Gary Patti
@gjpattij.bsky.social
📤 979
📥 420
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metabophile (muh-tab-uh-fil'): a person obsessed with all things metabolism, metabolomics
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Gary Patti
Roland Hatzenpichler
1 day ago
“The prohibited activities would include joint research, co-authorship on papers, and advising a foreign graduate student or postdoctoral fellow. The language is retroactive, meaning any interactions during the previous 5 years could make a scientist ineligible for future federal funding.”
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U.S. Congress considers sweeping ban on Chinese collaborations
Researchers speak out against proposal that would bar funding for U.S. scientists working with Chinese partners or training Chinese students
https://www.science.org/content/article/u-s-congress-considers-sweeping-ban-chinese-collaborations
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Gary Patti
Waggoner Lab
16 days ago
Gut microbiota protect against hepatic steatosis by degrading sorbitol derived from dietary glucose
@gjpattij.bsky.social
www.science.org/doi/10.1126/...
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Gary Patti
Your Local Epidemiologist
25 days ago
6/ So what can you do? ✔️ Choose supplements that are third-party tested for heavy metals (USP, NSF, or Informed Sport). ✔️ Prioritize whole-food protein sources when possible. ✔️ Advocate for stronger supplement regulation as the industry has little oversight.
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Gary Patti
Artem Khan
about 1 month ago
Excited to share our work on discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid import and carnitine biosynthesis.
@cp-cellmetabolism.bsky.social
www.cell.com/cell-metabol...
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Machine-learning-guided discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid import and carnitine synthesis
Khan et al. apply machine learning to identify substrates of UNC93A, SLC45A4, and SLC25A45. Biochemical assays and in vivo metabolite tracing establish SLC25A45 as a key mediator of mitochondrial impo...
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(25)00434-6
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Gary Patti
Your Local Epidemiologist
about 2 months ago
1/ RFK Jr.’s promised autism “report” landed this week. Instead of new science, we got headlines, a press conference, and far-reaching claims drawn from decades of existing research. Parents and pregnant people were left with overwhelming anxiety. Here’s what the evidence actually says 👇
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The Washington Post did a great job of summarizing a complex topic. There is still so much to learn about the connections between the exposome and cancer. Thanks for including me.
add a skeleton here at some point
about 2 months ago
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Gary Patti
Nature Portfolio
2 months ago
Research in Scientific Reports suggests that blue-throated macaws can learn new actions by watching other macaws interact. The study indicates that this approach to learning is not exclusive to humans.
go.nature.com/4g8p43m
🧪
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Gary Patti
Caroline Bartman
3 months ago
defunding children's brain cancer research.
@endpts.com
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Gary Patti
Jeremy Berg
3 months ago
I have a first serious attempt to estimate the consequences of multi-year funding for July. For new R01s, the amount of additional expenditure was $135 M The number of additional R01s that could have been funded is 182 1/9
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Gary Patti
Ian L Morgan
4 months ago
Here are some of the highlights of the appropriations bill that the Senate appropriations committee just approved: $48.7 billion for NIH, an increase of $400 million Rejects the proposal to cap indirect cost rates at 15% Includes a provision to prevent MYF that would reduce the number of grants
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https://www.appropriations.senate.gov/imo/media/doc/fy26_lhhs_senate_bill_summarypdf.pdf
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Gary Patti
Ian L Morgan
4 months ago
Even with flat funding for the NIH, under the current FY26 plan, there will be 60% less cancer research and much less research funded overall. We need to make sure Congress understands these tricks and protects against them in their budget plan.
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Odds of winning NIH grants plummet as new funding policy and spending delays bite
Funding multiyear grants up front will sharply cut number of investigators receiving awards
https://www.science.org/content/article/odds-winning-nih-grants-plummet-new-funding-policy-and-spending-delays-bite
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Gary Patti
Your Local Epidemiologist
4 months ago
1/ Since January, over 5,500 NIH-funded projects have been paused. That includes cancer trials, Alzheimer’s research, maternal health studies. This is work that directly impacts our lives. And people aren't talking about it enough. Let’s fix that 🧵
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Gary Patti
Mike Goodwin
5 months ago
RIP Alan Marshall, one of the greatest mass spectrometrists ever, and a great human to boot.
nationalmaglab.org/careers/meet...
