Proud to announce the publication of our new paper describing the design, chemical synthesis and testing of a novel class of Complement 3a Receptor (C3aR) agonists and antagonists derived from the TLQP-21 peptide @pubs.acs.org Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/...

📢Applications for the McEwen fellowship are now open! We expect to award 1-3 fellowships (up to $6,000 each) to early-career scientists with a proposal within the broad scope of our research network’s interests. Deadline: July 15 Apply here: www.animalsocialaging-network.org/funding/fell...

Reminder - funding opportunity available trough the @animalsocaging.bsky.social Pilot & Feasibility Awards Application period - June 1 to June 30 B. McEwen Career Development Fellowship Application period - June 15 to July 15 Small/Working Group Awards Application period - July 1 to July 31

📣 @animalsocaging.bsky.social NIA-funded high priority research network - funding available soon!📣 Stay tuned for 3 RFAs: 1. Pilot awards - June 30th 2. The Bruce McEwen Fellowship - July 15 3. Small/working group - July 31 More info on the network: www.animalsocialaging-network.org

New Study alert: “Epigenetic biomarkers of mortality risk in mice under chronic social stress" @geroscience.bsky.social lnkd.in/dqPGrQx4 Mathematical models identified epigenetic biomarkers of mortality risk and an association with blood glucose levels, informing on individual aging trajectories.

📢Applications are OPEN for our Pilot awards! Individual or mentored projects available with up to $20,000 in total costs! Read the full RFA and apply at the link below! www.animalsocialaging-network.org/funding/pilo... @smacklab.bsky.social @bartolomuccilab.bsky.social @jennytung.bsky.social

New Research Network publication alert! @sheehanmj.bsky.social and @matthewzipple.bsky.social, both recipients of Network Pilot & Feasibility awards, have published a paper in Aging Cell on ecological realism and epigenetic aging in mice. Congratulations, Mike and Matthew! doi.org/10.1111/acel...

📣New network funding available soon!📣 The Request for Applications for our Research Network's pilot awards (June 1-June 30), the Bruce McEwen Fellowship (June 15-July 15), and small/working group awards (July 1-July 31) will be live on our website (www.animalsocialaging-network.org) in two weeks!

That`s a big one! congrats to the outstanding team of co-authors

Our NIA funded High Priority Research network on Animal Models for the Social Dimension of Health and Aging just landed on Bsky @animalsocaging.bsky.social - follow us for updates and new RFAs www.animalsocialaging-network.org @smacklab.bsky.social @jennytung.bsky.social

🎤Hey, is this thing on? The Animal Models for the Social Dimensions of Health and Aging Research Network is on Bluesky! We are an NIA-funded network headquartered at UMN, ASU, UNC, and Duke that supports early-career scientists using animal models to study social aging. New funding available soon!

🚨 Great opportunity for an excellent post doc with a fantastic international group of top notch scholars.

Read here our original article showing the biological age prediction by accumulating stochastic variation alone. With @meyer.bsky.social and a wonderful cover art designed by @maayanvisuals.bsky.social www.nature.com/articles/s43...

Food insecurity drives obesity and adiposity, but how is unclear. A recent study by @clemmensenc.bsky.social developed a mouse model for this phenomenon lnkd.in/d8pEp2qv Happy to share a commentary written with @johnspeakman4.bsky.social with our take on that study doi.org/10.1002/oby....

The gap in life expectancy between the richest and poorest Swedes widened between 1960–2021. The cause of this trend was not increased inequality or a decline in social spending but an embrace of healthy lifestyles by the affluent. In PNAS: www.pnas.org/doi/10.1073/...

bad news for freshwater quality in minnesota and midwest, very bad in the Twin Cities.

🧠💥 For #Dopamine (DA) & #Memory lovers! 📢 New paper!! we show that memory capacity (MC) in mice can be expanded from 6 to 8 objects using low doses of a D1 receptor agonist. Higher doses? Paradoxically, they reduce MC. #Tigem #Consiglio Nazionale delle Ricerche lnkd.in/d9skfGeb

We recently published @geroscience.bsky.social the development and validation of the mouse social frailty index (mSFI) link.springer.com/article/10.1... We now report a detailed step-by-step resource paper describing how to conduct the mSFI. bio-protocol.org/en/bpdetail?...

🌟 Exciting News! 🌟 I am thrilled to share that my first paper as the first author, Food insecurity promotes adiposity in mice, is now published in #ObesityJournal #ObesitySociety doi.org/10.1002/oby.... #Foodinsecurity #Obesity #PhD 1/9🧵👇

Proud to share the work of my forst ever PhD student and first author of this paper @dylanduerre.bsky.social!! Here, he summarizes it perfectly! #brownfat #metabolism #BCAA #heme @uwmadison.bsky.social @uofutahcihd.bsky.social

"We could all use a little more X!" Thrilled our new study is out. Aging "wakes up" the silent X chromosome in the female brain - and this contributes cognitive resilience. Spearheaded by @margaretgadek.bsky.social in Science Advances. www.science.org/doi/10.1126/...

In an unprecedented move, the US National Institutes of Health (NIH) has begun mass terminations of research grants that fund active scientific projects because they no longer meet “agency priorities”…. 🧪 #AcademicSky www.nature.com/articles/d41...

Women tend to live longer than men and are often more resilient to cognitive decline as they age. Now researchers might have uncovered a source for this resilience: the second X chromosome in female cells that was previously considered ‘silent’ https://go.nature.com/3F40x10

Outdoor heat in older adults and accelerated biological (epigenetic) aging www.science.org/doi/10.1126/...

