1/ We are excited to share our new report in @jem.org showing that almost 40% cases of herpesvirus (HSV)-triggered fulminant viral hepatitis (FVH) are due to pre-existing autoantibodies neutralizing type I IFN (autoAbs-IFN) (doi.org/10.1084/jem....).

Exciting new #Zebrafish research from the #WeinsteinLab, led by Jong Park! “Specialized gas-exchange endothelium of the zebrafish gill” — www.biorxiv.org/content/10.6... Amazing to see red blood cells moving through the gills! Don’t forget to check out the supplemental movies ;-)

Kinesin-1-driven microtubule sliding helps pancreatic β cells reorganise their cytoskeleton in response to glucose. buff.ly/r3BlzFj

Neat trick if you polycolonal ab's suck. Incubate them with fixed cells with a KO of your protein of interest, then spin. Protocol here: www.med.upenn.edu/markslab/ass... I was amazed how well it worked on first try (I'm sure that I can completely eliminate unspecific bands) #WesternBlot #cellsky

So cool! Looking at skin cells to understand psychosis

Check out our new RAEFISH spatial transcriptomics technology published in Cell! This work represents the first time that transcripts from more than 20,000 genes were directly imaged in situ with any technology, and the first time numerous gRNAs were directly probed in an image-based CRISPR screen.

Ever since my early Evo-Devo days I have loved non-traditional models! Hope to get back to it some day, but in the meantime love to see scientists pioneering this type of work

The last publication (he says!) from Rich Losick, my PhD advisor. Historical in nature it focuses on a seminal paper in molecular biology, the study revealing the genetic code to be triplet in nature. Come for the science, appreciate the clear prose! www.sciencedirect.com/science/arti...

24 years ago today, I fell in love in NYC. In the shadow of Ground Zero & the horrors of that day. We have been married for 22 years now. And we have two fabulous children. I think of this whenever I worry about the darkness. There can be beauty, even when the worst of humanity is on display.

Please RP. We are thrilled to announce that our lab’s first preprint is out! ”Whole-genome single-cell multimodal history tracing to reveal cell identity transition” We report HisTrac-seq, a multiomic single-cell molecular recording platform. www.biorxiv.org/content/10.1...

Have $10M and want to cure some diseases? It costs ~$1B to invent a new medicine…but $10M buys you Project Encore, to see if ANY existing drug might be repurposed for ~100 diseases that have no treatments. Contact me - be a hero for desperate patients! docs.google.com/document/d/1...

A new tragedy for the Endocrine community An outstanding scientist leaves us too soon

I’m glad to know I’m not the only one who constantly googles “tocris calculator”

Nanopore technology might be able to sequence proteins soon! Read about the road ahead in this exciting Perspective rdcu.be/edWPi in @naturebiotech.bsky.social

💫NEW: @valentatormenta.bsky.social, Perry & co track the endogenous redox ratio (NAD(P)H/FAD) with live imaging in the mouse skin and find that maintaining a robust redox ratio is key to clonal prevalence. www.nature.com/articles/s41...

Love research applying newer microscopy techniques to liver biology!! Congrats @hannahhrncir.bsky.social and @graczlab.bsky.social

We have a new EO launching the MAHA Commission. There's a lot of enthusiasm in nutrition spaces that MAHA will finally bring a spotlight to food, but I have a number of concerns - from un-serious descriptions of the problems we face to chemophobic dogwhistles kcklatt.substack.com/p/the-maha-c...

We're seeing continued censoring from the administration of scientific and clinical information including this crucial webpage from FDA of "Approved Risk Evaluation and Mitigation Strategies (REMS)" which serve as critical programs for drug safety. No explanation, no notice. #MedSky

The correct term is conjunctival icterus. The expression "scleral icterus" was previously and incorrectly perpetuated. See this scathing remark in @jama.com by an ophthalmologist. jamanetwork.com/journals/jam... #Liversky #GiSky #Medsky @cwruim.bsky.social

A poem for today. www.poetryfoundation.org/poems/89897/...

