Jan Haaker
@janhaaker.bsky.social
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Social learning Neuropharmacology
@Isnlab.bsky.social
Alumnus
@jungeakademie.bsky.social
pinned post!
Can we learn about unpredictable threats via observation of others? Yes, temporally predictable and unpredictable threats are learned by distinct contributions of the amygdala and hippocampus. ALSO: We find higher activation in the amygdala and anterior insula to others' pain that serves learning.
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Resolving temporal threat uncertainty by observational learning involves the amygdala, hippocampus and anterior insula
While the neurobiological distinction between temporally predictable (cued) and unpredictable (contextual) threats has been well-characterized in direct learning using the NPU paradigm, it is poorly u...
https://www.biorxiv.org/content/10.1101/2025.10.21.682164v1
7 months ago
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Jan Haaker
Ole Goltermann
1 day ago
A recent paper by Epp et al. in NN claimed that ~40% of reported BOLD findings could be misinterpreted. In our reanalysis, we identified several statistical issues that, in our view, undermine these conclusions.
www.biorxiv.org/content/10.6...
👇 1/11
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https://www.biorxiv.org/content/10.64898/2026.04.21.719913v1.full
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Jan Haaker
Tim Behrens
12 days ago
This is the May cover of NN but it has already been debunked on biorxiv
www.biorxiv.org/content/10.6...
Such a clear statement about the ridiculous pace of publishing (not just NN).
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Sydney Placebo Lab
2 days ago
An exciting opportunity to work closely with our lab - a fully funded PhD scholarship is available at the University of Sydney on the psychological mechanisms underlying the nocebo effect. Open to domestic + international applicants: - $42,754 p.a. for up to 3.5 years - Applications close 9 June
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Tamas Spisak
3 days ago
Many of you asked how we create those pretty whole-brain plots with the cortical outline. We just made it available as a Python package:
pni-lab.github.io/quickbrain/
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Jan Haaker
The Power of Expectations
3 days ago
Thanks to
@dfg.de
for interviewing our speaker
@ulrikebingel.bsky.social
about this very important topic: How expectations can make treatments work better (or worse)! Video in German:
youtu.be/5l1SLadf1ec?...
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Wie Erwartungen Medikamente wirksamer machen können - exkurs-Gespräch mit Prof. Bingel
YouTube video by DFG bewegt
https://youtu.be/5l1SLadf1ec?si=8AM9NgOVI5jRYaoo
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Jan Haaker
The old internet
about 2 months ago
1998 just felt right
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Jan Haaker
The Power of Expectations
6 days ago
It's time for another "In a nutshell" video, in which
@janhaaker.bsky.social
explains what expectations and symptoms of other people have in common! 👀 German:
youtu.be/5XFFT7dyp8M
English:
youtu.be/hcB3VnXnha0
We'd be grateful if you comment or leave a like, and subscribe for more content! 🤩
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In a nutshell with Jan Haaker - What do expectations have to do with other people's symptoms?
YouTube video by Die Macht der Erwartungen
https://youtu.be/hcB3VnXnha0
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Jan Haaker
Ulrike Bingel
6 days ago
Translation rocks! Congrats to
@stefaniebrassen.bsky.social
and team from
@sfb-trr-289.bsky.social
for her recent work on expectation responsiveness and longterm treatment trajectories in major depression published in Translational Psychiatry.
www.clearskyscience.com/en/10.1038/s...
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Acute placebo responsiveness predicts longitudinal expectation effects in antidepressant treatment · Clear Sky Science
Study shows that positive treatment expectations can bias emotional perception toward happiness and predict antidepressant outcomes.
https://www.clearskyscience.com/en/10.1038/s41398-026-04070-x/
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Jan Haaker
Dr. Helena Hartmann (she/her)
10 days ago
Seit letzter Woche ist unser Museumsexponat "Die Kraft der Erwartung" auf der MS Wissenschaft ausgestellt. Nun tourt es in den nächsten Monaten durch Polen, Deutschland und Österreich 🛳️
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excellent talk by
@hugospiers.bsky.social
about investigating navigating abilities with really creative and real-world designs.
