1/ 👋 there #neurotwitter #neurocritcare, as part of my @neurocritcarej #SoMeAmbassador role, today we will be breaking down the following article:

On September 24, ERAS will open to programs. Which means applicants have only 2 weeks left to decide which programs to signal. And if you want to know how to allocate your signals in the most effective manner possible, I’ve got something for you: thesheriffofsodium.com/2025/09/10/t...

1/ Hello #medsky #neurosky #neurocritcare #FOAMEd have another brief case that I wanted to discuss with you and see if maybe you can learn something new or reinforce old knowledge!

🚨NEW RELEASE🚨 🔍Daily neurology connections, anyone? neuroconnections.me has launched with a free, fun micro-learning puzzle game every day! Still the initial release so let me know if you spot any bugs.🐛 Play and learn here: neuroconnections.me #Neurology #MedEd

🚨New thing release announcement! 🚨 StrokeBot.me is a free stroke code simulator for trainees! Practice workflows, interventions, disposition calls, and more! This is just the initial release so bugs are expected and updates ongoing! Enjoy! #Neurology #MedEd

Could a metal ion supplement that cost pennies per day protect from Alzheimer's disease? erictopol.substack.com/p/lithium-an...

1/ Hello #medsky #neurosky #neurocritcare #FOAMEd have a brief case that I wanted discuss with you and see if maybe you can learn something new or reinforce old knowledge!

A 50-year-old woman presented to the emergency department with a 10-day history of a throbbing headache that had suddenly started after she had felt a “pop” in her back. The headache worsened with upright positioning and improved with lying flat. 1/4 #MedSky

Case series w/ cumulative total n=110 pts support use of rivastigmine as alternative antidote to physostigmine for anticholinergic delirium. Both oral & transdermal formulations of rivastigmine may expedite recovery #medsky #EMsky #pharmsky #emimcc #FOAMed 👉 link.springer.com/article/10.1...

OpenEvidence is generally very good, but it's occasionally horrifically wrong One place it falls down a lot is drug allergy (where it's often too conservative) There are NO absolute contraindications to acetylcysteine for acetaminophen OD Reported "allergy" = anaphylactoid rxns... (#1/3) #EMIMCC

You had MS even before you had symptoms. This study found increased absenteeism from work 6 years prior to diagnosis. jnnp.bmj.com/content/earl...

This is what we were waiting for. A direct comparison between apixaban and rivaroxaban for the treatment of acute VTE. Apixaban reduces bleeding risk in the first 3 months by >50%! Practice changing investigator-initiated RCT. #ISTH2025

Peer review is being transformed by AI, whether we like it or not. From my own experience, most researchers are using it wrong… and that’s because no one’s talking about it! Let me share some ideas on how to harness its potential to improve scientific publishing.

Herpes zoster vaccination eligibility reduced the probability of new dementia diagnoses, suggesting its potential preventive effect. https://ja.ma/4lagSB6

What is the prevalence of elevated opening pressure in children with Alexander Disease? In the current issue of #pedneuro journal, Joung et al. explore this question through analysis of opening pressure, MRI and examination in a cohort of 43 patients. Read Here: buff.ly/UrvyLjh

INDEX trial: CT perfusion wasn't adequate for evaluating brain death. huge problem: they're using clinical exam as the gold standard I think most patients classified as brain dead by CT perfusion but alive by exam were dead... #1/2 #EMIMCC #CCR25

"Plasma p-tau217 reliably identified clinic patients with Alzheimer's"🆒 "definitive results in 86% of patients" 🆒 "Integration of plasma Aβ42 minimally improved diagnostic performance"🐟 "Plasma p-tau217 levels were increased in patients with kidney dysfunction"🫘

🚨 Excited to announce my brand-new, all-in-one ICH calculator page! It brings together multiple intracerebral hemorrhage stroke calculators in one comprehensive spot for assessments + decisions. 🧠🩸 Explore, use, share, and REMIX!💿📼 Check it out here: tinyurl.com/ICHcalc

#ThrowbackThursday to our episode on DAPT 🩸 Did you know that ticagrelor inhibits adenosine reuptake, which can cause bradycardia and dyspnea, sometimes resulting in patient self-discontinuation ‼️ www.coreimpodcast.com/2021/04/07/5...

For reasons, I was reading the 1902 memorial of early American neurologist J.T. Eskridge this morning - and Frank Norbury has some delightful thoughts on enthusiasm that I thought I'd share 1/5

In the TAK-861-2001 trial involving 112 participants with narcolepsy type 1, oveporexton significantly improved measures of wakefulness, sleepiness, and cataplexy over a period of 8 weeks. Full trial results and Research Summary: nej.md/3ZdlKNi  #MedSky #NeuroSky

A recent article seems to imply that we don't need to check an ECG before giving ondansetron. This is largely correct, but I disagree with some of their points. I wrote a letter to the editor that I posted in the blog, so you can access it easily here: emcrit.org/pulmcrit/twd... #EMIMCC

In a new editorial, Andrea L. Gropman, MD, and Alexis C. Komor, PhD, describe the foundations of an N-of-1 gene-editing study to treat an infant with a urea-cycle disorder. Read the editorial: nej.md/430hLWR #ASGCT2025 @asgct.bsky.social #ScienceSky

