Adaptive evolution of gene regulatory networks in mammalian neocortex www.nature.com/articles/s41... - very interesting work from Nenad Sestan and colleagues...

Happy to share my co-first-author paper, now published in Nature! In this work, we uncover gene regulatory networks that underlie the diversification and connectivity of excitatory neurons in the neocortex. www.nature.com/articles/s41...

1/ Our new study, led by Jingwen Ding, examines the role of transcription factors during human neurogenesis to identify gene regulatory networks influencing cell fate, maturation, and subtype specification www.nature.com/articles/s41...

Still think brain regions don’t exist? That everything is everywhere? That cell types don’t matter and that everything is a dynamical phase portrait? Wrong. Interconnected brain modules exist at the level of fine grained transcriptomics. www.nature.com/articles/s41...

🧠✨ Genetic Tools Atlas 3.0 is here! The GTA now has an additional 750 datasets, including 80+ mouse whole-brain light sheet microscopy images as well as the first macaque datasets. 🔗 https://portal.brain-map.org/genetic-tools/genetic-tools-atlas #neuroskyence

We often think of problems as separate buckets: disease, malnutrition, affordability or economic development. But “Climate change is not a separate bucket,” Hayhoe says. “The reason we care about climate change is that it’s the hole in every bucket.”

Psychedelics disrupt the link between vascular and neuronal activity, which complicates interpretations of fMRI data. Adopting a more holistic view of what constitutes brain activity may help. By @callimcflurry.bsky.social #neuroskyence www.thetransmitter.org/psychedelics...

Pharmaceutical industry money can’t replace NIH funding | STAT share.google/iZfAlSgXeIR3... #BasicScience #NIH #NSF #NASA #JOBS #RESEARCHFUNDING #RESEARCHMATTERS #InnovationNation #AmericaFirst

How Jane Goodall changed the way we see animals - and the world by @rowhoop.bsky.social for @newscientist.com www.newscientist.com/article/2498...

A spatially resolved transcriptomic atlas of the primate amygdala (human, macaque, and baboon) now out in Science Advances (www.science.org/doi/10.1126/...). The amygdala contains 32 types of neurons with many neuron types specific to particular subdivisions. Lots of updates from the preprint!

Very excited to share my second postdoc, now out in Science Advances! We used targeted snRNA-seq to profile four major subnuclei of the primate across three species (including humans). 1/13 www.science.org/doi/10.1126/...

Beautiful work out from Sestan lab!!

Asked about his decision to fire the entire vaccine advisory committee of the CDC, RFK Jr. asserted that "children get between 69 and 92 vaccines before they’re 18," among other lies. Fact check: the number is closer to between 24 and 50. https://trib.al/uUQLOgI

A wave of emotion | Science www.science.org/doi/10.1126/...

Just published, expansion in situ genome sequencing, where you can sequence DNA while still inside the cell, mapping its organization relative to proteins and other markers, with the help of expansion microscopy! Led by @jbuenrostro.bksy.social. www.science.org/doi/10.1126/...

My med school textbook says stimulants like Ritalin treat hyperactivity by “stimulating” the brain’s attention and cognitive control systems. We studied children taking stimulants in the ABCD Study, and the largest differences were actually in arousal and reward networks! Check out our preprint!

Excited to showcase as a co-first author our latest work "Adaptive Evolution of Gene Regulatory Networks in Mammalian Neocortical Neurons "https://www.biorxiv.org/content/10.1101/2025.05.20.652233v1

Day 25 (a need): Psychiatric conditions are diagnosed based on symptoms rather than biological tests like brain scans or blood tests. We do not yet know enough about what's happening in the brain of someone experiencing a depressive episode or psychosis to create such a test. #ElusiveCures30

Einstein: Scientists should not be silent about human affairs. Science shouldn’t be partisan, but scientists should embrace values that improve humanity. Science affects people and the people — humanity — affect science.

Podcast interview with me about spatial planning in London taxi drivers: youtube.com/watch?v=6gUR...

In fiscal year 2024, the report found, NIH awarded more than $36.9 billion to researchers, supporting more than 408,000 jobs and generating over $94.5 billion in new economic activity nationwide. news.harvard.edu/gazette/stor...

Excited to share this brief review where @katieinsel.bsky.social & I discuss studying adolescence to understand how brains work! We highlight avenues for future collaborative work at the intersection of cognitive, computational, & developmental neuroscience 🧠 journals.sagepub.com/doi/10.1177/...

When you've been in the cell culture hood all day and finally get to take off your gloves:

@michellemonje.bsky.social at @stanfordmedicine.bsky.social and Frank Winkler at Heidelberg University have won the 2025 @brainprize.bsky.social from the Lundbeck Foundation for their work in cancer neuroscience. By @sydneywyatt.bsky.social #neuroskyence www.thetransmitter.org/community/20...

I’m excited to share our publication from @dulaclab.bsky.social in @nature.com, where we illuminate the development of hypothalamic cell types involved in a broad range of functions, from social behaviors to thirst, thermoregulation, and sleep. Highlights below! 🧵 www.nature.com/articles/s41...

It continues to get worse. We can’t breathe a sigh of relief because it isn’t MY grant. We all risk being on the chopping block. Not even to mention the severe detriment to science, society, etc. 😢 www.nature.com/articles/d41...

