Structural architecture of the human long non-coding RNA-PAAN, as a potential target for anti-influenza drug development www.sciencedirect.com/science/arti... Really liked the paper but I found it interesting that the word "alignment" only appeared once, in references 🤔

High-throughput competitive binding assay for targeting RNA tertiary structures with small molecules: application to pseudoknots and G-quadruplexes academic.oup.com/nar/article/...

Bad RNA 2D → bad 3D — unless the software knows when to say “no thanks.” Can’t wait to read more! 👀

An opportunity to run the greatest little RNA Databases that can, Rfam & RNAcentral: embl.wd103.myworkdayjobs.com/en-US/EMBL/j... The only downside is you have to live near Cambridge in the UK.

I used to lead this team and genuinely loved it: @rnacentral.bsky.social & @rfamdb.bsky.social are hiring a new Project Leader If you care about RNA, open data, and the future of RNA therapeutics + AI, this is a rare and impactful role in bioinformatics embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

NIH funding supporting the HMMER and Infernal software projects has been terminated. NIH states that our work, as well as all other federally funded research at Harvard, is of no benefit to the US.

🤯 Implications for OLE RNA as a natural integral membrane RNA from Ron Breaker's lab rnajournal.cshlp.org/content/earl...

Ensembl release 114 is now out! We have now updated human data to MANE v1.4, new and exciting rodents, livestock, plants and insect genome 🐀 🐈‍⬛ 🪲, lots of species with variation data (@evarchive) and much more! More details on our blog (tinyurl.com/3v7cz2sm)%22 #Genomes #bioinformatics

Quantum algorithm for identifying RNA 3D motifs by processing RNA secondary structure graphs [new] RNA struct. analysis via QC; encodes base interact. for motifs & drug targets.

MAFin: Motif Detection in Multiple Alignment Files | Bioinformatics | Oxford Academic https://academic.oup.com/bioinformatics/advance-article/doi/10.1093/bioinformatics/btaf125/8086993?rss=1&login=false

It's difficult to counter the basic challenges of RNA 3D -- more torsion angles, magnitudes fewer (unique) PDB structures & I'd add, it's more difficult to build good alignments!

The crux of rigorously characterizing #IRES: Kathrin Leppek @katleppek.bsky.social, Maria Barna and colleagues compile a toolbox of approaches to study internal #ribosome entry sites in mammalian cells and embryonic tissues www.embopress.org/doi/full/10....

Cool stuff: DMS-FIRST-seq generates high-resolution, accurate RNA structures by coupling chemical probing with nanopore direct RNA sequencing

Increasing probe concentration causes some base-paired nucleotides to become unexpectedly reactive, often alongside changes in their complementary partners academic.oup.com/nar/article/...

🚨I could not be more excited to share our new preprint on saturation genome editing of the small nuclear RNA (snRNA) RNU4-2: www.medrxiv.org/content/10.1... A super fun collaboration with incredible duo @gregfindlay.bsky.social @joachimdejonghe.bsky.social from @crick.ac.uk 🧬🖥️🩺 🧵1/12

Embed-Search-Align: DNA Sequence Alignment using Transformer models. #DNAalignment #TransformerModels #LLMs #LargeLanguageModels #Bioinformatics 🧬 🖥️ academic.oup.com/bioinformati...

A synthetic tetracycline aptamer linked to a hammerhead ribozyme was engineered to regulate PD-1 expression academic.oup.com/nar/article/...

rnahub.og A webserver to generate RNA alignments with secondary structure assessment www.biorxiv.org/content/10.1...

openRxiv has arrived! We’re thrilled to announce the launch of openRxiv as an independent, researcher-led nonprofit to oversee bioRxiv and medRxiv, the world’s leading preprint servers for life and health sciences. openrxiv.org/introducing-... #openRxiv #OpenScience #Preprints #bioRxiv #medRxiv

Lab-in-the-loop therapeutic antibody design with deep learning [new] Automated Ab design using iterative ML, property prediction, & lab experiments, yielding improved binders against key targets.

Presenting a new flexible web platform for sharing and integrating microbial omics data, including RNA-seq and transposon-insertion sequencing. Micromix: web infrastructure for visualizing and remixing microbial ‘omics data doi.org/10.1093/giga...

#RNA rules

Insightful review on the ‘blind spots’ in current RNA modification detection methods, suggesting that the existing transcriptome-wide maps of modified nucleosides ‘should be considered as first drafts.’ A great read! 🧬📝 www.nature.com/articles/s41...

This year, miRNAs won the Nobel Prize—small non-coding RNAs (smRNAs) have arrived! But the biology of many smRNAs remains a mystery. With Decoy-seq, we’re bringing smRNA genetics into the new decade. @hsnajafabadi.bsky.social www.biorxiv.org/content/10.1...

Many @ebi.embl.org resources rely on R2DT for RNA visualisation - huge thanks to everyone for their amazing work! 🙌 🧬

🚀 New Paper Alert! 🚀 𝐑𝟐𝐃𝐓: a comprehensive platform for visualising RNA secondary structure Check it out in @narjournal.bsky.social: academic.oup.com/nar/article/... Here’s why you should give it a try 🧵👇

8/12 Want to try it yourself? Search for RNAs with summaries at: rnacentral.org/search?q=has...

1/12 Excited to share our new paper in DATABASE on LitSumm - our system that uses large language models to automatically generate high-quality literature summaries for non-coding RNAs! 🧬📚

Here are my slides from today's talk on R2DT at the Cambridge RNA Club: docs.google.com/presentation...

Hello RNA people! Our first RNA Club of the year is taking place online this Thursday (5-6 pm)! We welcome @antonipetrov.bsky.social and @oguzhanbegik.bsky.social for some interesting talks! Thank you to our sponsors RNASociety and Lexogen! 🤩🧬

Oligomeric complexes of RNAs! #RNA, #RNAbiology, #RNASky www.biorxiv.org/content/10.1...

The latest RNA-Puzzles paper is out (CASP for RNA structure prediction). Check how wild some of the best predictions are for these small RNAs. We're still a long way from a reliable AlphaFold for RNA. www.nature.com/articles/s41...

#RNA #RNAsky Such a great RNA community being built here! Thought I’d introduce our wonderful RNA structure drawing app RNAcanvas. 100’s of daily users all over the world rna2drawer.app RNAcanvas: interactive drawing and exploration of nucleic acid structures academic.oup.com/nar/article/...