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Alan Marshall: A scientist and a Gentleman - MagLab
Meet one of the greatest innovators in the history of mass spectrometry, hard at work.
https://nationalmaglab.org/careers/meet-our-scientist-staff/alan-marshall-a-scientist-and-a-gentleman/
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Gary Patti
Jeremy Berg
6 months ago
Join @drwendieberg.bsky.social for this half hour of discussion of supplemental breast cancer screening for women with dense breast tissue.
add a skeleton here at some point
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Gary Patti
Eric Topol
6 months ago
"Gold standard science"
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Gary Patti
Randall Munroe
6 months ago
Mass Spec
xkcd.com/3094/
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Gary Patti
John Yates
6 months ago
Here’s what we have going on at
#ASMS2025
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Gary Patti
Jeremy Berg
6 months ago
A strong statement about the importance of NIH on
@cbsnews.com.web.brid.gy
Sunday Morning (Part 1)
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Gary Patti
Eric Topol
6 months ago
"Protein may be hot, but it’s fiber that Americans need to eat a lot more of." "To get the full health benefits of fiber, it’s important to eat a variety of naturally fiber-rich foods and not rely on supplements...could actually lead to health problems..." gift link
www.wsj.com/health/welln...
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Americans Don’t Eat Enough Fiber. Here’s Why That Worries Nutrition Experts
The latest science suggests our fiber-poor diets trigger inflammation and contribute to a range of related diseases.
https://www.wsj.com/health/wellness/fiber-diet-americans-health-58cd8ca3?st=HSEzrh&reflink=desktopwebshare_permalink
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Gary Patti
Jeremy Berg
6 months ago
Video from the hearing yesterday
www.youtube.com/live/_Szx0jJ...
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Senate Democrats Host Forum on HHS: Day 2
YouTube video by Senator Peter Welch
https://www.youtube.com/live/_Szx0jJKcQI
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Gary Patti
Jeremy Berg
6 months ago
Another good use of 5 minutes of your time.
add a skeleton here at some point
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Gary Patti
Jeremy Berg
6 months ago
I have previously posted about the slow issuance of NIH award in fiscal year 2025 compared to fiscal year 2024.
jeremymberg.github.io/jeremyberg.g...
These data were across all of the institutes and centers at NIH. The results can be examined for each institute and center. 1/n
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NIH_since_1_20_25
https://jeremymberg.github.io/jeremyberg.github.io/
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Gary Patti
Phillip White
7 months ago
The Sable Award lecture at METPHYS2025 was really remarkable! Tremendous congratulations to this years exceptional member of our community Kivanc Birsoy
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Gary Patti
Dr. Lucky Tran
7 months ago
Deaths from heart disease down 75%, that’s NIH. Deaths from stroke down 75%, that’s NIH. HIV/AIDS no longer a death sentence, that’s NIH. 99% of FDA approved drugs in the last decade, that’s NIH. Please show this video to anyone who doesn’t understand why the NIH is so important.
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Gary Patti
Lydia Lynch
7 months ago
A beautiful day in Princeton
@princeton.bsky.social
to host our Ludwig Distinguished speaker Dr Kivanc Birsoy from Rockefeller
@ludwigcancer.bsky.social
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Gary Patti
Ardem Patapoutian
7 months ago
Here’s your chance to ask the new NIH director some questions. Don’t be shy!
add a skeleton here at some point
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Gary Patti
William C Phelps, PhD
7 months ago
A compelling letter from Nobel Laureate, William Kaelin, MD about the looming loss of US leadership in science and innovation. 🧪
www.amjmed.com/article/S000...
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Killing the Science Golden Goose
In the 1970’s I was probably one of the last American high school students who was told that if you wanted to go to medical school, you should learn to speak German. This was because in the late 19th ...
https://www.amjmed.com/article/S0002-9343(25)00226-8/fulltext?fbclid=IwY2xjawJxRThleHRuA2FlbQIxMQABHlhJMLcC3bYvdCmUgVxGTyJSM46jbChxq5ha3HxaOSY0ImS8uRuCafpXWVLL_aem_XmAXEU_KNmkDZsDxvnjD5w
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Gary Patti
Jeremy Berg
7 months ago
STAT story about freezing all payments to Columbia, Harvard, Brown, Northwestern, Cornell, and Cornell-Weill Medicine.
www.statnews.com/2025/04/18/n...
