Human pancreatic organoids derived from pluripotent stem cells recapitulate pancreatic organogenesis https://www.biorxiv.org/content/10.1101/2025.10.31.685661v1

Morphogen gradients applied basally to human embryonic stem cells to control and dissect tissue patterning https://www.biorxiv.org/content/10.1101/2025.10.30.682158v1

I am very excited to announce the opening of the submission site for the upcoming Conférences Jacques Monod on Developmental Biology, May 18-22, 2026 cjm.sb-roscoff.fr/en/conferenc... @lionlchristiaen.bsky.social and I have an exciting program of speakers and slots for selected short talks, etc.

We use CODA to map human endometrial tissue at single-cell resolution, a map that then serves as a blueprint to design a multi-compartment multicellular assembloid of the endometrium. Read about our approach to organoids/assembloids here: www.biorxiv.org/content/10.1...

Katia took the initiative to start a Xenopus project in the lab a few years ago —and now her work is highlighted by Development! Huge congrats, Katia!

The human proteome and organ age clocks across the lifespan, a tour de force report @cellpress.bsky.social www.cell.com/cell/abstrac...

🚨 After 7 years in the making, my PhD thesis work is finally published in @science.org 🧬✨ What does our gut say about how we became human? During my hitchhiking journey spanning 3 countries and multiple lab moves

Altogether, we identify the developing human intestinal epithelium as a rapidly evolving system, and show that great ape #organoids provide insight into human biology. 🙏Thanks 🙏 to all authors! Especially co-first authors: @CY_Qianhui_YU @KlkUmut @stefanosecchia 11/11

The gut's 'sixth sense' microbiome regulating eating behavior in real time, another new path for the gut-brain axis, "neurobiotic," in the mouse model www.nature.com/articles/s41...

🔊 Paper alert 1/ Tuft cells are perhaps the coolest cells in our gut orchestrating host defense, but how do they manage? @julian-buissant.bsky.social provides new insights into tuft cell differentiation, and the development of accurate in vitro models for experimental cell biology 🧫🔬🧬 rdcu.be/exou9

Elegant and insightful study on gut evolution and development - congratulations 🎊@graycamplab.bsky.social @umut-kilik.bsky.social www.science.org/doi/10.1126/...

Recent evolution of the developing human intestine affects metabolic and barrier functions @science.org @graycamplab.bsky.social www.science.org/doi/10.1126/...

My postdoc work at Treutlein lab and @graycamplab.bsky.social with @jasperjanssens.bsky.social is out in @science.org ! We screen for neuron subtypes using pro-neural TFs + morphogen combinations + scRNA-seq and profiled over 700,000 cells in 480 conditions. www.science.org/doi/10.1126/...

Pathology-oriented multiplexing enables integrative disease mapping @nature.com www.nature.com/articles/s41...

Pooled #CRISPR screens are a staple of functional genomics in mammalian cells. Yet somehow in the best genetic model™ no equivalent system was available. Until now! The @perrimonlab.bsky.social lab now presents efficient pooled CRISPR screening in #Drosophila cells. www.nature.com/articles/s41...

New OpenProblems paper out! 📝 Led by Malte Lücken with Smita Krishnaswamy, we present openproblems.bio – a community-driven platform benchmarking single-cell analysis methods. Excited about transparent, evolving best practices for the field! 🔗 www.nature.com/articles/s41...

We are very excited to close this years meeting with a keynote talk by Prof Jason Spence from @umich.edu. Understanding human lung development with bud tip, airway and Alveolar type2 (AT2)organoids. Unexpected transcriptional heterogeneity found in early postnatal AT2 cells occupying distinct niches

Episode 2️⃣ Comment la souris est devenue le modèle par excellence ? Les souris représentent près de 70 % des animaux utilisés en laboratoire. Comment expliquer ce choix ? S'est-il imposé dès le début de l'expérimentation animale ? Quelles sont les limites d’un tel modèle ? Avec Jean-Gaël Barbara 🐁

Collaborative science is just so much fun! From our brilliant collaboration with Liz Robertson from @dunnschool.bsky.social; embryology, single cell omics and computational biology deliver new insights into the intricacies of blood and endothelial development. www.sciencedirect.com/science/arti...

@bacell3d.bsky.social 2025 has begun with a bang! Time for a start selfie!

We’re all set! With 400 participants, 200 posters, and a stellar scientific program featuring both renowned experts and emerging researchers, BaCell3D 2025 is shaping up to be another unforgettable event—happening June 23–25 at the ZLF Hall, University of Basel.

How innate immunity starts? Early embryos eliminate bacterial infections by epithelial phagocytosis, a conserved process from zebrafish to human embryos. Check our story: www.cell.com/cell-host-mi...

The long-term goal is to grow human organs that can be harvested for transplantation https://go.nature.com/3ST2BN7

New work on dynamics of morphogen signaling: Cells decode BMP gradient via temporal integration of signaling level, not instantaneous thresholds. While GRN gates response to provide additional spatial input Morphogen signalling dynamics + GRN for tissue patterning www.biorxiv.org/content/10.1...

3D reconstruction of a human Carnegie stage 9 embryo provides a snapshot of early body plan formation

This week's genome editing triumph is a big deal. Here's why erictopol.substack.com/p/the-first-...

