Characteristic facial features in mice simultaneously encode not only currently used decision variables but also independent and unexpressed ones, and these features partially originate from neural activity in the secondary motor cortex @fannycazettes.bsky.social www.nature.com/articles/s41...

In this episode of “Brain Inspired,” @braininspired.bsky.social talks to @antihebbiann.bsky.social, who argues that molecular signaling, like protein expression, controls innate brain responses to varying environmental contexts. #neuroskyence www.thetransmitter.org/brain-inspir...

And we are live! Excited to announce the 2025 Multi-Agent Behavior Challenge on cross-lab supervised action recognition in mice 🐁🐀🖱️ Running on Kaggle until December 15th, with a $50,000 prize pool going to the top five submissions! www.kaggle.com/competitions...

One of the things I really like about Kaggle is that people there are super into sharing their analysis notebooks along the way. Less than a day online, and already there are eight notebooks to explore! www.kaggle.com/competitions...

@nicolecrust.bsky.social poses fundamental questions about emotions, and the terms we use to describe them, to other experts in this "Big picture" debate. #neuroskyence www.thetransmitter.org/the-big-pict...

Thrilled to share that our work is now published in Science! ✨ We found a preference for visual objects in the mouse spatial navigation system where they dynamically refine head-direction coding. In short, objects boost our inner compass! 🧭 www.science.org/doi/10.1126/... 🧵1/

Excited to share our latest paper - now out in @science.org - we showed how oxytocin modulates maternally-directed behavior in young mice (P15).

We're going to see a lot of bullshit in the coming days and weeks about "causes of autism", and most will be based on flawed, over-interpreted observational studies (1/n)

Kevin wrote the book on this stuff (literally; it’s titled “Innate”). He neither oversimplifies things or overcomplexifies them. Speaking as a brain researcher with decades of experience who has also read and thought about these issues a lot, this thread capture’s what’s what.

New Open dataset alert: 🧠 Introducing "Spacetop" – a massive multimodal fMRI dataset that bridges naturalistic and experimental neuroscience! N = 101 x 6 hours each = 606 functional iso-hours combining movies, pain, faces, theory-of-mind and other cognitive tasks! 🧵below

My new essay for @thetransmitter.bsky.social. Why is understanding emotion so challenging? The debates around what counts as an "emotion" shed insight. These disputes are multidimensional, principled and fascinating. Here, I unpack them. www.thetransmitter.org/the-big-pict...

Finding correlates of the same signal in different brain areas is not evidence against specialisation, it is evidence for interconnection. When I flush my toilet, the level in the tank and the flow rate in the supply pipe become perfectly correlated. Yet these toilet areas have distinct functions.

Excited to share our new preprint on the brain-wide organization of intrinsic timescales at single neuron resolution. Work w/ @roxana-zeraati.bsky.social, @intlbrainlab.bsky.social, Anna Levina, @engeltatiana.bsky.social : www.biorxiv.org/content/10.1...

New preprint + thread 🧵 #Psychedelics induce the formation of new synapses, but where do they connect? Our rabies tracing study reveals that #psilocybin shifts connectivity across specific cortical networks. www.biorxiv.org/content/10.1... 1/12

I still get chills Meet Mike *30+ years severe depression *first hospitalized @ 13y *20 meds *3 rounds of ECT *2 near-fatal suicide attempts Mike felt joy for the first time in decades after we turned on his new brain pacemaker or PACE see videos, read paper, follow thread doi.org/10.31234/osf...

A cross-species study captured an emotional brain state characterized by lingering brain activity in higher-order areas. “It’s one of those moments where you’re getting a first glimpse at a vast and complex landscape,” says @deisseroth.bsky.social. By @callimcflurry.bsky.social bit.ly/3U33raF

Proposal recommended for funding! Which means we have a fresh, 3-year-funded position available for a computational postdoc interested in studying dynamics of social interactions in rats, with simultaneous Neuropixels data to follow 🐀🐀🐀 Proper job ad pending, but email me if interested!

Great interview with Xiao-Jing Wang about his career in computational neuroscience - dynamical systems, FTW! open.spotify.com/episode/1hwl...

📅 Next week, we are excited to welcome Dr. @yoavlivneh.bsky.social from Weizmann Institute of Science. He will share his research on the #insular #cortex. 🥳 As always, everyone is welcome to join us at our Institute, and registration is not necessary! All info here: www.psych.mpg.de/events/40140...

The firing of neural populations is high-dim even if their subthreshold activity is low-dim! This work by @bio-emergent.bsky.social and @haydari.bsky.social shows how, with a solvable model, a data analysis technique, and data from mouse visual cortex: www.biorxiv.org/content/10.1...

Is it finally time for systems neuroscience to take hormones seriously? OMG YES! @meenakshiasokan.bsky.social and I share some of our thoughts about recent work in this review www.sciencedirect.com/science/arti...

Emotions are core to the human experience 😆😮🙂😊☹️😠😳😑 But how do they arise? Our brain-wide ⚡recordings in humans and mice reveal some answers @ScienceMagazine. A big team effort and debut paper from @Stanford's new Human Neural Circuitry program. bit.ly/4dEyX7Z

Congratulations to our Human Neural Circuitry team; bit.ly/4dEyX7Z publishes today in Science! This was the hardest challenge of my career, but one of the most rewarding, after years of rebuilding– & expanding my inpatient neuropsychiatry in the service of basic discovery bsky.app/profile/deis...

We got to write a short perspective piece for a very impressive paper published today in @science.org "Conserved brain-wide emergence of emotional response from sensory experience in humans and mice". Congrats to the team! www.science.org/doi/10.1126/... www.science.org/doi/10.1126/...

🧠What do random neural networks have in common with the motor cortex? Turns out, a lot! Both exhibit similar low‑dimensional dynamics across sensorimotor tasks.👇🧵

I’m excited to share a new paper from the lab. The study led by Xiaowei Gu reveals how the mPFC encodes complex emotional memories, using an internal model to infer emotional associations and memories via projections to the amygdala. a🧵(1/8) rdcu.be/el19t

🚀🔬🦠 Releasing 🤖Cellpose-SAM🤖, a cellular segmentation algorithm with superhuman generalization 🦸‍♀️. Try it now on 🤗 huggingface.co/spaces/mouse... paper: www.biorxiv.org/content/10.1... w/ @computingnature.bsky.social 1/n

My lab has several postdoctoral fellow and software engineering positions available. Please email me if you’re interested.

Does your research involve comparing experimental conditions? Then our latest publication is for you: We developed generalized contrastive PCA (gcPCA), a tool for comparing high-dimensional datasets. 🧠📊 doi.org/10.1371/journal.pcbi.1012747 This tool was born out of necessity, here is the story. 🧵 1/

Contrary to popular belief, what is important in science is as much its spirit as its product: it is as much the openmindedness, the primacy of criticism, the submission to the unforeseen, however upsetting, as the result, however new that may be. – Francois Jacob www.nature.com/articles/s41...

This is great! Would love to see similarly structured and rigorous quality controls for calcium imagining data

Kilosort4 detects a LOT of neurons, I recorded 15k neurons in one year 🤯 Traditionally, one would curate these detected units to see if they are well isolated single neurons. This is not feasible anymore, so today let's look at three options that are out there to automate this process! 🤖👇

Eva Dyer and I wrote an opinion piece for @thetransmitter.bsky.social on why neuroscience needs to embrace complexity and accept the "bitter lesson" by using a data-driven regime at scale. With commentary from several wonderful researchers! 🧠📈 #NeuroAI 🧪