Massimiliano Stagi
@mstagi.bsky.social
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📥 157
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Scientist 🧬 | Microscopy Enthusiast 🔬 pcwww.liv.ac.uk/~maxstagi/
pinned post!
Hello, world! Looking forward to connecting with new and old friends.
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over 1 year ago
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Blue Wave 🌊 2026•2028🗽
about 1 year ago
An
#NIH-funded
research team has developed an mRNA vaccine to treat pancreatic cancer. Results from the clinical trial were published this week in Nature.
#pancreas
#cancer
#mRNA
#vaccine
#medsky
#science
#medicine
#bluesky
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In Early-Phase Pancreatic Cancer Clinical Trial, Investigational mRNA Vaccine Induces Sustained Immune Activity in Small Patient Group
Learn how MSK researchers are deploying mRNA vaccines against pancreatic cancer.
https://www.mskcc.org/news/can-mrna-vaccines-fight-pancreatic-cancer-msk-clinical-researchers-are-trying-find-out
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about 1 year ago
Time for some mito-business. Or should we say methyl-business?? Let's ask our speaker Thomas MacVicar. This thursday, usual time and place.
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Our new study:
www.science.org/doi/10.1126/...
. It provides useful tools for studying LLOME lysosomal damage.
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RpH-ILV: Probe for lysosomal pH and acute LLOMe-induced membrane permeabilization in cell lines and Drosophila
The ratiometric lysosomal probe RpH-ILV enables improved pH tracking and reveals lysosomal dynamics and susceptibility to damage.
https://www.science.org/doi/10.1126/sciadv.adr7325
about 1 year ago
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Brett Collins
about 1 year ago
An important and beautiful structure of the native dystrophin glycoprotein complex!.
add a skeleton here at some point
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Chris Stringer
about 1 year ago
‘Dark proteome’ survey reveals thousands of new human genes | Science
www.science.org/content/arti...
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‘Dark proteome’ survey reveals thousands of new human genes
Database confirms that overlooked segments of the genome code for a multitude of tiny proteins
https://www.science.org/content/article/dark-proteome-survey-reveals-thousands-new-human-genes?utm_source=sfmc&utm_medium=email&utm_content=alert&utm_campaign=WeeklyLatestNews&et_rid=34814771&et_cid=5447239
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Ewa Bomba-Warczak
over 1 year ago
MITOtalks have not made it here (yet) but we are excited to host two fantastic trainee talks this week on MITOchats - Alia Edington from Friedman lab at UTSW and David Eberhardt from Chaudhuri at UUtah - visit
www.mitotalks.org
for more info and zoom link to join!
#mitochondria
please share!
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Carolyn Bertozzi
about 1 year ago
Exciting new discovery from colleagues
@stanfordmedicine.bsky.social
, astrocyte metabolism compromised by amyloid and tau oligomers leading to insufficient support for neurons. Possible new target for treating AD.
www.science.org/doi/10.1126/...
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Restoring hippocampal glucose metabolism rescues cognition across Alzheimer’s disease pathologies
Impaired cerebral glucose metabolism is a pathologic feature of Alzheimer’s disease (AD), with recent proteomic studies highlighting disrupted glial metabolism in AD. We report that inhibition of indo...
https://www.science.org/doi/10.1126/science.abm6131
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Fran Bottanelli
over 1 year ago
Beautiful imaging on the cover but also check out the beautiful imaging inside and our story on
#endosomes
and
#GTPase
cascades
add a skeleton here at some point
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Denise J. Cai, Ph.D.
over 1 year ago
We’re hiring tenure-track faculty focused on Systems &
#ComputationalNeuroscience
at the Friedman Brain Institute at Mount Sinai! We're starting to review applications so submit yours ASAP! 👇
add a skeleton here at some point
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MedCloudInsider
over 1 year ago
In a move that surprised the scientific community, DeepMind released the source code and model weights for AlphaFold 3, its groundbreaking AI system for predicting molecular interactions.
medcloudinsider.com/Articles/202...
#ai
#healthcaretech
#medicaltech
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DeepMind Releases AlphaFold 3 Code and Weights -- MedCloudInsider
In a move that surprised the scientific community, DeepMind, a division of Google parent company Alphabet focused on developing general-purpose artificial intelligence technology, has released the sou...
https://medcloudinsider.com/Articles/2024/11/18/DeepMind-Releases-AlphaFold-3-Code-and-Weights.aspx
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Jonny Nixon-Abell
over 1 year ago
Hullooooo Cell Biology friends. If you're heading to
#CellBio2024
in (hopefully!) sunny San Diego this year, then come and check out our session on 'ER structure and function across cell types' Room28C- Dec18th 09:00am! See you there! **Please RT** 🥳
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bioRxivpreprint
over 1 year ago
Phosphatidylethanolamine is a phagocytic ligand implicated in the binding and removal of microbial extracellular vesicles https://www.biorxiv.org/content/10.1101/2024.11.18.624161v1
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Phosphatidylethanolamine is a phagocytic ligand implicated in the binding and removal of microbial extracellular vesicles https://www.biorxiv.org/content/10.1101/2024.11.18.624161v1
The efficient recognition and removal of apoptotic cells by phagocytes is critical to prevent second
https://www.biorxiv.org/content/10.1101/2024.11.18.624161v1
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htw
over 1 year ago
Impact of
#Ageing
and Disuse on
#Neuromuscular
Junction and
#Mitochondrial
Function and Morphology: Current Evidence and Controversies
www.sciencedirect.com/science/arti...
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htw
over 1 year ago
Fueling neurodegeneration: metabolic insights into microglia functions
jneuroinflammation.biomedcentral.com/articles/10....
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Juan S. Bonifacino
over 1 year ago
Here are some free/open-source sites for the preparation of scientific illustrations, including icon libraries:
bioicons.com
,
scidraw.io
,
bioart.niaid.nih.gov
,
inkscape.org
,
biogdp.com
,
reactome.org/icon-lib
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Gabriele Corso
over 1 year ago
Thrilled to announce Boltz-1, the first open-source and commercially available model to achieve AlphaFold3-level accuracy on biomolecular structure prediction! An exciting collaboration with Jeremy, Saro, and an amazing team at MIT and Genesis Therapeutics. A thread!
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Sandhya Koushika
over 1 year ago
Evidence for heterogeneity in endosomal-origin organelles and their positions from
@melikel.bsky.social
No significant differences in the distance of the subpopulations from the nucleus. NPC1-positive late endosomes/lysosomes can be closely positioned to mitochondria
doi.org/10.1083/jcb....
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Hello, world! Looking forward to connecting with new and old friends.
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over 1 year ago
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Jim Hurley
over 1 year ago
Proud of new work
tinyurl.com/yhz4c6ry
from the lab by Zhicheng (Chen) Cui using single-particle cryo-EM on liposomes to show how mTORC1 integrates nutrient and growth factor signaling at lysosomes, collab. w/ G. Napolitano,A. Esposito, and A. Ballabio.
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Fran Bottanelli
over 1 year ago
This
#fluorescencefriday
I am gonna introduce some work from the lab :) We identified a new GTPase cascades that we believe drives cargo flow along post-Golgi pathways! Compartments positive for ARF1 shed ARF1 (green) to acquire Rab11 (magenta) to become recycling endosomes. Can you spot an event?
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