Nicola Lorè
@nicolaivan.bsky.social
📤 216
📥 165
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Biomedical researcher interested in host-pathogen interaction, microbes and lung Immunity.
pinned post!
Repost in Bluesky. Our paper on
#Dual
spatial gene expression approach to dissect
#host-#bacteria
interaction in respiratory infections.
rdcu.be/dWuBQ
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Dual spatial host-bacterial gene expression in Mycobacterium abscessus respiratory infections
Communications Biology - Dual spatial gene expression assay in tissues with chronic lung infection by Mycobacterium abscessus paves the way for the simultaneous detection of host and bacterial...
https://rdcu.be/dWuBQ
11 months ago
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Super interesting paper on Novel
#Genetic
Loci for Nontuberculous
#Mycobacterial
Pulmonary Disease. I'm glad to see that part of the validation was performed using our previous published data. Enjoy the paper!
atsjournals.org/doi/10.1164/...
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Novel Genetic Loci for Nontuberculous Mycobacterial Pulmonary Disease and Potential Protective Effect of Body Mass Index | American Journal of Respiratory and Critical Care Medicine | Articles in Pres...
https://atsjournals.org/doi/10.1164/rccm.202406-1253OC
about 1 month ago
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reposted by
Nicola Lorè
Cystic Fibrosis Trust
about 2 months ago
Do you have a story about how antibiotics have made a difference in your lives or the lives of your loved ones? Your story and photo could be up in lights at
#PiccadillyCircus
in London during
#WAAW25
. Visit the Fleming Initiative to find out more. ➡️
www.fleminginitiative.org/thank-you-an...
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reposted by
Nicola Lorè
Waggoner Lab
about 2 months ago
@biorxivpreprint.bsky.social
Requirements for development of T-helper1 and T-follicular helper cells from a common precursor
@unileiden.bsky.social
www.biorxiv.org/content/10.1...
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Rejected…..rejected….
2 months ago
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reposted by
Nicola Lorè
Ivan Zanoni
2 months ago
Finally officially out in the latest issue of
@cp-cell.bsky.social
as a
#free
#featured
#LeadingEdge
paper: everything you wanted to know about
#InterferonPower
! ❤️
@danielboehmer.bsky.social
@bostonchildrens.bsky.social
@harvardmed.bsky.social
www.cell.com/cell/fulltex...
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Interferons in health and disease
The cytokine messenger proteins known as interferons are central to protective immune responses against infections, but they are also involved in inflammatory and autoimmune diseases. This review maps...
https://www.cell.com/cell/fulltext/S0092-8674(25)00746-9
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Nicola Lorè
Science Magazine
3 months ago
"For half an hour, I vented everything I had been holding in for months … my supervisor … then calmly offered a line I’ll never forget: 'You are here to learn to ride a bicycle, not to invent a bicycle.' That one sentence landed softly, but it cracked something open."
https://scim.ag/4lt1Ru0
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Nicola Lorè
Bryan Yipp
5 months ago
Our latest work on how nerves safeguard lung fibrosis. Congrats to Dr. Hiroki and collaborators.
@cp-immunity.bsky.social
@kavithascranton.bsky.social
@hotchkissbrain.bsky.social
@ucalgary.bsky.social
@ucalgarymed.bsky.social
@libininstitute.bsky.social
www.cell.com/immunity/abs...
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Nociceptor neurons suppress alveolar macrophage-induced Siglec-F+ neutrophil-mediated inflammation to protect against pulmonary fibrosis
Sensory innervation impacts several lung diseases, but whether it influences pulmonary fibrosis (PF) is unclear. Hiroki et al. report that depletion of TRPV1+ nociceptors leads to worsening of inflamm...
https://www.cell.com/immunity/abstract/S1074-7613(25)00221-3
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Super interesting. Does it work for NTM?
add a skeleton here at some point
3 months ago
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reposted by
Nicola Lorè
Jose M. Adrover
4 months ago
I’m happy to share our latest work on tumour necrosis! During my time in the
@megeblad.bsky.social
lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13)
www.nature.com/articles/s41...
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Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature
Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.
https://www.nature.com/articles/s41586-025-09278-3
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Super happy to have attended “The Nontuberculous
#Mycobacteria
Conference 2025” in Fort Collins! Great talks, outstanding science, and a really cool location. Huge thanks to the organizers. Always a pleasure to reconnect with friends and colleagues!
