We are looking for a postdoc fellow to join the group. Focus on studying feeding-relevant slow dynamics in the brain using invivo microscopy approaches. Please share with anyone interested. Thank you. www.training.nih.gov/jobs/pdf-inf...

Proud to announce the publication of our new paper describing the design, chemical synthesis and testing of a novel class of Complement 3a Receptor (C3aR) agonists and antagonists derived from the TLQP-21 peptide @pubs.acs.org Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/...

We are proud of Omprakash Singh's new study just out in Cell Reports. Supported by Sepideh Sheybani-Deloui et al, Om's work identifies GHSR expressing SCN neurons as regulating food intake + feed efficiency at a single time of day, accounting for at least 7% of a mouse's BW doi.org/10.1016/j.ce...

Rigorous dissection of the signaling mechanisms and circuits underlying GLP1R agonist weight loss effects mice. Huge achievement by Claire Gao and team @mikekrashes.bsky.social. Potential avenues for harnessing complexity of signaling to create novel treatments. www.biorxiv.org/content/10.1...

Amid lots of uncertainty, anger, and exhaustion I am excited to share this work from my incredibly talented MSTP and @nuincomm.bsky.social student Haley Province. In it we explore the fascinating and powerful anti-aversive properties of GIPR agonists

Genomic convergence in hibernating mammals elucidates the genetics of metabolic regulation in the hypothalamus | Science www.science.org/doi/10.1126/...

Huge congratulations to Ivan and the rest of the @mikekrashes.bsky.social lab—formidable job! Grateful to have contributed a tiny piece to this.

🧵1/15 Delighted to share our study on the naked mole-rat (NMR): a mammal with bizarre thermal biology, notorious longevity, and cancer resistance. But how do NMRs maintain (or fail to maintain) their body temperature? Our latest work digs deep! #ThermalBiology #Thermogenesis

big if true

New Pub 🚨: Read how we’re tying a specific GABA A receptor subtype to the impact of HFD on central cardiac vagal motor neurons. www.cell.com/iscience/ful...

This is brilliant! And not by Charles Dar-wine 😂

An example of what we in the NIH Intramural program can accomplish. Excited to share our latest paper in close collaboration with Nick Ryba's group. We examined how inflammation transforms representation in somatosensory neurons to cause pain. Lots of surprises here: www.nature.com/articles/s41...

so they're mycoblogging

Three miles of wiring inside a speck of brain tissue. Here is my story on a milestone in neuroscience. Gift link: nyti.ms/42BWWR7 (Video courtesy Forrest Collman)

For >20 years obesity was thought to be associated with reduced dopamine receptors in brain reward regions. Now, a big study by @vdarcey.bsky.social shows that this may be have been an artifact (top figure panel) due to brain dopamine tone being positively associated with body fat (bottom).

eredivisiestand:

Beyond Mechanism—Extending Our Concepts of Causation in Neuroscience onlinelibrary.wiley.com/doi/10.1111/... - really pleased that this paper with Henry Potter is now published in the European Journal of Neuroscience 😊

Tried to google the word count of On the Road.

In addition to her speech on empathy at the SAG awards, Jane Fonda wore a #celegans gown to die for

www.nature.com/articles/s41.... Interesting but report of liver autonomous effects of MC3R a bit surprising given the very low expression of MC3R in liver, at least in humans

New preprint from the lab, here we study head waving stereotypy induced by some appetite suppressants www.biorxiv.org/content/10.1...

New paper from the lab!!! D2-expressing neurons in accumbens is rewarding but paradoxically it stops licking! journals.plos.org/plosone/arti...

I shouldn’t laugh at this but I somehow needed to.

