How does the body regulate blood pressure after SCI? Scientists mapped the precise nerve circuits causing dangerous spikes in mice, rats, and humans. By stimulating these circuits with epidural electrical stimulation, they activated a competing pathway that stabilized blood pressure. #neuroskyence

Blood pressure control after SCI has been challenging — until now. Swiss and Canadian researchers developed an implantable system that epidurally stimulates three thoracic segments, triggering a strong pressor response and rapidly reducing hypotensive symptoms. #neuroskyence #sci #onward

How far can intravascular electrodes reach? Scientists miniaturized stentrode-like electrodes to access small, deep cortical veins. Their probe goes beyond large vessels used by Synchron, enabling recordings from hand and speech regions with ECoG-level quality. #neuroskyence #bci #synchron

Might focused ultrasound one day replace DBS? UK Scientists built a 256-panel focused ultrasound helmet that can precisely target deep brain regions. Using theta-burst TUS, they stimulated the LGN and found visual cortex activity with effects lasting up to 40 minutes. #neuroskyence #ultrasound

Neuralink update 🧠 • 2 new patients implanted in Canada, marking first trials outside the US • US patent office rejects ‘telepathy’ and ‘telekinesis’ trademarks, as they were previously claimed by a lucid dreaming startup #neuroskyence #bci #neuralink

A password protected inner speech BCI 🧠 Researchers showed that inner speech can be decoded from motor cortex, offering a less fatiguing alternative to attempted speech. To ensure user privacy, the system only activated when participants said 'chitty-chitty-bang-bang'. #neuroskyence #neuro #bci

Sam Altman just got into BCI by backing Merge Labs 🧠 - Valued at $850M after a $250M raise - Developing high-performance, non-invasive brain-computer interfaces - Their bet: focused ultrasound + neuronal gene editing (sonogenetics) #neuroskyence #neuropapers #openAI #BCI

German BCI startup CorTec announces first in-human use of a fully implanted ECoG grid 🇩🇪🧠 The Seattle-based trial, led by Jeffrey Ojemann (U Washington) and Steven Cramer (UCLA), tests if cortical stimulation can aid upper limb recovery of stroke patients. #neuroskyence #neuropapers

Neuralink update 🧠 - P8 and P9 have been implanted within one day - 20 participants are expected by the end of 2025 - Bloomberg estimates $1B revenue by 2031, generously assuming 20k implantees

Meta published their EMG wristband in Nature 📄 They developed a non-invasive neuromotor interface using a wrist-worn device for decoding gestures and handwriting. Its performance scales with the number of participants and can be further enhanced through personalized user tuning. #Neuropapers #CTRL

Nudge just secured $100M Series A funding 💰 The company is developing whole-brain ultrasound interfaces to target psychiatric and cognitive disorders. They plan to enhance the Nudge Zero and validate its impact through clinical studies.

Great to see more BCI developments in asia!

Ripples segment experiences during natural viewing Scientists observed hippocampal ripples peak at event boundaries of movie scenes. Meanwhile, ripples in temporal cortex rise within events and predict which moments will be remembered. These fast oscillations seem to support memory formation.

How do central brain areas work together to create movement? New work from the Courtine lab showed that premotor areas encode movement plans (the why), while primary motor and somatosensory cortices handle execution (the how). Control flows through low-dimensional subspaces from plan to action.

🧠🕹️ Neuralink just shared an update: - 7 participants implanted (SCI & ALS) - Hand-knob area for now, speech motor cortex later this year - First vision BCI in 2026 with deeper threads (5cm/2inch) - 10k channels in 2027 - Full-brain coverage in 2028 for psychiatric diseases, epilepsy and pain

Scientists invented contact lenses that let you see infrared light 💡 These special lenses use embedded nanoparticles to shift near-infrared light into the visible spectrum. With them, people can detect shapes, flashes, and even color patterns - even with their eyes closed.

Neuropixel NHP 1.0 has just been published in Nature Neuroscience. The new probe, designed specifically for non-human primates, features an electrode array with roughly 4000 sites over 4.5 mm, 384 of which can be recorded simultaneously. The study details its design, fabrication, and performance.

Stavisky & Brandman published their speech prosthesis in Nature 🗣️🧠 They demonstrate streaming speech synthesis with a latency of only 50 ms in a man with ALS. The system captures paralinguistic features like pitch, intonation, and word emphasis - bringing BCI communication closer to natural speech.

Great to see an invasive BCI network developing in Europe!

How does the brain find the right words? Scientists identified two key language networks through 48 ECoG recordings. Semantic meaning is integrated in the IFG and MFG, while speech movements are planned in the IFG and precentral gyrus. Both networks work together to support word retrieval.

What if you could implant electrodes in the developing brain, so it grows around them? Researchers at Harvard implanted Axoft’s soft bioelectronics onto the neural plate — an early sheet of stem cells. As the brain grows and folds, the electronics became embedded within it.

