literature review / update on medications related to osteonecrosis of the jaw independent of bisphosphonates and denosumab. N Jawad et al. Br Dent J 2025 Nov 14 shorturl.at/WGP83 …as tyrosine kinase inhibitors, rapamycin inhibitors, monoclon Ab, radiopharmaceuticals, demethylation agents

Different pattern in circulating microRNA‐22‐3p levels between patients with primary (aging) versus secondary sarcopenia (heart failure). M Vatic et al. Aging Cell 14 Nov 2025 shorturl.at/5cnvT

The role of muscle fascia in heterotopic ossification and maintenance of skeletal muscle integrity in FOP. LR Hanson et al. bioRxiv preprint 13 Nov 2025 shorturl.at/XvO9E …muscle fascia serves a primary role in FOP pathogenesis by targeting fibro-adipogenic progenitors

Intermittent and Short-Term Empirical Ruxolitinib Regimen for Steroid-Refractory Flareups of Fibrodysplasia Ossificans Progressiva.Rong-Long Chen et al. Pharmacol Res Perspect 14 Nov 2025 shorturl.at/18F26 …successful case of emergency salvage of a patient with critical lower limb FOP flareups

Development of a new treatment for osteoporotic vertebral fractures using adipose-derived stem cell spheroids. Y. Sawada et al. Bone Joint Res 2025;14(10):915–926. shorturl.at/3ioCx

Cardiovascular involvement in primary hyperparathyroidism. J Pepe et al. JCEM 14 Nov 2025 shorturl.at/iuwju update meta-analysis …robust RCTs are needed to definitively answer whether in patients with PHPT cardiovascular disease depend on serum calcium, PTH or both to submit patients to surgery

Global, regional, and national burden of falls among midlife women from 1990 to 2021 and projections to 2050: syst. analysis for global burden of disease. L Wang et al. Aging Clin Exp Res 2025 Nov 14 shorturl.at/2ac5A … burden will likely remain at a high level in the future

dilan

Temporal Trends of All-Cause Mortality in Paget’s Disease of Bone: a Population-based Retrospective Cohort Study over 20 Years. L Michou et al. JBMR Plus 5 Nov 2025 shorturl.at/JKKZ0 … increase in mortality possibly related to aging of the pagetic cohort and vascular calcifications

Hydrochlorothiazide with salt restriction in non-surgical hypoparathyroidism: a placebo-controlled single-blinded randomized crossover trial. Vivek Jha et al. JBMR Plus 3 Nov 2025 shorturl.at/KQJJF … low-dose HCTZ may allow safe cost-effective adjunct to standard therapy …short-term study

Clinical characteristics of patients with bone marrow edema syndrome, transient osteoporosis or migratory osteoporosis: a scoping review. E Hasvik et al. Bone 2025 Sep shorturl.at/sqG1f … various designations refer to same clinical entity; bone marrow edema syndrome appears most suitable term

Transient osteoporosis of the hip or bone marrow edema syndrome: outcomes in eight cases after combined bisphosphonate, vit D and biophysical therapy. CP Pagliarello et al. J Clin Med 2025 Nov 6 shorturl.at/147La …retrospective short-term study

Pharmacist-led osteoporosis: varying views about need, lack of financial and policy drivers in primary care, workload challenges, varying pharmacist skills and autonomy and lack of coordination across the health system. A Sturrock et al. BJGP Open 2025 Nov 14 shorturl.at/rji8j ...very sad review

Parathyroidectomy is safe and effective in all age groups, including older patients with comorbidities. EJ Kim et al. J Clin Med 2025 Oct 31 shorturl.at/5xJxy …retrospective study in 596 patients of one Korean center …age should not preclude surgical intervention for PHPT

Musculoskeletal Responses to Spaceflight: Mechanisms, Countermeasures, and Key Gaps. BM Roberts et al. Am J Physiol Cell Physiol 2025 Nov 11 shorturl.at/GRC2L ... mini-review synthesizes current knowledge of musculoskeletal responses