🚀 Ouverture des pré-inscriptions ! 🚀 Rejoignez-nous à Nantes pour l’École Thématique Organoïdes 2025 🧬 Découvrez notre pré-programme complet ! ⚠️ Places limitées – La pré-inscription est indispensable pour participer. 📋 Plus d’infos et pré-inscription ici : organoides.sciencesconf.org

#Organoïdes2025 - École Thématique 2025 du #GDR_Organoïdes à #Nantes, 📅 7-11 Juillet 2025 Inscriptions ouvertes : c'est l'occasion de se former, réseauter & explorer les défis de demain 🧫🔬❤️ 🔗 organoides.sciencesconf.org @ferrandlab.bsky.social @cnrs.fr @inserm.fr @insermgrandouest.bsky.social

Integrated Organoid Atlas benchmarks new protocols, even more impressive as a Highly Variable Cohort for comparison against perturbation and disease models: nature.com/articles/s41... Lead by @quanxu.bsky.social, in collaboration with Lennard Halle and @fabiantheis.bsky.social

Choose Science. Choose Europe. A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open. With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond. Apply by 10 September → europa.eu/!fBTMgF

Learn how we are battling #Cancer at Cincinnati Children’s with innovations to accelerate treatments for #Leukemia, develop #CancerImmuneTherapies, and more. #RAR24 #MedSky #PedsSky #SciSky Check out our latest Research Annual Report: scienceblog.cincinnatichildrens.org/research-exc...

Beautiful LGR5 reporter line from Joep Beumer, Ninouk Akkerman, Yannik Bollen 🤩

Neonatal microbiota colonization primes maturation of goblet cell–mediated protection in the pre-weaning colon @jem.org @gobletcellguy.bsky.social rupress.org/jem/article/...

The colonic mucus barrier & sentinel goblet cells protect the distal gut from microbial challenges. Johansson, @gobletcellguy.bsky.social et al show that microbial colonization drives sequential development of both of these barrier mechanisms in the pre-weaning intestine. rupress.org/jem/article/...

Learned a lot working with Jonas Fleck, Daniil Bobrovskiy, Dominik Klein, Barbara Treutlein and @fabiantheis.bsky.social on CellFlow: generative single-cell phenotype modeling with flow matching. Virtual protocol screening is particularly innovative!

Reminder: deadline to apply for the Stem Cell Summer School is 30th May. And it's May already! So you have to apply this month! A limited number of bursaries are available. p.s. this year, the summer school coincides with the Spetses Armata Festival, so there will be a big party on the island 🙂

Bioprinted platform for parallelized screening of engineered microtissues in vivo

Registration for Single-cell genomics 2025 is now open! This year we’re back in beautiful Stockholm archipelago. We have a special session on clinical applications, but we also invite abstracts from both PIs and trainees, with plenty of slots for selected talks. conferences.weizmann.ac.il/SCG2025/

It was fun to learn about blood vessel organoids together with @marinanikolova.bsky.social and Barbara Treutlein! Thanks to Reiner Wimmer and @penningerlab.bsky.social for introducing us to this system! www.cell.com/cell/fulltex... Great support from editors and reviewers @cellpress.bsky.social!

What does “appropriate scientific justification” really mean in #stemcell and #embryoresearch? New article from @isscr.org Ethics Committee offers practical advice for review and oversight bodies, regulators, and researchers. bit.ly/3Yf6KhD

🚀 Ouverture des pré-inscriptions ! 🚀 Rejoignez-nous à Nantes pour l’École Thématique Organoïdes 2025 🧬 Découvrez notre pré-programme complet ! ⚠️ Places limitées – La pré-inscription est indispensable pour participer. 📋 Plus d’infos et pré-inscription ici : organoides.sciencesconf.org

Great collaboration on blood vessel organoids to model human vascular development and disease 🧫🔬

'Spheroids and organoids are the most common form of 3D culture. Spheroids are typically defined as 3D cell aggregates derived from immortalized cell lines, while organoids are 3D cell cultures originating from stem cells or primary tumor cells.' www.nature.com/articles/s41...

Yay, we built a thing! With @dominik1klein.bsky.social Daniil, Aviv Regev, Barbara Treutlein @graycamplab.bsky.social @fabiantheis.bsky.social we use flow matching to enable generalised sc phenotype modeling. From cytokine screens to fate programming and organoid engineering tinyurl.com/3xhju7db

Do you like Dev Bio ? Yes ! Do you like French Dev Bio ? Yes !! The SFBD (French Society for Dev Bio) is here to promote research in embryology and post-embryonic development, growth, differentiation, regeneration, teratology and genetics on all multicellular organisms using any kind of methology

Multi-zonal liver organoids from human pluripotent stem cells @nature.com @cincyresearch.bsky.social www.nature.com/articles/s41... www.nature.com/articles/s41...

Congratulations, Kristina and Vikas! Your passion, steady focus, and refusal to let glycolysis get boring made this metabolism project a reality! We uncovered a non-energetic role of glycolysis in regulating germ layer proportions.

In @nature.com today we report sensory #assembloids comprising four parts to recapitulate aspects of the pathway that processes pain stimuli and we use it to study genetic syndromes. Work pioneered by the brilliant Ji-il Kim & Kent Imaizumi in close collab with @gregscherrer.bsky.social ! Link 👇

The 2025 European Summer School in Stem Cell Biology and Regenerative Medicine will take place 12-19 Sept 2025, on the beautiful Greek island of Spetses. Keep an eye on our website www.stemcellsummerschool.org for updates, or give us a follow 😀 Deadline for applications: 30th May 2025

A short Perspective on xenotransplantation to study human neuron development, evolution and disease @thetransmitter.bsky.social More related articles on human neurobiology coming out soon - thanks a lot to Josh Sanes for the initiative and opportunity! www.thetransmitter.org/human-neurot...