Editorial: Society journals matter—supporting science through renewed commitment Editorial in @femsjournals.bsky.social microLife by @paulbrainey.bsky.social and colleagues academic.oup.com/microlife/ad...

💥 Fewer than 3,000 scientists worldwide are working on antibiotic discovery, and progress is slowing. We need bold action to develop new antibiotics that are both innovative and accessible to everyone, everywhere. That’s what drives GARDP’s DER programme. This is BIG. #WAAW2025 #AMR #ThisIsBig

🌍 #WAAW Spotlight 💬 Behind every resistant strain is a human story. Genomics shows patterns - but progress means tackling poverty, stigma & access.⚖️ 🧬 AMR solutions must centre people, not just pathogens. 🔗 Revisit Social science lessons from HIV: www.targetamr.org.uk/hdrevents/ta... #AMR

1/9 Metagenomics lets us read microbiomes in nature without cultivation, but writing (editing) them in their native context is still a major challenge. Meet MetaEdit: a platform for pathway-scale metagenomic editing inside the gut microbiome. science.org/doi/10.1126/...

#Tuberculosis (TB) is preventable and curable. Yet, it remains one of the world’s deadliest infectious killers, claiming 1.23 million lives in 2024. The WHO Global Tuberculosis Report 2025 talks about the gains made so far and the challenges ahead due to severe funding cuts: bit.ly/4qT5ihk

Are you interested in studying RNA phages? We are looking for a PhD student and a postdoc to join the lab! For more information and how to apply, see below 👇 Please RT!

Use antisense oligomers to silence phage genes and discover new biology. @jorg-vogel-lab.bsky.social @helmholtz-hiri.bsky.social @helmholtzhzi.bsky.social @uni-wuerzburg.de print: www.nature.com/articles/s41... highlight: www.nature.com/articles/s41... briefing: www.nature.com/articles/d41...

Biology is much more complicated than most non-biologists can imagine. And AI is not going to change this anytime soon. blog.genesmindsmachines.com/p/we-still-c...

#CRISPR is more than Cas9 ✂️ 🧬 @BeiselLab reveals a short tracrRNA from S. pyogenes is toxic in L. paracasei, even without Cas9, underscoring challenges of using CRISPR-Cas9 in non-native hosts. #microsky buff.ly/qWjkxdK

Finally out! A small screen helps understand a little more about how E. coli regulates major transporters, and reveals how caffeine induces phenotypical antibiotic resistance. Huge thanks to collab @andrenmateus.bsky.social (Umeå) and Christian L. Müller (Munich)! journals.plos.org/plosbiology/...

Very excited about our latest combining advanced cell culture, transposon-insertion sequencing, and statistical modeling to map Shigella virulence determinants in organoid models. Great collaboration w/ @mldm.bsky.social @sellinlab.bsky.social in @natgenet.nature.com www.nature.com/articles/s41...

Let’s give a big round of applause to Jakob Jung, who has successfully defended his dissertation! 👏 Congratulations, @jabster93.bsky.social‬! The #HIRI family is celebrating with you! 🥳 Read more: www.helmholtz-hiri.de/en/newsroom/...

🚩 A milestone in the fight against #AMR Congratulations to Roche Holding AG on advancing zosurabalpin into Phase 3 trials—a potential first-in-class antibiotic against Acinetobacter baumannii and other Gram-negative bacteria in over 50 years. 🔗 Read more: tinyurl.com/nhdjjt2f

www.hessenschau.de/gesellschaft... In den Osterferien ist eine aus Afghanistan stammende Familie nach Indien abgeschoben worden. Die früheren Mitschüler der beiden Söhne sind geschockt - und gingen in Frankfurt auf die Straße.

Analysing the gene activity of every single bacterial cell in a colony: A new technique of single-cell #transcriptomics developed with @helmholtz-hiri.bsky.social can do this more efficiently than other methods! Publication @natprot.nature.com www.uni-wuerzburg.de/en/news-and-...

MATQ-seq allows the detection of a large number of genes per single bacterium and is characterized by a high cell retention rate. 🦠 A #HIRI & @uni-wuerzburg.de research team recently published a step-by-step protocol in @natprot.nature.com. Learn more ⬇

Thrilled to see our work on targeted #mRNA blockade using high-throughput #antisense screening, now published in Advanced Science! 🚀 A true team effort in close collaboration with the @jorg-vogel-lab.bsky.social with special credit to Popella & Danti! ASOs for the people! bsky.app/profile/gior...

First post, first paper 🤭 Proud to share with all of you our work on mRNA blocking using our own high-throughput antisense approach! doi.org/10.1002/advs... Many thanks to @hmariclab.bsky.social, @jorg-vogel-lab.bsky.social and especially Linda for the amazing collaboration 😸

An unexpected bacterial blocker 🦠🛑 Fusobacteria are suspected of playing a role in cancer progression. #HIRI researchers have now identified a novel compound that effectively halts the growth of five Fusobacterium species. Just out in @asm.org journal mBio: www.helmholtz-hiri.de/en/newsroom/...