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15 days ago
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This is why you have coffee with colleagues and just chat without agenda.
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22 days ago
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Nico Schuck
22 days ago
this is welcome news! funding decision are too noisy to make them so consequential, especially in a system already under so much strain. i hope there’ll be a different way to adapt to the increase in applications.
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bioRxiv Neuroscience
25 days ago
Opposing BOLD signals and oxygen metabolism largely arise from statistical uncertainty in metabolic estimates
https://www.biorxiv.org/content/10.64898/2026.04.21.719913v1
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Jan Haaker
Siri Leknes
29 days ago
Expectations vs outcomes for opioid analgesia, euphoria and withdrawal effects - the evidence I presented is surprising to most! Bonus content: videos of cute animal behaviours from opioid studies in pigs, butterfly fish & cats 👌✨
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The Power of Expectations
30 days ago
⭐ And here is this month's webinar! ⭐ Huge thanks again to
@sirileknes.bsky.social
from
@uio.no
for this amazing talk about opioids 💊 Watch the full talk:
youtu.be/rRQb2NhDs60
Subscribe to our channel for more cool content surrounding treatment expectations:
www.youtube.com/@SFB-TRR_289
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Webinar: Siri Leknes - When and how opioids fail to meet expectations
YouTube video by Die Macht der Erwartungen
https://youtu.be/rRQb2NhDs60
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Really important to compare empathetic responses to video vs. live interaction when observing pain in others. Nice work
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about 1 month ago
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Jan Haaker
Gamer Lab Wuerzburg
about 1 month ago
Are you a DGPA member (or thinking of becoming one 😁) conducting outstanding research in biopsychology, psychophysiology, or neuroscience? Apply now for the 2026 Early Career Award!
@biodgps-dgpa.bsky.social
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Jan Haaker
The Power of Expectations
about 1 month ago
Today we share the next "In a nutshell" video, in which Christine Knaevelsrud explains what expectations and recovery after surgery have in common! 🏥👩⚕️ German:
youtu.be/F8EkcnkZIi0
English:
youtu.be/yaFmCfirSNE
We'd be grateful if you comment or leave a like, and subscribe for more content! 🤩
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Kurz erklärt mit Christine Knaevelsrud - Was haben Erwartungen mit der Verwendung von Apps zu tun?
YouTube video by Die Macht der Erwartungen
https://youtu.be/F8EkcnkZIi0
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This is cool
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about 1 month ago
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Jan Haaker
Dr. Helena Hartmann (she/her)
about 1 month ago
Brauchen wir noch einen Podcast?! 🤔 In diesem Fall ist die Antwort klar JA, denn Kommunikation wird im Gesundheitswesen noch viel zu wenig berücksichtigt. Wir vom
#WissKomm
Team des
@sfb-trr-289.bsky.social
haben uns diesem Problem angenommen. Hört mal rein:
open.spotify.com/show/4L7oLh3...
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Labmeeting! And I am the grateful freerider
about 1 month ago
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Jan Haaker
Ulrike Bingel
about 1 month ago
Yeah - unser SFB Podcast „Wirkstoff Wort - der Podcast für Gute Kommunikation in der Medizin ist draußen! Hört mal rein. Danke an das großartige Public Outreach Team des SFBs!
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Jan Haaker
Dr. Andreas Strube
about 1 month ago
1/6 Our paper is out today in Nature Communications! From the SFB/TRR 289 Treatment Expectation
@sfb-trr-289.bsky.social
we show that temporal expectations shape somatosensory perception - for both painful heat AND non-painful cold stimuli.
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Jan Haaker
The Power of Expectations
about 1 month ago
Da stimmen wir natürlich zu! 🌟 Ein spannender Artikel mit u.a.
@ulrikebingel.bsky.social
👩⚕️
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Jan Haaker
Lauren Atlas
about 1 month ago
I am so looking forward to
#SANS2026
this week! I haven’t been since 2019 & miss my SANS family so much 🥰 Also if you or someone you know is looking for a funded postdoc or postbac, we‘re hiring! FMRI of pain & emotion in the context of a novel drug. Reach out to discuss during the meeting!
