An update on the model of connectivity of the hippocampal formation (I): the perforant pathway to the dentate gyrus https://www.biorxiv.org/content/10.64898/2026.04.23.720458v1

Film you've watched more than six times with a gif. Hard mode: no Star Trek, Star Wars, LOTR, DC, Marvel, Disney, Pixar, Spielberg, Cameron, Wachowskis, or Ghibli

Ha! Joke's on you the cells are dead 🥲

Spend less time processing cell images with the Allen Cell Structure Segmenter. This #OpenScience python-based toolkit helps #cellscience researchers navigate complex images by automatically capturing the boundaries of structures. Access at: https://lnkd.in/gpWA7xWH

Don't be shy to take on a little two-week side project. These five months will be the most precious three years of your academic journey.

In August, Jay Bhattacharya said “Training future biomedical scientists” was the 1st priority for his version of NIH. But talk is cheap. Let’s see how JB’s doing. 🤔 NIH supports trainees mostly via fellowship (F), training (T), and career development (K) awards. Here are funding curves for each.🧵

orthogene bioconductor.org/packages/rel... Map your genes of interest across >700 species Can do many:many bioRxiv 2026 www.biorxiv.org/content/10.6...

"The bird with four (mating) sexes." In Zonotrichia albicollis, tan-striped males seek out white-striped females, while white-striped males court tan-striped females. Morphs are behaviorally "masculine" & "feminine", separate from gonadal sex. (🧑‍🎨: Rebecca Gelernter, @nearbirdstudios.bsky.social )

Modifications will remain until morale improves... er October. grants.nih.gov/grants/guide...

As a recipient of federal grants from #NIH (for now! 😭) that funds research in my lab, I'd like to sincerely thank American taxpayers on #TaxDay for investing in scientific research that lays the foundation for medical and technological innovation in this country and keeps us ALL safe and healthy

🧵New paper from the lab @isd-research.bsky.social @lmu-klinikum.bsky.social @lmu.de in STM @science.org! A human #iPSC-derived #Tauopathy model that endogenously develops late-stage Tau pathology. Free personal PDF: www.science.org/eprint/5H5YD.... Here's what we found👇 1/10

Gas works park!

Cherry blossoms at the University of Washington 🌸🥰

And if anyone has any recs for what to get up to in my three evenings there I'm all ears! big fan of food and museums but I'll take all offerings

Heading out to the @alleninstitute.org's Cell Types workshop! In a fun twist it look likes I'm leaving a rainy Boston for an at-least-partly sunny(!) Seattle 🤩🌤️ I'm excited!!

Our paper is now online at @nataging.nature.com! Alzheimer’s disease begins decades before symptoms—but what drives those earliest changes is still not well understood. We set out to understand how APOE4 disrupts neuronal and network function across aging. 🧵: 1/15 www.nature.com/articles/s43...

Single-nucleus transcriptomics identifies a shared vulnerable excitatory neuronal population across typical and atypical Alzheimers disease https://www.biorxiv.org/content/10.64898/2026.03.30.715299v1

Beyond excited to share new work using super resolution microscopy to reveal how a tau mutation drives early changes in the autophagy lysosome pathway led by the amazing Dr Mirfakhar

Some totally awesome updates from grant-witness.us All of my funding curves and more in an easily useful form! grant-witness.us/funding_curv... 🧵 1/7

Comprehensive investigation of AAV tropism across human iPSC-derived neuronal subtypes https://www.biorxiv.org/content/10.64898/2026.03.24.713895v1

If you use GitHub (especially if you pay for it!!) consider doing this *immediately* Settings -> Privacy -> Disallow GitHub to train their models on your code. GitHub opted *everyone* into training. No matter if you pay for the service (like I do). WTH github.com/settings/cop...

NEW: Wikipedia has banned AI-generated content.

Molecular characterization of humanized #APOE mouse models reveals source and #genotype dependent differences Na Wang, Gefei Yu, Zhen Wang, Alla Alnobani...Takahisa Kanekiyo & Chia-Chen Liu & Guojun Bu #AlzheimersDisease #lipids link.springer.com/article/10.1...

Delighted to share that our study is now out @cp-cellstemcell.bsky.social www.cell.com/cell-stem-ce... Congrats to Dr. @federicamosti.bsky.social for the culmination of a beautiful thesis!

Pics from the last few days in Colorado! We got so lucky with the snow, getting a few inches and some skiing in right before the weather got even warmer 🤩⛷️ Now back to optimizing my genotyping PCR...

I have a joke about a grant but you probably won’t get it

NRSA levels for FY26. grants.nih.gov/grants/guide...

