For 40 years the 8-nt ‘Kozak Sequence’ was thought to mark sites of translation initiation. In a new study, we revise this model by identifying an ~80-nt sequence—the extended Translation Initiation Sequence (eTIS)— that guides ribosomes to correct start sites. 🧵 www.biorxiv.org/content/10.6...

𝗠𝗮𝗷𝗼𝗿 𝗱𝗲𝗽𝗿𝗲𝘀𝘀𝗶𝗼𝗻 𝘁𝗵𝗿𝗼𝘂𝗴𝗵 𝘁𝗵𝗲 𝗹𝗲𝗻𝘀 𝗼𝗳 circuit 𝗱𝘆𝗻𝗮𝗺𝗶𝗰𝘀 Finally research is considering the functional/ anatomical complexity of the brain. It's not about regions, but how circuits function dynamically. www.cell.com/neuron/abstr... #neuroskyence

Amazing….Mike D doing "So What’cha Want" with his sons' band 🔥

How about that. A post of mine reached an @medium digest. medium.com/@JohnLighton...

Congrats Haley and @lbeutler.bsky.social !

Domino: it makes me happy to see people happy because people are happy 😃

When they go round the moon, the Artemis astronauts will be completely out of contact for 40 minutes. What's the single funniest (yet feasible) thing they could do when they get back in touch?

🌶️ Why does spicy food make you feel hot—but actually cool you down? 👇 (thread)

🧠🌡️ New Comment in Nature Reviews Neuroscience: Neural adaptation to climate change: mechanisms, limits and opportunities (with Patrick Haggard, UCL). 🔗 [ rdcu.be/e8BEJ ]

Neural adaptation to climate change: mechanisms, limits and opportunities — a Comment article by Jan Siemens & Patrick Haggard @jansiemens.bsky.social #neuroscience #neuroskyence www.nature.com/articles/s41...

Schrödinger's dumpster!

1. Yesterday I was fortunate enough to visit the Alfa Romeo museum in Milan. What a gorgeous museum of design. Over the next few days I'll be posting a thread of pictures from my visit. Here's a teaser.

Distinct neurons, distinct functions 🧠🟤 Our Nature Metabolism paper (now out!) shows that separate sympathetic projections to brown adipose tissue independently control thermogenesis and glucose tolerance. Congrats Daniele Neri and team 🥳 www.nature.com/articles/s42...

How does fever work? Our new Science paper shows how elevated body temperature can protect against severe influenza and that avian-origin viruses escape this defence. This is likely one reason why bird flus and some pandemic influenzas can be so severe.🧵 www.science.org/doi/10.1126/...

When you zoom in

Really nice work from our neighbours Stephanie Fulton and team investigating links between inflammation, anxiety, and microglia! www.sciencedirect.com/science/arti...

My first first-author paper is published! At the intersection of metabolism and reproduction, we wrote this review with a broad audience in mind, and hope that there is something for everyone. Excited for the future of the field and honored to be a part of it! academic.oup.com/endo/article...

Woo hoo @paulvander24.bsky.social !

Mars was the Roman god of war. That’s why we say ‘martial arts,' ‘martial law,' and 'court martial.' Marshall was the Roman god of designer fashion at discount prices. That’s why we have Marshall’s.

We are looking for a postdoc fellow to join the group. Focus on studying feeding-relevant slow dynamics in the brain using invivo microscopy approaches. Please share with anyone interested. Thank you. www.training.nih.gov/jobs/pdf-inf...

Proud to announce the publication of our new paper describing the design, chemical synthesis and testing of a novel class of Complement 3a Receptor (C3aR) agonists and antagonists derived from the TLQP-21 peptide @pubs.acs.org Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/...

We are proud of Omprakash Singh's new study just out in Cell Reports. Supported by Sepideh Sheybani-Deloui et al, Om's work identifies GHSR expressing SCN neurons as regulating food intake + feed efficiency at a single time of day, accounting for at least 7% of a mouse's BW doi.org/10.1016/j.ce...

