New study from group, extends the BOADICEA/CanRisk breast cancer risk model to include continuous mammographic density (MD) from automated tools like Volpara & STRATUS Available via CanRisk (www.canrisk.org) 📄 Ficorella et al, JCO Precision Oncology: doi.org/10.1200/PO-2...

Are you looking for a statistics/ML postdoc? Come to work with @antonis02.bsky.social and me in the NEMO study, an international collaboration aiming to detect ovarian cancer earlier through cutting-edge multi-omics, funded by the Alliance for Cancer Early Detection. www.cam.ac.uk/jobs/researc...

1/🧬 Excited to share our latest paper in Nature Communications @natcomms.nature.com. We analyzed germline sequencing data from 400,000+ women to strengthen how we classify BRCA1 & BRCA2 variants. 🔗 www.nature.com/articles/s41... 🧵

Just published in The Lancet, interim results from the BRAID randomised trial of supplemental breast imaging for women with dense breast tissue. Read the open access Article here 👉 www.thelancet.com/journals/lan... @thelancet.com

This thread reminded me of the work of my late father as a medic and epidemiologist in Papua New Guinea in the 1960's. In the highlands of PNG endemic goitre was very common and in some remote valleys endemic cretinism was also common. The Jimi Valley was one such area. 1/n

Are you a new PhD interested in cardiovascular disease, big data, cohorts, or multi-omics? Join our Cardiovascular Epidemiology Unit at the University of Cambridge for a British Heart Foundation-funded postdoctoral position. Open to those not currently in the CVD field. 🔗: buff.ly/R7YJvfl

This research, published in the @thelancet.bsky.social Oncology, was led by Hend Hassan, a PhD student at the Centre for @ccge-cambridge.bsky.social @dphpc.bsky.social. Read more: crukcambridgecentre.org.uk/news/removin...

Online first: Long-term health outcomes of bilateral salpingo-oophorectomy in BRCA1 and BRCA2 pathogenic variant carriers with personal history of #breastcancer: a retrospective cohort study using linked electronic health records www.thelancet.com/journals/lan...

📢 New publication from the group in @thelancetoncol.bsky.social led by Hend Hasan for her PhD, we used linked EHR + genetic testing data to study 3,400+ BRCA1/2 carriers with history of breast cancer. What happens long-term after BSO? 📄 Paper: www.thelancet.com/journals/lan... 🧵

Only 10 days left to apply for these positions👇

After UK, Denmark announces a national gateway to access health data novonordiskfonden.dk/en/news/new-...

This study is a big deal. Is it going to be the one that kicks down the PRS door? Maybe. And that’s saying something. Assessment of a Polygenic Risk Score in Screening for Prostate Cancer www.nejm.org/doi/full/10....

📣📣 New postdoc in biomedical data science available in our lab!! www.jobs.cam.ac.uk/job/50966/ Flexible funding - many research areas in scope + ideas welcome Check out our group www.inouyelab.org/home And the awesome Cambridge research environment! @vpd-hlri.bsky.social @uniofcam.bsky.social

[1/5] We welcome today’s Government announcement of the creation of a Health Data Research Service. This is a vital step towards enabling cancer researchers to access the right data at the right time, improving outcomes for patients ⏱️🔍 www.gov.uk/government/n...

[1/5] Getting the right data at the right time is essential for researchers looking to beat cancer sooner. Using advanced data modelling and AI, the CD3 programme is a £10m commitment to understanding who is likely to get cancer and when. 🔬 However to deliver on its promise Government must:

CCGE researchers evaluate the contribution of gene variants to cancer risk for multiple cancer types. The results highlight several potential new susceptibility genes including the DNA repair gene NHEJ1. Follow the link below to find out more www.cell.com/ajhg/fulltex...

“It’s been exhaustively studied.” www.nytimes.com/2025/03/07/h...

📣 Job Opportunities - Alongside our recently advertised Senior Research Programme Manager position, we now have 2 more exciting opportunities to join the Cancer Data-Driven Detection (CD3) programme 1️⃣ Research Programme Manager shorturl.at/Cs1kg 2️⃣ Research Community Coordinator shorturl.at/4w9Na

📣 Excited to share our new tutorial with @training.ebi.embl.org ! The course covers the basics of polygenic scores and describes the PGS Catalog resources (buff.ly/L8e6a3J, including pgsc_calc), a great overview of the area. Access the course online at buff.ly/CEBWMio!

📣 New from the lab: The contribution of genetic determinants of blood gene expression and splicing to molecular phenotypes and health outcomes www.nature.com/articles/s41... Check out the INTERVAL RNAseq portal www.intervalrna.org.uk Led by @alextokolyi.bsky.social & Elodie Persyn!

Calling all healthcare providers and researchers! Join us at #BRCA 2025, the 10th International Symposium on Hereditary Breast and Ovarian #Cancer, from May 6-9th 2025 ✅Inspiring speakers ✅In-depth sessions ✅Networking opportunities Visit www.brcasymposium.ca for more info!

📣CanRisk v.3 for breast and ovarian cancer risk prediction released today www.canrisk.org Includes 1️⃣ Adaptations to the U.K. ethnically diverse population: Pre-print: doi.org/10.1101/2025... 2️⃣ Continuous measures of mammographic density: Pre-print: doi.org/10.1101/2025...

Genetics, primary care records and lifestyle factors for short-term dynamic risk prediction of colorectal cancer bmjoncology.bmj.com/content/4/1/... Wonderful stuff from Samantha Ip, @antonis02.bsky.social , Angela Wood and co!

