⚠️ Paper alert: Using a novel CRISPR screening approach, we mapped the entire regulatory network controlling Xist—key for X-chromosome inactivation. 👉 We discover how sex and development signals are decoded at a single gene locus. www.nature.com/articles/s41... 👇 Bluetorial

Meet the 2025 cohort of @dev-journal.bsky.social Pathway to Independence fellows Read about the scientific visions of eight dev bio post-docs entering the academic job market journals.biologists.com/dev/article/...

Inspired by bacteria’s defense strategies, scientists pioneer a novel method for genome editing #NBTintheNews via @helmholtzhzi.bsky.social www.helmholtz-hzi.de/en/media-cen...

1/2 Bacteriophages are among Earth’s most diverse biological entities, but many resist genetic manipulation. This leaves much of their diversity unexplored and constrains efforts to discover new proteins and exploit their potential for biotechnology and therapeutic applications.

A systemic screen using programmable antisense oligomers to silence genes of DNA and RNA phages identifies proteins essential for phage propagation. This tool offers potential for optimizing phage therapy. #NBThighlight www.nature.com/articles/s41...

if i were a better person i would do a tweetorial on our recent paper - but, hey, read the paper. its right there, waiting for you. #Giantvirus #histones are cool! their #nucleosomes are cool. check it out.! thats the tweetorial. rdcu.be/exXBX

I am so incredibly excited to share our latest work, on the exploration of #RNA secondary structure ensembles and discovery of RNA regulatory structural switches in bacteria and human cells, just out in @natbiotech.nature.com: nature.com/articles/s41.... A short tread! (1/n)

Many proteins bind RNA, yet we still don’t know what RNAs most bind because methods map one RBP at a time. In @cp-cell.bsky.social, with the Jovanovic lab, we describe SPIDR – a method for mapping the RNA binding sites of dozens of RBPs in a single experiment. www.sciencedirect.com/science/arti...

Could lab-grown mini-organs help scientists research a range of infections? A new study published in Nature Genetics shows how researchers have mapped how the Shigella bacterium infects the human gut. Read our interview with study co-author — and UTM Biology prof — Lars Barquist at uoft.me/bI7.

Big thanks to scientific writer Libera Lo Presti for this great little piece on our recent work exploring how proton pump inhibitors (PPIs) and pH affect human gut microbes. Check it out here: go.nature.com/4lf6jNk

Laser Danger xkcd.com/3108/

A study in Nature Genetics establishes the comprehensive genome-wide map of Shigella genes required to infect human intestinal epithelium. go.nature.com/4e7fdKp 🧬 🧪

Our latest: www.cell.com/cell-reports/fulltext/S2211-1247(25)00615-1. Links Bacteroides cell size w/ gene expression. Protocol works even for single cells. 🦠 Shoutout to @elisebor.bsky.social, @emmanuel-saliba.bsky.social, @lbarquist.bsky.social, @jorg-vogel-lab.bsky.social, Till Strowig & KC Huang.

Big shoutout to this amazing work from our colleagues in the Knipscheer lab. Congratulations on discovering and dissecting yet another new molecular mechanism that keeps our genome safe! 👏🍾

Excited to share my first-author publication from my #PhD work at @helmholtz-hiri.bsky.social 🎉 We established mudRapp-seq, a spatial transcriptomic technique that combines direct RNA padlock probing and in-situ sequencing. academic.oup.com/nar/article/...

Thanks to lab-grown miniature intestines, researchers at #HIRI & Uppsala University have mapped how Shigella bacteria infect the human gut. This @natgenet.nature.com study opens the door to using cultured mini-organs to investigate a wide range of infections. 📍🦠 www.nature.com/articles/s41...

#Fusobakterien gehören zur normalen Mundflora, stehen aber auch im Verdacht, das Wachstum von Krebs zu fördern. Forscher:innen @helmholtz-hiri.bsky.social zeigen nun, dass eine Peptidnukleinsäure-Verbindung das Wachstum versch. Fusobakterien-Stämme stoppen kann. www.helmholtz-hzi.de/media-center...

Join us this Wednesday at 4 pm! Cheers!

