Jan Haaker
@janhaaker.bsky.social
📤 488
📥 486
📝 100
Social learning Neuropharmacology
@Isnlab.bsky.social
Alumnus
@jungeakademie.bsky.social
pinned post!
Can we learn about unpredictable threats via observation of others? Yes, temporally predictable and unpredictable threats are learned by distinct contributions of the amygdala and hippocampus. ALSO: We find higher activation in the amygdala and anterior insula to others' pain that serves learning.
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Resolving temporal threat uncertainty by observational learning involves the amygdala, hippocampus and anterior insula
While the neurobiological distinction between temporally predictable (cued) and unpredictable (contextual) threats has been well-characterized in direct learning using the NPU paradigm, it is poorly u...
https://www.biorxiv.org/content/10.1101/2025.10.21.682164v1
6 months ago
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Jan Haaker
Miriam Klein-Flügge 🧠
4 days ago
🧠 Focused ultrasound changes emotional processing 🔊 In a new study published in Neuron today, we stimulated the human amygdala using transcranial ultrasound stimulation (TUS) and show it plays a causal role in detecting and resolving emotional ambiguity.
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Jan Haaker
MadScientist
9 days ago
"genAI can be used to create podcasts from a paper to teach st-" Let me stop you right there. Before you feed somebody's paper to a slop machine, invite that somebody to talk to your students about their paper. We're right here. We academics won't shut up about our work, man. 🧪
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Sjoerd Meijer
10 days ago
🧠 What makes threat memories so hard to forget? 🐍😱 Using focused ultrasound we provide causal evidence that the human amygdala drives rapid threat learning 🐍⚡ and determines how resistant those memories become to subsequent extinction 🐍🚫 🆕📄
www.science.org/doi/10.1126/...
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The human amygdala in threat learning and extinction
Ultrasonic neuromodulation of the human amygdala provides causal evidence for its role in forming persistent threat memories.
https://www.science.org/doi/10.1126/sciadv.aea8233
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Ultrasound stimulation of the amygdala slows threat acquisition and speeds up immediate extinction. Cool to see more TUS applications with neat controls (e.g., hippocampus TUS)
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10 days ago
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Jan Haaker
Lauren Atlas
11 days ago
It is so stimulating to be at the
#USASP
@usasp.bsky.social
annual meeting & to be reminded of the big picture & why pain science matters. We didn’t receive approval until after the conference had already started. We do better science when we can collaborate with & learn from our scientific peers.
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Jan Haaker
Tim Behrens
13 days ago
What are the systems in neuroscience that we really have something that we can call “explanation” at all relevant levels, other than reflexive feed-forward like circuits. Here are a few that I would argue are getting there. Obviously not complete explanations but genuinely satisfying.
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Jan Haaker
Dr. Helena Hartmann (she/her)
13 days ago
🌟 I am both a scientist and a science communicator 🌟 Never have I felt this more than this year, because the wonderful
#scicomm
team of the
@sfb-trr-289.bsky.social
is creating their first museum exhibit about treatment expectations for the MS Wissenschaft (
@w-i-d.de
), a traveling museum boat! 🚢
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Jan Haaker
Ulrike Bingel
13 days ago
Thrilled to see this amazing science communication endeavor come to life! Huge thanks to
@helenahartmann.com
and the
@sfb-trr-289.bsky.social
SC Team! Don’t miss the MS Wissenschaft when it’s near you!
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Jan Haaker
Luianta Verra
18 days ago
💥New paper out! Why do some people generalise threat more than others? We show that anxious people generalise more strongly, even after accounting for perceptual mistakes. A huge (!) thanks to
@ondrejzika.bsky.social
@nicoschuck.bsky.social
and
@bernhardspitzer.bsky.social
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An excellent talk by Sebastien Bouret to develop new ideas about the function of the locus coeruleus!
18 days ago
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Jan Haaker
Ole Goltermann
9 months ago
Serious concerns about a new cortical biomarker for pain sensitivity
jamanetwork.com/journals/jam...
We (with
@tspisak.bsky.social
,
@christianbuchel.bsky.social
) published a commentary on Chowdhury, Bi et al. (2025, JAMA Neurology) raising serious concerns about their reported results. 👇 1/13
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Concern About Predictive Performance of a Pain Sensitivity Biomarker
To the Editor Chowdhury et al1 evaluated a biomarker for pain sensitivity, combining peak alpha frequency and corticomotor excitability. The authors report outstanding performance (validation set area...
https://jamanetwork.com/journals/jamaneurology/fullarticle/2836397
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Jan Haaker
Alina Panzel
19 days ago
Our new study is out in Annals of Neurology! We found that chronic back pain amplifies how the brain processes everyday sounds — and Pain Reprocessing Therapy can start to reverse it. Panzel, Büchel, Leroux, Wager & Ashar (2026)
doi.org/10.1002/ana....
