We combined cell biology, #AI based image analysis & a mathematical model to show how migratory behaviour changes with branching For now macrophages & endothelial cells, but we have many more, stay tuned ;) Kudos to all authors for the effort, especially to a great Padawan @jboixcampos.bsky.social

✨ Blinking #nanobodies that work for single-molecule localization 🔬 Our new preprint shows that the self-blinking dye JF635b restores robust, buffer-free blinking in #nanobodies, enabling reliable #dSTORM, #MINFLUX, and more, without chemical-switching buffers. Opening new possibilities for #ExM!

I tried q.e.d recently and was pleasantly surprised by the nuanced suggestions it shares. What makes it even more exciting is that it’s absolutely free and allows us to share detailed feedback on the model’s outputs. A must try for all researchers!

🔬📊 PhD (100%) – Statistics & ML for self-driving microscopy Joint PhD with David Ginsbourger (Stats) & Pertz Lab (Cell Biology). Gaussian Processes, Bayesian design, active learning on live-cell experiments. ohws.prospective.ch/public/v1/jo... #PhD #Statistics #MachineLearning #Bayesian

🔬 We're hiring a Junior Group Leader for Data-Driven Digital Twins/System Models in medicine/life sciences at @uni_goettingen! Perfect opportunity for early-career researchers who want to: - Lead their own research group - Work at the intersection of AI, simulation, and biomedicine

#PhotoFiTT proposes a standard label-free and quantitative protocol, including #AIImageProcessing, to measure #phototoxicity derived cell stress 🧮 By systematically assessing deviations in cell behaviour, we can optimize #livecell experiments and stop blindly frying our cells💡🧫

💡 Key insights we uncovered: Near-UV light delays mitosis at doses as low as 0.6 J/cm². Longer wavelengths need higher doses, and surprisingly, continuous low-intensity illumination (slow scan) can be more damaging than brief high-intensity bursts (fast scan). Data-driven phototoxicity thresholds! ✨

🗞️ New preprint from the lab, led by our postdoc Ana Garoña (not on here) in collab with @andreagiometto.bsky.social: “Experimental evolution of cellular miniaturization reveals a mechanism for cell size evolution”, aka: “honey, we shrank the yeasts!” 🎥 www.biorxiv.org/content/10.6...

🚨Amazing news for a cloudy Monday!🌩️😎 I'm extremely happy to share that our last adventure is finally out!🚀🎉Phototoxicity fitness time trial (#PhotoFiTT) - a quantitative framework for assessing phototoxicity in live-cell microscopy experiments 🔬❤️‍🔥⚡️ doi.org/10.1038/s414...

🌍 Imaging 4 All — 3rd Call Open! Fully funded mobility grants for low/middle-income country researchers to access imaging technologies for experiments and training. 🗓 Deadline: 28 Feb 2026 More info: globalbioimaging.org/i4a For questions: [email protected] #Imaging4All

Do you know how far phototoxicity can hinder your experiments?🤔 @mariodelr.bsky.social and @gomez-mariscal.bsky.social have just published their work on #PhotoFiTT in @natcomms.nature.com where they explain how to quantitatively measure it in live-cell imaging.⚡🧫🔬 Read more at: shorturl.at/ly9Zn

🚨🔬🤖🚀 #PhotoFiTT is out! With @guijacquemet.bsky.social's & @microbematos.bsky.social's labs, we launched a new phototoxicity measurement for live microscopy using cell clocks⏱️. By rockstars @mariodelr.bsky.social @gomez-mariscal.bsky.social et al! AI-powered + label-free doi.org/10.1038/s414...

ICYMI, our #preprint list is now up on FocalPlane, highlighting the latest research using #microscopy to answer questions in #biology. As always, send us any recommendations for preprints that we've missed: focalplane.biologists.com/2025/12/12/m...

Happy to finally share micromorph with everyone! If you are interested in performing morphological measurements of bacteria, and like using Python and Napari then this is for you! You can read about it in our preprint, and find the code on our Github repo, PyPi or directly from the napari hub!