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NIH said to have halted awarding of new grants to top universities
Universities whose NIH funding has been frozen may face further strain as the agency holds off awarding new grants to at least a half dozen of them, according to an internal email.
https://www.statnews.com/2025/04/18/nih-halts-grants-to-universities-with-frozen-funds-harvard-columbia-northwestern-cornell/
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Gary Patti
Jeremy Berg
7 months ago
Inside High Ed article about Advisory Council meetings resuming.
www.insidehighered.com/news/governm...
1/n
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NIH Resumes Key Grant Review Panels
After a months-long pause, advisory councils for the National Institutes of Health are restarting, paving the way for the final approval of grants. Experts say it’s an encouraging sign for the $47 bil...
https://www.insidehighered.com/news/government/science-research-policy/2025/04/16/nih-resumes-key-grant-review-panels#
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Gary Patti
Jeremy Berg
7 months ago
Here is a key paragraph: The proposal would reduce the more than $47 billion budget of the NIH to $27 billion — a roughly 40 percent cut. It would consolidate NIH’s 27 institutes and centers into just eight. 2/n
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Gary Patti
Jeremy Berg
7 months ago
More from the Washington Post (and this one is a doozy) regarding the President's Budget. Note that this is an aspirational document and Congress has to act (or ignore it). [Gift Link]
wapo.st/42gLz0Z
1/n
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Internal budget document reveals extent of Trump’s proposed health cuts
HHS would be asked to absorb a $40 billion cut, about one-third of its discretionary budget.
https://wapo.st/42gLz0Z
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Gary Patti
Magdalena Skipper
7 months ago
Airborne microplastics enter plant leaves & end up in our food New evidence emerges for a previously overlooked route for microplastics to enter plant tissues & crops and has implications for ecology and human health Original work
www.nature.com/articles/s41...
🧪
www.nature.com/articles/d41...
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Airborne microplastics enter plant leaves and end up in our food
Evidence for a previously overlooked route for microplastics to enter crops and reach plant tissues has implications for ecology and human health.
https://www.nature.com/articles/d41586-025-00909-3
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Gary Patti
Susanne Ahmari
7 months ago
🚨🚨🚨 Now ALL GRANTS to Columbia are being frozen!!! 🚨🚨🚨
www.science.org/content/arti...
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NIH freezes all research grants to Columbia University
Amid negotiations with Trump, the university could risk losing nearly $700 million
https://www.science.org/content/article/nih-freezes-all-research-grants-columbia-university
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Gary Patti
Magdalena Skipper
7 months ago
Science’s big problem is a loss of influence, not a loss of trust, argue Heidi Larson and David Bersoff Science & scientists remain highly trusted. But genuine scientific voices are not shouting loud enough over the noise to hold sway 🧪
#AcademicSky
www.nature.com/articles/d41...
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Science’s big problem is a loss of influence, not a loss of trust
Evidence shows that science and scientists remain highly trusted. But genuine scientific voices are not shouting loud enough over the noise to hold sway.
https://www.nature.com/articles/d41586-025-01068-1
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Gary Patti
Nikolai Slavov
8 months ago
NIH contributed to 354 of 356 drugs (99.4%) approved from 2010 to 2019.
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Gary Patti
Eric Topol
8 months ago
A pie graph worth keeping in mind as the NIH budget plummets
jamanetwork.com/journals/jam...
for 356 new FDA drugs approved
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Gary Patti
8 months ago
theanalyticalscientist.com/business-edu...
. Well said.
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The Diminishing of American Science
If US laboratories will have less money to pay staff, conduct research, and collaborate American science will be greatly diminished
https://theanalyticalscientist.com/business-education/the-diminishing-of-american-science
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Gary Patti
Bini Ramachandran
8 months ago
"The changes the current government is attempting to make to American science will greatly diminish our scientific standing in the world." Guess no questions there.. Period..
add a skeleton here at some point
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Gary Patti
The Francis Crick Institute
8 months ago
Researchers at the Crick have found that pregnancy in mice leads to the irreversible growth of their small intestine.
www.crick.ac.uk/news/2025-03...