#ntm
5 months ago
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reposted by
Nicola Lorè
Elisabeth Bik - Perpetrator 5, a fraudulent microbiologist
6 months ago
What a great day to be at
@childrensphila.bsky.social
and
@pennmedicine.bsky.social
Published today:
www.nejm.org/doi/full/10....
add a skeleton here at some point
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reposted by
Nicola Lorè
Nature
6 months ago
A strain of bacterium that often causes infections in hospital can break down plastic
https://go.nature.com/3SvsiTC
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Microbe that infests hospitals can digest medical-grade plastic ― a first
Nature - The bacterium Pseudomonas aeruginosa produces an enzyme that breaks down biodegradable plastics.
https://go.nature.com/3RWi0vK
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reposted by
Nicola Lorè
Ivan Zanoni
6 months ago
#WeekendRead
#NoTimeToDie
! Matt, Better &co show @ Science Immunology that efferocytosis of apoptotic neutrophils (not epithelial cells) by alveolar macrophages reprograms their metabolism, boosting glutaminolysis & decreasing ROS, thus favoring repair but facilitating secondary bacterial infections
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Cell type–specific efferocytosis determines functional plasticity of alveolar macrophages
MPO activates an immunometabolic rheostat to restrict the functional plasticity of macrophages in favor of proresolving properties.
https://www.science.org/doi/10.1126/sciimmunol.adl3852
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Totally agree! “The term antibiotic—literally "opposing life", from the Greek roots ἀντι anti, "against" and βίος bios, "life"…..” I hope to work in this field in the future!
add a skeleton here at some point
6 months ago
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reposted by
Nicola Lorè
Journal of Experimental Medicine
7 months ago
Fahd Al Qureshah,
@casanovalab.bsky.social
, Qian Zhang et al. show that a common form of dominant human IFNAR1 deficiency impairs IFN-α and -ω but not IFN-β-dependent immunity.
rupress.org/jem/article/...
📘In Genes & Immunity collection:
rupress.org/jem/collecti...
#HKS2025
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New cell cell communication…….mitochondrial exchanges!
www.nature.com/articles/d41...
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Cells are swapping their mitochondria. What does this mean for our health?
Researchers are studying why the energy factories are moving between cells and whether the process can be harnessed to treat cancer and other diseases.
https://www.nature.com/articles/d41586-025-01064-5?utm_source=x&utm_medium=social&utm_campaign=nature&linkId=13878441
7 months ago
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Ready for the
#telethon
2025 scientific convention!
#Rimini
#italy
8 months ago
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reposted by
Nicola Lorè
Olivier Neyrolles
8 months ago
Excited to share our last study. Huge congrats to Sarah Monard, Arnaud Métais,
@gclugo.bsky.social
,
@chrisverollet.bsky.social
and all colleagues! We have found a mysterious cell type inside TB lung lesions that seems neuron-like but isn't quite a nerve cell. Let's dive in👇
shorturl.at/x4Sb5
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reposted by
Nicola Lorè
Achille Broggi🧪👨🏼🔬🔬
8 months ago
#interferon
history is immunology history! the original cytokine :)
add a skeleton here at some point
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reposted by
Nicola Lorè
1980/1985 News
8 months ago
[January 16th, 1980] Scientists at Biogen have successfully produced human interferon, a natural virus fighter, in a laboratory using gene-splicing techniques, potentially making it a more affordable treatment for various viral infections and cancers.
#history
#1980s
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reposted by
Nicola Lorè
Seth Thomas Scanlon
9 months ago
"If I had to name a person who has done more for the benefit of human health, with less recognition than anyone else, it would be Maurice Hilleman."—Richard Gallo
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The man who developed 40 vaccines
Microbiologist Maurice Hilleman, PhD’44, and his feathered friends.
https://mag.uchicago.edu/science-medicine/man-who-developed-40-vaccines
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Nicola Lorè
European Society of Mycobacteriology
9 months ago
Hello
@bsky.app
🦋! We’re the European Society of Mycobacteriology (ESM) on a mission to decode the mysteries of mycobacteria 🦠🔬. Stay tuned for exciting research, TB updates, and more. Let’s shape the future of global health together!
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edition.cnn.com/2025/01/29/s...
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Unprecedented asteroid samples contain organic compounds and minerals crucial to life, scientists say | CNN
Scientists have detected organic compounds and minerals necessary for life in the samples collected by the OSIRIS-REx mission from a near-Earth asteroid named Bennu.
https://edition.cnn.com/2025/01/29/science/asteroid-bennu-building-blocks-of-life/index.html
9 months ago
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Super cool work! Congrats to the authors. Spatial bacterial transcriptomics is coming up! “Highly multiplexed
#spatial
transcriptomics in
#bacteria
”
www.science.org/doi/10.1126/...
