Yutong Zhang
@zyt0329.bsky.social
📤 154
📥 228
📝 40
Incoming Postdoc at UT Southwestern Medical Center A chemistry student trying to understand Biology
pinned post!
Beyond thrilled to share my PhD work out today in
@natcellbio.nature.com
, uncovering a nanoscale acidic environment around lysosomes that controls their mobility through proton signaling.🥳🥳🥳 Great thanks to my advisors and excellent peers for helping me!
www.nature.com/articles/s41...
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DNA nanodevices detect an acidic nanolayer on the lysosomal surface - Nature Cell Biology
Tan and colleagues develop DNA nanodevices to detect the pH of the lysosomal outer surface, observing an acidic layer generated by TMEM175 that regulates lysosome positioning in response to changes in...
https://www.nature.com/articles/s41556-025-01855-y
3 months ago
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reposted by
Yutong Zhang
Peking University
1 day ago
Professor Chen Peng from
#PekingUniversity
has been named the 2026 recipient of the Emil Thomas Kaiser Award by The Protein Society — becoming the first scholar from an Asian institution to receive this honor.
#TheProteinSociety
#PKUScholars
#ChemicalBiology
@proteinsociety.bsky.social
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reposted by
Yutong Zhang
MRC Laboratory of Molecular Biology
2 days ago
The LMB Rising Talent Fellowship is open for new applicants! Aimed at Black heritage scientists, the Fellowship offers a 3-year postdoctoral position beginning Oct-Dec 2026. Visit our website for more info:
mrclmb.ac.uk/careers-and-...
Please circulate this post to anyone who might be interested!
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great!
add a skeleton here at some point
10 days ago
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reposted by
Yutong Zhang
Nature Reviews Molecular Cell Biology
27 days ago
ICYMI: New Online! Technologies to measure and modulate protein subcellular localization
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Technologies to measure and modulate protein subcellular localization
Nature Reviews Molecular Cell Biology, Published online: 19 March 2026; doi:10.1038/s41580-026-00957-1Subcellular localization is important for protein function. This Review discusses advances in spatial subcellular proteomics, assesses the strengths and weaknesses of technologies that measure and control protein localization, and considers their potential uses in cell biology and medicine.
http://dlvr.it/TRdhnm
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Yutong Zhang
Stella Hurtley
about 1 month ago
Join Matthew Vander Heiden (MIT), Sarah-Maria Fendt (VIB), Ralph J. DeBerardinis (UTSW), and me (Deputy Editor
@science.org
) online Wed March 18 to hear about the influence of metabolism on cancer progression. Free registration below.
lifesciences.westlake.edu.cn/media/events...
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Rethinking Cancer Metabolism - Westlake x Science\/AAAS Joint Online Symposium #01 (2026)
Altered metabolism is a hallmark of cancer: malignant cells re-engineer nutrient acquisition and utilization to fuel unchecked growth and survival. Beyond functioning as a simple energy powerhouse, metabolic rewiring reshapes virtually every layer of cell regulation, from chromatin architecture a...
https://lifesciences.westlake.edu.cn/media/events/20260318/rethinking-cancer-metabolism-2026-symposium-01.html
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Coooool!
add a skeleton here at some point
about 2 months ago
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reposted by
Yutong Zhang
Nature Chemical Biology
about 2 months ago
Mast cell extracellular granules are found to be condensates formed through sugar-metabolite interactions with elevated pH and higher metal concentration that enrich and enhance the activity of immune modulators, such as cytokines and proteases
www.nature.com/articles/s41...
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Mast cell extracellular granules are bioactive condensates assembled by heparin and polyamine - Nature Chemical Biology
Mast cells are immune cells that release membraneless mast cell extracellular granules (MCEGs) in response to allergic inflammation and pathogen infection. MCEGs are found to be condensates formed thr...
https://www.nature.com/articles/s41589-026-02165-6?utm_source=bluesky&utm_medium=social&utm_campaign=nchembio
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Yutong Zhang
Carolyn Bertozzi
about 2 months ago
Congratulations to new Sloan Fellow
@grant.rotskoff.cc
@stanfordchemistry.bsky.social
!!
sloan.org/fellowships/...
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2026 Fellows | Alfred P. Sloan Foundation
Our mission is to make the world a better place through the advancement of scientific knowledge.
https://sloan.org/fellowships/2026-Fellows
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Happy Chinese New Year!🐴 A horse year 2026!
2 months ago
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add a skeleton here at some point
2 months ago
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Excellent work!
add a skeleton here at some point
2 months ago
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reposted by
Yutong Zhang
MRC Laboratory of Molecular Biology
2 months ago
How did life arise from simple chemical building blocks? New
#LMBResearch
led by
@edogia.bsky.social
in
@philholliger.bsky.social
group has identified a small self-replicating ribozyme that could be the answer. Read more:
mrclmb.ac.uk/news-events/...
