Henning Fenselau
@henningfenselau.bsky.social
📤 414
📥 356
📝 15
Neurobiologist at the Max Planck Institute for Metabolism Research www.sf.mpg.de/research/fenselau
reposted by
Henning Fenselau
Lin Tian, PhD
about 1 month ago
Thanks to
@nature.com
for featuring our work in this piece on genetically-encoded sensors. The article does a great job highlighting their importance for both basic research and translational impact, such as in our lab's research on serotonin.
www.nature.com/articles/d41...
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How genetically encoded sensors have lit up neuroscience
Tools that track specific molecules in neurons have enabled researchers to probe previously unexplored aspects of neurobiology — although important caveats remain.
https://www.nature.com/articles/d41586-025-03639-8
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reposted by
Henning Fenselau
Yoav Livneh
13 days ago
lab preprint! Interopceptive predictions are central to many brain-body interactions theories, but it's unclear if/how they affect bodily physiology. We (fearless Einav Litvak et al) show that insular cortex predictions are essential for glucose homeostasis-THREAD..
www.biorxiv.org/content/10.6...
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Insular cortex predictions regulate glucose homeostasis
Brain-body interactions are essential for physical and emotional homeostasis. The brain uses information from the external world to predict upcoming bodily changes. This process involves interoceptive...
https://www.biorxiv.org/content/10.64898/2025.12.09.693191v1
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reposted by
Henning Fenselau
thewilliamslab
13 days ago
Wonderful to have
@henningfenselau.bsky.social
visit us at
#UTSouthwestern
. Fantastic talk on targeting neural plasticity in obesity.
@maxplanck.de
|
@unicologne.bsky.social
|
@zigmanlab.bsky.social
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reposted by
Henning Fenselau
Sophie Steculorum
24 days ago
🤩 I’m beyond excited to finally share our paper! 🎉 It’s been a long journey and a true team effort. Congratulations to our outstanding first authors,
@lcreimon.bsky.social
and Ayden Gouveia, and to all of the co-authors who made this possible 🙌!
www.nature.com/articles/s42...
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Fat sensory cues in early life program central response to food and obesity - Nature Metabolism
Non-nutritive sensory components of high-fat diet, such as bacon flavour, are sufficient to impair metabolic health in offspring in mice.
https://www.nature.com/articles/s42255-025-01405-8
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reposted by
Henning Fenselau
Carlos Ribeiro
about 1 month ago
My passion is to bring together people from different worlds. Science Kitchen started with
@pamado.bsky.social
and Joana Lamego. We made it real: chefs+scientists side by side
@champalimaudf.bsky.social
- curiosity meets flavor. Discovery became a shared experience. Just the beginning.
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reposted by
Henning Fenselau
Lori Zeltser, PhD
about 1 month ago
Exciting that our first post gets to share that our paper in Nature Communications is now available! This work uncovers the circuits that mediate sex differences in responsiveness to social stress, but don't take our word for it, check it out! Congrats, Marie Francois and team 🎉
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Amygdala AVPR1A mediates susceptibility to chronic social isolation in female mice - Nature Communications
Females are more sensitive to social exclusion and loneliness, risk factors for anxiety and stressrelated disorders. Here, the authors identified molecular signals in the amygdala that make females mo...
https://www.nature.com/articles/s41467-025-64742-y?utm_source=rct_congratemailt&utm_medium=email&utm_campaign=oa_20251104&utm_content=10.1038/s41467-025-64742-y
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reposted by
Henning Fenselau
Carlos Ribeiro
2 months ago
New essay in
@currentbiology.bsky.social
special brain-body issue! Fly lab meets psychiatrist: how bodily signals shape cognition and mental health. Great collaboration with Albino Oliveira-Maia showing
@champalimaudf.bsky.social
discovery ↔️ clinic at its best.
www.cell.com/current-biol...
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From cognition in the body to the body in cognition
Carlos Ribeiro and Albino Oliveira-Maia propose how brain–body interactions may inform the study of ‘higher’ cognitive functions such as learning and memory across model systems.
https://www.cell.com/current-biology/fulltext/S0960-9822(25)01128-5
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reposted by
Henning Fenselau
The Rockefeller University
2 months ago
Rockefeller's Jeff Friedman has won the 2025 Albany Medical Center Prize, one of the nation’s most prestigious prizes in biomedicine. Friedman is recognized for his discovery of leptin, which established a biological basis for obesity. Congrats, Jeff!