Paradromics just completed its first in-human clinical trial. The procedure took place at the university of michigan in collaboration with @matthewwillsey.bsky.social. An epilepsy patient undergoing surgery was implanted with the device to prove safety.

Meet us at the #BCI25 meeting by the @bcisociety.bsky.social in Banff, Canada, this week! 🧠 We have a poster on tuesday afternoon and are looking forward to connect with new and familiar colleagues!

Emergence of language in the developing brain 🧠🗣️ Scientists recorded intracranial activity from 46 children aged 2–18 as they listened to The Little Prince. Toddlers showed phonetic encoding in the superior temporal gyrus, while word-level meaning emerged later in associative cortices.

ONWARD Medical implanted two more spinal cord injury patients with their ARC-BCI system. A 48-year-old man and a 37-year-old woman received the ECoG implants in Lausanne earlier this year - totaling five participants overall for the study.

Flexible brainstem implant enables high-resolution hearing in macaques A soft, multichannel implant targeting the cochlear nucleus produced precise, frequency-specific brain responses (ECoG) and clear behavioral reactions

Closed-loop vagus nerve stimulation boosts recovery after spinal cord injury 🧠⚡️ Real-time stimulation during rehab was guided by non-invasive external movement sensors. This approach enhanced arm and hand function by fostering synaptic plasticity and supporting meaningful recovery.

Pain states can be decoded from low-frequency activity in deep and cortical brain regions, as well as from facial expressions 💊 Using iEEG, videos, and self-reports, scientists tracked pain in natural settings. Pain was found to be decodable (up to 75% accuracy), even during brief acute moments.

Scientists just created a new color - and only 5 study participants have seen it so far 🔴🟢🔵 By selectively stimulating M-cone cells in the retina with a high precision laser, participants perceived a unique color described as blue-green with unprecedented saturation.

Speech motor cortex enables cursor control. Researchers at UC Davis showed that signals from ventral motor cortex, traditionally used for speech BCIs, can also enable fast, accurate cursor control and independent computer use for individuals with ALS.

Object-like sensations can be evoked through intracortical microstimulation. Using self-guided selection of multielectrode stimulation patterns, participants created distinct tactile percepts linked to virtual objects. Both humans and algorithms could reliably identify the associated patterns.

Human spiking activity can be modulated by theta burst stimulation (TBS) to the amygdala. TBS has been shown to alter memory performance and change firing in ~30% of neurons across the hippocampus, amygdala, OFC, and ACC, revealing how targeted stimulation shapes cognitive circuits.

Stanford Neurosurgery has just been awarded a $30M grant to develop neurotech solutions for aphasia. The neural prosthetics translational lab (NPTL, Henderson & Willett) therefore received $10M in funding to develop a closed-loop BCI for speech restoration in aphasic stroke patients.

Science Corp., founded by Max Hodak, just raised $104 million in a new funding round. The round was led by Khosla Ventures, a VC firm known for backing medical AI companies like Synchron, Kernel, and Flow Neuroscience.

Neurons in the subthalamic nucleus (STN) synchronize with cortical theta rhythms during speech. Speech errors were found to occur when spike-phase coupling was delayed—highlighting the role of precise STN-cortex interactions in fluent production.

Nudge unveiled a non-invasive ultrasound brain interface that targets deep brain regions with millimeter precision. Using a high-channel phased-array system, it can modulate areas like the thalamus to treat addiction and pain - and eventually enhance everyday cognition. nudge.com/blog/about/

Consciousness is linked to thalamus-to-cortex communication. Human sEEG reveals that during conscious perception, theta-phase activity in the thalamus drives prefrontal cortex responses—supporting a dynamic gating role of the thalamus in shaping awareness moment to moment.

Imagined writing of Chinese signs can be decoded using Utah Arrays. Neural activity is found to transition through states linked to handwriting phases. Neurons’ tuning stays stable within states, but gain and direction shift as the brain progresses. Modeling these states improved decoding by 69%.

BrainGate just proposed an intuitive Brain2QWERTY text neuroprosthesis. Using 3 Utah arrays in two participants, they decoded attempted finger movements to type on a QWERTY keyboard at 22 words per minute with 1.6% error—matching able-bodied accuracy and surpassing current iBCI systems. 🧪🧠

Synchron reports stable motor intent signals in low and high gamma bands from the Stentrode in two ALS patients. Over 3 months, attempted foot movements showed strong modulation, with classification accuracy of 91.4% and 70.4% for each participant.

Nature news article on chang's recent streaming speech prosthesis. BCI researcher @cherff.bsky.social comments that streaming prosthesis are 'the next level', although 'a delay larger than 50 ms really confuses you'. Chang's current neuroprosthesis has quite a big delay of about 1 second.

Chang Lab just published a streaming speech neuroprosthesis using 256-channel ECoG. Their decoder—combining a neural encoder, text model, and speech model—achieves real-time speech with ~1s latency for 1024 words. Their approach also translates to micro-electrode arrays and vocal cord EMG. 🧪