Oh. Looky here #SciSky. New work from former PhD student Sabrina Chau along with our collaborators in the Laxman lab. A couple of main points: 1. Attenuation of a yeast dsRNA virus is accomplished through amino acid restriction.

Essays, written on the same occasion but a decade apart, by two lovers of genetics ❤️ @genetics-gsa.bsky.social @schacherer.bsky.social

Our new paper was, by definition, an adventure: stepping outside of our comfort zone, embracing the unknown, and engaging in activities where the outcome is uncertain. Includes discovery of a new species and working with a Native American tribe to name it… 🧵👇 onlinelibrary.wiley.com/doi/10.1002/...

Not being able to access the @ukbiobank.ac.uk is becoming a significant issue for a PhD student in our group and I can only imagine this is mirrored in many other places. It would be fantastic to at least have a timeline we could work with.

Our paper on the evolution of cellular miniaturization is now out in PNAS! www.pnas.org/doi/10.1073/... A short recap 🧵

Congratulations to @schacherer.bsky.social @unistra.fr recipient of the #Yeast26 GSA Medal! Great to hear the journey to identifying structural variants in #1011YeastGenomes, tackling heritability, genetic diversity, and genotype-phenotype @genetics-gsa.bsky.social

Super excited to share our lab's work led by PhD student Margot Ruffieux on domestication of Saccharomyces cerevisiae, with a focus on sourdough and baking associated yeast! 🍞

14th Ekiden for the HaploTeam already - I can't believe it. But first since we moved to @igbmc.bsky.social! The competition between the Haplo and Diplo subteams was tough but as always, great fun and team spirit!

⏰ Only 2 DAYS left for early registration! Join us at #Yeast26 (June 13-17, Pacific Grove, CA) for cutting-edge research in #genetics, #genomics, #disease, #regulation, #systemsBiology, #cellBiology, #lifeCycle, #syntheticBiology, & more. Register by April 16 to save! 🧬 genetics-gsa.org/yeast-2026/

New from my lab: Ancestral sequence reconstruction analysis indicates the furin-cleavage-site insertion in the SARS-CoV-2 spike gene likely interrupted a codon academic.oup.com/ve/article/1...

🌊 Get ready for YGM2026- the ultimate #Yeast genetics experience! World-class science meets Pacific Grove paradise June 13-17 🏨 Stay on-site: deadline April 8 ⏰ Conference registration ends April 22 This is THE meeting you don't want to miss! We'll see you there! #Yeast26 #Asilomar #YeastGenetics

🎤 Meet the PYFF9 speakers! Yeast & Fungi Conference 2026 in Valencia (8–11 Sept) 📢 Registration & abstract submission open 🔗 yeastfungi.efbiotechnology.org/home #Yeast #Fungi #Biotechnology #CallForAbstracts @pyff-9.bsky.social

#Yeast #Genetics Meeting 2026 is in June - Abstract deadline is TODAY! Submit your abstract, attend the meeting this summer in Pacific Grove, CA at #Asilomar Conference Grounds, a 107-acre protected coastal state park located on the Monterey Peninsula. #Yeast26 #YGM2026 genetics-gsa.org/yeast-2026/

We have started a project trying to predic the interactions/structures of all yeast protein pairs using an AlphaFold pooling approach. We are making the current dataset open and we welcome collaborations. www.evocellnet.com/2026/03/mapp...

📢 Reminder: March 5 is the abstract submission deadline for the Yeast Genetics Meeting. Don’t miss the chance to share your work—submit an abstract and encourage colleagues to attend! genetics-gsa.org/yeast-2026/

Thrilled and honored to be part of the 2026 GSA Award recipient! This honor reflects years of teamwork - huge thanks to everyone who has been part of the #haploteam. Proud to share this with you all! @genetics-gsa.bsky.social genestogenomes.org/the-2026-gsa...

We are deeply saddened to share the news of the passing of David Botstein, a towering figure in modern #genetics and a foundational force behind SGD. www.yeastgenome.org/blog/in-memo... #yeast #modelOrganism

Sad to learn that David Botstein has passed away. Few people truly shape how you think and do science, and David was definitely one of them. I had a fun and influential time at Princeton with the Botstein, Kruglyak and co gangs. It shaped the way I do science. www.online-tribute.com/DavidBotstein

www.biorxiv.org/content/10.6... comparison of commercially available #Saccharomyces #mead yeasts. Our new preprint w/ @balintnemeth.bsky.social and colleagues compares 13 mead #yeast strains for their phenotype, genome, and presents data on metabolites in experimental mead fermentations.

Finally…

New Perspective!🔥It's fascinating how scientists from different fields but interested in the same question [e.g. genotype-phenoytpe relationship] can have such different perspectives. Here we put in our 2 cents wrt genetic effects being context-dependent, and pheno variation being mostly polygenic

Our paper is now out in Nature: “Ancient co-option of LTR retrotransposons as yeast centromeres” www.nature.com/articles/s41... A short thread on how retrotransposons helped give rise to yeast point centromeres. 1/14

With @litinice.bsky.social, we built a haploid resource from 33 wild Taiwanese Saccharomyces cerevisiae strains — including some of the most genetically divergent Asian lineages — to bring natural yeast diversity into a genetically tractable framework. www.biorxiv.org/content/10.6...

Registration is open for the inaugural GRC conference in the Function of Evolving Systems. Aug 9-14, 2026, Waterville Valley. Truly stellar speaker lineup. Student/postdoc fellowships are available! Please come join us! www.grc.org/function-of-... @joybergelson.bsky.social

New lab preprint - Common and rare variant studies for the same trait identify different genes and here Diederik Laman Trip developed a protein network AI enconding to investigate if traits studied by different approaches converge on the same molecular pathways www.biorxiv.org/content/10.6...