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Jeffrey M. Friedman is awarded the 2025 Albany Medical Center Prize - News
Jeffrey M. Friedman has been awarded the 2025 Albany Medical Center Prize in Medicine and Biomedical Research, one of the nation's most prestigious prizes in biomedicine. Friedman, who is Rockefeller's Marilyn M. Simpson Professor, a Howard Hughes Medic...
https://www.rockefeller.edu/news/38474-jeffrey-m-friedman-is-awarded-the-2025-albany-medical-center-prize/
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reposted by
Henning Fenselau
Jan Siemens
2 months ago
What a great Titisee Conference! “Warm, cold, and life” brought together brilliant minds exploring how temperature shapes the brain, physiology, and behaviour — from mice, wild animals to humans. Thanks to Boehringer Ingelheim Fonds for the support!
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reposted by
Henning Fenselau
Aaron Mercer
3 months ago
That title is a mouthful 😆 Congrats to Darleen,
@seeleyrj.bsky.social
,
@henningfenselau.bsky.social
and team.
www.sciencedirect.com/science/arti...
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Weight Loss Reverses Obesity-Associated Impairments in Acute Gastrointestinal Stretch-Induced Suppression of Food Intake and Glucose Homeostasis
https://www.sciencedirect.com/science/article/pii/S221287782500167X?dgcid=raven_sd_aip_email
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reposted by
Henning Fenselau
Ali D. Güler
4 months ago
🚨 We’re hiring! 🧪
@uvabio.bsky.social
UVA Biology is recruiting multiple tenure-track Assistant Professors in neuroscience as part of a $75M Brain & Neuroscience Initiative. 🧠 Apply by Oct 15, 2025. Start Aug 2026. 👉
apply.interfolio.com/172892
#Neuroscience
#FacultyJobs
#NeuroJobs
#Biology
#UVA
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Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
https://apply.interfolio.com/172892
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reposted by
Henning Fenselau
The Real Zigman Lab
4 months ago
We are proud of Omprakash Singh's new study just out in Cell Reports. Supported by Sepideh Sheybani-Deloui et al, Om's work identifies GHSR expressing SCN neurons as regulating food intake + feed efficiency at a single time of day, accounting for at least 7% of a mouse's BW
doi.org/10.1016/j.ce...
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reposted by
Henning Fenselau
Carlos Ribeiro
4 months ago
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reposted by
Henning Fenselau
The Betley Lab at UPenn
4 months ago
What's next for the
#BetleyLab
? We're diving deep into
#EXERCISE
! 🏃♀️💪 Our emerging studies show exercise doesn't just change your body – it literally rewires brain circuits and impacts
#dopamine
response. It’s a whole new world of
#body-brain
interaction. Stay tuned !
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reposted by
Henning Fenselau
FEBS Letters
5 months ago
🚀 What’s it like to launch a new lab? Hans-Georg Sprenger shares challenges, early wins & the joy of mentoring in molecular metabolism research.
@mpiage.bsky.social
Read the interview:
febs.onlinelibrary.wiley.com/doi/10.1002/...
#ScienceCareers
#Mentoring
#ResearchLife
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reposted by
Henning Fenselau
Eric Topol
5 months ago
The brain is the master regulator of food intake and energy balance. A brilliant new
@cellpress.bsky.social
review, including the mechanism of GLP-1 drugs, by
@clemmensenc.bsky.social
and colleagues, open-access
www.cell.com/cell/fulltex...
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reposted by
Henning Fenselau
Melanie Mittenbühler
5 months ago
‼️ We're looking for a postdoc to join our team starting January 1st, 2026! ‼️ Are you curious about how exercise promotes positive changes at the molecular level in obesity and diabetes? If so, consider applying or reach out with any questions.
ddz.de/job/postdoct...
ddz.de/en/research/...