🛑 ⚠️ Registration Deadline: December 12th! ⚠️ Don’t miss your chance to join! 🔬👷‍♀️🛠️ You'll need a Motivation Letter, CV, and a Reference Letter 📝 👉 Course details & registration: meetings.embo.org/event/26-mic... #Microscopy #OpenScience #Bioimaging #EMBOmicroscope

This work was made possible thanks to the incredible contributions of Sophie Brasselet, @stevethechemist.bsky.social, @samofmidworld.bsky.social, Ezra Bruggeman, and @hannah-superres.bsky.social Have a look 👇 www.biorxiv.org/content/10.1...

🤩 It all start with an idea and some space on the optical table. 🔬🧫🪛🥽! Amazing work @agvesga.bsky.social 🙌

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Talking about impostor syndrome..... I'll be a teacher in the EMBO "Hack your Microscope" together with some of the very best researchers in the field. 5.5 days of hacking and microscope/fluidics shenanigans in Portugal. You can apply here: meetings.embo.org/event/26-mic... #EMBOmicroscope

Registration is now open to attend Journal of Cell Science's meeting on Imaging Cell Dynamics, organised by Francesca Bottanelli, Guillaume Jacquemet, Michael Way and Giulia Zanetti. Find out more: biologists.com/meetings/jcs... #JCSimaging #Microscopy #Microscope #Imaging #Cells #CellScience

🚀 Exciting news for the imaging community! The EMBO Practical Course – Hack Your Microscope is coming to ITQB NOVA (Oeiras, Portugal) on April 20–25, 2026 🧠🔬 👉 Course details & registration: meetings.embo.org/event/26-mic... #Microscopy #OpenScience #Bioimaging #EMBOmicroscope

🔬🤖 ICYMI: impressive preprint from @owenlabuob.bsky.social tackling a major bottleneck – how to systematically compare super-resolution microscopy across experiments. Novel ML framework embeds single-molecule data for cross-sample analysis. Integrated with nano-org database✨ doi.org/10.1101/2025...

microfabricated stamps, fresh off the printer :)

🦠🔬🤖🧑‍💻 #mAIcrobe is out! With @pinholab.bsky.social's lab, we launched an open-source framework for high-throughput bacterial image analysis. By rockstars A. Brito & B. Saraiva et al, making #DeepLearning for phenotyping accessible! Easy to use, plus model training 📜 www.biorxiv.org/content/10.1...

🤯 Amazing!!

for #FluorescenceFriday : is your ExM sample too large to be imaged with high NA objectives? VIPS it! Very clever way to tackle one of the biggest challenge in large volumetric ExM www.science.org/doi/10.1126/...

Our article "Ångström-resolution imaging of cell-surface glycans" made it to the cover of Nature Nanotechnology! 🤩 @natnano.nature.com www.nature.com/nnano/volume...

I am hiring! - looking for a Staff Scientist to co-run my research group with me. Staff Scientist is a senior professional scientist role at EMBL. Please forward to people you might know who could be interested! embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Job alert! We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks? See also on the forum: forum.image.sc/t/research-e...

Happy #FluorescenceFriday. Christophe Leterrier⭐in #TheMicroscopists and reflects on the make-or-break moment at the end of his postdoc when he came close to leaving academia before securing his CNRS position and how these experiences shape the way he mentors others. Stream: bit.ly/microscopist...

... and 7 academic labs! @olivierpertz.bsky.social @toettch.bsky.social @hannah-superres.bsky.social @alfredorates.bsky.social Your implementation is missing? Want to join our monthly meetings on smart microscopy approaches? Contact us & find out more on smartmicroscopy.github.io

Want to get started with smart microscopy? 🧠🔬 Check out our online repository with implementations from labs and industry -- lots of practical tips and links to sample code! smartmicroscopy.github.io/implementati... More details in the ✨updated preprint!✨ www.biorxiv.org/content/10.1...