1/ Hi 👋 #medtwitter #neurotwitter #neurocritcare #FOAMed #meded have an impressive image to show you in the form of another case, albeit, this one with a sad ending

NEW EPISODE: Is there really a spoon's worth of plastic in our brain? A paper came out recently making this claim, and it went viral, tons of splashy headlines. But some scientists are VERY skeptical. 🧪 🧪🧪 Find out why 👇 available wherever you listen open.spotify.com/episode/2ZwZ...

youtube.com/shorts/CuSwN... I made some people big mad with this one

For this teacher appreciation week, I’m going to talk a little about graduate medical education. What is it? It’s the education of resident and fellow physicians. These trainees have finished medical school & are doctors but need to complete residency +/- fellowship to work in their speciality.

The gylmphatics of our brain, which clear waste products, interact with our immune system and are key to preserving brain health, modulating its aging process, and propensity for neurodegenerative diseases A superb review @cp-immunity.bsky.social @jonykipnis.bsky.social

A breakthrough in #MultipleSystemAtrophy (MSA) research: Dr. Victor Dieriks and his team in NZ have identified that the cause of this neurodegenerative disorder is toxic α-synuclein protein aggregates that invade neuron nuclei. buff.ly/YKLxq6O

To the older physicians that have attacked me for being part of the contemporary data showing the rarity of central pontine myelinolysis and explain that only because of their success at slowing the correction of hyponatremia has CPM become rare, I provide an editorial by Robert Narins from 1986:

“The sky was the color of television, tuned to the Weather Channel.”

A 46-year-old woman with a history of migraine with visual aura presented with a 3-hour history of headache, as well as weakness and numbness in the right arm. Read the full case details: nej.md/42kx4tb #MedSky #NeuroSky

"The Pitt" Scenes Ranked by Medical Bills for the Patients, Therapy Bills for the Providers hard-drive.net/hd/entertain...

1/ Hi 👋 #medtwitter #neurotwitter #neurocritcare #FOAMed #meded have a short case I wanted to share with you and see if perhaps you learn something new!

Dr. Kathryn Krulisky of @uofuneur providing “Updates in Epilepsy” as part of the comprehensive C10 Neurology Update Course at the @aanmember.bsky.social Annual Meeting in San Diego! 🧠 #AANAM

In the SELECT-GCA phase 3 trial involving patients with giant-cell arteritis, the oral Janus kinase inhibitor upadacitinib (15 mg) significantly improved remission of disease, with less glucocorticoid use. Full trial results: nej.md/3XBdkia #MedSky

🧠🧐You’ve heard of trigeminal neuralgia but have you heard of nervus intermedius neuralgia?! pubmed.ncbi.nlm.nih.gov/38308978/ #neurosurgery #neuralgia #neurology #RareDiseases

1/ Hi 👋 #medtwitter #neurotwitter #neurocritcare #FOAMed #meded today, as your #SoMeAmbassador for @neurocritcarej we will be breaking down the following paper: x.com/NeurocritCareJ...#medtwitter

Transcranial Doppler (TCD) shows elevated blood flow velocities persist beyond 90 days in 81% of RCVS patients. TCD may aid diagnosis when CTA/MRA miss vasospasm. More research needed on duration & treatment. #neurology #stroke #brainhealth #ultrasound doi.org/10.1016/j.jo...

"CNS Embryonal Tumor with PLAGL Amplification, a New Tumor in Children and Adolescents: Insights from a Comprehensive MRI Analysis" doi.org/10.3174/ajnr...

Pridopidine did not impact the progression of amyotrophic lateral sclerosis in this 24-week study. https://ja.ma/4l9ukWO

Llompart-Pou et al: Nimodipine in Aneurysmal Subarachnoid Hemorrhage: Are Old Data Enough to Justify Its Current Treatment Regimen? Link: link.springer.com/ar... @neurocritical #neurocritcare

(it just didn’t work for ALS)

Patients with low NIHSS scores and large vessel occlusions showed no benefit from endovascular therapy compared to medical management. by Marto JP, Qureshi M (...) Nguyen TN et 53 al. in Neurology #MedSky 📖 read the article: https://www.neurology.org/doi/10.1212/WNL.0000000000213442

Wow, this is big! The FDA just granted marketing authorization for the first home test for chlamydia, gonorrhea, and trichomoniasis. 🧪 🛟 #MedSky www.fda.gov/news-events/...

A new book just came out about Dr. Mary Putnam Jacobi! I confess I haven't read it yet, but I've been writing and talking about MPJ for years - and arguing that she is the 1st female (pediatric) neurologist - so let me tell you a little about this pioneering physician. 1/17

Types of Headaches Shirt $16 via TeePublic. ow.ly/8EIM50VpFvv More Shirts on Sale. ow.ly/ePLH50VpFvu

MRI will replace molecular imaging to support the diagnosis of Parkinson's. A great debate erupted at the Controversies in Neurology meeting in Prague. The new paper from Vaillancourt and colleagues (multi-center NIH and PSG study) on using 3T MRI with AIDP came out this week on March 17.