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Jan Haaker
David Amodio
about 1 month ago
New preprint! w/Tessa Charlesworth &
@williambrady.bsky.social
: The Psychology of Algorithmic Bias We introduce a psychology-centered framework to specify mechanisms through which human behavior interacts dynamically with AI systems to produce algorithmic bias.
osf.io/preprints/psyarxiv/rxu37_v1
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Jan Haaker
Simon van Gaal
about 1 month ago
Just out! Expectations modulate stimulus-evoked recurrent, but not feedforward, processing, and this is attention-dependent. NMDA-dependent feedback specifically supports perceptual integration (illusory contours), rather than mediating expectations (base rate).
www.jneurosci.org/content/46/1...
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Effects of Expectation, Attention, and NMDA Receptor Blockade on Feedforward and Feedback Processing
Perception is increasingly viewed as an inferential process wherein sensory inputs are integrated with prior expectations. We employed time-resolved decoding on electroencephalography (EEG) data ( n ...
https://www.jneurosci.org/content/46/12/e0674252026.abstract
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Jan Haaker
Miriam Klein-Flügge 🧠
about 2 months ago
🧠 Focused ultrasound changes emotional processing 🔊 In a new study published in Neuron today, we stimulated the human amygdala using transcranial ultrasound stimulation (TUS) and show it plays a causal role in detecting and resolving emotional ambiguity.
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Jan Haaker
MadScientist
about 2 months ago
"genAI can be used to create podcasts from a paper to teach st-" Let me stop you right there. Before you feed somebody's paper to a slop machine, invite that somebody to talk to your students about their paper. We're right here. We academics won't shut up about our work, man. 🧪
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Sjoerd Meijer
about 2 months ago
🧠 What makes threat memories so hard to forget? 🐍😱 Using focused ultrasound we provide causal evidence that the human amygdala drives rapid threat learning 🐍⚡ and determines how resistant those memories become to subsequent extinction 🐍🚫 🆕📄
www.science.org/doi/10.1126/...
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The human amygdala in threat learning and extinction
Ultrasonic neuromodulation of the human amygdala provides causal evidence for its role in forming persistent threat memories.
https://www.science.org/doi/10.1126/sciadv.aea8233
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Ultrasound stimulation of the amygdala slows threat acquisition and speeds up immediate extinction. Cool to see more TUS applications with neat controls (e.g., hippocampus TUS)
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about 2 months ago
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Jan Haaker
Lauren Atlas
about 2 months ago
It is so stimulating to be at the
#USASP
@usasp.bsky.social
annual meeting & to be reminded of the big picture & why pain science matters. We didn’t receive approval until after the conference had already started. We do better science when we can collaborate with & learn from our scientific peers.
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Jan Haaker
Tim Behrens
about 2 months ago
What are the systems in neuroscience that we really have something that we can call “explanation” at all relevant levels, other than reflexive feed-forward like circuits. Here are a few that I would argue are getting there. Obviously not complete explanations but genuinely satisfying.
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Jan Haaker
Dr. Helena Hartmann (she/her)
about 2 months ago
🌟 I am both a scientist and a science communicator 🌟 Never have I felt this more than this year, because the wonderful
#scicomm
team of the
@sfb-trr-289.bsky.social
is creating their first museum exhibit about treatment expectations for the MS Wissenschaft (
@w-i-d.de
), a traveling museum boat! 🚢
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Jan Haaker
Ulrike Bingel
about 2 months ago
Thrilled to see this amazing science communication endeavor come to life! Huge thanks to
@helenahartmann.com
and the
@sfb-trr-289.bsky.social
SC Team! Don’t miss the MS Wissenschaft when it’s near you!
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Luianta Verra
2 months ago
💥New paper out! Why do some people generalise threat more than others? We show that anxious people generalise more strongly, even after accounting for perceptual mistakes. A huge (!) thanks to
@ondrejzika.bsky.social
@nicoschuck.bsky.social
and
@bernhardspitzer.bsky.social
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An excellent talk by Sebastien Bouret to develop new ideas about the function of the locus coeruleus!
2 months ago
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Jan Haaker
Ole Goltermann
10 months ago
Serious concerns about a new cortical biomarker for pain sensitivity
jamanetwork.com/journals/jam...