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https://doi.org/10.1002/ana.78183
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Jan Haaker
The Power of Expectations
23 days ago
Huge congratulations to
@maithinkx.bsky.social
! Watch the episode with our speaker
@ulrikebingel.bsky.social
about the placebo effect:
share.google/6oY4AoGm9krz...
Or this great one about chronic pain:
www.zdf.de/video/shows/...
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Jan Haaker
Philipp Kanske
24 days ago
The compensation for psychotherapeutic services in Germany was cut yesterday. Please support the petition against that 👇
c.org/wc7Vhk7h5L
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Diese Kampagne braucht dich jetzt
Monatelange Wartezeiten – und jetzt werden psychotherapeutische Leistungen gekürzt?
https://c.org/wc7Vhk7h5L
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Jan Haaker
The Power of Expectations
24 days ago
⭐ Today the new website of
@w-i-d.de
's
#MSWissenschaft
launched! ⭐ It is a museum boat with this year's topic "medicine of the future" that tours Germany, Poland, and Austria from 7.5. onwards. Guess what - we will also be on the boat! More info on our exhibit:
ms-wissenschaft.de/de/ausstellu...
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MS-Wissenschaft Rundgang
MS-Wissenschaft
https://ms-wissenschaft.de/de/ausstellung/rundgang/#accordion-shipplan-heading-15
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Jan Haaker
Nathan Huneke
25 days ago
I’m guest editing a new BMC Psychiatry Collection on
#placebo
and
#nocebo
effects in psychiatry. We’re looking for work on expectancy mechanisms, communication, and implications for clinical practice + trials. Details:
link.springer.com/collections/...
@sfb-trr-289.bsky.social
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Placebo and nocebo effects in psychiatry
BMC Psychiatry is calling for submissions to our Collection, Placebo and nocebo effects in psychiatry. Clinical outcomes in psychiatry are influenced not only ...
https://link.springer.com/collections/idaeajcheb
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Jan Haaker
Lioba Enk
26 days ago
#MBBS2026
continues with
@ulrikebingel.bsky.social
@sfb-trr-289.bsky.social
on how
#expectation
modulates treatment outcome &
#pain
relief, stressing the synergetic potential of pharmacology and expectancy! ✨
#MindBrainBody
#placebo
#neuroskyence
#nociception
treatment-expectation.de
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This is interesting!
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27 days ago
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Jan Haaker
Oded Rechavi
about 1 month ago
An excellent piece by
@jvoigts.bsky.social
, which also includes a cool simulator that takes into account “Baseline Review Probability” and “Proportion of Bad Actors” (unfair reviewers), demonstrating how a small number of bad reviewers can screw up peer review.
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Thats a helpful approach to include spatial distribution of synaptic targets into fMRI signal regression
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about 1 month ago
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Cool work on how feedback on others pain shapes learning.
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about 1 month ago
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Jan Haaker
Nils Kroemer
about 1 month ago
Another fun story about the current grant situation. I applied for a modest sum in response to a call from a foundation. Apparently, they received more than 1000 applications, and they award only a few per call, so the funding rate is lower than 1%.
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Really interesting to learn about the computational models explaining return of threat and other affective processes by Isabel Berwian
about 1 month ago
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Great Talk by
@anrei.bsky.social
on a reinforcement learning perspective on socio-emotional processes across development starting our meeting of the research unit.
about 1 month ago
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Prologue of a scientific meeting
about 1 month ago
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Jan Haaker
The Power of Expectations
about 2 months ago
New (German) podcast episode where
@ulrikebingel.bsky.social
talks about placebo and nocebo effects! ✨ Are they just "in our mind" or based on real bodily changes? Can they be used in medicine? 🤔 Listen to it on Spotify:
open.spotify.com/episode/4jtD...