Rigorous dissection of the signaling mechanisms and circuits underlying GLP1R agonist weight loss effects mice. Huge achievement by Claire Gao and team @mikekrashes.bsky.social. Potential avenues for harnessing complexity of signaling to create novel treatments. www.biorxiv.org/content/10.1...

Amid lots of uncertainty, anger, and exhaustion I am excited to share this work from my incredibly talented MSTP and @nuincomm.bsky.social student Haley Province. In it we explore the fascinating and powerful anti-aversive properties of GIPR agonists

Genomic convergence in hibernating mammals elucidates the genetics of metabolic regulation in the hypothalamus | Science www.science.org/doi/10.1126/...

Huge congratulations to Ivan and the rest of the @mikekrashes.bsky.social lab—formidable job! Grateful to have contributed a tiny piece to this.

🧵1/15 Delighted to share our study on the naked mole-rat (NMR): a mammal with bizarre thermal biology, notorious longevity, and cancer resistance. But how do NMRs maintain (or fail to maintain) their body temperature? Our latest work digs deep! #ThermalBiology #Thermogenesis

big if true

New Pub 🚨: Read how we’re tying a specific GABA A receptor subtype to the impact of HFD on central cardiac vagal motor neurons. www.cell.com/iscience/ful...

This is brilliant! And not by Charles Dar-wine 😂

An example of what we in the NIH Intramural program can accomplish. Excited to share our latest paper in close collaboration with Nick Ryba's group. We examined how inflammation transforms representation in somatosensory neurons to cause pain. Lots of surprises here: www.nature.com/articles/s41...

so they're mycoblogging

Three miles of wiring inside a speck of brain tissue. Here is my story on a milestone in neuroscience. Gift link: nyti.ms/42BWWR7 (Video courtesy Forrest Collman)

For >20 years obesity was thought to be associated with reduced dopamine receptors in brain reward regions. Now, a big study by @vdarcey.bsky.social shows that this may be have been an artifact (top figure panel) due to brain dopamine tone being positively associated with body fat (bottom).

eredivisiestand:

Beyond Mechanism—Extending Our Concepts of Causation in Neuroscience onlinelibrary.wiley.com/doi/10.1111/... - really pleased that this paper with Henry Potter is now published in the European Journal of Neuroscience 😊

Tried to google the word count of On the Road.

In addition to her speech on empathy at the SAG awards, Jane Fonda wore a #celegans gown to die for

www.nature.com/articles/s41.... Interesting but report of liver autonomous effects of MC3R a bit surprising given the very low expression of MC3R in liver, at least in humans

New preprint from the lab, here we study head waving stereotypy induced by some appetite suppressants www.biorxiv.org/content/10.1...

New paper from the lab!!! D2-expressing neurons in accumbens is rewarding but paradoxically it stops licking! journals.plos.org/plosone/arti...

I shouldn’t laugh at this but I somehow needed to.

Did I receive a follow from a new philanthropist on the block? 😂

Voluteering to help soldering at a science class today This is how they told the kids to be careful 😂 … the lead may get in your body … gets stored in your brain … you go insane … AND YOU LOOSE ALL YOUR FRIENDS

Hypothalamic Vasopressin Neurons Enable Maternal Thermoregulatory Behaviors https://www.biorxiv.org/content/10.1101/2025.01.23.634569v1

Probability probably does not exist Frank Ramsey was a genius of probability. He worked only in the mornings, devoting his after-hours to a wife and a lover, playing tennis, drinking and enjoying exuberant parties while laughing “like a hippopotamus” www.nature.com/articles/d41...

My Dispatch on the thermoregulatory inversion article: "Speculatively, hypothermia circuits may be employed naturally to rescue an endotherm animal in extremely dire situations. This could even exist in humans: ... authors.elsevier.com/a/1kOXg3QW8S...

Congratulations to Domenico Tupone and lab and collaborators for more fascinating work identifying neural circuits that reverse thermoregulation, involving the preoptic area, parabrachial nucleus and dynorphin! Torpor in non-torpid species! 🧠🌡 www.sciencedirect.com/science/arti...

Neurobiology behind an inverse thermoregulatory response to cold 👇🏼 www.cell.com/current-biol...