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Thank you for highlighting our work with very visionary perspectives!
@mstagi.bsky.social
@natcellbio.nature.com
Decoding the proton veil around lysosomes
www.nature.com/articles/s41...
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Decoding the proton veil around lysosomes - Nature Cell Biology
A newly discovered acidic nanolayer that envelopes lysosomes reveals that proton gradients extend beyond the organelle lumen, identifying a nanoscale regulatory interface that links luminal pH, TMEM17...
https://www.nature.com/articles/s41556-025-01869-6
3 months ago
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reposted by
Yutong Zhang
Cell Biology J-Club
3 months ago
www.nature.com/articles/s41...
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DNA nanodevices detect an acidic nanolayer on the lysosomal surface - Nature Cell Biology
Tan and colleagues develop DNA nanodevices to detect the pH of the lysosomal outer surface, observing an acidic layer generated by TMEM175 that regulates lysosome positioning in response to changes in...
https://www.nature.com/articles/s41556-025-01855-y
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reposted by
Yutong Zhang
RSC Chemical Biology
3 months ago
📢 #RSCChemBio is sponsoring two poster prizes at the EMBO-EMBL Chemical Biology Workshop 2026! 📅 8 - 11th September 2026 📍 EMBL Heidelberg, Germany 🔗
www.embl.org/about/i...
Submit your abstract by 2nd June 2026 to a part of the event!
EMBO
#RSCChemBio
#ChemicalBiology
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Beyond thrilled to share my PhD work out today in
@natcellbio.nature.com
, uncovering a nanoscale acidic environment around lysosomes that controls their mobility through proton signaling.🥳🥳🥳 Great thanks to my advisors and excellent peers for helping me!
www.nature.com/articles/s41...
loading . . .
DNA nanodevices detect an acidic nanolayer on the lysosomal surface - Nature Cell Biology
Tan and colleagues develop DNA nanodevices to detect the pH of the lysosomal outer surface, observing an acidic layer generated by TMEM175 that regulates lysosome positioning in response to changes in...
https://www.nature.com/articles/s41556-025-01855-y
3 months ago
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Congrats to my advisor Weihong and team!
doi.org/10.1126/scie...
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SPARK-seq: A high-throughput platform for aptamer discovery and kinetic profiling
Cell surface proteins are key disease biomarkers and therapeutic targets, yet high-throughput methods for aptamer discovery targeting these proteins in situ remain limited. We introduce single-cell pe...
https://doi.org/10.1126/science.adv6127
4 months ago
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Cheers!Finally get my doctoral diploma and become Dr.Zhang🥳🥳 Look forward!
4 months ago
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reposted by
Yutong Zhang
Nature Reviews Bioengineering
6 months ago
ICYMI: Molecular bioengineering of functional nucleic acids
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Molecular bioengineering of functional nucleic acids
Nature Reviews Bioengineering, Published online: 17 October 2025; doi:10.1038/s44222-025-00361-yFunctional nucleic acids (FNAs) achieve specific target recognition, molecular binding and catalytic activity by folding into defined secondary and tertiary structures. This Review focuses on two major classes of FNAs — aptamers and DNAzymes — and discusses their structural features, production strategies and engineering approaches as well as their clinical applications in diagnostics, targeted therapy and precision medicine.
https://www.nature.com/articles/s44222-025-00361-y?utm_source=bluesky&utm_medium=social&utm_campaign=natrevbioeng
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First time to make an offline flash talk to present my PhD work🤩🤓 Really good opportunity😍
6 months ago
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Glad to share my work and to receive first prize award of poster !🤩🤩🤩
6 months ago
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reposted by
Yutong Zhang
Nature
6 months ago
These intriguing materials - the world's most porous sponges - won today's Nobel Prize in Chemistry
go.nature.com/3VVjXug
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World’s most porous sponges: intricate carbon-trapping powders hit the market
Metal-organic frameworks were the next big thing in chemistry when they were invented more than three decades ago. Now, these intriguing materials are becoming commercial tools for capturing carbon dioxide and harvesting water from the air.
https://go.nature.com/3VVjXug
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reposted by
Yutong Zhang
Nature
7 months ago
Being named as a Nobel laureate is the ultimate prize for many scientists, but how do other science prizes compare?
go.nature.com/4nvVk3p
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These science prizes want to rival the Nobels: how do they compare?
Nature - Being named as a Nobel laureate is the ultimate prize for many scientists, but how do other science prizes compare?
https://go.nature.com/4nvVk3p
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Congrats to Yuting and Prof.Qiu! I'm glad to participate in this nice work as well🤩
add a skeleton here at some point
7 months ago
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reposted by
Yutong Zhang
Peking University
8 months ago
2022 Nobel Prize winner in Chemistry,
#Stanford
Prof. Carolyn Bertozzi, delivered an inspiring lecture on
#BioorthogonalChemistry
at
#PekingUniversity
on Aug. 28.