New work by @gozziale.bsky.social on the phenotypic heterogeneity in autism spectrum disorder and underlying processes, with two major subtypes—hypo- & hyper-connectivity—linked to synaptic dysfunction transcriptional regulation/chromatin remodeling, respectively 🧪🧠🧬 www.biorxiv.org/content/10.1...

Poor old Pavlov. Eventually every time he heard a bell ring he wanted to feed a dog.

So. It has officially happened. I have been officially let go from my position at CDC. I wasn’t a probationary employee. I had stellar performance reviews every year. I’ll be ok. But please understand that many worked HARD to get into these positions and were doing great public health work.

🧪🧠

I have been talking to the media, Time, Fortune, NBC, etc., to explain how the onslaught on science and NIH will impact the health of all Americans. Everyone knows someone who has cancer, heart disease, or depression. Spread the word about how cutting science impacts all. time.com/7216299/nih-...

Constrained roads to complex brains Neural development and brain circuit evolution converged in birds and mammals www.science.org/doi/10.1126/...

Amazing work!

Hello BlueSky world! This might sound crazy but today we publish in @natureMedicine a paper showing that neurostimulation can revert motoneuron dysfunction produced by a neurodegenerative disease! www.nature.com/articles/s41...

This is really sad! 50% of population is women. Just putting a little rationality in perspective that thinking of having healthy human future and produce more healthy kids without investing in women health is plain stupidity.

Navjot Kaur I am thrilled to share our latest paper from Sestan lab on the development of the claustro-amygdalar complex, is published at nature.com/articles/s41.... A big thank you to all our collaborators and mentors. @marinap63.bsky.social

Great study from Nenad Sestan’s lab and collaborators (led by @babyamygdala.bsky.social) on the specification of claustro-amygdalar and ‘palaeocortical’ neurons and circuits — with a key role for TFAP2D dosage, now out in @nature.com www.nature.com/articles/s41...

Mice lacking microglia (Csf1r∆FIRE/∆FIRE) have normal -synapse number and maturation -seizure susceptibility and hippocampal-prefrontal cortex coherence -segregation of inputs into the lateral geniculate nucleus -neuronal and astrocytic gene expression www.nature.com/articles/s41...

Our latest work led by @claraliao.bsky.social is a collaboration with the other Kwan lab @kwanlab.bsky.social We used single-nucleus RNA sequencing to measure transcriptional responses in the mouse medial frontal cortex following a single dose of psilocybin. 🍄 🧠 🧬 www.biorxiv.org/content/10.1...

This story is another great example of why we can’t just extrapolate what we know about neuroscience in the developed brain to neuroscience in the developing brain. www.jneurosci.org/content/44/4...

Reposting new preprint investigating sex-differentially expressed (DE) genes in human ventromedial hypothalamus and arcuate 🧠. Data identifies extensive sex DE, which is linked to genetic risk for sex-biased disorders including autism, depression, and schizophrenia www.biorxiv.org/content/10.1...

Have you ever wanted to run studies with #PrairieVoles but didn't have access to the animals? Now you can! The Cornell Vole Core is now open and able to ship voles to your lab! The webpage is currently minimalistic, but contact them to inquire. [pls RT] volecore.research.cornell.edu

An exhibit that opened last weekend at Yale shows drawings from the influential duo Santiago Ramón y Cajal and Camillo Golgi, recasting them as collaborators rather than rivals. It also reveals lessons for modern scholars. By @claudia-lopez.bsky.social www.thetransmitter.org/art-in-scien...

Today we report in 𝘾𝙚𝙡𝙡 𝙎𝙩𝙚𝙢 𝘾𝙚𝙡𝙡 a systematic approach to generate neural #organoids resembling various domains of the neural axis Neal Amin & @kevinkelley.bsky.social developed a multiplexed morphogen screen to generate #organoids that mapped to almost 2/3 of the clusters in the 1st trimester CNS

After 4yrs of work, "Mind Matter" exhibit opens this week! I am the curator. It was a collaboration between Peabody Museum @yaleuniversity.bsky.social and @wutsaiyale.bsky.social. The exhibit includes original drawings from Cajal & Golgi never exhibited before peabody.yale.edu/news/mind-ma... 1/

Excited to share work that @ceriweber.bsky.social started and drove in my lab. Tails!! We know a lot about limb bone growth, but vertebrae have completely different embryonic and evolutionary origins. What controls growth and proportion in the vertebral skeleton? www.biorxiv.org/content/10.1...

Different Subregions of Monkey Lateral Prefrontal Cortex Respond to Abstract Sequences and Their Components www.jneurosci.org/content/44/4... #neuroscience

Exciting directions for fMRI! https://buff.ly/3UZLaMd #neuroscience 🧠 🧪 #fMRI

Hello numerous people who joined and followed! I want to hear your neuroscience takes, but not the same old debates. There's so much we can discuss that's truly new. Here I'll start: -The brain: too big, or not big enough -Most overrated region of cortex -manifolds: isn't just one fold sufficient

xcited to share our new results! We (huge team effort led by post-doc extraordinaire Sylvie Lesuis) examined the effects of acute stress on threat memory generalization and engram ensemble architecture. www.sciencedirect.com/science/arti...