@microbingle.bsky.social
📤 663
📥 1414
📝 298
reposted by
🪭LINA لينا
about 20 hours ago
Never seen anything so relatable
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reposted by
Twlldun
about 11 hours ago
Don’t disagree but the “they” who had been trending that way in my answer there is the right who have been trending towards climate change denial
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reposted by
Rebecca Drummond 🍄
2 days ago
Worried about the
#meningitis
outbreak in the UK? I've answered some common questions in this
@uk.theconversation.com
article:
theconversation.com/two-people-h...
#immunosky
#microsky
🧪
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Two people have died from bacterial meningitis in the UK. An expert answers your questions
Two people have died in a bacterial meningitis outbreak in the south of England. Here’s what you need to know.
https://theconversation.com/two-people-have-died-from-bacterial-meningitis-in-the-uk-an-expert-answers-your-questions-278434?utm_medium=article_native_share&utm_source=theconversation.com
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reposted by
Microbes.Info
4 days ago
Turning
#penicillin
into a lethal force against
#bacteria
again ... |
#antibiotic
|
#antibiotictolerance
|
#betalactam
|
#cholera
| By
@cornelluniversity.bsky.social
via
@sciencex.bsky.social
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Turning penicillin into a lethal force against bacteria again
When many disease-causing bacteria encounter penicillin, they are not always destroyed right away, shifting into a temporary survival state called antibiotic tolerance. This state allows them to…
https://phys.org/news/2026-03-penicillin-lethal-bacteria.html
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reposted by
Asimov Press
20 days ago
A Visual Guide to DNA Sequencing. Learn how different DNA sequencing technologies work, from Sanger sequencing to Illumina to nanopores. (Complete with illustrations!) Written by Evan DeTurk. Illustrated by Ella Watkins-Dulaney.
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reposted by
Alvaro San Millan
5 days ago
Final version of our last paper is out!
www.nature.com/articles/s41...
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Plasmids promote antimicrobial resistance through insertion sequence-mediated gene inactivation - Nature Microbiology
Inactivation of chromosomal genes through plasmid-encoded IS elements is an extended mechanism of antimicrobial resistance evolution in bacteria.
https://www.nature.com/articles/s41564-026-02290-x
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Antibiotics need coordinated G7 investment
www.theguardian.com/business/202...
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Antibiotics need coordinated G7 investment | Letter
Letter: Grace Hampson on ways to address the worryingly thin pipeline of new effective drugs
https://www.theguardian.com/business/2026/mar/12/antibiotics-need-coordinated-g7-investment?CMP=Share_AndroidApp_Other
6 days ago
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reposted by
Tracy Palmer
7 days ago
2 year fellowship available in AMR research
www.medicalresearchfoundation.org.uk/grants/antim...
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Medical Research Foundation | Antimicrobial Resistance Research
Antimicrobial Resistance Research
https://www.medicalresearchfoundation.org.uk/grants/antimicrobial-resistance-research
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reposted by
James McInerney
7 days ago
I'm thankful to MBE for publishing this paper. I wan't sure anybody would. The handling editor (I now know was Jeff Townsend) was great, as were the 2 reviewers. It is not an outcome/product/discovery, it is my way of thinking about HGT & pangenomes 1/3
academic.oup.com/mbe/article/...
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Genomic perplexity and the evolution of context-dependent function
Abstract. The fundamental principle that selection acts on a gene's function often assumes implicitly that this function is fixed and intrinsic. However, e
https://academic.oup.com/mbe/article/43/3/msag041/8497498
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reposted by
Helen Czerski
9 days ago
Oil prices wouldn't be all over the news today if more of our economy was powered by local, secure renewable energy. This isn't an "energy crisis". It's a fossil fuel crisis. 44% of UK electricity came from renewables in 2025. More of that plus an electrified economy => no more oil shocks.
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reposted by
Los Angeles Review of Books
11 days ago
"Many biographies use a singular life as a kaleidoscope to refract a historical period and view its patterns. Cobb’s biography does something different." Angela Creager reviews Matthew Cobb’s new book:
https://lareviewofbooks.org/article/francis-crick-james-watson-double-helix-dna-biography
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reposted by
STCmicrobeblog
11 days ago
(bacterial) chromosome segregationists take note 👇 membrane-anchoring of the 𝘰𝘳𝘪𝘊 region to ensure proper daughter chromosome segregation after replication initiation – proposed decades ago but never substantiated... 👉now shown for 𝘚. 𝘢𝘶𝘳𝘦𝘶𝘴 by mariana pinho's lab
add a skeleton here at some point
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reposted by
The Author, Séamas O'Reilly
11 days ago
Have said this before in other forms, but will reiterate it here: if you're doing long-form writing of any sort, reading the words aloud into a microphone is a completely unparalleled cheat code. It's free, easy, and so effective it feels like it shouldn't be allowed. I do it in a few stages...