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Postdoctoral Researcher (Ph.D./Dr. rer. nat., m/f/div., E13 TV-L, 100%) - Deutsches Diabetes-Zentrum (DDZ)
Institut für Klinische Biochemie und Pathobiochemie (Direktor: Univ.-Prof. Dr. rer. nat. Hadi Al-Hasani), Nachwuchsforschungsgruppe Crosstalk (Leiterin: Melanie Mittenbühler, Dr.) (25019)
https://ddz.de/job/postdoctoral-researcher-ph-d-dr-rer-nat-m-f-div-e13-tv-l-100/
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reposted by
Henning Fenselau
Daniel Drucker
5 months ago
And you thought
#metformin
lowered glucose via the liver? Here loss-of-function and gain-of-function studies suggest that VMH Rap1 is indispensable for the antidiabetic effects of metformin in mice
#diabetes
www.science.org/doi/10.1126/...
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Low-dose metformin requires brain Rap1 for its antidiabetic action
Metformin lowers blood glucose by inhibiting Rap1 in ventromedial hypothalamic neurons that regulate glucose balance.
https://www.science.org/doi/10.1126/sciadv.adu3700
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reposted by
Henning Fenselau
Ivan Alcantara
5 months ago
How do animals decide if they should forage for food or stay home to take care of newborn offspring? Whose needs come first? For my PhD work now out in Nature, we examined how hunger and parenting neurons interact and are reshaped postpartum in mice 🧵⬇️
www.nature.com/articles/s41...
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A hypothalamic circuit that modulates feeding and parenting behaviours - Nature
Single-cell transcriptomic analysis of mouse hypothalamus and behavioural experiments show that specific hypothalamic networks regulate conflicting feeding versus parenting behaviours of female mice.
https://www.nature.com/articles/s41586-025-09268-5
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reposted by
Henning Fenselau
thewilliamslab
5 months ago
Our very own
@runningdar.bsky.social
in the
#DiabetesSpotlight
#DiabetesBio
add a skeleton here at some point
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Finally… BBQ, and excellent and very creative journal club on our rooftop! Enjoying Cologne summer with the amazing team!
5 months ago
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reposted by
Henning Fenselau
MPI-Metabolism
5 months ago
Not feeling hungry after cooking? Janice Bulk chatted about the latest study by the Steculorum Lab in an interview with German radio. 👃 🍲 📻 Great job, Janice!
www.swr.de/leben/gesund...
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Geruch von Essen kann Sättigung auslösen – neue Erkenntnisse
Essverhalten: Schon der Geruch von Essen kann das Sättigungsgefühl auslösen – zeigen Forschende am Max-Planck-Institut. Bei Übergewicht scheint dieser Mechanismus gestört zu sein.
https://www.swr.de/leben/gesundheit/essverhalten-geruch-riechen-aktiviert-saettigung-100.html
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reposted by
Henning Fenselau
MPI for Biology of Ageing
5 months ago
Stephanie A. Fernandes selected for Minerva Fast Track Programme! 🎉 Congrats on this amazing achievement!
@stephalcantara.bsky.social
@cga-age.bsky.social
www.age.mpg.de/428071/25071...
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Stephanie A. Fernandes selected for the Minerva Fast Track Programme
https://www.age.mpg.de/428071/250718_Steph_Minerva_Fast_Track
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reposted by
Henning Fenselau
Kevin Hall
5 months ago
Excited to announce my new book FOOD INTELLIGENCE coauthored with brilliant journalist
@juliabelluz.bsky.social
! Cutting through the confusion about diet & health,
#FoodIntelligence
describes the fascinating science of how food both nourishes & harms us.
www.penguinrandomhouse.com/books/671334...
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Food Intelligence by Julia Belluz, Kevin Hall, PhD: 9780593332306 | PenguinRandomHouse.com: Books
The essential guide for understanding what you’re eating, and the forces that are driving you to eat it. Nutrition isn’t rocket science; it’s harder. There are new diet fads, bold...
https://www.penguinrandomhouse.com/books/671334/food-intelligence-by-julia-belluz-and-kevin-hall-phd/
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reposted by
Henning Fenselau
Daniel Drucker
6 months ago
Molecular mechanisms and brain regions that promote hyperphagia in the clinical expression of fructose-mediated
#obesity
www.sciencedirect.com/science/arti...
