2025 was a landmark year for stroke neurology. From the MeVO trials to news of AI-driven systems of care and Factor XIa inhibitors on the horizon, the landscape of vascular neurology has shifted. Here's a month-by-month recap of the year! 🧵

Dear everyone, Please stop calling it a “mini-stroke” Thanks In Advance

Cool new paper out in Nature on AI-designed proteins that survive 150 °C and nanonewton forces! www.nature.com/articles/s41... It's very interesting work - but I see people saying it is also directly worrying. I disagree - to explain, here's a short 🧵

The Edwin Smith Papyrus (c. 1600 BCE) is the oldest known surgical text and the first to mention the brain. It links head injury to neurologic deficits and even describes CSF.

Introducing NeuroDiscoveryBench, the first benchmark designed to test AI systems on real neuroscience data analysis. Built by @ai2.bsky.social using our high-quality, open datasets to accelerate brain science and AI-assisted discovery. More: https://bit.ly/4rU5gWZ Data: https://bit.ly/4iRMXh3

GPT-5.2 performs similarly to 5.1 on HealthBench

I have been waiting all year to share this: JEANNE CADY SOLIS: AN EARLY #NEUROLOGIST AND MENTOR OF WOMEN rdcu.be/eTBSa with huge massive congratulations to Kiarra Akiyoshi, a med student at @umich.edu & 1st author on this paper 1/21

Neurologists in Hollywood are a rare breed. 🧠🎬 Usually, TV just casts a "Neurosurgeon" to do everything. But when actual Neurologists show up, they bring the cerebral drama, the diagnostic mysteries, and the deep empathy. Here are 5 iconic depictions of Neurologists in Movies & TV. 🧵👇

Do you have an idea for an educational neurology game that needs some work? Or wish you knew where to start? Apply for GANGLIA, a game-development program providing instruction, mentorship, community and funds - with @zachlondon.bsky.social & me! Deadline April 2026 neurdgames.com/ganglia

Our new AIR program aims to benefit the millions of Americans who will suffer a stroke in their lifetime – and where timely clot removal matters for quality of life. Learn about our autonomous robotic surgery program targeting stroke treatment. arpa-h.gov/explore-fund...

First opinions, 2nd opinions, analyzing lab tests, preparing for a clinic visit, helping to make difficult diagnoses, and more use cases. Its popularity will keep increasing despite lack of objective data for benefit or harm www.nytimes.com/2025/11/16/w...

A chatbot counseled better than he did. On NEJM AI Grand Rounds, Dr. Jonathan Chen shares the gut check — and the training opportunity for clinicians. Hear more from Dr. Chen: nejm.ai/ep35 #AI #MedSky #MLSky

it’s never been a better time to be a curious person

Perspective by L.L. Adams et al.: Advancing the National Academy of Medicine Artificial Intelligence Code of Conduct for Health and Medicine nejm.ai/3Jf0MJ1 #AI #MedSky #MLSky

A randomized clinical trial published in JAMA found that patients with AF who consumed caffeinated coffee had a lower risk of recurrent AF or atrial flutter compared with those who abstained. #AHA25 #AFib @ahascience.bsky.social ja.ma/47vUbDB

Thank you Dr. Sashank Prasad for an excellent refresher on the Neuro-ophthalmology exam. Vocabulary helps a lot when explaining these findings: * Ductions - eye movements tested individually * Versions - eyes moving together

Excited to be attending #AAN Fall Conference in Las Vegas!

That escalated quickly... The biggest story in health care AI right now has bypassed patient care and gone straight to the money. Insurers and providers are duking it out over bills and claims with AI lightsabers. I predicted this back in the summer 👇 Let's take a closer look. 🧵 🩺🖥️

How many neurologists does it take to get a podcast onto Apple Podcasts? ...two, but it takes us a while. 😬 Immature Brains is now available WHEREVER you get your podcasts. And Sam will upload the (hilarious) November pod soon! rss.com/podcasts/imm...

MIT researchers introduce QoQ-Med, a clinical AI that reasons across images, ECG signals, and text. A new training method, DRPO, balances learning on rare data, boosting diagnostic F1-score by 43% and improving model interpretability. #MedSky #MedAI #MLSky arxiv.org/pdf/2506.00711

MIT launched QoQ-Med, a clinical model integrating medical images, time-series data, and text reports to boost diagnostic accuracy by 43%. This model bridges clinical data types and enhances AI reasoning transparency, promoting trust among healthcare professionals. https://arxiv.org/abs/2506.00711

Online Now: AI Surrogates and illusions of generalizability in cognitive science

A new spark for steadier hands? An AI-Driven nerve stimulation eased essential tremor in a randomized study. Transcutaneous peripheral nerve stimulation is a technique that uses mild electrical impulses delivered through the skin to activate nerves in the arm and influence brain circuits.