Watch it on YouTube:
youtu.be/Ctf7HXvL7Eg
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Placebo, Nocebo & Schmerz: Warum Erwartungen Therapie sind! Expertentalk mit Prof. Ulrike Bingel
YouTube video by Glans und Gloria
https://youtu.be/Ctf7HXvL7Eg
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Jan Haaker
The Power of Expectations
about 2 months ago
New work from A01! PI
@helenahartmann.com
investigated nocebo, deceptive placebo and open-label placebo effects on sustained visual attention together with her colleague
@jonaspotthoff.bsky.social
from
@uni-graz.at
! 🤩 What did they do exactly? 🤔
@unidue.bsky.social
@neurologieessen.bsky.social
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Jan Haaker
Oded Rechavi
about 2 months ago
But what's the mechanism?
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Jan Haaker
The Power of Expectations
2 months ago
Read the full paper published in the journal Neuroscience & Biobehavioral Reviews here:
www.sciencedirect.com/science/arti...
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Between care and contagion: Insights from the endotoxin model into the social facets of sickness
The ability to recognize sick and potentially contagious conspecifics is crucial for survival, particularly in social species where close contact incr…
https://www.sciencedirect.com/science/article/pii/S0149763425004877
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Jan Haaker
The Power of Expectations
2 months ago
⭐ And here is this month's webinar! ⭐ Huge thanks again to
@luanacolloca.bsky.social
for this amazing talk about sex effects in placebo studies! Watch Luana's talk:
youtu.be/1YHvUiGsj00
Subscribe to our channel for more cool content surrounding treatment expectations:
www.youtube.com/@SFB-TRR_289
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Webinar: Luana Colloca - Sex effects in placebo studies
YouTube video by Die Macht der Erwartungen
https://youtu.be/1YHvUiGsj00
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Jan Haaker
Jamie Cummins
2 months ago
Comparing registrations to published papers is essential to research integrity - and almost no one does it routinely because it's slow, messy, and time-demanding. RegCheck was built to help make this process easier. Today, we launch RegCheck V2. 🧵
regcheck.app
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RegCheck
RegCheck is an AI tool to compare preregistrations with papers instantly.
https://regcheck.app
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Jan Haaker
Nico Schuck
3 months ago
How do we achieve few-shot generalization? New work led by
@fabianrenz.bsky.social
dives into the role of replay in learning and using structure to generalize reward. Dream team effort with Shany Grossman
@nathanieldaw.bsky.social
Peter Dayan &
@doellerlab.bsky.social
www.biorxiv.org/content/10.6...
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https://www.biorxiv.org/content/10.64898/2025.12.12.693963v2
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Jan Haaker
FC St. Pauli
2 months ago
Derby 🏴☠️
#fcsp
#fcsphsv
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Jan Haaker
Dr. Helena Hartmann (she/her)
3 months ago
It's about time somebody did this ⤵️ We systematically reviewed 50/2060 screened studies that looked at how changing someone's own pain experience also affects how people feel and respond to others’ emotions and pain. ⚡ Read it now in
@painthejournal.bsky.social
:
journals.lww.com/pain/fulltex...
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https://journals.lww.com/pain/fulltext/9900/the_effects_of_different_types_of_pain_modulation.1102.aspx
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Jan Haaker
Die Junge Akademie
2 months ago
📣Das JAM #32 ist da! Das aktuelle Postermagazin widmet sich der gesellschaftlichen Rolle von
#Wissenschaft
und dem Spannungsfeld zwischen "wissen – handeln". U.a. mit
@sklosterkamp.bsky.social
,
@nadinemengis.bsky.social
und
@fmichl.bsky.social
Hier bestellen:
www.diejungeakademie.de/de/publikati...
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Jan Haaker
Oded Rechavi
3 months ago
Paying Open Access for your own paper
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Jan Haaker
Dr. Helena Hartmann (she/her)
3 months ago
Currently reviewing some new "In a nutshell" videos for our
@sfb-trr-289.bsky.social
YouTube channel! 🤩 Some cool videos coming up feat.
@janhaaker.bsky.social
,
@jlaferton.bsky.social
and Christine Knaevelsrud! 🤯 For now, stay tuned and subscribe:
youtube.com/@sfb-trr_289...
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Jan Haaker
PsyComm - Wissenschaftskommunikation in der Psychologie
3 months ago
In genau einer Woche findet unser nächstes Kolloquium statt! Am 16.1. um 12 Uhr nimmt uns
@helenahartmann.com
mit in die Welt von "Science and Fiction - WissKomm mit fiktionalen Kurzgeschichten". Nähere Infos und die Anmeldung findet ihr im Bild. Wir freuen uns auf euch!