“If left unchallenged, a rising wave of white nationalism in many parts of the globe could threaten the progress that has been made in science — and broader society — towards a more equitable world,” writes Genevieve Wojcik in a Comment article for Nature. 🧬 🧪

Lack of access to antibiotics is driving spread of superbugs, finds research. Learn more about GARDP’s new research reveals a major access gap for patients with multidrug-resistant infections in this article by @theguardian.com 👇 www.theguardian.com/global-devel...

The new book by @johngreensbluesky.bsky.social, Everything is Tuberculosis, shines a light on an important topic—and we’re glad to see TB getting more attention & thoughtful writing. Our team is really enjoying reading the book. We’re also very happy to see that our work was useful in the process!

Our latest preprint is out describing amr.watch - a platform for monitoring AMR trends from global genomics data: www.biorxiv.org/content/10.1... (1/6)

"Ours may be a pernicious history, but the trajectory of genetics has been one that tends towards progress and equity" Excellent explainer from @adamrutherford.bsky.social on why racial groupings have no sound biological basis. www.bbc.com/future/artic...

Metabolites are not genes — avoiding the misuse of pathway analysis in metabolomics www.nature.com/articles/s42...

Dalmau et al. automate non-linear ML workflows for tiny chemical datasets. With robust hyperparameter tuning and an overfitting-aware metric, random forests, gradient boosting, and NNs rival or surpass linear regression, expanding chemists’ low-data modeling toolbox. pubs.rsc.org/en/Content/A...

Rightwing populists will keep winning until we grasp this truth about human nature | George Monbiot

Intramacrophage RIL-seq uncovers an RNA antagonist of the Salmonella virulence-associated small RNA PinT https://www.biorxiv.org/content/10.1101/2025.04.07.647523v1

In the fight against bacterial pathogens, researchers are combining vaccination with targeted colonization of the intestine by harmless microorganisms. This approach could potentially mark a turning point in the antibiotics crisis. www.biozentrum.unibas.ch/news/detail/...

Eloff et al.’s InstaNovo uses transformers plus a diffusion refinement to perform high-throughput de novo peptide sequencing. It recovers more novel peptides at low FDR, outperforms current tools, and extends proteomics beyond database limits. www.nature.com/articles/s42...

Bookmarked for reading later! #AMR #IDSky #UTISky

Nice piece to every tech bro who keeps telling us that "you're just prompting it wrong"

The newly discovered lariocidine has shown promise against AMR bacteria by targeting ribosomes with a novel mechanism of action. While still years away from market approval, its potential to combat #AMR infections offers hope in addressing the global AMR crisis. www.thevermilion.com/why-could-a-...

OUT NOW: Inducible transposon mutagenesis identifies bacterial fitness determinants during infection in mice #microsky 🧪 www.nature.com/articles/s41...

Severe resource shortages are threatening the global response to end #tuberculosis (TB). A quarter of the world’s population could be infected with TB and not even know it. Is there a cure? What is the treatment? How do we diagnose TB? Listen in to Dr Tereza Kasaeva on Science in 5. bit.ly/4kRdJXE

As we can expect PubMed dysfunction more and more or to be swamped with fake journals I suggest you get acquainted to this nice alternative: europepmc.org

So happy to see this awesome work finally out in its final form! Congrats to Ben, Muntathar, and team!

Now, more than ever, we must embrace #diversity, #equity, and #inclusion in education. A #FEMSMicrobiolLett article explores approaches that empower learners, foster belonging, and spark lifelong learning. #InclusiveEducation https://academic.oup.com/femsle/article/doi/10.1093/femsle/fnad103/72…

Today’s good read is an article in @theatlantic.com about Elon’s attempt to take down @wikipedia.org www.theatlantic.com/technology/a... also - I learn some new things about Wikipedia: “sock-puppets” and “meat puppets” - 🫣🤭

Nearly two-thirds of antibiotics were introduced during the “golden age of antibiotics”! (short thread)

Interested in collecting, sharing, and interacting with large collections of bacterial functional genomics data (RNA-seq, Tn-seq/TraDIS, etc.)? Check out our new web platform, Micromix, with case studies for Salmonella and Bacteroides! 🧫🧬🖥️🧪 Thread 1/n academic.oup.com/gigascience/...

An LLM "creates textual claims, and then predicts the citations that might be associated with similar text. Obviously, this practice violates all norms of scholarly citation. At best, LLMs gesticulate toward the shoulders of giants." Bender, West, and I contributed to this pro/con piece in PNAS.

Check out our latest npj, Antimicrobials and Resistance @natureportfolio.bsky.social! With AI, we can now discover antibiotics faster than ever. Congrats Angelica Cesaro and our fantastic collaborators at IBMResearch, Sam Hoffman, and Payel Das. www.nature.com/articles/s44...

Interested in predicting AMR in bacteria? We show ignoring phylogenetic structure in genome collections leads to overly optimistic evaluations of machine learning methods for AMR prediction. With @nwheeler443.bsky.social and former PhD student Yanying Yu. 🦠🧫🧬🖥️🧪 www.biorxiv.org/content/10.1...

OUT NOW: Explainable deep learning and virtual evolution identifies antimicrobial peptides with activity against multidrug-resistant human pathogens By Beilun Wang, Zhou Yu, Yihan Wu & colleagues www.nature.com/articles/s41...