Read more about our recent collaborative work on multimodal dynamic risk modelling for colorectal cancer from the talented Sam Ip and Hannah Harrison. 👇

📣Vacancy alert!!! You'll need significant planning and organisational skills to coordinate and monitor across complex projects with multiple institutions (including us). 👉Cancer Data-Drive Detection (CD3) programme is a major new national research initiative. www.jobs.cam.ac.uk/job/50376/

Hello BlueSky colleagues – this is the new official account of the Centre for Cancer Genetic Epidemiology! Please follow us for updates and news related to our research.

📣 Exciting new opportunity to join the Cancer Data-Driven Detection (CD3) program as Senior Research Programme Manager based at @dphpc.bsky.social @cambridgeuni.bsky.social Closing date 16 March 2025 Please repost! More about CD3 below. 👇 www.jobs.cam.ac.uk/job/50376/

This interesting study linked germline testing and EHR/registry data from the UK NHS to characterize the risk of 2nd primary cancers for pts w/ pathogenic variants in BRCA1/BRCA2. 10-yr cumulative risk of contralateral BC was 16% in BRCA1+ and 12% in BRCA2+ ascopubs.org/doi/10.1200/...

Through linking test results to electronic health records in England from 1995-2019, researchers estimated relative & absolute second primary #cancer risks for #BRCA carriers after #breastcancer. Read the full article to learn more: ascopubs.org/doi/10.1200/... @tpalmd.bsky.social

📣📣Genomic data sharing: you don’t know what you’ve got (till it’s gone) www.nature.com/articles/s41... A comment @natrevgenet.bsky.social from @katholt.bsky.social and me

Hello BlueSky community, and welcome to our official account! 🎉 Follow us for the latest updates, events, and news. Stay connected and engage with our community!

This is a very sad day. It diminishes the USA; it will drive people into poverty and it will lead to many needless deaths

Happy PM day to all who celebrate! PubMed, that is. BMJ Oncology is proud to announce that all our content is now available on PubMed! 🎉 🍾 🥂 @journal-kristoffer.bsky.social @mazer.us @eabhalynn.bsky.social @oncoalert.bsky.social

🚨🌱 Interested in making scientific computing greener? Here is a chance to do just that in Cambridge: 2 open research roles to work with me and the Green Algorithms project. More details about the roles below👇 and at www.lannelongue-group.org/join/ ⏳ Closing: Feb 4 for one, Feb 17 for the other

There is a full weekend ahead to look into our open Postdoc position. If you'd like to study breast cancer tissue architecture with cutting-edge imaging data and novel computational methods, please apply! The deadline to apply is next Wednesday, the 29th 😉

A huge thank you to our funders for making this possible! It’s been truly inspiring to work alongside an extraordinary community of co-investigators & patient and public partners, in developing the proposals. Deeply grateful for the constant support from the central CRUK team throughout the process.

This Medical News article discusses the ongoing debate about whether the word #cancer should be dropped from the names of indolent tumors of the prostate and breast. #MedSky #OncSky

Many, many, many things have been tried in trying to improve access to general practice. @thisinstitute.bsky.social and @healthfoundation.bsky.social have curated those efforts: bjgpopen.org/content/earl...

Looking for a PhD studentship to commence October 2025?   The Early Cancer Institute invites applications from UK students for two 3.5 year fully funded non-clinical studentships.  Application deadline: 16 February 2025 Find out more ➡️ zurl.co/1HyFJ

Excited to share our latest study in @nature.com We used a humanized-mouse ES cell model to explore the functional consequences of all possible BRCA2 missense variants. We've clinically classified >6,500 variants and >1,200 reported in ClinVar! www.nature.com/articles/s41...

The latest publication from the group, led by talented early career researchers Carmen Petitjean and Xin Yang @xinyang6699.bsky.social on the performance of BOADICEA/CanRisk for breast cancer risk prediction in UKBiobank out now in JNCI. Paper: doi.org/10.1093/jnci... 🧵👇

Looking forward to speaking in this session today at #SABCS24 @sabcs.bsky.social on the latest work on CanRisk tools (www.canrisk.org) for breast cancer risk prediction, including adaptations to ethnically diverse populations. @crukcamcentre.bsky.social

NEW PAPER A scoping review of updating methods in AI/ML based prediction models doi.org/10.1016/j.jc... w/ @lottameijerink.bsky.social and others

Dr. Judy Garber shared the OlympiA Phase 3 trial results in today's #SABCS24 General Session. #olaparib #BRCA1 #BRCA2 #BreastCancer

Have you ever wondered how knocking out every single gene in the human genome, one by one, might affect your intracellular pathogen of interest? We did, & boy was it a wild ride! Happy to share our preprint discovering the essential host genome for Cryptosporidium - www.biorxiv.org/content/10.1...

Long awaited peer review finally completed!! Our paper comparing quantitative metabolomics disease risk prediction with PGS is accepted in Nature Comms!! 🥳🥳 @nightingalehealth.com #riskprediction #metabolomics #nmr #genomics #polygenicscore www.nature.com/articles/s41...

Looking for collaborators to work on federated Real World Evidence studies related to cancer. We are building our infrastructure and need high value demonstaror projects. #OHDSI #EHDEN #OMOP #RWE please get in touch

If you're interested in the PGS Catalog Calculator we're hosting a free training webinar @ebi.embl.org on December 4th: www.ebi.ac.uk/training/eve... (registration required). Come along, or catch up with the recording after! cc @iamslambert.bsky.social

📢 Don’t miss our next Cancer Biology and Medicine talk tomorrow! DNA Repair Prof Steve Jackson @cruk-ci.bsky.social Thurs 28 Nov, 9:30-10:30 Theo Chalmers lecture theatre, School of Clinical Medicine All welcome! @cuhnhs.bsky.social @cambridgeuni.bsky.social