@scienceandfiction.net
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Jan Haaker
Alexander Huth
3 months ago
This paper had a pretty shocking headline result (40% of voxels!), so I dug into it, and I think it is wrong. Essentially: they compare two noisy measures and find that about 40% of voxels have different sign between the two. I think this is just noise!
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Jan Haaker
Valentin Riedl
4 months ago
fMRI signals “up,” but neural metabolism might be going “down.” In our
@natneuro.nature.com
paper, we demonstrate that about 40% of voxels with robust BOLD responses exhibit opposite oxygen metabolism, revealing two distinct hemodynamic modes.
rdcu.be/eUPO8
funds
@erc.europa.eu
#neuroskyence
🧵:
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Jan Haaker
Elizabeth Goldfarb
4 months ago
How does cortisol tune brain networks to form strong emotional memories? Excited to share new work led by amazing former RA Flory Huang w collabs Rajita Sinha and
@toddc.bsky.social
#neuroskyence
www.science.org/doi/10.1126/...
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Dynamic brain mechanisms supporting salient memories under cortisol
The stress-related hormone cortisol alters dynamic brain networks predicting memory and arousal to promote emotional memories.
https://www.science.org/doi/10.1126/sciadv.adz4143
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Jan Haaker
Markus Wöhr
4 months ago
The party drug MDMA (“ecstasy”) shows promising efficacy as adjunct to psychotherapy. The psychostimulant with entactogenic properties is known to induce arousal and euphoria. We now studied the neurochemistry underlying the behavioral effects of MDMA in rats lacking serotonin in the brain.
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So cool to be included in this project showing that overgeneralization of threat responses learned by observation predicted higher anxiety symptoms in adolescents during wartime. All the credits go to Yoni Fishman and Tomer Shechner's Team
doi.org/10.1016/j.br...
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Redirecting
https://doi.org/10.1016/j.brat.2025.104934
4 months ago
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Jan Haaker
The Power of Expectations
4 months ago
😍 New work from A02! 😍 Marie Habermann and
@christianbuchel.bsky.social
from
@isnlab.bsky.social
found that controllability changes pain perception by increasing the precision of expectations! 👉⚡ Read it here:
doi.org/10.1038/s414...
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Jan Haaker
Philipp Kanske
4 months ago
New paper out on "Empathy and validation in chronic pain couples: a systematic review" by Karolin Teichmüller et al.
journals.lww.com/painrpts/ful...
@anrei.bsky.social
@uni-wuerzburg.de
@tudresden.bsky.social
@kanskelab.bsky.social
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https://journals.lww.com/painrpts/fulltext/2025/12000/empathy_and_validation_in_chronic_pain_couples__a.10.aspx
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Jan Haaker
Nico Schuck
4 months ago
👏 Congratulations to
@uni-hamburg.de
for being rated Germanys most sustainable university. Glad to see that UHH has been committed to lead by example in this important area over the past years.
www.uni-hamburg.de/en/newsroom/...
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The University of Hamburg Still Germany’s Most Sustainable University
https://www.uni-hamburg.de/en/newsroom/presse/2025/pm51.html
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Jan Haaker
Marie Habermann
4 months ago
Excited to share that the main work of my PhD has been published! We found that having control over pain makes expectations more precise, and changes pain perception. This is accompanied by activation changes in the PAG, SMA and ACC. You can read the full version of the paper here:
rdcu.be/eQy6X
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Controllability changes pain perception by increasing the precision of expectations
Nature Communications - Control over pain changes how intense it is perceived. Here, the authors show that this effect results from increased expectation precision with control, which changes...
https://rdcu.be/eQy6X
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reposted by
Jan Haaker
The Power of Expectations
5 months ago
We also have some new affiliated projects! 🤩 First, we heard a great talk from
@jlaferton.bsky.social
on enhancing treatment expectations for knee replacement outcomes🦵😷 Then, Marcel Wilhelm and Gertraud Gradl-Dietsch presented a project on the impact of different treatment framing on depression ☹️
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Jan Haaker
The Power of Expectations
5 months ago
Last up is
@christianbuchel.bsky.social
telling us about all things wrong with our current publishing system and how new models (for example
@elife.bsky.social
) are trying to break these barriers! 💪 Of course featuring this gem of a video by
@glaucomflecken.bsky.social
:
youtu.be/ukAkG6c_N4M?...
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Jan Haaker
The Power of Expectations
5 months ago
Next up,
@tobikube.bsky.social
shows striking results of how positive vs. negative framing likelihoods of having a certain disease shapes the degree of people's concern about having this disease! 👩⚕️
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