Let’s talk about Bruno! Bruno’s lab is focused on the development and use of computational tools for the design and engineering of proteins, with the aim to develop new protein-based therapeutics, vaccines, biosensors and more. Learn more about Bruno in our April 2026 newsletter. zurl.co/X2o4z

imagine trying to explain this to someone from 1776

Every time I see someone talk about Claude I think about how they switched from female to male names as soon as they wanted the robots to seem like experts vs personal assistants.

The NIH Vigils has become a place for community and support as we endure censorship and antiscience policies inside NIH. Every week for a year, we have gathered to mourn the losses to science and the harms to public health. And we will continue to gather every Saturday until NIH is rebuilt.

More details on the firing of the National Science Board. The NSF now has no director, deputy director, or board. They have issued almost no new awards in 2026. The plan appears to be to completely destroyed the agency. The details are horrifying and have Russ Vought written all over them.

Why are de novo designed proteins so extremely thermostable? We try to answer this question by dissecting the thermodynamics of unfolding of mini-binders emerging from our protein design pipeline – and establish a convenient GUI for data analysis in the process. doi.org/10.64898/202...

This is not lets-propose-this-and-see-what-Congress-says. Their plan is more like USAID: eliminate before Congress can weigh in.

AS PER MY LAST POST: Google's AI Overview scanned a hoax paper (loaded with Star Wars references) that @neuroskeptic.bsky.social wrote. AI Overview said "Kyloren syndrome" is a real disease. See "The garbage'll do", July 2017, in Stinging the Predators: bit.ly/StingPred

I'm curious how these plots on year-to-year NIH funding levels compare to those @jeremymberg.bsky.social has been compiling. In my recollection, they're meaningfully different than the ones he was showing at the @biophysicalsoc.bsky.social meeting. grants.nih.gov/news-events/...

More context on this #Artemis II image: * This is the night side, lit by moonlight. You can see city lights in Spain & Portugal, & a sliver of day at lower right * The Sun is entirely behind Earth, which makes it a kind of solar eclipse, but w/ Earth doing the eclipsing instead of the Moon: ☀️🌍🚀🌕

"Experts are Dubious" !?!?

THE TRUMP TRAP. Do not give up your integrity to keep your job, your funding, your lab, your organization, your science…you’ll end up with neither. If you wait for them to forcefully take it, you still have your integrity. Choose wisely, history watches.

After almost 10 years, my name is finally right in SCU's digital systems 🎉🎉 Depending on how implementation rolls out, my students and advisees should finally know how to find me, I shouldn't miss as many communications and payments. Thanks to the HR/IS team who make it happen!! #WomeninSTEM

Another informative and thought provoking piece by @dereklowe.bsky.social

…Noem was just fired because of public pressure, articles of impeachment getting serious, and tanking polls. And immigration has ALWAYS BEEN Trump’s number one issue. He shoots the hostage every time. Why would he spare an unpopular Kennedy? RFK Jr is not a sacred cow.

What a good idea for an article! Very interesting. It's worth contemplating whether you would have also recognized the warning signs -- or have someone in your life who would. www.science.org/content/arti...

I mean, it's this, or we just send chatbot-written e-mails back and forth to each other forever

Let's hit the streets on Saturday, March 7th! The mission is simple: Save Science, Protect Health, Defend Democracy. Find a rally near you, start your own, or just get some friends together and have a pop-up protest! Links in bio, or visit standupforscience.net/march7 #science #standupforscience

I’m looking to hire a research technician for my lab at Harvard & DFCI, who would primarily work in the wet lab expressing and characterizing designed proteins, starting this summer. A great role for a recent college grad looking for an immersive research experience before grad school.

DOCTOR Rümeysa Öztürk has earned her PhD!!

@altfda.altgov.info challenged us to list #5Things that each of us Alts think have caused the most damage in our agencies over the past year. Each of the five items is chock full of sub-items…adding up to far more “things.” Here goes.

We should also note that these vaccines were limited to the most vulnerable populations or not approved at all due to these rare side effects (1 in 200,000). And now this detective work will help ensure future vaccines are even safer. Truly important work!

#goals @ncfdd.org

Preaching to the choir, but...

