The @ragoninstitute.bsky.social is launching a new faculty search for a computational immunologist! Applications are open now and reviewed on a rolling basis. Please share broadly with your networks! #immunosky www.nature.com/naturecareer...

Plasma-localized IgG glycosylation is dynamically altered by the endothelium www.pnas.org/doi/10.1073/...

A common progenitor gives rise to fibroblastic reticular cells and vascular smooth muscle cells in murine lymph nodes @jem.org rupress.org/jem/article/...

B lymphocytes that enter the germinal center late preferentially differentiate into memory cells that recognize subdominant epitopes https://www.biorxiv.org/content/10.1101/2025.10.30.685663v1

Autoantibody origins in lupus and in relapse post CAR-T therapy https://www.biorxiv.org/content/10.1101/2025.10.20.683393v1

Cooler techniques available every day!

Enhanced human antigen-specific B cell responses using in vitro 3D tonsil cultures containing stromal cells https://www.biorxiv.org/content/10.1101/2025.09.30.679470v1

In the US it is called “Dawn”. We haven’t tried this, but the U.K. and Belgian brands both work fine. If you try Dawn please let us all know!

Just take a look. The Foxp3 fix/perm kit is good for TFs, but kills endogenous GFP. The eBio preserves GFP, but is incomplete at allowing TF staining. Burton's Best Buffer is as good as the best under all conditions (except phospho-flow), and preserves dye integrity too. Plus it is dirt cheap. 🎤

PRDM1 shapes germinal center B-cell clonal diversity by gating chromatin accessibility during light-to-dark zone transition https://www.biorxiv.org/content/10.1101/2025.08.27.672737v1

Modulation of B cell receptor activation by antibody competition @cp-cellreports.bsky.social www.cell.com/cell-reports...

Isolation of genetically diverse influenza antibodies highlights the role of IG germline gene variation and informs the design of population-comprehensive vaccine strategies https://www.biorxiv.org/content/10.1101/2025.07.04.663145v1

Pre-print time! Our new study on #systemsimmunology analysis of #Alzheimers patients is out now on @medrxivpreprint.bsky.social. This is the culmination of a long collaboration with Rik Vandenberghe, Stephanie Humblet-Baron and Lidia Yshii's labs at KU Leuven. 🧵1/8 www.medrxiv.org/content/10.1...

Preprint: In vitro induction of human germinal center B-cells www.researchsquare.com/article/rs-6...

We are still recruiting a B-cell immunologist to join our team and lead projects funded by the Gates Foundation and NIH. If you are looking for a postdoc or a more senior Staff Scientist position, please apply! Please repost to help reach out to our colleagues affected by recent RIFs. Thank you!

Don't sleep on LINE1s!

Rest in peace to inspiring scientist and mentor Michael Cancro www.cell.com/immunity/ful...

We are #Hiring! Please share! #ImmunoSky 🧪 Join our multi-disciplinary B-cell team @Emory/ATL to lead exciting projects on human immunology funded by the Gates Foundation and the NIH (Position fully funded and not dependent on future grants). ghosnlab.science/join-us #BYourCell

Two distinct durable human class-switched memory B cell populations are induced by vaccination and infection @cp-cellreports.bsky.social www.cell.com/cell-reports...

Cool

Our latest study by PhD student #RomainGailleton shows that upon #influenza infection, #Bcell can respond rapidly by forming ectopic #GerminalCenter within the nasal tissue. The work has just been published in @pnas.org (1/N) www.pnas.org/doi/10.1073/...

@labonnelab.bsky.social overcast.fm/+AA5AWObyBF8 What an unbelievably great appearance with amazing focus and insight by Professor LaBonne. Thank you so much!

I'm happy to have played a small part in this first paper from an ongoing collaboration between the Marasco, Sage, Haigis, and Hemberg labs to decipher mechanisms of poor influenza vaccine response in older individuals

Online now: Online now: Early influenza virus exposure shapes the B cell response to influenza vaccination in individuals 50 years later

The NIH funding freeze has blocked 3 of our grant proposals (so far), which threatens to shut down our Lyme disease research program within a year. 🦠🧫🧪🧬🔬 #MicroSky www.reuters.com/business/hea...

NIH indirects case update: Hearing ongoing now, and I'll try to live tweet some notable exchanges. Prior to more detailed arguments, Judge Kelley starts off with a few point questions to both sides: (I'm paraphrasing here)

☀️📣 Looking for a STATE LEAD and VOLUNTEERS to help us #standupforscience2025 in North Carolina! Know someone interested? Fill out this form: airtable.com/app4h5wUssMG... #scienceforall #sciencenotsilence

A large portion of grants awarded by the U.S. National Institutes of Health cannot be funded for the foreseeable future because of an indefinite hold on submissions to the Federal Register, according to an email reviewed by The Transmitter. By @avaskham.bsky.social bit.ly/3X8ngz8

ATTENTION (PLEASE SHARE) If anyone has or knows of any positions that might be appropriate for the NIH staff members who were terminated, please post the information in this thread. There are lots of talented and accomplished people who may be looking for new opportunities.

Did you know that human immunoglobulin constant genes are crazy diverse? It's got me thinking...Proud of Uddalok Jana! And grateful for collabs @guryaari.bsky.social @williamlees.bsky.social @ayeletperes.bsky.social @e-engelbrecht1.bsky.social @yscientist.bsky.social www.biorxiv.org/content/10.1...

That's a strange mistake to make!

Delighted to share our latest paper describing a method to read the levels of hundreds of metabolites or drugs in parallel using DNA sequencing. This method, which we call ‘smol-seq’ (Small MOLecule sequencing), harnesses the power of DNA sequencing for metabolite detection: rdcu.be/d8xLv (1/6)

Absolutely fascinating story showing different functions for CD4 vs CD8 regulatory cells in humoral immunity and the role of Foxp3 vs Granzyme B. #ImmunoSky #GCBcellSky #TfhSky www.nature.com/articles/s41...

Here is a quick thread to promote my research! After years of dedicated research, I'm thrilled to share our article just published at Nature Communications :) www.nature.com/articles/s41... #metabolism #CRISPRscreens #mitochondria

Seeking New Englanders with pre-2020 ME/CFS!

Interested in B cell receptor repertoire analysis? We have a great set of speakers lined up for the “2025 Immcantation Users Group Meeting!” Check out the program and register for this free virtual meeting 1/30/25 10AM-1:40PM (ET) at: immcantation.github.io/users-meetin...

Cool

Thrilled to share our latest work on how the non-essential amino acid #asparagine metabolically regulates germinal centers. Huge thanks to my PhD supervisor @ajclarke.bsky.social, colleagues, and collaborators at the @ndorms.bsky.social @ox.ac.uk and @crick.ac.uk www.science.org/doi/10.1126/...

I’ve tried to put together a starter pack of immunologists/scientists exploring B Cell Repertoires and Antibody Affinities. Please feel free to share/join! go.bsky.app/4P64DmM