@stanford.edu
@carolynbertozzi.bskyverified.social
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Have same lysosome slide with
@carolynbertozzi.bskyverified.social
happy to chat with you my work as a chemistry student doing cell biology🤩🤩🤩
8 months ago
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reposted by
Yutong Zhang
André Nadler
8 months ago
Out today in
@nature.com
: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...
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reposted by
Yutong Zhang
Carolyn Bertozzi
8 months ago
Another piece of the
#glycoRNA
puzzle revealed by
@raflynn5.bsky.social
and
@vijayrathinam.bsky.social
!! RNAs with modified base acp3U activate TLR3/7, but not when acp3U is N-glycosylated. This is how cell surface/secreted glycoRNAs avoid stimulating autoimmunity.
www.nature.com/articles/s41...
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RNA N-glycosylation enables immune evasion and homeostatic efferocytosis - Nature
N-glycans on glycoRNAs prevent innate immune sensing of endogenous small RNAs, and the natural mechanism they use demonstrates how glycoRNAs exist on the cell surface and in the endosomal network with...
https://www.nature.com/articles/s41586-025-09310-6
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reposted by
Yutong Zhang
Nature Reviews Molecular Cell Biology
9 months ago
New Online! Lysosomal membrane homeostasis and its importance in physiology and disease
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Lysosomal membrane homeostasis and its importance in physiology and disease
Nature Reviews Molecular Cell Biology, Published online: 04 August 2025; doi:10.1038/s41580-025-00873-wLysosomes degrade cellular components, and their membrane is an important signalling hub. Recent insights into the mechanisms that maintain lysosomal membrane homeostasis — including the interplay between membrane damage, repair, lysophagy and lysosome biogenesis — highlight their importance in physiology, in disease and during ageing.
https://bit.ly/41q21uT
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reposted by
Yutong Zhang
Nature
9 months ago
Scientists have mapped individual sugar molecules on the surface of cells at a resolution once thought to be impossible for light microscopes
go.nature.com/40I9Ewv
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Cell's sugar coating mapped at below-nanometre resolution
Nature - Super-resolution technique works with off-the-shelf optical microscopes.
https://go.nature.com/40I9Ewv
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reposted by
Yutong Zhang
Nature
9 months ago
Scientists have mapped individual sugar molecules on the surface of cells at a resolution once thought to be impossible for light microscopes
go.nature.com/4l2wVjS
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Cell's sugar coating mapped at below-nanometre resolution
Super-resolution technique works with off-the-shelf optical microscopes.
https://go.nature.com/4l2wVjS
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reposted by
Yutong Zhang
JungmannLab
9 months ago
Ever wondered what happens when therapeutic antibodies bind to cancer cells? In our latest study, we used multiplexed 3D-RESI to directly visualize how anti-CD20 antibodies interact with their receptors, revealing their precise arrangement at single-protein resolution. (1/6)
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Yutong Zhang
Nature Nanotechnology
9 months ago
New paper online: Ångström-resolution imaging of cell-surface glycans. The molecular organization of sugars in the native
#glycocalyx
has been resolved at 9 ångström using bioorthogonal metabolic labeling and
#superresolution
imaging of DNA barcodes.
#Glycotime
www.nature.com/articles/s41...
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Ångström-resolution imaging of cell-surface glycans - Nature Nanotechnology
By combining bioorthogonal metabolic labelling and resolution enhancement through sequential imaging of DNA barcodes, the molecular organization of individual sugars in the native glycocalyx has been ...
https://www.nature.com/articles/s41565-025-01966-5?utm_source=bluesky&utm_medium=social&utm_campaign=nnano
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reposted by
Yutong Zhang
Xu Zhou lab @ BCH & HMS
9 months ago
Beyond excited to share our
#NewPaper
in
@cellcellpress.bsky.social
! Inflamed environments acidify intracellular
#pH
. BRD4 senses this via transcriptional condensates, tuning
#macrophage
responses to match demand and consequences of
#inflammation
authors.elsevier.com/sd/article/S...
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Summer🍻
10 months ago
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reposted by
Yutong Zhang
Sarafan ChEM-H
10 months ago
#ICYMI
This year's Chemistry/Biology Interface (CBI) Retreat showcased cutting-edge research of graduate students who take a molecular approach to advance human health & featured a keynote lecture + fireside chat with Prof. Paula Hammond @mitcheme.bsky.social :
chemh.stanford.edu/news/annual-...
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reposted by
Yutong Zhang
Max Planck Institute for Medical Research
10 months ago
📣Paper alert! Interested in faster and brighter protein labeling than before? 👀
@steffi-k.bsky.social
& other colleagues have developed an improved tool for labeling proteins with synthetic fluorophores for bioimaging. Also works in STED microscopy 🤩🔬 Congratulations!🥳
www.nature.com/articles/s41...