Our new preprint is up! This is the main postdoc work of @wiesner-t.bsky.social focusing on exocytosis along the axon shaft and its regulation by the sub membrane actin-spectrin scaffold: www.biorxiv.org/content/10.1... Read the thread below for a summary of our findings 🧵1/11

It is all implemented as a Pyton-based open source control widget that seamlessly interfaces with a commercial @abberior.rocks MINFLUX microscope and its control software Imspector. Try it for yourself, and let me know if you have any questions! github.com/jonatanalvel...

etMINFLUX uses confocal monitoring and triggers MINFLUX acquisitions at rapid and rare events in living cells previously unreachable with MINFLUX, exemplified by tracking the 3D membrane topography in dynamin-mediated endocytosis (10 s) and virus budding (min) in action.

Excited to share my postdoc work from the Eggeling lab in Jena (@leibnizipht.bsky.social, #FSUJena, #KTHuniversity) on bringing smart microscopy to super-resolution MINFLUX: event-triggered MINFLUX microscopy.

Sounds like an interesting comparison of resolution assessment methods for super-resolution… Would anyone with access send me the pdf (christophe dot leterrier dot gmail dot com)? Thanks! link.springer.com/article/10.1...

Hello! Very excited to share our latest preprint, which is great news for us but terrible news for any diehard fans of PSNR and SSIM as image quality metrics in microscopy... (1/5) www.biorxiv.org/content/10.1...

PS: Also check out our other paper on smart microscopy that came out this week! Current applications, technical details of different implementations. The issue of missing standards in microscopy control / poor interoperability & how we think it could be solved! www.biorxiv.org/content/10.1...

Automated optogenetic control of hundreds of cells in parallel. Each cell is individually steered, collectively acting as a "tissue printer". Preprint & code out! www.biorxiv.org/content/10.1...

🚨 New preprint on bioRxiv! 🚨 Smart microscopy🔬 is reshaping life sciences—but progress is slowed by fragmentation. @lhinderling.bsky.social & the Smart Microsopy Working Group maps the field & proposes a path toward an open, interoperable future. 🧵👇 doi.org/10.1101/2025...

Join us at #BNMI2025 today at 11:30 for our talk ‘Euro-BioImaging – another kind of smart microscopy’. Also, don’t miss our poster on the Smart Microscopy Working Group! More info:

Real-time feedback control microscopy for automation of optogenetic targeting https://www.biorxiv.org/content/10.1101/2025.08.17.670729v1

☀️🌊 On my way to Gothenburg 🇸🇪 for #BNMI2025. Especially looking forward to the pre-symposium Smart-Microscopy Workshop 🔬👾 and to connect to the Nordic microscopy community 🤩!

🚨 New EMBO Practical Course! Ultrastructure Expansion Microscopy: From Cells to Tissue 🔬 📅 20–24 Apr 2026 | 📍 EMBL Heidelberg Co-organised with @banterlegroup.bsky.social @gautamdey.bsky.social 💡 Register your interest to get notified when registration opens: 🔗 www.embl.org/about/info/c...

🚨Scaling multiplexed imaging 📈 We are excited to share Pathology-oriented multiPlexing (PathoPlex). Now out in @nature.com: www.nature.com/articles/s41... 🧵Walk-through thread below ⬇️

Do you like developing new AI vision methods for microscopy image analysis? You love theory & implementation? 1 week left to apply for a fully funded PhD position in our lab in Dresden 🇩🇪! Topics: object detection/tracking, multimodal models & more. DM/email for details! #PhD #AcademicJobs #GPUsgoBrr

🚨 Important detail in the #ExM & #eSRRF protocol: #eSRRF is not only available as plugin in #ImageJ /Fiji 🌴, #NanoPyx also brings it into the #python world 🐍: doi.org/10.1038/s415... How to get started? Check out the training manual: doi.org/10.5281/zeno...

🧾New paper now on ‪‪‪‪Nature Protocols ‬🎉The #ExSRRF protocol gives you all details on how to merge Expansion Microscopy technique with #eSSRF analysis. Developed by Dominik Kylies, @puellesv.bsky.social and @hannah-superres.bsky.social, @henriqueslab.bsky.social 🔗: www.nature.com/articles/s41...

👇Check it out! 🔬🧫🏄‍♀️🌊