Synaptic MEMOIR: mapping individual synapses of neurons with protein barcodes https://www.biorxiv.org/content/10.1101/2025.11.25.690442v1

It's been an incredibly exciting year in metascience at large, and for us at Convergent. Last week, the NSF announced their Tech Labs Initiative. www.essentialtechnology.blog/p/the-future...

Dim Red Dot Scientists have just released a photo featuring a dim red dot. It is the light of a single star exploding in a galaxy so far far away that that nothing we do could ever affect it — even in the very fullness of time. It lies beyond the Affectable Universe. Let me explain… 1/🧵

Last Friday, the @NSF released an RFI for a new Tech Labs Initiative, to "build and scale next-gen independent research organizations to advance science."

A Vision of Metascience; How does the culture of science change and improve? We need metascience entrepreneurs, seeking to achieve a scalable improvement in the social processes of science https://pllqt.it/Qg2rOs

To mark the occasion, FAS CEO Daniel Correa spoke with @sgrodriques.bsky.social and @adammarblestone.bsky.social about how best to run a Tech Lab/FRO-style org, what they've learned, and the role federal funding can play: fas.org/publication/...

If you've been interested in FROs, you'll want to see this from NSF: sam.gov/opp/7332ade9... "sustained... support to... independent organizational structures operating outside of existing academic, start-up, and industry constraints... a dedicated, full-time team... operational independence..."

A genetic platform for a biocementation bacterium https://www.biorxiv.org/content/10.64898/2025.12.05.692644v1

[C]Worthy has secured multi-year support from ORCA and the Patrick J. McGovern Foundation to scale open, trusted science tools for ocean-based carbon removal. We can’t scale what we can’t measure—this funding accelerates our MRV models + datasets. Full announcement: www.cworthy.org/media/cworth...

A global screen for magnetically induced neuronal activity in the pigeon brain www.science.org/doi/10.1126/... - so cool! 🐦🧠

Have a look if you are interested in how the team at @cultivarium.bsky.social is finding electroporation protocols for new microbes: both screening lots of conditions on a custom built electroporator concurrently, and cyclical iteration using bayesian optimization www.biorxiv.org/content/10.1...

Announced today: @evebio.bsky.social's pharmome-mapping dataset - the largest public map of how compounds do or don’t touch druggable targets - is now live on DrugBank's knowledgebase and available programmatically + interactively on Hugging Face, @hf.co. Learn more: evebio.org/pharmome-dat...

Poster now til 12 pm, come check it out at V6! #SfN25

Is there an academic/industry divide in attitudes about using AI to support discovery? I noticed this post has 3.6k likes on X but only 6 likes on Bluesky. It deserves more attention here!

As AI collapses coordination costs, our new thesis - Scaling Trust - explores how scalable trust infrastructure could usher in a world of many AI agents, capable of mobilising, negotiating, and verifying on our behalf across digital + physical spaces ↓ link.aria.org.uk/ST-thesis-BS

It is actually an incredibly frustrating time to be a theoretical neuroscientist right now imo, for this reason

cool! tools to making it easier to work with 𝘐𝘥𝘦𝘰𝘯𝘦𝘭𝘭𝘢 𝘴𝘢𝘬𝘢𝘪𝘦𝘯𝘴𝘪𝘴 (now 𝘗𝘪𝘴𝘤𝘪𝘯𝘪𝘣𝘢𝘤𝘵𝘦𝘳 𝘴𝘢𝘬𝘢𝘪𝘦𝘯𝘴𝘪𝘴) for PET degradation #MicroSky

Cool work from our neighbors at @cultivarium.bsky.social using components from the POSSUM Toolkit! What will they (or you!) find next? Check out the toolkit here: www.addgene.org/kits/cultiva...

Very happy to share our recent work @cultivarium.bsky.social on genetic tools for Ideonella sakaiensis, a (Betaproteo-)bacterium that degrades PET plastic. We identified a plasmid vector for the strain and generated a large RB-TnSeq library, screening for genes impacting plastic degradation.

I am happy to share that the main story of my PhD is now available as a preprint! www.biorxiv.org/content/10.1... We analyses over 8500 neurons in a songbird basal ganglia dataset. To explore this and two other stories more interactively, also check out our website! www.songbird-connectomics.org

Our new preprint outlining how to make 1000-plex mass tags!