Interested in how T cells are regulated in a tissue-specific manner? Karthik Varanasi’s exciting work shows Bile Acid synthesis impedes tumor-specific T cell responses during liver cancer @science.org Huge THANKS to all the amazing collaborators + @salkinstitute, SBP www.science.org/doi/10.1126/...

Impressive paper out in @science.org by the Kaech lab investigating the role of bile acids in mediating T-cell response in HCC. #Liversky #Gastrosky www.science.org/doi/full/10....

This. This is what good science, medicine and public health can achieve!

We present Gene Regulatory nETwork Analsyis (GRETA), a framework to infer, compare and evaluate gene regulatory networks #GRNs. With it, we have benchmarked multimodal and unimodal GRN inference methods. Check the results here 👇 Paper: doi.org/10.1101/2024.12.20.629764 Code: github.com/saezlab/greta

Been looking forward to sharing this for a long time! Great collaboration with folks from across the world in which we identified a SVA_E insertion missed by standard clinical testing in individuals with Canavan disease, an early onset neurodegenerative disease. www.medrxiv.org/content/10.1...

I’ve been out of the microbiome field field for a few years now but every time I see amazing work like this I’m impressed at how far we have come! Congrats @gangfang.bsky.social and @yufan01.bsky.social

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

eLife will send WOS a partial feed of "solid" articles. This decision will be applauded by some supporters but lamented by others as de facto re-introduction of an accept/reject decision... elifesciences.org/inside-elife...

It's that time of the year again. In no particular order, I would like to share a few of #livertwitter in 2024 with #liversky These could be original research, guidance statement, position paper or editorial. This is def not an inclusive list. Feel free to add to the 🧵

If you're looking for GI/Liver people to follow, we have you covered:

This one I'm very proud of: we identified a common genetic variant 🧬 that protects 5-fold from neonatal jaundice (replicated in different ancestries) which increases UGT1A1 (main bilirubin enzyme) expression in the gut, but not in the liver! 🖥️🧪🧬 A lot more here: www.nature.com/articles/s41...

Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..

Researchers have spoken!

Such a cool idea! One of the hardest parts of clinical genetics is understanding the functional outcome of any given variant. By using CRISPRa to induce transcription of endogenous variants in patient cells, the authors can screen variants more easily

New work on #tuft cells, rare guardians of our #gut against invaders. How they work is not known. We show that intestinal tuft types 1&2 are sequentially expressed phenotypes during differentiation. And…we can now generate mature immune-related tuft-2’s in #organoids for more 🔬🧫🧬🔥 shorturl.at/EImjA

The NIH is amazing. Sure, it could use some tuning-up. Peer review, funding decisions, and priorities could all be improved. But...not at the cost of abandoning high-quality health science. My thoughts are included in this article by @emilyanthes.bsky.social : www.nytimes.com/2024/12/01/h...

Just starting out on here, but clearly blueskyroast.com thinks I am cooler than I am 🤣😎 will try to post up to the hype

This is so cool! Mapping multiple histone marks + TFs with small cell # input. Congrats @mitchguttman.bsky.social and team!! (Also, ChIP-DIP is a cool name 😎)

Congrats Dr. Johnson! Your work on using implementation science to better understand treatment of HIV and TB around the globe is truly inspirational! Can’t wait to see what’s next! #YaleMSTP #YalePublicHealth @ldavismd.bsky.social @yaleschoolofmed.bsky.social @meganranney.bsky.social

Truly brilliant work. Calling it a foundation model is a stretch (a mistake many people in the field make). But, the only single-cell AI model in its class that I think is worth the GPU energy expended and one that I excited to utilize. My stamp of approval. www.nature.com/articles/s41...

who knew it would be easier to get everyone to switch social media platforms than getting them to use hg38

My first #FluorescenceFriday post on BlueSky 😱.🤞 that this platform makes for a great space to share science. #bioart #sciart #pathart #histoart #microscopy #intestine