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Fructose-induced synaptic and neuronal adaptations at Neuropeptide Y/agouti-related peptide neurons
Fructose is a naturally-occurring sugar, consumed in excess as sweeteners, and is linked to the development of obesity. Fructose is consumed with gluc…
https://www.sciencedirect.com/science/article/pii/S2212877825001164
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reposted by
Henning Fenselau
Eric Topol
6 months ago
The gut hormone mimetic era in medicine is just getting started
www.nature.com/articles/s42...
erictopol.substack.com/p/the-gut-br...
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Shaping the future of cardiometabolic innovation: advances and opportunities - Nature Metabolism
Obesity is a global public health concern closely linked to cardiometabolic complications. This Comment provides our views on recent breakthroughs, emerging innovations and future needs of therapeutic...
https://www.nature.com/articles/s42255-025-01343-5
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reposted by
Henning Fenselau
Juleen R. Zierath
6 months ago
Obesity is a global public health concern closely linked to cardiometabolic complications. This Comment provides views on recent breakthroughs, emerging innovations and future needs of therapeutic interventions to counteract obesity and its associated health risks.
www.nature.com/articles/s42...
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Shaping the future of cardiometabolic innovation: advances and opportunities - Nature Metabolism
Obesity is a global public health concern closely linked to cardiometabolic complications. This Comment provides our views on recent breakthroughs, emerging innovations and future needs of therapeutic...
https://www.nature.com/articles/s42255-025-01343-5
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reposted by
Henning Fenselau
MPI-Metabolism
6 months ago
We have a new research group at MPI for Metabolism Research!👩🔬 A warm welcome to
@svaltcheva.bsky.social
!👋 For a first impression find her introduction below⬇️ and further informations under
sf.mpg.de/2112068/Silvan
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reposted by
Henning Fenselau
Max Planck Institute of Psychiatry
6 months ago
📅 Next week, we are excited to welcome Dr.
@yoavlivneh.bsky.social
from Weizmann Institute of Science. He will share his research on the
#insular
#cortex
. 🥳 As always, everyone is welcome to join us at our Institute, and registration is not necessary! All info here:
www.psych.mpg.de/events/40140...
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reposted by
Henning Fenselau
Claire Foldi
6 months ago
Writing this was like any other act of love - awkward at the start, frustrating at times, but something to be proud of. Very grateful to Dr Kristi Griffiths for agreeing to take on this challenge with me for
@natrevneuro.nature.com
www.nature.com/articles/s41...
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Examining the biological causes of eating disorders to inform treatment strategies
Nature Reviews Neuroscience - Recent years have seen a growth in our understanding of the biological drivers of eating disorders and their interactions with environmental and psychosocial factors....
https://www.nature.com/articles/s41583-025-00940-3.epdf?sharing_token=fOFPQmTbgWhR6ATrKwpyOtRgN0jAjWel9jnR3ZoTv0MI8cN6y2miXnqbI0GFNO5b8jqevxxDSB2zND-EFqyd1IqDm_LyzOgnSIbreGh178E79oCtxx6fovf1T-Bkb48Q6b6anpQgIJAAX0hzo3ONeVWmSM8BKS4Yv6jW9Vn3Tbs%3D
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Henning Fenselau
Carlos Ribeiro
6 months ago
Heading to one of my favorite meetings where the
#Drosophila
neuronal circuits world will come together to discuss science in Crete. We will celebrate the golden age of our field and there is so much more to come. Sad that the stete of the world is stopping some of us joining. Science will prevail.
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reposted by
Henning Fenselau
Sophie Steculorum
7 months ago
📢 🤩Excited to share our latest paper👃🧠! Huge thanks to the amazing first author
@janice-bulk.bsky.social
and all co-authors, especially
@andreas-t-schaefer.bsky.social
and @tobiasackels.bsky.social 🙌!
www.nature.com/articles/s42...
