Valentin Jaumouillé
@jaumouillelab.bsky.social
📤 197
📥 254
📝 16
Exploring the mechanobiology of phagocytes. Assistant prof at SFU.
reposted by
Valentin Jaumouillé
Marie Monniaux
3 days ago
Have you ever heard that women have more chances than men of getting grants or positions in academia? Of course you have, and here are my personal views on this. With the shocking revelation that no, it is NOT TRUE ! (1/n)
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Shout out to my post-doc adviser. An exceptional scientist, indeed.
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about 2 months ago
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@mmorrissey.bsky.social
's lab is on 🔥
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3 months ago
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Another awesome paper from
@mmorrissey.bsky.social
lab!
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3 months ago
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reposted by
Valentin Jaumouillé
Hawa Racine Thiam
3 months ago
We look forward to hearing feedback from the community on our
#preprint
where we used
#NETosis
as a platform to show that chromatin decompaction inside the nucleus directly regulates cell mechanics. This work identifies long-range biophysical impacts of chromatin in mammalian cells.
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Really excited about this! Lucy Shapiro pioneered research on the cell biology of bacteria and was a huge inspiration for my PhD project.
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4 months ago
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reposted by
Valentin Jaumouillé
LinderLab
5 months ago
Our paper on podosome regulation by myosins 1e/f is now online. We introduce the concept of the podosome base, a region of plasma membrane-associated components 🔬 Cool collaboration with
@renaudpoincloux.bsky.social
and Krendel labs
www.sciencedirect.com/science/arti...
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If you're interested in biophysics in the context of infection and immunity, we're looking forward to seeing you at the ASCB/EMBO meeting.
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5 months ago
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reposted by
Valentin Jaumouillé
Journal of Cell Science
5 months ago
Why would anyone want to be a scientist? Check out our new Essay from Martin Schwartz:
journals.biologists.com/jcs/article/...
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reposted by
Valentin Jaumouillé
6 months ago
Comment on our @Reproducibility project in @Drosophila immunity. It is a normal that findings—however exciting and important at the time—may later prove to be more complex than initially believed. Re-evaluations is essential to the self-correcting nature of science.
www.science.org/content/arti...
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Majority of fruit fly immunity studies can be replicated, huge analysis finds
Verification of 50 years of data bolsters immunology research, but identifies “suspicious” papers that don’t hold up
https://www.science.org/content/article/majority-fruit-fly-immunity-studies-can-be-replicated-huge-analysis-finds
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reposted by
Valentin Jaumouillé
SFU Faculty of Science
6 months ago
Congratulations to
#SFU
Molecular Biology and Biochemistry distinguished professor Fiona Brinkman who has received a
@genomebc.bsky.social
Award for Scientific Excellence from Life Sciences BC!
www.sfu.ca/science/news...
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Valentin Jaumouillé
Esther Verheyen 🇨🇦
8 months ago
SFU invites applications from world renowned researchers for the prestigious Canada Excellence Research Chairs (CERC) 2026 Competition. Please see the ad to see if you qualify. In Vancouver, BC
www.sfu.ca/vpacademic/a...
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Canada Excellence Research Chairs (CERC) 2026 Competition
https://www.sfu.ca/vpacademic/academic-careers/current-canada-research-chair-opportunities/canada-excellence-research-chairs--cerc--2026-competition.html
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reposted by
Valentin Jaumouillé
Johanna Ivaska
8 months ago
Latest from
@ivaskalab.bsky.social
@jrwconway.bsky.social
in NCB. We find that SHP-2 inhibition stops TNBC invasion and limits metastasis by blocking integrin dephosphorylation! Read more at:
www.nature.com/articles/s41...
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Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells - Nature Cell Biology
Conway et al. show that integrin β1 phosphorylation is regulated through balanced activities of tyrosine kinases, such as Src and Arg, and phosphatases, such as PTP-PEST and Shp2, facilitating invadop...
https://www.nature.com/articles/s41556-025-01663-4?utm_source=rct_congratemailt&utm_medium=email&utm_campaign=oa_20250526&utm_content=10.1038/s41556-025-01663-4
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Somehow, I only started to realize this while I became a faculty member. Although, I wonder whether having a better awareness of these challenges would have been discouraging.
