Researchers pioneer method to rapidly design proteins Their strategy revealed new details that open the door to designing proteins with powerful abilities that could ultimately benefit medicine and manufacturing.

Dallas life-2 week's already ！

I am so grateful for this honor - grateful to my mentors, lab, and family. Thank you @seanjmorrison.bsky.social for your support. And how great to be elected with some very good friends and two awesome UTSW colleagues, Elizabeth Chen and Joel Elmquist. Feeling very fortunate today.

What's better than one #HHMIInvestigator being elected to the @nasonline.org? Ten! Meet the newest members, recognized by their peers for distinguished, ongoing contributions to original research: bit.ly/4cCxRuv.

The LMB Rising Talent Fellowship is open for new applicants! Aimed at Black heritage scientists, the Fellowship offers a 3-year postdoctoral position beginning Oct-Dec 2026. Visit our website for more info: mrclmb.ac.uk/careers-and-... Please circulate this post to anyone who might be interested!

great!

ICYMI: New Online! Technologies to measure and modulate protein subcellular localization

Join Matthew Vander Heiden (MIT), Sarah-Maria Fendt (VIB), Ralph J. DeBerardinis (UTSW), and me (Deputy Editor @science.org) online Wed March 18 to hear about the influence of metabolism on cancer progression. Free registration below. lifesciences.westlake.edu.cn/media/events...

Coooool！

Mast cell extracellular granules are found to be condensates formed through sugar-metabolite interactions with elevated pH and higher metal concentration that enrich and enhance the activity of immune modulators, such as cytokines and proteases www.nature.com/articles/s41...

Congratulations to new Sloan Fellow @grant.rotskoff.cc @stanfordchemistry.bsky.social !! sloan.org/fellowships/...

Happy Chinese New Year！🐴 A horse year 2026！

Excellent work！

How did life arise from simple chemical building blocks? New #LMBResearch led by @edogia.bsky.social in @philholliger.bsky.social group has identified a small self-replicating ribozyme that could be the answer. Read more: mrclmb.ac.uk/news-events/...

Thank you for highlighting our work with very visionary perspectives! @mstagi.bsky.social @natcellbio.nature.com Decoding the proton veil around lysosomes www.nature.com/articles/s41...

📢 #RSCChemBio is sponsoring two poster prizes at the EMBO-EMBL Chemical Biology Workshop 2026! 📅 8 - 11th September 2026 📍 EMBL Heidelberg, Germany 🔗 www.embl.org/about/i... Submit your abstract by 2nd June 2026 to a part of the event! EMBO#RSCChemBio#ChemicalBiology

Beyond thrilled to share my PhD work out today in @natcellbio.nature.com , uncovering a nanoscale acidic environment around lysosomes that controls their mobility through proton signaling.🥳🥳🥳 Great thanks to my advisors and excellent peers for helping me！ www.nature.com/articles/s41...

Congrats to my advisor Weihong and team！ doi.org/10.1126/scie...

Cheers！Finally get my doctoral diploma and become Dr.Zhang🥳🥳 Look forward！

ICYMI: Molecular bioengineering of functional nucleic acids

First time to make an offline flash talk to present my PhD work🤩🤓 Really good opportunity😍

Glad to share my work and to receive first prize award of poster ！🤩🤩🤩

These intriguing materials - the world's most porous sponges - won today's Nobel Prize in Chemistry go.nature.com/3VVjXug

Being named as a Nobel laureate is the ultimate prize for many scientists, but how do other science prizes compare? go.nature.com/4nvVk3p

Congrats to Yuting and Prof.Qiu！ I'm glad to participate in this nice work as well🤩

2022 Nobel Prize winner in Chemistry, #Stanford Prof. Carolyn Bertozzi, delivered an inspiring lecture on #BioorthogonalChemistry at #PekingUniversity on Aug. 28. @stanford.edu @carolynbertozzi.bskyverified.social

Have same lysosome slide with @carolynbertozzi.bskyverified.social happy to chat with you my work as a chemistry student doing cell biology🤩🤩🤩

Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism. www.nature.com/articles/s41...

