How do cells convert mechanical information into a molecular process? The @alushinlab.bsky.social has captured the first snapshot of a mechanical signaling complex in action, findings in @nature.com that have implications for disorders related to myosin dysfunction. 🔗: https://bit.ly/41Kshjw

Exciting to see this out in its final form! Wonderful work led by @probablycarmen.bsky.social. Want to know why protrusions are better at initiating immune signaling in #Tcells? Look no further. Link to Carmen’s 🧵 on the preprint bsky.app/profile/prob...

Two papers on important roles of the Arp2/3 complex in microglia in the CNS microenvironment by the labs of Jeremy Rotty and Tim Lämmermann @laemmermann-lab.bsky.social @mpi-ie.bsky.social and ZMBE @uni-muenster.de. Read more: link.springer.com/article/10.1... link.springer.com/article/10.1...

$2.45 billion NIH grant cuts and ~2300 terminated active research grants were DOGE'd in early 2025 Who were most affected? www.pnas.org/doi/full/10.... Early career and women researchers

Podosomes in phagocytosis! 😋 + Candida auris Our new paper "Phagocytic podosomes enable efficient uptake of Candida auris by primary human macrophages" has now been published in Cell Reports: pubmed.ncbi.nlm.nih.gov/41863801/

CIHR funding rate: 13.6%. Early 2000s: 30%+. Canada’s new $1.7B Impact+ program recruits talent — but without increased Tri-Council base funding, we risk further strain on an already stretched system. We’re calling for $1B over 5 years. Support here: tinyurl.com/33c5av46

#ProtistsOnSky no 'swimming' by 𝘝𝘢𝘮𝘱𝘺𝘳𝘦𝘭𝘭𝘢, definitively no 'staying still'. just a relaxed walk towards the lunch...

Have you ever heard that women have more chances than men of getting grants or positions in academia? Of course you have, and here are my personal views on this. With the shocking revelation that no, it is NOT TRUE ! (1/n)

Shout out to my post-doc adviser. An exceptional scientist, indeed.

@mmorrissey.bsky.social's lab is on 🔥

Another awesome paper from @mmorrissey.bsky.social lab!

We look forward to hearing feedback from the community on our #preprint where we used #NETosis as a platform to show that chromatin decompaction inside the nucleus directly regulates cell mechanics. This work identifies long-range biophysical impacts of chromatin in mammalian cells.

Really excited about this! Lucy Shapiro pioneered research on the cell biology of bacteria and was a huge inspiration for my PhD project.

Our paper on podosome regulation by myosins 1e/f is now online. We introduce the concept of the podosome base, a region of plasma membrane-associated components 🔬 Cool collaboration with @renaudpoincloux.bsky.social‬ and Krendel labs www.sciencedirect.com/science/arti...

If you're interested in biophysics in the context of infection and immunity, we're looking forward to seeing you at the ASCB/EMBO meeting.

Why would anyone want to be a scientist? Check out our new Essay from Martin Schwartz: journals.biologists.com/jcs/article/...

Comment on our @Reproducibility project in @Drosophila immunity. It is a normal that findings—however exciting and important at the time—may later prove to be more complex than initially believed. Re-evaluations is essential to the self-correcting nature of science. www.science.org/content/arti...

Congratulations to #SFU Molecular Biology and Biochemistry distinguished professor Fiona Brinkman who has received a @genomebc.bsky.social Award for Scientific Excellence from Life Sciences BC! www.sfu.ca/science/news...

SFU invites applications from world renowned researchers for the prestigious Canada Excellence Research Chairs (CERC) 2026 Competition. Please see the ad to see if you qualify. In Vancouver, BC www.sfu.ca/vpacademic/a...

Latest from @ivaskalab.bsky.social @jrwconway.bsky.social in NCB. We find that SHP-2 inhibition stops TNBC invasion and limits metastasis by blocking integrin dephosphorylation! Read more at: www.nature.com/articles/s41...

Somehow, I only started to realize this while I became a faculty member. Although, I wonder whether having a better awareness of these challenges would have been discouraging.