add a skeleton here at some point
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Sunderland climbing wall - a beautiful bright & frosty morning outside but somehow feels much colder in here 🥶
11 days ago
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reposted by
The EMBO Journal
13 days ago
Asgard
#archaea
: have we found our microbial ancestors? New review (also for newcomers to the field!) by Christa Schleper and Thiago Rodrigues-Oliveira
link.springer.com/article/10.1...
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reposted by
Marie Le Conte
12 days ago
my view on this is that publishers should stop it with the 80k wordcount obsession, so many contemporary non-fic books are obviously 40-50k pieces of work stretched to the extent that they become very boring to read - just let people write cheaper, shorter books!
www.theguardian.com/books/2025/d...
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Are we falling out of love with nonfiction?
In the early 2020s, readers flocked to books to explain political turbulence. But is the world now too grim to read about – and are podcasters taking the place of authors?
https://www.theguardian.com/books/2025/dec/17/are-we-falling-out-of-love-with-nonfiction?CMP=Share_iOSApp_Other
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reposted by
Martin Paul Eve
15 days ago
Ha! The original Lancet article on the dangers of reading in bed is here:
doi.org/10.1016/S014...
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reposted by
Mart Krupovic
15 days ago
With Eugene Koonin, we propose a concept of “the selfish ribosome”, under which evolution of life is viewed as a ribosomal takeover, where the ribosome evolved to consume most of the cell’s resources, while other cellular componentry ensures the propagation of the ribosome.
arxiv.org/abs/2602.23268
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reposted by
Helen Branswell 🇨🇦
16 days ago
Stanley Plotkin had a major hand in the development of a number of vaccines in use today; he designed the rubella vaccine. He remembers the world before widespread use of vaccines & knows what's coming as vaccine policy is rewritten & vaccine confidence is eroded.
www.statnews.com/2026/03/02/s...
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A titan of vaccine development sees his field’s achievements slip away
Stanley Plotkin, the 93-year-old "godfather of vaccines," is watching his field’s achievements slip away.
https://www.statnews.com/2026/03/02/stanley-plotkin-profile-godfather-of-vaccines-worried/
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reposted by
Adam Bienkov
17 days ago
As Nigel Farage is now so concerned about the influence of "foreign-born voters" can he finally explain why a Kazakhstan-born billionaire appears to be bankrolling his own political party?
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Wasn't expecting this Ukrainian dry red (from Lidl) to be quite so delicious. Слава українському вину!
17 days ago
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Testosterone might make males more prone to skin infection.
add a skeleton here at some point
17 days ago
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reposted by
Andrew Rambaut (🐏🎀)
18 days ago
So I pleased to announce the conceptual spawn of FigTree: PearTree (acronym still to be finalised). If you want to dive right in it is hosted as a web app here:
artic-network.github.io/peartree
(click the “Example...” button for immediate candy and then click every button you can find).
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PearTree — Phylogenetic Tree Viewer
http://artic-network.github.io/peartree
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reposted by
Drugs for Neglected Diseases initiative (DNDi)
19 days ago
🚀 Huge news for people living with
#sleepingsickness
! Acoziborole, a one-day, single-dose oral treatment developed with Sanofi, has received a positive opinion from
@ema.europa.eu
for the treatment of the most common form of sleeping sickness. 👉
bit.ly/46ZFpEi
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reposted by
Grant Jacobs BioinfoTools/NotJustDNA 🔬🧬🖥️✍️📚
about 1 month ago
🧪 This bacterial strain has been maintained in sterile water since 1994. Possible carbon sources incl. “phthalic acid - a plastic degradation product likely leached from inoculation tubes“. Genomic variations accumulated between 1994 and 2022 suggested adaptations to long-term nutrient deprivation
add a skeleton here at some point
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reposted by
BejaLab
21 days ago
Convergent MurJ flippase inhibition by phage lysis proteins
www.nature.com/articles/s41...
