An #NIH-funded research team has developed an mRNA vaccine to treat pancreatic cancer. Results from the clinical trial were published this week in Nature. #pancreas #cancer #mRNA #vaccine #medsky #science #medicine #bluesky

Time for some mito-business. Or should we say methyl-business?? Let's ask our speaker Thomas MacVicar. This thursday, usual time and place.

Our new study: www.science.org/doi/10.1126/.... It provides useful tools for studying LLOME lysosomal damage.

An important and beautiful structure of the native dystrophin glycoprotein complex!.

‘Dark proteome’ survey reveals thousands of new human genes | Science www.science.org/content/arti...

MITOtalks have not made it here (yet) but we are excited to host two fantastic trainee talks this week on MITOchats - Alia Edington from Friedman lab at UTSW and David Eberhardt from Chaudhuri at UUtah - visit www.mitotalks.org for more info and zoom link to join! #mitochondria please share!

Exciting new discovery from colleagues @stanfordmedicine.bsky.social, astrocyte metabolism compromised by amyloid and tau oligomers leading to insufficient support for neurons. Possible new target for treating AD. www.science.org/doi/10.1126/...

Beautiful imaging on the cover but also check out the beautiful imaging inside and our story on #endosomes and #GTPase cascades

We’re hiring tenure-track faculty focused on Systems & #ComputationalNeuroscience at the Friedman Brain Institute at Mount Sinai! We're starting to review applications so submit yours ASAP! 👇

In a move that surprised the scientific community, DeepMind released the source code and model weights for AlphaFold 3, its groundbreaking AI system for predicting molecular interactions. medcloudinsider.com/Articles/202... #ai #healthcaretech #medicaltech

Hullooooo Cell Biology friends. If you're heading to #CellBio2024 in (hopefully!) sunny San Diego this year, then come and check out our session on 'ER structure and function across cell types' Room28C- Dec18th 09:00am! See you there! **Please RT** 🥳

Phosphatidylethanolamine is a phagocytic ligand implicated in the binding and removal of microbial extracellular vesicles https://www.biorxiv.org/content/10.1101/2024.11.18.624161v1

Impact of #Ageing and Disuse on #Neuromuscular Junction and #Mitochondrial Function and Morphology: Current Evidence and Controversies www.sciencedirect.com/science/arti...

Fueling neurodegeneration: metabolic insights into microglia functions jneuroinflammation.biomedcentral.com/articles/10....

Here are some free/open-source sites for the preparation of scientific illustrations, including icon libraries: bioicons.com, scidraw.io, bioart.niaid.nih.gov, inkscape.org, biogdp.com, reactome.org/icon-lib

Thrilled to announce Boltz-1, the first open-source and commercially available model to achieve AlphaFold3-level accuracy on biomolecular structure prediction! An exciting collaboration with Jeremy, Saro, and an amazing team at MIT and Genesis Therapeutics. A thread!

Evidence for heterogeneity in endosomal-origin organelles and their positions from @melikel.bsky.social No significant differences in the distance of the subpopulations from the nucleus. NPC1-positive late endosomes/lysosomes can be closely positioned to mitochondria doi.org/10.1083/jcb....

Hello, world! Looking forward to connecting with new and old friends.

Proud of new work tinyurl.com/yhz4c6ry from the lab by Zhicheng (Chen) Cui using single-particle cryo-EM on liposomes to show how mTORC1 integrates nutrient and growth factor signaling at lysosomes, collab. w/ G. Napolitano,A. Esposito, and A. Ballabio.

This #fluorescencefriday I am gonna introduce some work from the lab :) We identified a new GTPase cascades that we believe drives cargo flow along post-Golgi pathways! Compartments positive for ARF1 shed ARF1 (green) to acquire Rab11 (magenta) to become recycling endosomes. Can you spot an event?