This is how you can predict an individual's risk of an age-related disease 2 decades ahead of their showing up. More on this erictopol.substack.com/p/the-emerge...

Protein organ clocks, as assessed in over 6,000 people (~4,000 plasma proteins, 8 organs) with 20-year follow-up are predictive for over 30 age-related diseases www.thelancet.com/journals/lan...

Really awesome work here 👇🏼👇🏼👇🏼

1/4 I am very pleased to share this new manuscript, “A crucial role for the cortical amygdala in shaping social encounters”, led by 2 spectacular postdocs, Dr. Tony Aubry who is on the job market, and coauthor @neuromanonyc.bsky.social Read it here: www.nature.com/articles/s41...

Nature research paper: Macrophages protect against sensory axon loss in peripheral neuropathy https://go.nature.com/3QfyvC4

I am excited to share our latest paper @Nature where we construct a hi-res spatial map of the human hypothalamus, the brain region central in appetite control. It is a collaboration between @IMS_MRL @Cambridge_Uni & @MPI_Metabolism www.nature.com/articles/s41...

Spatial multi-omics has just gone to the next level! www.nature.com/articles/s41... www.nature.com/articles/s41... —Integration of 5 omic modalities w/ spatial resolution at 20 -50 μm —"a new era for characterizing tissue & cellular heterogeneity that single-modality studies alone could not reveal"

Muscle-derived myostatin is a major endocrine driver of follicle-stimulating hormone synthesis | Science science.org/doi/10.1126/sc…. Major advance in endocrinology. So fascinating that new important hormonal actions of TGFBeta family members are still being discovered.

Today, we report that chronic intermittent fasting impairs beta-cell maturation and function in adolescent mice. Using scRNAseq, we delineated a "maturation score" for beta-cells. Long-term IF good if you're older, might be harmful if you are still developing! 👇 www.cell.com/cell-reports...

Very interesting structural Cryo-EM study on the C3aR1 receptor confirming our earlier demonstration (pubmed.ncbi.nlm.nih.gov/38072064/) that SB290157 and JR14a are full agonists and not antagonists Luo et al. Cell Discov 11, 7 (2025). doi.org/10.1038/s414...

Review @cp-cellmetabolism.bsky.social Decoding aging clocks: New insights from metabolomics www.cell.com/cell-metabol...

Taking 5 min from my 2-week 🎅 Holidays break 🥂 to share our new review out today 🤓 the hard work of 3 super talented 🧪 PhD students *Béatrice *Laura & *Valérie covering implication of 🧠 #vascular #BBB cells in #anorexia #stress #depression #Parkinson #Alzheimer www.sciencedirect.com/science/arti...

An impressive new issue of Neuron on the science of brain aging with 10 papers on everything from sex differences, role of astrocytes, immune system, waste clearance, autophagy, DNA damage, and rejuvenation cell.com/issue/S0896-...

Thrilled to see this paper out!! 🧪 Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors! Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social! rdcu.be/d33uQ 🧵

Intermittent fasting triggers interorgan communication to suppress hair follicle regeneration www.cell.com/cell/fulltex...

Worryingly high prevalence of retraction among top-cited researchers By Shaoxiong Brian Xu & Guangwei Hu @nature.com.web.brid.gy www.nature.com/articles/d41...

A chimeric peptide promotes immune surveillance of senescent cells in injury, fibrosis, tumorigenesis and aging Xinliang Ming, et al. www.nature.com/articles/s43...

Chronic social stress accelerates brain aging by causing neurons to enter a harmful "senescent" state, linked to inflammation and aging diseases, according to new research. #ChronicStress #BrainHealth #Neuroscience #MentalHealth #Aging

🚨 Tenure track positions at Physiology Dept UMN. Join a vibrant research environment: med.umn.edu/physiology med.umn.edu/aging med.umn.edu/about/center... Areas of interest: aging biology, molecular metabolism, cardiovascular, inflammation, stress etc. Apply here: z.umn.edu/9zxj

Pleased to announce the publication of our new manuscript, "Late-life protein or isoleucine restriction impacts physiological and molecular signatures of aging" in Nature Aging today! www.nature.com/articles/s43... Free link: rdcu.be/d1DGk

How Chronic Social Stress Contributes to Aging. #NatureAging Life stress can shorten lifespan and increase risk for aging-related diseases, but the biology underlying this phenomenon remains unclear. This study provides a potential mechanism. Read more www.nature.com/articles/s43...

Mouse and human macrophages and their roles in cardiovascular health and disease Alexandre Gallerand, Jichang Han, Stoyan Ivanov & Gwendalyn J. Randolph Nature Cardiovascular Research (2024) www.nature.com/articles/s44...

Happy birthday evolution...'The origin' was published today in 1859. Probably one of the most significant science books of all time.

Want to know more about the 'Expanding applications of therapies based on #GLP1' Check out this latest review by Daniel Drucker 🧪🔬🥼 @natureportfolio.bsky.social 👇👇 #CardiacSky #NephSky #Diabetes #obesity #cardiovascular #kidneydisease #LiverDisease www.nature.com/articles/s41...

🚨 Tenure track positions at Physiology Dept UMN. Join a vibrant research environment: med.umn.edu/physiology med.umn.edu/aging med.umn.edu/about/center... Areas of interest: aging biology, molecular metabolism, cardiovascular, inflammation, stress etc. Apply here: z.umn.edu/9zxj