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A food-sensitive olfactory circuit drives anticipatory satiety - Nature Metabolism
The authors describe a sensory circuit involving the medial septum (MS), where MS glutamatergic neurons integrate food odours to prime satiety and regulate nutrient intake.
https://www.nature.com/articles/s42255-025-01301-1
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reposted by
Henning Fenselau
MPI-Metabolism
7 months ago
Exciting news from
@sophiesteculorum.bsky.social
Lab!🤓 👃🧠 Smelling food primes your brain for satiety. Find out more in 🧵 or under 🔗
www.nature.com/articles/s42...
Congrats to
@sophiesteculorum.bsky.social
, first author
@janice-bulk.bsky.social
and all contributing authors!
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A food-sensitive olfactory circuit drives anticipatory satiety - Nature Metabolism
The authors describe a sensory circuit involving the medial septum (MS), where MS glutamatergic neurons integrate food odours to prime satiety and regulate nutrient intake.
https://www.nature.com/articles/s42255-025-01301-1
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reposted by
Henning Fenselau
7 months ago
So much fun at our Open Day, exploring how the brain powers our energy! 🧠⚡ Thanks to the organizers
@mpi-metabolism.bsky.social
@mpiage.bsky.social
@cecad.bsky.social
for the chance to share science with everyone curious about metabolism research 🔬
@hannahwilhelms.bsky.social
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Henning Fenselau
CECAD Cologne
8 months ago
👏Congratulations to Professor Jens Brüning on receiving the
#University
#Award
for Research 2024 in recognition of his exceptional scientific achievements and his contribution to
#Cologne’s
reputation as a leading research hub! ➡️
uni.koeln/QG3SW
@unicologne.bsky.social
@mpi-metabolism.bsky.social
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University of Cologne honors Jens Brüning with Research Award
CECAD congratulates Professor Jens Brüning on receiving the University Award for Research 2024 in recognition of his exceptional scientific achievements and his contribution to Cologne’s reputation as...
https://uni.koeln/QG3SW
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reposted by
Henning Fenselau
Zachary Knight
8 months ago
Nice article in NY Times today about AgRP neurons, GLP1s, and hunger. By Gina Kolata.
www.nytimes.com/2025/04/26/h...
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What Nearly Brainless Rodents Know About Weight Loss and Hunger
https://www.nytimes.com/2025/04/26/health/hunger-brain-ozempic.html
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reposted by
Henning Fenselau
Chen Ran
8 months ago
Lots of recent papers discuss the nucleus of the solitary tract in interoception. In this review, we take a sensory processing perspective on how interoceptive signals are encoded in the NTS:
www.sciencedirect.com/science/arti...
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Interoceptive processing in the nucleus of the solitary tract
The interoceptive nervous system continuously monitors the status of visceral organs to synthesize internal perceptions and regulate behavioral and ph…
https://www.sciencedirect.com/science/article/pii/S0959438825000522
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Henning Fenselau
CECAD Cologne
9 months ago
Congratulations to
#CECAD
Prof. David Vilchez
@thevilchezlab.bsky.social
on securing
#DFG
funding for a new research group on organismal proteostasis! This project, involving also Prof. Hoppe, will explore how proteostasis regulates
#aging
and
#disease
.
@dfg.de
#Proteostasis
uni.koeln/ZCFFX
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CECAD Scientists Receive DFG Funding for Proteostasis Research
A new DFG-funded research group investigates how proteostasis is regulated at the organismal level and its impact on aging and disease.
https://uni.koeln/ZCFFX
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reposted by
Henning Fenselau
Christoffer Clemmensen
10 months ago
On
#WorldObesityDay
, we have contributed a SnapShot to a special Issue on Obesity in
@cp-cellmetabolism.bsky.social
covering brain actions of the current and emerging weight loss drugs.
@jonaspetersen.bsky.social
@johansenvbi.bsky.social
Free access link:
authors.elsevier.com/a/1kiaA5WXUlaX…
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reposted by
Henning Fenselau
Giles Yeo
10 months ago
Today March 4, is world obesity day. People with obesity are not bad, they’re not morally bereft, they are fighting biology
#obesityisnotachoice
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Henning Fenselau
Tune H Pers
10 months ago
Passionate about genetics, metabolism, and neuroscience? Join us for a Postdoc to explore how obesity-associated genetic variants impact hypothalamic circuits using CRISPR-based Perturb-seq & in vivo metabolic phenotyping
candidate.hr-manager.net/ApplicationI...