Another piece of the #glycoRNA puzzle revealed by @raflynn5.bsky.social and @vijayrathinam.bsky.social!! RNAs with modified base acp3U activate TLR3/7, but not when acp3U is N-glycosylated. This is how cell surface/secreted glycoRNAs avoid stimulating autoimmunity. www.nature.com/articles/s41...

New Online! Lysosomal membrane homeostasis and its importance in physiology and disease

Scientists have mapped individual sugar molecules on the surface of cells at a resolution once thought to be impossible for light microscopes go.nature.com/40I9Ewv

Scientists have mapped individual sugar molecules on the surface of cells at a resolution once thought to be impossible for light microscopes go.nature.com/4l2wVjS

Ever wondered what happens when therapeutic antibodies bind to cancer cells? In our latest study, we used multiplexed 3D-RESI to directly visualize how anti-CD20 antibodies interact with their receptors, revealing their precise arrangement at single-protein resolution. (1/6)

New paper online: Ångström-resolution imaging of cell-surface glycans. The molecular organization of sugars in the native #glycocalyx has been resolved at 9 ångström using bioorthogonal metabolic labeling and #superresolution imaging of DNA barcodes. #Glycotime www.nature.com/articles/s41...

Beyond excited to share our #NewPaper in @cellcellpress.bsky.social! Inflamed environments acidify intracellular #pH. BRD4 senses this via transcriptional condensates, tuning #macrophage responses to match demand and consequences of #inflammation authors.elsevier.com/sd/article/S...

Summer🍻

#ICYMI This year's Chemistry/Biology Interface (CBI) Retreat showcased cutting-edge research of graduate students who take a molecular approach to advance human health & featured a keynote lecture + fireside chat with Prof. Paula Hammond ‪@mitcheme.bsky.social‬ : chemh.stanford.edu/news/annual-...

📣Paper alert! Interested in faster and brighter protein labeling than before? 👀 @steffi-k.bsky.social & other colleagues have developed an improved tool for labeling proteins with synthetic fluorophores for bioimaging. Also works in STED microscopy 🤩🔬 Congratulations!🥳 www.nature.com/articles/s41...

Started a gallery of our past (and future) @led3hub.bsky.social Lectures and Virtual @chembiotalks.bsky.social. Thanks so much to all the speakers, organizers, attendees and institutes for making this possible! www.universiteitleiden.nl/en/science/l... www.universiteitleiden.nl/en/science/l...

Chemists Stuart Schreiber of Harvard University and Arena BioWorks and Peter Schultz of @scripps.edu will split the 2025 Welch Award in Chemistry for their work in the field of chemical biology. cen.acs.org/people/award... #chemsky🧪

Down to my last few post-it notes, that my group members made for me in 2014, after I got tenure at MIT. Each post-it note contains something that I said often enough, that my group members thought it would save me time, to simply hand out a post-it note, whenever the wisdom was needed :)

Summer jogging with ice americano☕

More insights into #glycoRNA, this time found within exosomes! www.nature.com/articles/s41...

Just posted, “Engineering Serendipity,” a lightly edited (to accommodate the transition from spoken to written form) version of the commencement speech I gave at my high school, the Texas Academy of Mathematics and Science, May 8, 2025: engineeringx.substack.com/p/engineerin...

From a little PhD to a little Dr.Zhang！ Great thanks to my advisors🥰

Are you interested in learning about the intersection of #AI and molecular #biology? Come to our @keystonesymposia.bsky.social this September in beautiful Santa Fe! keysym.us/KSAIBio26 #KSAIBio26 Scholarship + short talk deadline May 20 so apply soon! Look forward to seeing you there! #AcademicSky

🌇🍻

Check it out - amazing new work by @raflynn5.bsky.social and Kostas Tzelepis labs, discovery of a cell surface RNA/glycoRNA binding protein that is also a cancer antigen, new target for antibody therapy! www.nature.com/articles/s41...