NEWS 📰: New drug combination could tackle advanced #ProstateCancer 40% of advanced prostate cancer patients could be treated with a combination of 2 drugs. The drugs are already in use or in trials to treat cancer. Read more about the work published in @natcomms.nature.com ⬇️

🚨 Delighted to share our latest paper, from @asharpmedonc.bsky.social team in collaboration with Johann de Bono’s team at @icr.ac.uk and international colleagues, published in Nature Communications @natureportfolio.nature.com Read here: bit.ly/477pYt7 🧵1/4

Could targeting MCL1 be a new treatment approach for hormone therapy-resistant #ProstateCancer? A study in @natcomms.nature.com by @juanjimenezvacas.bsky.social, @asharpmedonc.bsky.social and the @icr.ac.uk team explores precision therapy strategies. Grab a ☕ and read: doi.org/10.1038/s414...

Waiting for the water to return. Still a 🏃 just not by 💦

A great talk Adam, really enjoyed hearing about the breadth of your work!

Thanks for coming out today. A home game 🥰

We keep pushing. Wishing you all some Friday happiness 🥰.

Fitness 📉

Sleep seems to be optional currently! Big love to all 🥰

Thank you for the invite and the innovative format. Was great to chat with such an enthusiastic and engaged group. Super hospitality. Thank you for the awesome discussion 😊

So he has opted for our bed tonight with Mrs S. Double sleep divorce 😞

Timeline cleanse. Does this make me Batman 🥰

Jet lag is real.

The unit and sensitivity of measurement may change, but good is good and bad is bad, we may need more innovation to move from incremental to transformational.

One upon a time it was punter and pige - having now met @profiand.bsky.social @craiggedye.bsky.social in person - I have new favourite 🇦🇺!

We need to be mindful - we have little knowledge on how the androgen receptor works in prostate cancer. Remains a key area of research and for me the main target.

Thank you Seattle and San Fransisco for a lovely week. @fredhutch.bsky.social @ascocancer.bsky.social #GU

Loved this 😊

Morning Manchester!

Looking forward to #JING25 - annual meeting for early career researchers in experimental cancer medicine. Welcome to Manchester, everyone. @cancerresearchuk.org @oncocook.bsky.social @mcrcnews.bsky.social @asharpmedonc.bsky.social @ukecrc.bsky.social www.ecmcnetwork.org.uk/jing-tng

@annaminchom.bsky.social and I will be doing a very slow jog on Tuesday am at ECMC JING meeting. Meet in foyer around 7am. Plenty of time for it to be a social jog, shower and breakie before we begin day 2. Can’t wait (for the meeting)!

Huge thanks to you and your colleagues for all you do to improve outcomes for cancer patients and their families. Research is where hope starts!

We’re on our way! Looking forward to hearing from your researchers @icrlondon.bsky.social and the hope for prostate cancer patients in the future

An inspirational day for @pjmcg.bsky.social and me @icrlondon.bsky.social with @asharpmedonc.bsky.social and his team of researchers. Thanks for all you’re doing to bring hope to men with #prostatecancer. @ethansgrumps.bsky.social - great to meet you at last. Thanks for all you do too! ❤️

Beyond grateful to @ethansgrumps.bsky.social @sueduncombe.bsky.social @pjmcg.bsky.social for the time spent with our fabulous team @icrlondon.bsky.social. Supporting them develop the ability to describe complex science to public/patients and asking tough questions on how we translate to the clinic.

@ethansgrumps.bsky.social @sueduncombe.bsky.social @pjmcg.bsky.social all giving up their valuable time to visit the @icrlondon.bsky.social tomorrow and see what we are after. Very much looking forward to having them.

More water on a Sunday. Trying to ensure in 2025 that my family and I get a bit more of my focus 🏃🏼‍♀️ 💧

Trying to keep up!

Putting me to shame!

The sleep divorce of 2024 continues into 2025….

[1/8] Let’s take a closer look at how NXP800, which inhibits the Heat Shock Factor 1 (HSF1) pathway that helps protect cells from proteotoxic stress, could be a new approach to tackling #prostatecancer that has become resistant to hormone therapy. 🧵

Great to see this @prostatecanceruk.bsky.social funded work published! 🥳 Congrats team @asharpmedonc.bsky.social & everyone from @icrlondon.bsky.social #prostatecancer #research 🧬🧫🔬 This was particularly exciting for me as I was interviewed about the impact of the paper for radio #faceforradio

Second both of these 👆 fantastic clinician scientists who care deeply about improving treatment and supporting trainees

I spy two amazing bluesky-less candidates for the @AACR board of directors. Please consider Johann de Bono @ICR_London @royalmarsdenNHS and Timothy Yap @MDAndersonNews. www.aacr.org/professional...

Could targeting the Heat Shock Factor 1 (HSF1) pathway be a new avenue for treating hormone therapy-resistant #prostatecancer? @asharpmedonc.bsky.social and the team @icrlondon.bsky.social share their exciting new findings. Grab a ☕and read: doi.org/10.1158/1078...

With huge thanks to @asharpmedonc.bsky.social, one of our fantastic @prostatecanceruk.bsky.social mentors🙏.

Pleasure. Just trying to pay back in some small way for those many who have helped me 🥰

Fam (-1)

Following the early morning pace setter @eileenparkes.bsky.social. Little mid-afternoon run.

Hair done.

Stunning. I tried to get a run in whilst Jacob was at his class…. He said please don’t I am scared you won’t come back 😢

Great work from @asharpmedonc.bsky.social and the wider team @icrlondon.bsky.social

Study co-lead Adam Sharp @asharpmedonc.bsky.social said: "While hormone therapies have extended the lives of lots of men with advanced prostate cancer, drug resistance is inevitable. We need to tackle the problem from a new angle."

📰 NEWS: Hormone therapy-resistant #ProstateCancer could be treated with a new ICR-discovered drug, NXP800. ICR scientists found that the drug, currently in trials for ovarian cancer, slowed the growth of prostate cancer cells in the lab.

@tylersbrt.bsky.social - very different to your water 🏃

As many of you know (from my pics) we are in the midst of sleep divorce here (about 12 months now). However, tonight the chance to look after the eldest (whilst the youngest got mummy) who has a sickness bug and wanted to hang out with daddy (rare/non event) downstairs 🥰

Happy Thursday Team 🥰

Love it 😊 🏃🏼‍♀️

A very first for the sharp family - a 4km run as one. Wishing you all the very best year that 2025 can be whatever the situation and circumstance 🤗 🥰

Thank you to my lab, thank you to our clinical teams, thank you to my collaborators, thank you to my mentors, thank you to my friends thank you to our patients and their families, and thank you to my family who give up the most to allow me to do something I love ❤️