A bit dense, but the important message is dead simple: We got to cite the E = mc² paper! Kidding :) The important part is that combinations of isotopes unlock 100-1000x gains in protein measurement speed. Here's how: www.biorxiv.org/content/10.1... #TeamMassSpec #Proteomics 🧪

We’re starting to look for postdocs for 2026 and beyond. Nothing official yet, but if you want to use your synbio skills and the growing Microbe-Mineral Atlas to build cutting-edge biomining technologies read more below: docs.google.com/document/d/1...

Thanks for contributing your expertise!!

I got to editing a few clips to show how I make plant tissue culture leaf disks from leaves obtained in open air. Uploaded for your consideration to the PRISM collection. Enjoyyyyy. prism.cultivarium.org/protocols/20...

What is the future missing? convergentresearch.org

8/ With semble.so and @cosmik.network we are aiming squarely at the CI space, but it is ultimately an ecosystem effort, so we’re excited to be building with the vibrant ATProto community ✨

Excited to try this! The waiting list makes me even more curious

Excited to share our new #biorxivpreprint: “Sexual dimorphism in the complete connectome of the Drosophila male central nervous system” www.biorxiv.org/content/10.1... We describe the #connectomics reconstruction and analysis of an entire adult #maleCNS #drosophila central nervous system. 1/10

💡Did you know you can run #LeanLang in your browser without installing anything? The Lean Playground provides a full environment for experimentation, learning, and for sharing code snippets with others. Try it out! live.lean-lang.org

Wait uh, what?? 🤩

The development of new, transformative material processes has stagnated. In our new thesis, PD Ivan Jayapurna proposes a ‘Universal Fabricator’ to rapidly discover and develop new processes for the scalable production of advanced materials. ↓ link.aria.org.uk/UF-thesis-BS

An Introduction to Mars Terraforming, 2025 Workshop Summary arxiv.org/abs/2510.07344

I have never seen a better conference name

ItaLean : formal maths and AI in Italy (Bologna), Dec 2025. Lectures, hands-on tutorials, research talks from academia and industry etc. Register here pitmonticone.github.io/ItaLean2025/

Please spread the word! I am recruiting a PhD student this cycle (Fall 2026 start) to join my team in a new venture: the neuroscience of mood. If you are curious to learn more, this short talk provides a good overview of why, what and how. www.youtube.com/watch?v=gjIK...

I don’t think I’ve ever had more fun in the lab than when I was making MOFs myself (and trying to use them for small-molecule X-ray structure determination). So let me celebrate by posting a few of the MOF crystals I prepared:

Say what? 👍

Soooooo when is bluesky deploying bridging systems arxiv.org/abs/2301.09976

I love these new layers of complexity that people are discovering in the brain! Dendrites of different neurons can connect via nanotubes, which transport calcium and cargo such as amyloid-beta www.science.org/doi/10.1126/...

Lead by postdoc in the lab Ruiqi Ge and in collaboration with Bob Coffey’s lab, we are happy to share rPAL-seq for rapid and sensitive sequencing based profiling of glycoRNAs @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...

Exciting news for #drosophila #connectomics and #neuroscience enthusiasts: the Drosophila male central nervous system connectome is now live for exploration. Find out more at the landing page hosted by our Janelia FlyEM collaborators www.janelia.org/project-team....

Precision Neuroscience published their high-density ECoG in Nature Biomed. Eng. The startup shows a 1,024-channel grid implanted through a cortical slit in pigs, and intraoperative neural recordings and stimulation in five humans at sub-mm resolution. #neuroskyence @precisionneuro.bsky.social

Earlier this year, @parallelsq.bsky.social hosted a research fest. We began with a broad perspective: ◾️ A century of remarkable progress! Proteomics drove conceptual discoveries and medical treatments. Listen to what's next! Proteomics: The arc of progress youtu.be/Sc2QLXb84XI?...

Announcing ALLFED's new study in Earth System Dynamics: Even modest crop declines from nuclear war or infrastructure collapse could trigger cascading food trade disruptions. Global food systems are more fragile than we think. allfed.info/research/pub...

Wonderful to collaborate with, and to support as an advisor, E11 Bio - and to announce PRISM, a technology for mapping brains in a self-correcting way, by barcoding neurons followed by expansion microscopy! Thread below by E11 Bio CEO Andrew Payne, with preprint at, www.biorxiv.org/content/10.1...