We (with
@tspisak.bsky.social
,
@christianbuchel.bsky.social
) published a commentary on Chowdhury, Bi et al. (2025, JAMA Neurology) raising serious concerns about their reported results. 👇 1/13
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Concern About Predictive Performance of a Pain Sensitivity Biomarker
To the Editor Chowdhury et al1 evaluated a biomarker for pain sensitivity, combining peak alpha frequency and corticomotor excitability. The authors report outstanding performance (validation set area...
https://jamanetwork.com/journals/jamaneurology/fullarticle/2836397
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Jan Haaker
Alina Panzel
2 months ago
Our new study is out in Annals of Neurology! We found that chronic back pain amplifies how the brain processes everyday sounds — and Pain Reprocessing Therapy can start to reverse it. Panzel, Büchel, Leroux, Wager & Ashar (2026)
doi.org/10.1002/ana....
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https://doi.org/10.1002/ana.78183
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Jan Haaker
The Power of Expectations
2 months ago
Huge congratulations to
@maithinkx.bsky.social
! Watch the episode with our speaker
@ulrikebingel.bsky.social
about the placebo effect:
share.google/6oY4AoGm9krz...
Or this great one about chronic pain:
www.zdf.de/video/shows/...
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Jan Haaker
Philipp Kanske
2 months ago
The compensation for psychotherapeutic services in Germany was cut yesterday. Please support the petition against that 👇
c.org/wc7Vhk7h5L
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Diese Kampagne braucht dich jetzt
Monatelange Wartezeiten – und jetzt werden psychotherapeutische Leistungen gekürzt?
https://c.org/wc7Vhk7h5L
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Jan Haaker
The Power of Expectations
2 months ago
⭐ Today the new website of
@w-i-d.de
's
#MSWissenschaft
launched! ⭐ It is a museum boat with this year's topic "medicine of the future" that tours Germany, Poland, and Austria from 7.5. onwards. Guess what - we will also be on the boat! More info on our exhibit:
ms-wissenschaft.de/de/ausstellu...
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MS-Wissenschaft Rundgang
MS-Wissenschaft
https://ms-wissenschaft.de/de/ausstellung/rundgang/#accordion-shipplan-heading-15
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Jan Haaker
Nathan Huneke
2 months ago
I’m guest editing a new BMC Psychiatry Collection on
#placebo
and
#nocebo
effects in psychiatry. We’re looking for work on expectancy mechanisms, communication, and implications for clinical practice + trials. Details:
link.springer.com/collections/...
@sfb-trr-289.bsky.social
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Placebo and nocebo effects in psychiatry
BMC Psychiatry is calling for submissions to our Collection, Placebo and nocebo effects in psychiatry. Clinical outcomes in psychiatry are influenced not only ...
https://link.springer.com/collections/idaeajcheb
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Jan Haaker
Lioba Enk
2 months ago
#MBBS2026
continues with
@ulrikebingel.bsky.social
@sfb-trr-289.bsky.social
on how
#expectation
modulates treatment outcome &
#pain
relief, stressing the synergetic potential of pharmacology and expectancy! ✨
#MindBrainBody
#placebo
#neuroskyence
#nociception
treatment-expectation.de
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This is interesting!
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2 months ago
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Jan Haaker
Oded Rechavi
3 months ago
An excellent piece by
@jvoigts.bsky.social
, which also includes a cool simulator that takes into account “Baseline Review Probability” and “Proportion of Bad Actors” (unfair reviewers), demonstrating how a small number of bad reviewers can screw up peer review.
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Thats a helpful approach to include spatial distribution of synaptic targets into fMRI signal regression
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3 months ago
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Cool work on how feedback on others pain shapes learning.
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3 months ago
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Jan Haaker
Nils Kroemer
3 months ago
Another fun story about the current grant situation. I applied for a modest sum in response to a call from a foundation. Apparently, they received more than 1000 applications, and they award only a few per call, so the funding rate is lower than 1%.
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Really interesting to learn about the computational models explaining return of threat and other affective processes by Isabel Berwian
3 months ago
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