Final stretch to apply for undergraduate summer internships in the Rosetta Commons! Come design proteins, develop AI and physics-based methods to model biomolecules, and impact health, materials, and sustainability! Application deadline is Sunday Feb 1. rosettacommons.org/education/reu/

Do what you can. ❤️‍🩹Take care of yourself. 🫂Take care of each other. ☎️Call 5calls.org 🧑‍💻Write democracy.io#!/thanks 🚫Boycott ICE: www.boycottcitizens.org/ice ✊Support MN: www.standwithminnesota.com

Jane Richardson was born #OTD in 1941 + Developed the Richardson (ribbon) diagram to represent proteins' 3D structure (becoming a standard representation for protein structures) + MacArthur Fellow, 1985 + Elected, Nat'l Academy of Sciences, 1991 + President, Biophysical Society, 2012 #WomenInSTEM

We've raised a lot of money for my school community neighbors. And I predict all of it will be depleted by the end of this week. If you're in a position to donate, please help: paypal.me/lyndalepto (donations are tax deductible) 3/3

Here’s a preprint from the Keating Lab: www.biorxiv.org/content/10.6.... Foster Birnbaum and Amy E. Keating demonstrate that sequence design models, such as ProteinMPNN, are limited because they were trained only on native sequences.

“We shouldn’t be aiming to nudge a few % points in public opinion. Our goal should be to make freedom of mobility so compelling that people demand it. Help people visualize & demand a future where kids can bike to school, seniors can walk to stores, couples can bike to dinner.” @usa.streetsblog.org

Here for the right reasons

Exciting new work from @aliceyting.bsky.social and coworkers @stanfordbiosci.bsky.social @stanfordmedicine.bsky.social www.science.org/doi/10.1126/...

I have started updating my website because I am no longer at San Francisco State. I also wrote on my website landing page that I am writing a book about my favorite topic: evolution of drug resistance. That's my biggest goal for the year! pleunipennings.wordpress.com

here’s hoping 2026 is just one year

#JohnsHopkins @ucsfmedicine.bsky.social and @stanfordmedicine.bsky.social are not obliged to take back Marty Makary, Vinay Prasad & Jay Bhattacharya when they leave the administration.

One of the best DOGE report cards I’ve seen is from @petridishes.bsky.social www.theatlantic.com/newsletters/...

Imagine, if you will, that NASA updated its website to suggest gravity might not exist, prompting CalTech and CERN to release statements saying, "With great sadness, we can no longer recommend listening to NASA." This is what's happening in epidemiology.

A Sharon Begley byline, almost 5 years after her death. Upon hearing the news James Watson had died, a STAT reporter said in our Slack, "I wish I could read what Sharon would have written." Incredible news: Sharon in fact did pre-write a Watson obit. And it is masterful and excoriating. 🧪🧬🧫

Seems like a good day to share one of my favorite videos on the internet 🧬

In honor of Halloween, one of my all-time favorite cartoons by @katiemckissick.bsky.social #MedSky #IDSky #HappyHalloween 💊👻🎃

STOP ASKING MIKE JOHNSON ABOUT THE NEWS! HE IS PROTECTING HIS MENTAL SPACE!

Public Citizen has an annual pumpkin carving competition. The Litigation Group won this year with this portrayal of the White House with the East Wing having been demolished. Entries from other groups to come

chef's kiss 😘

Pres. Kornbluth articulates such moral clarity in this rejection of the proposed “compact”: “the premise of the document is inconsistent with our core belief that scientific funding should be based on scientific merit alone” orgchart.mit.edu/letters/rega...

I am super excited to announce that we have a tenure-track faculty position in biophysics open in the Department of Physics at Carnegie Mellon! 🧪 Interfolio link: apply.interfolio.com/174360 PLEASE, share widely across the blue skies! Let me briefly explain what we're looking for: 1/10

Loyola Marymount University claims religious exemption with the NLRB, claws back recognition of NTT faculty union The sudden decision of the LMU Board of Trustees has left many NTT faculty in shock; the union plans a response.

DUCK AROUND, FIND OUT! With our duck delivery in tow, we waddled up to the Hill to let our representatives know that it's time to send the Quack-In-Chief packing. #ImpeachRFK

Update on this story: As many of us feared, it turns out that Berkeley wasn't the only UC to release personal info on its pro-palestine anti-genocide professors to the justice department, it looks they they all did. Berkeley was just the only one to tell profs they did it.

NSF GRFP announcement was posted! Have not read the details to see if any changes from previous years... www.nsf.gov/funding/oppo...