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Convergent MurJ flippase inhibition by phage lysis proteins - Nature
A common mechanism of inhibition of the essential lipid II flippase MurJ by three distinct phage-encoded single-gene lysis proteins provides insights into potential new targets for antimicrobial devel...
https://www.nature.com/articles/s41586-026-10163-w
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reposted by
Ákos T Kovács
21 days ago
Sad to hear the passing of Jeff Cole. I appreciated the small talks with him during my research stay in Birmingham (in 2004); an unforgettable personality, his passion about microbial biotechnology was adherent via
@efbiotechnology.org
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reposted by
Jeff, Stopping by Woods
22 days ago
Cladonia sp
#lichen
#Newfoundland
Canada. Lichens are about 3cm high
#fungi
#fungifriends
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Accessing underexplored biosynthetic potential by initiation unit engineering of nonribosomal peptide synthetases in Proteobacteria
pubs.acs.org/doi/10.1021/...
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Accessing Underexplored Biosynthetic Potential by Initiation Unit Engineering of Nonribosomal Peptide Synthetases in Proteobacteria
Nonribosomal peptide synthetases (NRPSs) represent a valuable yet underexplored resource for producing bioactive natural products. However, most NRPSs remain silenced potentially due to factors such as dysfunction of the initiation unit. The starter condensation (Cs) domain of the initiation unit catalyzes the lipoinitiation of nonribosomal peptides via the incorporation of an N-terminal fatty acyl chain. The concept of initiation unit engineering introduced herein encompasses the replacement of the native initiation unit of NRPSs with a foreign and well-characterized Cs domain-containing initiation unit to activate the NRPS and optimize its expression. This strategy was employed herein to successfully access three of the six previously silent NRPS pathways in Mycetohabitans rhizoxinica HKI 454, a bacterium of the class β-proteobacteria, resulting in the identification of three classes of lipopeptides. This strategy was then extended to access two NRPS pathways in Pseudomonas syringae (γ-proteobacteria) and obtain novel lipopeptides, thereby establishing a feasible complement to existing genome mining strategies for natural product discovery. Furthermore, change of the initiation regions of biosynthetic pathways of nonlipidated chitinimide (β-proteobacteria) and pseudotetraivprolide (γ-proteobacteria) with heterologous Cs-containing initiation units enabled the successful incorporation of fatty acyl chains into the N-terminus of both peptide backbones, launching a workable approach to create artificial lipopeptides. Overall, this study provides a practical strategy for the rational recovery of silent BGCs and introduction of fatty acyl chains into nonribosomal peptides, at least in Proteobacteria, thereby enriching genome mining and combinatorial biosynthesis approaches for accessing the underexplored biosynthetic potential of NRPSs from various bacteria.
https://pubs.acs.org/doi/10.1021/jacs.6c01193
22 days ago
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reposted by
hoskas
23 days ago
How perfect is this
add a skeleton here at some point
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It surprises me when I notice signs like this in 2026 (and they are still everywhere if you look). You'd think people would scrub away these reminders at the first opportunity, but for some reason that don't / can't.
23 days ago
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The origins of agar
www.asimov.press/p/agar
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The Origins of Agar
First introduced into laboratories in 1881, agar remains indispensable as a culture medium.
https://www.asimov.press/p/agar?publication_id=76313&utm_medium=email&utm_campaign=email-share&triggerShare=true&r=2b9zdf
24 days ago
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reposted by
NEJM.org
24 days ago
Ethionamide has been used to treat tuberculosis for decades, but dose-dependent toxic effects have limited its use. In a new trial, alpibectir enabled the ethionamide dose to be reduced by two thirds. Full trial results:
nej.md/46PP9Rn
#MedSky
#IDSky
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reposted by
Prof Tanya Parish
28 days ago
Are you interested in being the first biologist in our new team? Come join our small but growing group. Deadline for applications is 3rd March.
#Tuberculosis
🧪🦠
#TBDrugDiscovery
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Technical Programme Manager | Liverpool School of Tropical Medicine
Technical Project ManagerLocation: LiverpoolContract: Fixed-term contract until March 2028Salary: £47,389 - £59,967The Parish Lab at the Liverpool School of Tropical Medicine focuses on antimicrobial ...
https://app.vacancy-filler.co.uk/salescrm/Careers/CareersPage.aspx?e=LMo8nnTwYNbqsnWXJFxCfMpA1POHrg8Jx_FlyUQrwI_HEMgGLtuweUO9NUJLeDQlS1Mr5zK7zUU&iframe=True&iframe=false
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reposted by
Brett Baker
about 1 month ago
Asgard archaeal origin of microtubules
www.biorxiv.org/content/10.6...