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8 months ago
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reposted by
Valentin Jaumouillé
Renkawitz Lab
9 months ago
Excited to share our discovery
www.science.org/doi/10.1126/...
that the
#centrosome
is prone to breakage! Using
#motile
cells, we identify centrosome breakage during
#pathfinding
, caused by
#actin
#forces
, & prevented by
#Dyrk3
Kudos to 1st author Madeleine & thanks to all collaborators! (1/6)
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reposted by
Valentin Jaumouillé
Eric Topol
9 months ago
It used to be thought that T-cell priming occurred as single phase. Now we know it takes two.
www.science.org/doi/10.1126/...
@science.org
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A distinct priming phase regulates CD8 T cell immunity by orchestrating paracrine IL-2 signals
T cell priming is characterized by an initial activation phase that involves stable interactions with dendritic cells (DCs). How activated T cells receive the paracrine signals required for their diff...
https://www.science.org/doi/10.1126/science.adq1405
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reposted by
Valentin Jaumouillé
MIT Press
9 months ago
We're disappointed to see Ben Barres's powerful book "The Autobiography of a Transgender Scientist" among the ~400 titles removed from the Naval Academy Library. Needless to say, we're proud to have published his book and will keep it — and his memory — alive.
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The Coming Out of a Transgender Scientist
"I know that I am making the right decision because whenever I think about changing my gender role, I am flooded with feelings of relief."
https://thereader.mitpress.mit.edu/the-coming-out-of-a-transgender-scientist/
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reposted by
Valentin Jaumouillé
Anh Hoang Le, PhD 🏳️🌈
10 months ago
I knew there would be an effect! This has been one of the questions that I had for the longest time. Changing the mechanics of the substrate affects phagocytosis. Very interesting paper!
www.cell.com/iscience/ful...
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A crosstalk between adhesion and phagocytosis integrates macrophage functions into their microenvironment
Cell biology; Organizational aspects of cell biology; Specialized functions of cells; Functional aspects of cell biology
https://www.cell.com/iscience/fulltext/S2589-0042(25)00327-X?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS258900422500327X%3Fshowall%3Dtrue
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reposted by
Valentin Jaumouillé
10 months ago
Excited to share our latest work on how Ca²⁺ regulates actin in cell protrusions—now available as a preprint on bioRxiv! 🎉 Huge congrats to Ernest Iu for leading the project, and a special thanks to our amazing collaborators!
www.biorxiv.org/content/10.1...
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A TRPV4–dependent calcium signaling axis governs lamellipodial actin architecture to promote cell migration
Cell migration is crucial for development and tissue homeostasis, while its dysregulation leads to severe pathologies. Cell migration is driven by the extension of actin–based lamellipodia protrusions...
https://www.biorxiv.org/content/10.1101/2025.03.28.646012v1
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reposted by
Valentin Jaumouillé
Florence Niedergang
10 months ago
Our latest publication on
#macrophages
congrats Anna Mularski and
@manondepierre.bsky.social
@institutcochin.bsky.social
@actin-paris-saclay.bsky.social
Martial Balland
@grenoblealpes.bsky.social
@cnrsbiologie.bsky.social
cnrs physique @anr
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reposted by
Valentin Jaumouillé
Journal of Cell Biology
10 months ago
Wu et al
@sickkidsto.bsky.social
show that Snx10 regulates PI(3,5)P2 accumulation on
#lysosomes
by controlling PI(3)P delivery. Deleting Snx10 inhibits ClC-7, thereby impairing (phago)lysosome resolution. This mechanism may account for Snx10-related
#osteopetrosis
.
rupress.org/jcb/article/...
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reposted by
Valentin Jaumouillé
Journal of Cell Biology
10 months ago
In Memoriam: Wolfenson, Giannone, and Schwartz recall the life and many contributions of Michael Sheetz, who passed away on January 30, 2025.
rupress.org/jcb/article/...