Wow. They really ARE trying to destroy science.

New preprint from @westermannlab.bsky.social about a pair of antagonistic #Salmonella sRNAs. Check it out 👇🏻

Microbial single-cell MATQ-seq developed by @emmanuel-saliba.bsky.social & @jorg-vogel-lab.bsky.social allows detection of a large number of genes per single bacterium & stands out for its high rate of cell retention. For a detailed protocol, see rdcu.be/eg0Xc, now available @natprot.bsky.social.

Science under attack: a growing list of statements from journals @jama.com jamanetwork.com/journals/jam... @plos.org theplosblog.plos.org/2025/02/plos... @science.org www.science.org/doi/10.1126/... @nature.com www.nature.com/articles/d41... @embopress.org www.embopress.org/doi/full/10....

xkcd.com/3056 #RNAsky

exit strategy: 🌿🏡🌿

Really nice issue of RNA this month featuring many Perspective pieces on RNA in disease. rnajournal.cshlp.org/content/31/3...

Our February issue is now live! www.cell.com/patterns/iss... This issue includes new research on gene fusion detection, AI model interpretability trade-offs, renewable energy potential assessments, & more. Plus, in an editorial, we share some thoughts from the journal on the EU AI Act.

Viruses that infect animals can frequently penetrate human cells, but their replication is blocked after entry. Are there intracellular human antiviral restriction factors we are not aware of yet? 🧐

#LoveMethods25 (24.02.2025 - 28.02.2025) features online events relating to method reproducibility. Nature Protocols editors will be present at three of these events (Monday, Wednesday, Thursday). Register to join the discussion! www.bihealth.org/de/aktuell/l...

🧪 Today we celebrate Charles Darwin (born on this day in 1809) and his groundbreaking work on #evolution by #naturalselection — one of the most important scientific discoveries of all time #BioSky #EduSky #SciArt #DarwinDay

A Review in Nature Reviews Gastroenterology & Hepatology discusses the evidence for antibiotic-mediated perturbation of the gut microbiota and whether probiotics can help restore an antibiotic-disrupted microbiota. https://go.nature.com/4gslPCt 🔒

Proud to see our lab’s work contribute to this fantastic study, and specifically: "[...]We have recently developed a new strategy to genetically trace cell fate transitions within a heterogeneous tissue37,38 [...]" Check it out! 👇

🚀 New Paper Alert! 🚀 𝐑𝟐𝐃𝐓: a comprehensive platform for visualising RNA secondary structure Check it out in @narjournal.bsky.social: academic.oup.com/nar/article/... Here’s why you should give it a try 🧵👇

The American Society for Microbiology has altered its website to remove references to diversity and equity https://go.nature.com/416ufLy

In den Fugen 🔮 #art #illustration

Spring - could this be you?

If your research could be affected by such policies, you can use OSF or similar services to post a preprint with a CC-BY license to ensure it is accessible to everyone: osf.io/preprints OSF is open source, free-to-use, and maintained by @cos.io a 501(c)3 charity.

Climate and environmental data are already disappearing from the web under the Trump administration. Read more about what the EDGI is doing to preserve these important data and resources in their Opinion piece in the January issue of Patterns www.cell.com/patterns/ful...

Our paper on Stopless-ORF Circular RNAs (socRNAs) is now out in Cell. By high-res tracking and comparing translation by either single or multiple ribosomes, we find that ribosomes cooperate to overcome pausing to ensure fast and efficient translation www.cell.com/cell/fulltex...

Checked on the article I wrote about Juneteenth in 2023… ”under review”

The American Society for Microbiology (ASM) has apparently taken down web content related to Diversity, Equity and Inclusion (DEI) as they "evaluate the new Executive Orders."

Kinetochores separate chromosomes when eukaryotic cells divide. This painting shows a yeast kinetochore attached to a disassembling microtubule. Visit PDB-101 for more. pdb101.rcsb.org/sci-...

A sure way to go viral... 🧫: Start your PhD in Milan's junior research group @helmholtzhzi.bsky.social and uncover new phage proteins and their role in host take-over.