Did I receive a follow from a new philanthropist on the block? 😂

Voluteering to help soldering at a science class today This is how they told the kids to be careful 😂 … the lead may get in your body … gets stored in your brain … you go insane … AND YOU LOOSE ALL YOUR FRIENDS

Hypothalamic Vasopressin Neurons Enable Maternal Thermoregulatory Behaviors https://www.biorxiv.org/content/10.1101/2025.01.23.634569v1

Probability probably does not exist Frank Ramsey was a genius of probability. He worked only in the mornings, devoting his after-hours to a wife and a lover, playing tennis, drinking and enjoying exuberant parties while laughing “like a hippopotamus” www.nature.com/articles/d41...

My Dispatch on the thermoregulatory inversion article: "Speculatively, hypothermia circuits may be employed naturally to rescue an endotherm animal in extremely dire situations. This could even exist in humans: ... authors.elsevier.com/a/1kOXg3QW8S...

Congratulations to Domenico Tupone and lab and collaborators for more fascinating work identifying neural circuits that reverse thermoregulation, involving the preoptic area, parabrachial nucleus and dynorphin! Torpor in non-torpid species! 🧠🌡 www.sciencedirect.com/science/arti...

Neurobiology behind an inverse thermoregulatory response to cold 👇🏼 www.cell.com/current-biol...

Relax for the holidays by listening to this month's podcast with #KirkMHabegger, #DarleenSandoval, & @thewilliamslab.bsky.social as well as our amazing #diabetesbio authors! link: shorturl.at/lg8Op Apple podcast: shorturl.at/fTa7n Spotify: shorturl.at/F6F0k YouTube: shorturl.at/W3phX

Resharing a starter pack i made a while back for those interested in Neuroscience and Metabolism research. Some recent additions are included. Let me know if you want to join! go.bsky.app/DGJS44y Neuroskyence: 🧠🟦 or 🧠📈 Interoception: 🧠🫀 or 🧠🫁

No single cell sequencing

Congrats, Jan!

I joined 75+ @nobelprize.bsky.social laureates urging US Senators to oppose RFK Jr.'s confirmation as DHHS Secretary. If you’re in a state with GOP senators, PLEASE reach out to them! I’d deeply appreciate it if you amplified this post! 🙏 www.nytimes.com/2024/12/09/h...

Exciting and beautiful new paper from Jan Siemens’ group shows that preoptic area neurons mediate heat acclimation, a process that spans days to weeks! www.nature.com/articles/s41...

New work stemming from an amazing collaboration with @addisonwebster0 and @AUGCsoup using a combination of rabies mapping and single cell sequencing to identify a GLP1R-expressing local input to AgRP cells that curbs appetite rdcu.be/d2gB5

A little late for Thanksgiving but if you have friends and family members curious about anti-obesity medications, this is very easy to digest piece (nailed that pun....still got it) authors.elsevier.com/a/1kCED3QW8S...

Beautiful study by Maddy from the Gracheva Lab describes a mechanism for long-term thirst suppression during hibernation in hibernating ground squirrels 🐿️💧 www.science.org/doi/10.1126/...

I made a starter pack for the Hypothalamus Gordon Research Conference 2024 - #HypoGRC based on 2022 and 2024 attendance. Please let me know if you would like to join the starter pack! Also, keep an eye out for announcements of #HypoGRC2026. go.bsky.app/RaSD1gV

What would Plato say about systems biology? In his Allegory of the Cave, prisoners can only see shadows on a wall and so they have a distorted reality. Also our measurements of genes, RNAs, proteins & metabolites are the shadows, not the reality of the complex biological systems.

Good slogan, @washingtonpost.com

12 year old Annika’s #KindnessRocks are to keep with you as a reminder to be kind to everyone including yourself, or pass it on! DC —Did you find a #KindnessRocks? #Annika #Art #kindnessrocks @washingtonpost.com @nbcnews.com @popville.bsky.social @washingtonian.bsky.social

Today in relatable science: Gulls making a mysterious daily trip that turned out to be to a potato chip factory

My first flutter is an oversized neuron in the preoptic area

On Twitter, you tweeted. On Blue Sky, do you BS?