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Highly multiplexed spatial transcriptomics in bacteria
Single-cell decisions made in complex environments underlie many bacterial phenomena. Image-based transcriptomics approaches offer an avenue to study such behaviors, yet these approaches have been hin...
https://www.science.org/doi/10.1126/science.adr0932
10 months ago
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Nicola Lorè
ᐯIᑕTOᖇ ᑎIᘔET, ᗰᗪ
10 months ago
Great recent work from Sanika Vaidya and Knut Drescher Lab Mammalian innate immunity recognizes bacterial cell wall peptidoglycan (PG) via TLR2 Turns out multiple bacteria also sense PG from their lysed compatriots as a danger signal to trigger biofilm formation!
www.nature.com/articles/s41...
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reposted by
Nicola Lorè
Alessandro Sessa
10 months ago
I have position for research assistant in my Lab at Ospedale San Raffaele in Milan. Please spread the voice and drop me a message if interested
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reposted by
Nicola Lorè
Science Magazine
11 months ago
Climate change is driving global extinction risks, with 1.6% of species threatened at 1.3°C of warming and risks escalating to 29.7% at 5.4°C, according to a new meta-analysis in Science encompassing more than 30 years of research. Read more:
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Climate change extinctions
Climate change is expected to cause irreversible changes to biodiversity, but predicting those risks remains uncertain. I synthesized 485 studies and more than 5 million projections to produce a quantitative global assessment of climate change ...
https://scim.ag/3OZgGGX
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Repost in Bluesky. Our paper on
#Dual
spatial gene expression approach to dissect
#host-#bacteria
interaction in respiratory infections.
rdcu.be/dWuBQ
loading . . .
Dual spatial host-bacterial gene expression in Mycobacterium abscessus respiratory infections
Communications Biology - Dual spatial gene expression assay in tissues with chronic lung infection by Mycobacterium abscessus paves the way for the simultaneous detection of host and bacterial...
https://rdcu.be/dWuBQ
11 months ago
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5
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reposted by
Nicola Lorè
Nature Portfolio
11 months ago
An essay in Nature discusses how it’s an astonishing achievement that all of statistics and much of science depends on probability considering no one’s sure what it is. 🧪
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Why probability probably doesn’t exist (but it is useful to act like it does)
All of statistics and much of science depends on probability — an astonishing achievement, considering no one’s really sure what it is.
https://go.nature.com/3P2umAV
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Nicola Lorè
Ivan Zanoni
11 months ago
#LocationLocationLocation
! Burrows, Mortha &co show
@cellcellpress.bsky.social
that a gut commensal protozoan induces ILC2 migration from the gut to the lung & interaction with T & B cells, recruiting lung eosinophils that shield the vasculature aggravating
#asthma
but protecting from
#Mycobacterium
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Redirecting
https://doi.org/10.1016/j.cell.2024.11.020
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reposted by
Nicola Lorè
Kat Mayer-Barber,PhD
11 months ago
State of the art
#review
on lung pathology of
#tuberculosis
www.science.org/doi/10.1126/...
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Immunopathology in human tuberculosis
The balance between protective and pathological immune responses shapes progression of Mycobacterium tuberculosis infection.
https://www.science.org/doi/10.1126/sciimmunol.ado5951
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Nicola Lorè
Kat Mayer-Barber,PhD
11 months ago
Best
#Nikolaus
🎅! Our paper on how the 🫁 microenvironment can shape
#innate
immunity against
#viruses
is out
@sciimmunology.bsky.social
This was a herculean effort brilliantly led by
@pauljbaker.bsky.social
who singlehandedly established the model in the lab during the pandemic. 🧪
#Immunosky
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Nicola Lorè
Paul Bollyky
11 months ago
Excited to share our work on broadly effective phage-antibiotic cocktails. We report 4 cocktails that each work against 96% of 153 antibiotic resistant Pseudomonas isolates. Check it out here:
www.nature.com/articles/s41...
Congrats to Kevin Kim @KevinMinyo6651
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A blueprint for broadly effective bacteriophage-antibiotic cocktails against bacterial infections - Nature Communications
The application of phage therapy for multidrug-resistant infections is mainly limited to personalized therapy due to the narrow host range of individual phages. Here, Kim et al. identify groups of pha...
https://www.nature.com/articles/s41467-024-53994-9
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reposted by
Nicola Lorè
Pierre Santucci
11 months ago
🚀💥🔥Happy to Share that Our Latest Story is Now Published in FEBS Letters! 💙💎💡 Have a look & find out about the new subset of Mycobacterial CRISPRi vectors we optimised for our community! 🦠🔦🔬💊
@cnrs.bsky.social
@addgene.bsky.social
👇👇👇
febs.onlinelibrary.wiley.com/doi/full/10....
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FEBS Press
Genetic engineering and quantitative fluorescence imaging are key approaches in modern biology research. In this research letter, we report the development and the validation of a new subset of Esche...
https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1873-3468.15071
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