Excited to share our discovery www.science.org/doi/10.1126/... that the #centrosome is prone to breakage! Using #motile cells, we identify centrosome breakage during #pathfinding, caused by #actin #forces, & prevented by #Dyrk3 Kudos to 1st author Madeleine & thanks to all collaborators! (1/6)

It used to be thought that T-cell priming occurred as single phase. Now we know it takes two. www.science.org/doi/10.1126/... @science.org

We're disappointed to see Ben Barres's powerful book "The Autobiography of a Transgender Scientist" among the ~400 titles removed from the Naval Academy Library. Needless to say, we're proud to have published his book and will keep it — and his memory — alive.

I knew there would be an effect! This has been one of the questions that I had for the longest time. Changing the mechanics of the substrate affects phagocytosis. Very interesting paper! www.cell.com/iscience/ful...

Excited to share our latest work on how Ca²⁺ regulates actin in cell protrusions—now available as a preprint on bioRxiv! 🎉 Huge congrats to Ernest Iu for leading the project, and a special thanks to our amazing collaborators! www.biorxiv.org/content/10.1...

Our latest publication on #macrophages congrats Anna Mularski and @manondepierre.bsky.social @institutcochin.bsky.social @actin-paris-saclay.bsky.social Martial Balland @grenoblealpes.bsky.social @cnrsbiologie.bsky.social cnrs physique @anr

Wu et al @sickkidsto.bsky.social show that Snx10 regulates PI(3,5)P2 accumulation on #lysosomes by controlling PI(3)P delivery. Deleting Snx10 inhibits ClC-7, thereby impairing (phago)lysosome resolution. This mechanism may account for Snx10-related #osteopetrosis. rupress.org/jcb/article/...

In Memoriam: Wolfenson, Giannone, and Schwartz recall the life and many contributions of Michael Sheetz, who passed away on January 30, 2025. rupress.org/jcb/article/...

On this day in 1879, Maud Menten was born in Port Lambton, Ontario. In her work as a medical researcher, she became a leading expert in histochemistry and enzyme kinetics while fighting against sexism in her field. Let's learn more about her life! 🧵1/10

Many thanks to the young immunologists of @yefis-immunology.bsky.social for this interview as part of their #WomeninSTEM 🧪 series! Really enjoyed discussing ways to improve #gender #equality and all forms of #inclusion & #diversity - esp. important now 🙏 Interview 🎥 www.youtube.com/watch?v=4CRx...

A hybrid microscope born at the MBL allows scientists to, for the first time, simultaneously image the full 3D orientation and position of an ensemble of molecules. @czbiohub.bsky.social @hhmi.org @hhmijanelia.bsky.social @pnas.org More: www.mbl.edu/news/new-mic... www.youtube.com/watch?v=-b3X...

Revisiting 'Women in cancer research & oncology' 🧪⚕️ Thanks to Cancer Cell & @montse-rojo.bsky.social for this article from International Women's Day in 2021 It was great to be part of this perspective - and it all still applies in 2025 - here some thoughts on how much our microenvironment matters!

We've been studying mechanisms of resilience that protect lysosomes from damage and wrote a review on the topic. We consider lysosomal stress and damage on a spectrum. Please help me share as this is my first post 😀 and I don't have many followers! 🙏 Open Access: www.embopress.org/doi/full/10....

Everyone thinks that B cells make antibodies. And everyone is correct. BUT…B cells are also phagocytes! More on this interesting discovery can be found in our new preprint, which is a product of a collaborative research project led by my colleagues in the Kerfoot lab: www.biorxiv.org/content/10.1...

Wyatt Miller's thesis project is on bioRxiv! We describe the signaling cascade that allows the 'Don't Eat Me' signal CD47 to inhibit phagocytosis. www.biorxiv.org/content/10.1...

🔔🧪 I'm deeply saddened by the passing of Michael Sheetz, a true pioneer in #mechanobiology. I'll always cherish our lovely times in NYC, Singapore, Zurich, and Sydney. My heartfelt condolences to his family and friends in this difficult time. So long, Mike 🥺😔

go.bsky.app/JDAwbAJ Trying again with the actual link this time. Please tag yourself or others who study macropinocytosis, phagocytosis or efferocytosis, and I’ll add you to the pack!