Darya Yanushko (Dasha)
@yanushkod.bsky.social
📤 88
📥 149
📝 16
PhD candidate, Metzger lab, IGBMC prostate cancer plasticity & tumor microenvironment
pinned post!
Extremely happy to share that a part of my PhD project just got published in Cell Death and Disease
rdcu.be/d7x68
In this work, we uncover how prostate tumor microenvironment drives tumor cell plasticity
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p53-loss induced prostatic epithelial cell plasticity and invasion is driven by a crosstalk with the tumor microenvironment
Cell Death & Disease - p53-loss induced prostatic epithelial cell plasticity and invasion is driven by a crosstalk with the tumor microenvironment
https://rdcu.be/d7x68
8 months ago
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reposted by
Darya Yanushko (Dasha)
Mikala Egeblad
2 months ago
As a new postdoc in my lab (
@cshlnews.bsky.social
→
@jhu.edu
)
@adrover.bsky.social
(now
@crick.ac.uk
) saw NETs in tumors—I shrugged. But he looked closer in 3D: NETs block tumor vessels, driving necrosis, hypoxia, EMT & metastasis. 🔗
www.nature.com/articles/s41...
@jhu-bdps.bsky.social
@nature.com
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Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature
Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.
https://www.nature.com/articles/s41586-025-09278-3
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An avant-première presentation of a new study by
@marinelab.bsky.social
at the
#EACR2025
on immunosuppressive NK cells in melanoma
3 months ago
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See you tomorrow at the
#EACR2025
poster session to discuss about hypoxia and myeloid cells in prostate cancer!
@helloeacr.bsky.social
3 months ago
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reposted by
Darya Yanushko (Dasha)
Olivier Saulnier
3 months ago
Oncogenic and tumor-suppressive forces converge on a progenitor-orchestrated niche to shape early tumorigenesis
www.biorxiv.org/content/10.1...
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Oncogenic and tumor-suppressive forces converge on a progenitor-orchestrated niche to shape early tumorigenesis
The transition from benign to malignant growth is a pivotal yet poorly understood step in cancer progression that marks the shift from a pathologically inert condition to a clinically lethal disease. ...
https://www.biorxiv.org/content/10.1101/2025.06.10.656791v1
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got to see it irl :) great talk of
@ardemp.bskyverified.social
at
@unistra.fr
add a skeleton here at some point
4 months ago
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I will once again run for cancer research, this time with
@fondationarc.bsky.social
for Paris half-marathon 2026! Je cours pour la Fondation ARC le 8 mars 2026, vous pouvez soutenir ma course en faisant un don pour la recherche sur le cancer:
semi-paris.dossards-solidaires.org/fundraisers/...
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Mon Semi-Marathon pour la recherche sur le cancer !
Chers amis, cher réseau,Je me lance le défi de courir le Semi de Paris 2026, que j'aimerais courir avec un Dossard Solidaire pour la Fondation ARC, pour la recherche sur le cancer.Cette association so...
https://semi-paris.dossards-solidaires.org/fundraisers/darya-yanushko?locale=fr&week=20
4 months ago
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Great time at the CRCL symposium! It was a real pleasure to present our work (available here
lnkd.in/dS254Hrz
) and to discuss. Thank you for such a warm welcome and for the poster prize by
@fondationarc.bsky.social
!
8 months ago
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reposted by
Darya Yanushko (Dasha)
8 months ago
Daniel Metzger doing an overview of our lab’s research on prostate cancer at the
#CRCL
symposium in Lyon.
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reposted by
Darya Yanushko (Dasha)
Barbara Marte
8 months ago
on this paper in Nature Medicine
www.nature.com/articles/s41...
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Digoxin for reduction of circulating tumor cell cluster size in metastatic breast cancer: a proof-of-concept trial - Nature Medicine
This proof-of-concept phase 1 trial shows that the size of circulating tumor cell clusters (which can promote metastatic spread) can be reduced by treatment with the Na+/K+ ATPase inhibitor digoxin in...
https://www.nature.com/articles/s41591-024-03486-6
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Extremely happy to share that a part of my PhD project just got published in Cell Death and Disease
rdcu.be/d7x68
In this work, we uncover how prostate tumor microenvironment drives tumor cell plasticity
loading . . .
p53-loss induced prostatic epithelial cell plasticity and invasion is driven by a crosstalk with the tumor microenvironment
Cell Death & Disease - p53-loss induced prostatic epithelial cell plasticity and invasion is driven by a crosstalk with the tumor microenvironment
https://rdcu.be/d7x68
8 months ago
1
14
1
reposted by
Darya Yanushko (Dasha)
Johanna Joyce
8 months ago
"Adaptations of
#neutrophils
in
#cancer
" Ng et al, 2025 A great new review on these fascinating immune cells! In the first
#Immunity
issue of this year - with lots of other amazing immunology 🧪 check it out 🤩
@cp-immunity.bsky.social
www.cell.com/immunity/iss...
www.cell.com/immunity/abs...
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reposted by
Darya Yanushko (Dasha)
Pietro Berico
9 months ago
Finally out our work showing the specific inhibition of melanoma-lineage identity genes using a new generation of ecteinascidin. Kudos to the only one Frédéric Coin and collaborators!
www.nature.com/articles/s41...
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Pan-inhibition of super-enhancer-driven oncogenic transcription by next-generation synthetic ecteinascidins yields potent anti-cancer activity - Nature Communications
Super-enhancers (SEs) drive specific gene expression programmes underlying different cancer cell states offering opportunities for therapeutic targeting. Here, the authors suggest targeting SE-depende...
https://www.nature.com/articles/s41467-024-55667-z
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reposted by
Darya Yanushko (Dasha)
Elizabeth McKenna
9 months ago
Now online in Cancer Discovery: Chronic
#ViralMimicry
Induction Following
#p53
Loss Promotes Immune Evasion - by
@cishak.bsky.social
, Sajid Marhon,
@daniel-decarvalho.bsky.social
, and colleagues
@pmresearch-uhn.bsky.social
@mdanderson.bsky.social
doi.org/10.1158/2159...
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reposted by
Darya Yanushko (Dasha)
Gilles Laverny
9 months ago
Lovely Christmas party with the group after such an amazing year! 🎄🎅Hope the best is to come next year Thanks to the Secret Santa 😜
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First publication here! 😄 It was a great pleasure to present my work at the annual meeting of the ARTP, loved the questions session :)
@metzgerlab.bsky.social
10 months ago
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reposted by
Darya Yanushko (Dasha)
Adam Sharp
10 months ago
Great little starter pack from
@ravimadan.bsky.social
go.bsky.app/ANw3D3j
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Prostate Cancer
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