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SNAP-tag2 for faster and brighter protein labeling - Nature Chemical Biology
SNAP-tag is a widespread tool for labeling protein for bioimaging. Now, Kühn et al. report SNAP-tag2 with increased labeling kinetics and brightness, which translates into a better performance in live...
https://www.nature.com/articles/s41589-025-01942-z
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Yutong Zhang
Stephan Hacker
10 months ago
Started a gallery of our past (and future)
@led3hub.bsky.social
Lectures and Virtual
@chembiotalks.bsky.social
. Thanks so much to all the speakers, organizers, attendees and institutes for making this possible!
www.universiteitleiden.nl/en/science/l...
www.universiteitleiden.nl/en/science/l...
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reposted by
Yutong Zhang
C&EN (Chemical & Engineering News)
11 months ago
Chemists Stuart Schreiber of Harvard University and Arena BioWorks and Peter Schultz of
@scripps.edu
will split the 2025 Welch Award in Chemistry for their work in the field of chemical biology.
cen.acs.org/people/award...
#chemsky🧪
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2025 Welch Award honors chemical biologists
Recipients Schreiber and Schultz will each receive $500K prize for work on chemical probes, unnatural amino acids, and new therapeutics
https://cen.acs.org/people/awards/2025-Welch-Award-honors-chemical/103/web/2025/05?sc=250522_sc_eng_blue_cen
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reposted by
Yutong Zhang
Ed Boyden
11 months ago
Down to my last few post-it notes, that my group members made for me in 2014, after I got tenure at MIT. Each post-it note contains something that I said often enough, that my group members thought it would save me time, to simply hand out a post-it note, whenever the wisdom was needed :)
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Summer jogging with ice americano☕
11 months ago
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Yutong Zhang
Carolyn Bertozzi
11 months ago
More insights into
#glycoRNA
, this time found within exosomes!
www.nature.com/articles/s41...
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Extracellular exosomal RNAs are glyco-modified - Nature Cell Biology
Sharma, Jiao and colleagues report glycosylation of small RNAs within exosomes and propose a glycosylation-dependent mechanism for RNA targeting into exosomes, which may influence intercellular commun...
https://www.nature.com/articles/s41556-025-01682-1
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Yutong Zhang
Ed Boyden
11 months ago
Just posted, “Engineering Serendipity,” a lightly edited (to accommodate the transition from spoken to written form) version of the commencement speech I gave at my high school, the Texas Academy of Mathematics and Science, May 8, 2025:
engineeringx.substack.com/p/engineerin...
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Engineering Serendipity
Three Short Stories About How to Increase Luck Through Skill
https://engineeringx.substack.com/p/engineering-serendipity
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From a little PhD to a little Dr.Zhang! Great thanks to my advisors🥰
11 months ago
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Yutong Zhang
Dr. Jean Fan
12 months ago
Are you interested in learning about the intersection of
#AI
and molecular
#biology
? Come to our
@keystonesymposia.bsky.social
this September in beautiful Santa Fe!
keysym.us/KSAIBio26
#KSAIBio26
Scholarship + short talk deadline May 20 so apply soon! Look forward to seeing you there!
#AcademicSky
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🌇🍻
12 months ago
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reposted by
Yutong Zhang
Carolyn Bertozzi
12 months ago
Check it out - amazing new work by
@raflynn5.bsky.social
and Kostas Tzelepis labs, discovery of a cell surface RNA/glycoRNA binding protein that is also a cancer antigen, new target for antibody therapy!
www.nature.com/articles/s41...
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Treatment of acute myeloid leukemia models by targeting a cell surface RNA-binding protein - Nature Biotechnology
An RNA-binding protein on leukemia cells provides an effective target in mouse models.
https://www.nature.com/articles/s41587-025-02648-2
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Finally submit my Ph.D thesis-Hope to be Dr.Zhang this summer!🥰🥰🥰
12 months ago
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Yutong Zhang
cryoEM papers
about 1 year ago
Structure and dynamics of a multidomain ligand-gated ion channel revealed under acidic conditions
www.biorxiv.org/content/10.1101/2025.02.27.640520v1
#cryoem
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reposted by
Yutong Zhang
Nature Reviews Chemistry
about 1 year ago
Ahead of his 60th birthday on the weekend, we spoke to Omar Yaghi about his life in science so far and where he believes is the exciting space for future developments.
www.nature.com/articles/s41...
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The man of MOFs and more - Nature Reviews Chemistry
Ahead of his 60th birthday, Omar Yaghi discussed his life in science so far and where he believes is the exciting space for future developments.
https://www.nature.com/articles/s41570-025-00691-w
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