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Pregnancy irreversibly remodels the mouse intestine
Researchers at the Francis Crick Institute have found that the small intestine grows in response to pregnancy in mice. This partially irreversible change may help mice support a pregnancy and prepare ...
https://www.crick.ac.uk/news/2025-03-19_pregnancy-irreversibly-remodels-the-mouse-intestine
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Thank you for the highlight!
add a skeleton here at some point
8 months ago
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Gary Patti
Magdalena Skipper
8 months ago
“We are in a different era right now where nothing is normal” What’s in store for US science as funding bill averts government shutdown
@nature.com
🧪
#AcademicSky
www.nature.com/articles/d41...
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What’s in store for US science as funding bill averts government shutdown
Spending on research, including at the NIH, will see modest cuts this year. But the threat of big reductions in future remain.
https://www.nature.com/articles/d41586-025-00827-4
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Gary Patti
Gabrielle Brewer
8 months ago
Interesting panelist discussion at
#KSTumorMetab25
on communicating science effectively to combat misinformation in this era. Check out this
#WorldView
that we,
@natrevcancer.bsky.social
, published from
@juliabauman.bsky.social
who posts 60-second TikToks explaining recent papers.
bit.ly/41trLps
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Maximize your research impact with storytelling - Nature Reviews Cancer
Although sometimes overlooked, storytelling is a powerful tool for communicating scientific research. In this World View, Julia Bauman outlines what is needed to convey a strong scientific narrative, ...
https://www.nature.com/articles/s41568-023-00616-z
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Fantastic work out of Ramon Sun’s lab using mass spectrometry imaging to study glycogen in lung cancer.
www.nature.com/articles/s42...
8 months ago
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Gary Patti
Erin Baker
8 months ago
I had the opportunity to give my perspective to The Analytical Scientist about recent events. With this article, I hope to give a voice to others who may not have the ability to speak out.
#StandUpForScience
theanalyticalscientist.com/business-edu...
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A Bleak Future?
Recent layoffs and funding cuts have not only crippled morale among scientists, they’ve also set an alarming precedent for the future of science
https://theanalyticalscientist.com/business-education/a-bleak-future
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Gary Patti
Nicole Tersigni
8 months ago
you’re fired. wait you’re rehired. email us a list of things you’ve done today wait forget it you’re fired again. come back your job was important. you’re fired. or hired. come in to the office. wait the office has no computers go home. we are the department of government efficiency.
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Gary Patti
Max Kozlov
8 months ago
NIH announces that it will move all grant reviews to Center for Scientific Review (CSR) and terminate about half of its review staff. This comes as there is already a building backlog from cancelled review meetings and layoffs. "We're already massively behind schedule," a review officer tells me.
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NIH centralizes peer review to improve efficiency and strengthen integrity
The proposed approach is expected to save more than $65 million annually.
https://www.nih.gov/news-events/news-releases/nih-centralizes-peer-review-improve-efficiency-strengthen-integrity
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Gary Patti
Stand Up for Science!
8 months ago
STAND UP FOR SCIENCE SPEAKER ANNOUNCEMENT! ☀️ Dr. Francis Collins will be speaking at Stand Up for Science in D.C. on March 7th! More speaker announcements coming soon, stay tuned! 👀☀️
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Gary Patti
Khalimonchuk Lab
8 months ago
Structure of mitochondrial pyruvate carrier and its inhibition mechanism
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Structure of mitochondrial pyruvate carrier and its inhibition mechanism - Nature
Structural findings define the architecture of the mitochondrial pyruvate carrier, delineate its substrate-binding site and translocation pathway, and reveal its major conformational states, providing...
https://www.nature.com/articles/s41586-025-08667-y
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Gary Patti
Science Magazine
8 months ago
A federal judge in Massachusetts today blocked an attempt by the National Institutes of Health to cut some $4 billion annually that goes to universities to cover the cost of supporting research on their campuses.
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U.S. judge blocks NIH’s plan to slash overhead cost payments
Injunction allows universities to keep receiving billions to recover costs of supporting federal research on campus
https://scim.ag/4koY4P3
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Gary Patti
Ardem Patapoutian
9 months ago
Important 🧵 about a Bill that would devastate researchers' ability to study viruses (and vaccines). Copying our congressmen
@levin.house.gov
@repscottpeters.bsky.social
. Please amplify!
add a skeleton here at some point
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