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reposted by
Valentin Jaumouillé
Canadian History Ehx
10 months ago
On this day in 1879, Maud Menten was born in Port Lambton, Ontario. In her work as a medical researcher, she became a leading expert in histochemistry and enzyme kinetics while fighting against sexism in her field. Let's learn more about her life! 🧵1/10
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Valentin Jaumouillé
Johanna Joyce
10 months ago
Many thanks to the young immunologists of
@yefis-immunology.bsky.social
for this interview as part of their
#WomeninSTEM
🧪 series! Really enjoyed discussing ways to improve
#gender
#equality
and all forms of
#inclusion
&
#diversity
- esp. important now 🙏 Interview 🎥
www.youtube.com/watch?v=4CRx...
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yEFIS Women in Immunology: Interview with Professor Johanna Joyce
YouTube video by yEFIS
https://www.youtube.com/watch?v=4CRxH_kEUYk
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reposted by
Valentin Jaumouillé
Marine Biological Laboratory
11 months ago
A hybrid microscope born at the MBL allows scientists to, for the first time, simultaneously image the full 3D orientation and position of an ensemble of molecules.
@czbiohub.bsky.social
@hhmi.org
@hhmijanelia.bsky.social
@pnas.org
More:
www.mbl.edu/news/new-mic...
www.youtube.com/watch?v=-b3X...
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Polarized dual-view light sheet microscopy
YouTube video by Marine Biological Laboratory
https://www.youtube.com/watch?v=-b3XGpByzXw
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reposted by
Valentin Jaumouillé
Johanna Joyce
10 months ago
Revisiting 'Women in cancer research & oncology' 🧪⚕️ Thanks to Cancer Cell &
@montse-rojo.bsky.social
for this article from International Women's Day in 2021 It was great to be part of this perspective - and it all still applies in 2025 - here some thoughts on how much our microenvironment matters!
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reposted by
Valentin Jaumouillé
The Freeman Lab
11 months ago
We've been studying mechanisms of resilience that protect lysosomes from damage and wrote a review on the topic. We consider lysosomal stress and damage on a spectrum. Please help me share as this is my first post 😀 and I don't have many followers! 🙏 Open Access:
www.embopress.org/doi/full/10....
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reposted by
Valentin Jaumouillé
🍁 Bryan Heit, PhD 🍁
11 months ago
Everyone thinks that B cells make antibodies. And everyone is correct. BUT…B cells are also phagocytes! More on this interesting discovery can be found in our new preprint, which is a product of a collaborative research project led by my colleagues in the Kerfoot lab:
www.biorxiv.org/content/10.1...
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B cell subsets have different capacities for phagocytosis and subsequent presentation of antigen to cognate T cells
B cells have been shown to be phagocytic under some circumstances. However, the phagocytic capacity of different B cell subsets and how this is linked to Antigen (Ag) presentation or other functions h...
https://www.biorxiv.org/content/10.1101/2025.01.28.635276v1
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Valentin Jaumouillé
Meghan Morrissey
11 months ago
Wyatt Miller's thesis project is on bioRxiv! We describe the signaling cascade that allows the 'Don't Eat Me' signal CD47 to inhibit phagocytosis.
www.biorxiv.org/content/10.1...
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CD47 prevents Rac-mediated phagocytosis through Vav1 dephosphorylation
CD47 is expressed by viable cells to protect against phagocytosis. CD47 is recognized by SIRPα, an inhibitory receptor expressed by macrophages and other myeloid cells. Activated SIRPα recruits SHP-1 ...
https://www.biorxiv.org/content/10.1101/2025.02.11.637707v1
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Valentin Jaumouillé
🦋 Gourdon Lab 🦠🔬
12 months ago
🔔🧪 I'm deeply saddened by the passing of Michael Sheetz, a true pioneer in
#mechanobiology
. I'll always cherish our lovely times in NYC, Singapore, Zurich, and Sydney. My heartfelt condolences to his family and friends in this difficult time. So long, Mike 🥺😔
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reposted by
Valentin Jaumouillé
Natalie Thiex
about 1 year ago
go.bsky.app/JDAwbAJ
Trying again with the actual link this time. Please tag yourself or others who study macropinocytosis, phagocytosis or efferocytosis, and I’ll add you to the pack!
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