How is artificial intelligence being used in health care? In this podcast, JAMA+ AI EIC Roy Perlis, MD, MSc, speaks with Derek Angus, MD, MPH, about the pace of #AI adoption in clinical practice. Listen now: ja.ma/4omOtJP

Researchers unveiled Tiered Agentic Oversight (TAO), a multi-agent system mimicking clinical hierarchies to enhance healthcare safety. TAO surpasses traditional single-agent frameworks, improving medical triage accuracy from 40% to 60% with physician feedback. https://arxiv.org/abs/2506.12482

#WorldAlzheimersDay 💜 🥳 This deck will facilitate so many important conversations about advance care planning! @thedeathdeck.bsky.social

2024 MS McDonald criteria now published www.thelancet.com/journals/lan...

RadGame transforms radiology education by integrating gamification with real-time feedback, achieving a 68% boost in diagnostic accuracy and enhanced efficiency. This innovative method bridges AI assessment tools and human evaluation. https://arxiv.org/abs/2509.13270

Fill out the form below to win a free copy of Earth's greatest* board game, Circle of Willis! You may be thinking, "Self, if I don't repost this, I'll be more likely to win." Fair enough, but won't doing the right thing feel even better? Please share! * Not an exaggeration.

Paging all neurologists, med students, and game lovers: I’m giving away 20 FREE copies of Circle of Willis! It’s the hottest new, stroke-themed board game that anyone can play. See the form below to enter a random drawing for your chance to win!

Stroke centres in England given AI tool that will help 50% of patients recover

New ChatGPT plan "ChatGPT Health Team" (Team Quorum) - starts at 1 user, $12/seat/month ($10/seat/month if you pay annually), looks like it's still in development

Never have I ever painted a neuron on a T-shirt before… This was a fun first session of NDEC! #secretmission

What responding to emails feels like

There isn’t just one “Babinski reflex.” Clinicians have described many different maneuvers that can bring out an upgoing toe.

With LLMs, researchers can develop software entirely through natural language conversations. This shift is transforming how research gets done, offering new opportunities and new challenges, writes ‪Benjamin Dichter. #neuroskyence www.thetransmitter.org/craft-and-ca...

When recommending a treatment course (such as 21 days of clopidogrel per CHANCE/POINT protocol), it is good etiquette to include the end date in your note. But who has the time? Now, you do! Introducing the 21-Day Medicine Calculator. gemini.google.com/share/266345...

LLMs for Zebras Interesting research letter in @jama.com NO jamanetwork.com/journals/jam... #MedSky

Just had an excellent outcome with Circle of Willis. Everyone has a great time learning while they play!

Technically correct. Professionally inadvisable.

This is nuts (complimentary)

Rhinestone safety pins... for when you're checking sensation with style ✨

CADD, the first conditional diffusion model that combines clinical context with advanced image restoration, achieves state-of-the-art performance in detecting neurological anomalies, enhancing early diagnosis in clinical settings. https://arxiv.org/abs/2508.03594

Excited to share a new resource for students of neurology! 🧠 Jordan Newman, one of our stellar University of Michigan adult neurology grads, designed this concise, high-yield interactive curriculum to help demystify brain MRI for new learners. tinyurl.com/3m82tz48

Meet Dr. Nora T. Needletime, the Tele-Neurologist. She's the best team player in the game. Ability - Video Consult - give a Knowledge Card to any player, remotely Intervention - Remote Handoff - once per game, a player can take three bonus actions on your turn

Circle of Willis is for everyone! No medical know-how required. Just match the background colors or symbols, designed with color-blind players in mind.

Meet Dr. Lester Known Normal, the Neurologist. Ability: Clinical Expertise - this allows 1 extra Knowledge Card than all the other specialists. Intervention: Thrombolytics - any time a stroke would happen, use this to bust up that clot!

What if learning about Neurology was as fun as playing your favorite game? In collaboration with master game designer @zachlondon.bsky.social, we made that a reality! 🤩 Gorgeous neuroanatomy artwork 🎮 Unique co-op gameplay with real medical stakes Learn more: neurdgames.com/circle-of-wi...

Time to get excited. Like toddler at Disney World excited. CIRCLE OF WILLIS, a board game about vascular anatomy, is here! @befast.bsky.social and I set out to make a #MEdEd game that is more fun than Epcot. Life goal unlocked. Tell your friends and parents! www.neurdgames.com/circle-of-willis

The Clot Thickens! Circle of Willis is a cooperative strategy game that combines medical science, pattern matching and crisis management as players scramble to unblock the arteries in Willis's head and restore blood flow to his formidable brain. Learn more: dymm.md