@metabolcenter.bsky.social
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Postdoc in Genetic and Molecular Mechanisms of Metabolic Regulation
https://candidate.hr-manager.net/ApplicationInit.aspx?cid=1307&ProjectId=163445&DepartmentId=19212&MediaId=5&IsAdPreviewRequest=true&AdvertisementId=117610
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www.science.org/doi/10.1126/...
very excited to share our latest work, out now in Science. Congratulations to Marielle who led our studies! And, all other authors - this was a wonderful collaborative effort
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Thalamic opioids from POMC satiety neurons switch on sugar appetite
High sugar–containing foods are readily consumed, even after meals and beyond fullness sensation (e.g., as desserts). Although reward-driven processing of palatable foods can promote overeating, the n...
https://www.science.org/doi/10.1126/science.adp1510
10 months ago
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Henning Fenselau
MPI for Biology of Ageing
11 months ago
⏰The countdown is on! In just a few days, we will welcome 25 candidates from around the world to our CGA Recruitment Week! To get them - and you - excited, we're giving you an exclusive sneak peek at our programme. 🎥 Stay tuned for our full video and more insights coming soon.👀
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Henning Fenselau
Giles Yeo
11 months ago
I am excited to share our latest paper @Nature where we construct a hi-res spatial map of the human hypothalamus, the brain region central in appetite control. It is a collaboration between @IMS_MRL @Cambridge_Uni & @MPI_Metabolism
www.nature.com/articles/s41...
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A comprehensive spatio-cellular map of the human hypothalamus - Nature
HYPOMAP integrates single-nucleus RNA sequencing and spatial transcriptomic data to create a comprehensive spatio-cellular map of the human hypothalamus.
https://www.nature.com/articles/s41586-024-08504-8
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Henning Fenselau
eLife
11 months ago
Fruit flies have a different type of blood to us, and their insulin comes from neurons instead of pancreatic cells. But important similarities mean scientists could use them to better understand human health.
https://elifesciences.org/digests/98514/a-closer-look-at-insulin-producing-cells?utm_sour…
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A closer look at insulin-producing cells
New research sheds light onto the mechanisms controlling insulin release in live fruit flies, highlighting important similarities with humans.
https://buff.ly/4jxBxzb
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Henning Fenselau
MPI for Biology of Ageing
11 months ago
The Science Day with the MPI for Metabolism Research last Thursday was an amazing success. Great networking opportunity and showcase for our extensive collaborations. That's the spirit for this year! 🔬🧬🤩
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Henning Fenselau
Graziana Gatto
11 months ago
New paper from the @KononenkoLab! Happy to be part of this great work showing that less sugar is better your motor control, and autophagy makes sure you keep rocking on low sugar 😉 from molecules to behavior: tour de force!!!!
www.nature.com/articles/s42...
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Autophagy regulator ATG5 preserves cerebellar function by safeguarding its glycolytic activity - Nature Metabolism
Tutas et al. show an unconventional role for autophagy in the regulation of glycolytic flux in cerebellar Purkinje cells by maintaining the levels of the glucose transporter GLUT2.
https://www.nature.com/articles/s42255-024-01196-4
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reposted by
Henning Fenselau
Lin Tian, PhD
11 months ago
Registration for the 2025
@mpfneuro.bsky.social
Neurotechniques Course closes this Wednesday! Co-directed by Ryohei Yasuda &
@denisejcai.bsky.social
and led by an amazing team of experts, this hands-on course is a great opportunity to learn cutting-edge methods in neuroscience 🔬🧠
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Henning Fenselau
Graziana Gatto
11 months ago
Last week to apply for a PhD position in my lab to dissect the cortico-spinal circuits for hindlimb control in healthy and Huntington mice. Email me CV, cover letter at the latest by Jan 22.
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Henning Fenselau
Amelia Douglass
11 months ago
My systems neuroscience lab at ISTAustria is hiring a tech. Please check out and share!
ista.ac.at/en/job/?titl...
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Job details
Job details
https://ista.ac.at/en/job/?title=Systems+Neuroscience+Research+Technician+%26+Laboratory+Manager+%E2%80%93+Douglass+group
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