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https://www.biorxiv.org/content/10.64898/2026.02.15.705738v1
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reposted by
Carl Zimmer
28 days ago
One of the biggest questions in biology is how complex cells evolved about 2 billion years ago. Here's my new story on how scientists are solving the mystery of eukaryotes like us. Gift link:
nyti.ms/4qMbo22
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SAFC posted Ramadan Mubarak earlier on FB and people whinged so much they had to post a "Peaceful Lent" message. But I don't remember anyone who wasn't a priest *ever* saying that to me before - surely it's not a thing?
28 days ago
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reposted by
Carl T. Bergstrom
29 days ago
1. I’m quite happy with this popular piece that Lee Dugatkin and I wrote recently. For the next two weeks it’s free to read on the American Scientist website.
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Humbled by Evolution
Understanding the history and diversity of life inspires awe and wonder.
https://www.americanscientist.org/article/humbled-by-evolution
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reposted by
Claus Wilke
about 1 month ago
AI agent goes nuts on open source maintainer after having its pull request denied. This is a pretty insane story. Open source development as we've been used to for the last few decades is likely over. 1/
theshamblog.com/an-ai-agent-...
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An AI Agent Published a Hit Piece on Me
Summary: An AI agent of unknown ownership autonomously wrote and published a personalized hit piece about me after I rejected its code, attempting to damage my reputation and shame me into acceptin…
https://theshamblog.com/an-ai-agent-published-a-hit-piece-on-me/
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reposted by
Dan Davies
about 1 month ago
"everyone has to get back to the office because the important thing about business is human interaction" is dying, but "white collar jobs will be replaced by AI agents within 18 months" cannot yet be born; in this interregnum a variety of morbid symptoms appear.
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reposted by
Amanda Moehring
about 1 month ago
Ooooh. Cool new paper on origins of life. A simple 45-nucleotide RNA molecule that can perfectly copy itself.
www.science.org/doi/10.1126/...
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A small polymerase ribozyme that can synthesize itself and its complementary strand
The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...
https://www.science.org/doi/10.1126/science.adt2760
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reposted by
Rubin Lab
about 1 month ago
Check out our latest preprint from
@jnvmartinson.bsky.social
and
@leosong.bsky.social
! 🌟🦠 We found that conjugative plasmids can actively eliminate recipient bacteria that resist plasmid acquisition. 🧵
add a skeleton here at some point
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reposted by
Billy Bragg
about 1 month ago
Just going to leave this here
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reposted by
Hypoautonomic, BS
about 1 month ago
Parhogens have been jumping species to species since the dawn of time but the null is somehow something else. These people undoubtedly look at opinion polls and then decide what reality is
add a skeleton here at some point
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reposted by
Otto English
about 1 month ago
This is pretty menacing. Sarah Pochin wrote to Bangor's university student run debating society requesting that she attend to "answer questions from students." When they said "no" Reform rolled all it's tanks onto the lawns and said they'll cut funding to the entire university if they win.
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reposted by
Tony Yates
about 1 month ago
Mars far, Moon near. In a few years we will get 'Actually Moon is quite far too'.
add a skeleton here at some point
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reposted by
Theo Sanderson
about 1 month ago
I made a map of 3.4 million Bluesky users - see if you can find yourself!
bluesky-map.theo.io
I've seen some similar projects, but IMO this seems to better capture some of the fine-grained detail
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Bluesky Map
Interactive map of 3.4 million Bluesky users, visualised by their follower pattern.
http://bluesky-map.theo.io/
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reposted by
Grainger Lab
about 1 month ago
@ewarman.bsky.social
has followed up on her discovery of bidirectional promoters in bacteria by defining their basic rules for regulation and links to gene expression noise...
academic.oup.com/nar/article/...
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Bidirectional promoters in Escherichia coli: regulatory rules and implications for gene expression noise
Abstract. In prokaryotes, bidirectional promoters are pseudo-symmetrical DNA sequences that stimulate divergent transcription. Ubiquitous, and far more lik
https://academic.oup.com/nar/article/54/3/gkag028/8437503?login=true
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Surprise gastronomic discovery today - delicious pupusas (stuffed tacos) the national dish of El Salvador, from a tiny takeaway that's just opened on Holmeside, Sunderland.
about 1 month ago
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reposted by
Matthew Perren
about 1 month ago
There really is a TED Talk on tying your shoelaces correctly. It actually works.
www.youtube.com/watch?v=zAFc...
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How to tie your shoes | Terry Moore
YouTube video by TED
https://www.youtube.com/watch?v=zAFcV7zuUDA
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