Excited to announce our latest publication in reporting evidence for three (3!) new whole genome duplications (WGDs) in yeasts. Scientists have often wondered why WGD is so rare in fungi, it turns out we may just not have been looking hard enough! 🧪 🍄 🧬 www.sciencedirect.com/science/arti...

Expressions of interest: Director at MPI EvolBio (f/m/d) — We invite expressions of interest from distinguished scientists in evolutionary biology with a bold, long-term research vision that complements our Institute. More information: www.evolbio.mpg.de/3856225/Dire...

✨ Latest exciting story of the group in @nature.com. Here, we go beyond SNPs and built a species-wide atlas of genetic variants in yeast. With >1,000 near T2T genomes, we show how large genomic variations affect trait diversity. www.nature.com/articles/s41...

📣 #EMBOEvoEco returns in 2026 to uncover the mechanistic foundations of ecological and evolutionary change! Keynote lectures will spotlight the ecology and evolution of symbiosis. Submit your abstract for the EMBO Workshop: https://s.embl.org/eae26-01-bl#EMBOEvoEco

Abstract submission for #Yeast26 is now open! 🍞🍺 Browse abstract submission topics online and start preparing your abstract today. Topics include disease models & aging, evolution & population genetics, gene regulation, genomics & systems biology, and more! Learn more: buff.ly/qotaLne

2026 is the 50th anniversary of the Cellular and Molecular Fungal Biology GRC. It will be June 21-26, 2026. Consider attending this is a great meeting if you work in the fungal biology field at genetic / genomic / molecular scale. www.grc.org/cellular-and... 🍄🧬🖥️

Last work of the lab showing that Repeated losses of self-fertility shaped heterozygosity and polyploidy in yeast evolution | PNAS www.pnas.org/doi/10.1073/...

First paper of the year for the HaploTeam, showing how domestication repeatedly reshapes sexual–asexual life cycle trade-offs in yeast, and revealing convergent evolution. Huge kudos to the team, brilliantly led by Jing Hou! www.pnas.org/doi/10.1073/...

#Yeast #Genetics Meeting abstract submission and registration sites are open! Abstracts due March 5! community.alliancegenome.org/t/yeast-gene...

📢 Open PhD position Phasing polyploid genomes to decipher their phenotypic & adaptive potential 📍 IGBMC - Strasbourg ⏰ Start: Spring 🔍 Profile: MSc in bioinformatics, Python/Bash, R, sequencing data experience a plus. 📩 Application: see below

Haploteam christmas dinner 🎄 to celebrate an intense and demanding year, but one punctuated by great successes. What a fantastic team! Thanks to everyone!

🗞️ New preprint from the lab, led by our postdoc Ana Garoña (not on here) in collab with @andreagiometto.bsky.social: “Experimental evolution of cellular miniaturization reveals a mechanism for cell size evolution”, aka: “honey, we shrank the yeasts!” 🎥 www.biorxiv.org/content/10.6...

Don't wait to book your stay at Fungal 2026! The reservation site for Asilomar Hotel and Conference Grounds is open until January 13, 2026, but spots are filling up fast #Fungal26 genetics-gsa.org/fungal-2026/...

🧬 Join us at #Yeast26 - Yeast Genetics Meeting! 📍 Asilomar, Pacific Grove, CA 📅 June 13–17, 2026 📝 Abstracts & registration open Jan 5 | Abstracts due March 5 🔗 genetics-gsa.org/yeast-2026/ @genetics-gsa.bsky.social

🚨 New preprint! 🚨@haploteam We built a barcoded collection of 520 natural S. cerevisiae isolates and screened 600+ natural compounds. Six functional response clusters and 100+ GWAS associations reveal how natural variation shapes chemical sensitivity. 🔗 Read the preprint: doi.org/10.64898/202...

🚨 PhD opportunity in Strasbourg! 🚨 We’re looking for a motivated PhD student to join the @haploteam within the IMCBio program (PhD-2026-17). 🔗 imcbio-phdprogram.unistra.fr Please spread the word or contact me if you’re interested!

Fun new preprint from the lab, headed up by two incredible undergraduate researchers: Using Experimental Evolution to Correct Mother-Daughter Separation Defects in Brewing Yeast. www.biorxiv.org/content/10.1...

New preprint with @pyjiang.bsky.social and @kelleyharris.bsky.social! The discovery and patterns of the underlying long-standing mild-effect mutator alleles in S. cerevisiae populations www.biorxiv.org/content/10.1...

Thrilled to share our latest review! T2T assemblies are reshaping how we study genomic diversity. Pangenomes unlock structural variants, gene presence-absence, and genotype-phenotype relationship, across humans, plants, animals, and fungi. www.cell.com/cell-genomic...

2026 #Yeast #Genetics Meeting is 13–17 June 2026 in Pacific Grove CA. Conference website has invited speakers, abstract submission topics, preliminary schedule, etc. Bookmark the site as additional updates will be published as they become available. #YEAST26 genetics-gsa.org/yeast-2026/

Research briefings in @nature.com about our latest story on large genomic variations and trait diversity! www.nature.com/articles/d41...

Had a great visit to @cicbiogune.bsky.social. Impressive science and a welcoming atmosphere!

Nature research paper: From genotype to phenotype with 1,086 near telomere-to-telomere yeast genomes go.nature.com/4nVsl9z

Very excited to see the final version of our kingdom-scale fungal genome defense manuscript out in @plosbiology.org ! This work has been a major project of @tbadet.bsky.social during his time in our lab. We hope to stimulate much more exciting work on fungal TEs. journals.plos.org/plosbiology/...

Incredible new paper from @schacherer.bsky.social et al rdcu.be/eLcTH