My attempt to explain-like-I'm-5 the OMB apportionment fiasco - how did I do?

Download our database of free database of postdoc fellowships. 276 funding opportunities. For entry, we provide eligibility/requirements, amount, deadline, link, description, etc. Download database here: research.jhu.edu/rdt/funding-...

Applications are now open for the Stem Cell & Development Biology Early Career Symposium! Together with @isscr.org and @socdevbio.bsky.social, we're hosting a scientific focused on incubating the next generation of research leaders. Apply by May 1 at: https://bit.ly/4lriiZm

Lately all I do is talk about my @plasmidsaurus.bsky.social sponsorship... 🦖🧬✨ Free limited edition Plasmidsaurus x OpenFlower postcards extended to 3/16. Last chance!!!

EXCLUSIVE: @standupforscience.bsky.social sent an investigator to Guinea-Bissau and shared their unpublished findings with members of Congress. I obtained a copy of that report, which details how deeply the researchers are enmeshed - and what that means for US: www.theguardian.com/us-news/2026...

The data is in: the NIH goalposts have shifted. What were once almost certain fundable scores have become coin flips and what used to be likely grants have become aspirational, leading to fewer awards. Another manifestation of how HHS policies have led to fewer awards and less science.

A human iPS cell line for ready-to-use human iAstrocytes that support human neurons https://www.biorxiv.org/content/10.64898/2026.03.02.709009v1

$1B per day is about $42 million per hour. About 30 min worth of that spending can fund my lab for my ENTIRE career (~20 3-year NSFs or ~10 5-year R01s). Please wrap your head around that.

Since people are liking the Bocchi colors, I have a whole collection of color palettes on my GitHub: github.com/cxli233/Colo... You will find the hex code, the preview, and the inspiration for each color palette. I hope some of them will be used. #DataVis

🚨NEW SCIENCE ALERT!🚨Our paper, led by Dr. Paul Sereno, is now available in @science.org! We describe a new African #dinosaur species with a unique cranial crest—Spinosaurus mirabilis. Beautiful #paleoart by Dani Navarro graces the cover of the February 19 issue! doi.org/10.1126/scie...

I can highly recommend the NIH Outstanding Scholar in Neuroscience Award Program (nice backronym for OSNAP)! Need to be 2 years before/after PhD, due March 23. Great opportunity to visit and present at NIH and meet some amazing colleagues. www.nimh.nih.gov/research/res...

Alysa Liu telling 60 Minutes “I love struggling, it makes me feel alive” is a legit revolutionary statement from a Bay Area native in a time when copious amounts of time and resources are being put toward convincing us to opt out of experiencing struggle, friction and self-actualization

Under the Government Use License, NIH-funded authors have the right to submit an AAM to PMC without an embargo, contrary to any publisher assertion or requirement that an author publish under an open access license and pay an APC.

Congrats @handekarahan.bsky.social & our team members! A potential new drug target for Alzheimer's disease. Targeting the APOE pathway more effectively. Might also enhance neuroprotective pathways, offering resilience against disease progression. alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Sorry to get radical but I don’t think it’s my job or yours to embrace, accept, understand - and certainly not to use - the thing being sold to us as AI. I don’t like any part of it, so I won’t. I’m missing out? Good, that’s what I want. You’re worried about me missing out? That’s fuckin weird, man.

During #NeuronalDifferentiation, #organelles dramatically reorganize. #Microtubules are essential tracks for transport. But are they just highways, or can they instruct organelle behavior? Are tubulin modifications a regulatory code that guides organelle position or function? 1/9

Cells come in many shapes and sizes, with diverse physiological functions. But how do #organelles and their interaction networks remodel during #differentiation of stem cells into different cell types? Here’s what we discovered about neuronal differentiation: 1/13

We made Valentine’s Dinograms! 🦖❤️ Free printable cards for your favorite lab mates, collaborators, and science friends. Download, print, and share! 🔗 plasmidsaurus.com/dino-valentine

Defining brain cell types is no longer a matter of classification alone, but of embedding their genetic identities within the dynamical organization of population activity, writes @lmprida.bsky.social. #neuroskyence www.thetransmitter.org/defining-cel...

Attention lovebirds: It’s time to crown your favorite Penguin Power Couple 🐧💌🐟 Our 8 bonded African penguin pairs have enough love to go around, but they’re looking for a different kind of adoration this week: Your votes! Head to bit.ly/PenguinLove26 every day thru Feb. 13 to vote on iconic pairs.

In honor of Black History Month, I want to celebrate Henrietta Lacks. Her immortal cells were unjustly taken without her consent. Without HeLa cells, science wouldn’t be what it is today. Learn more about Ms. Lacks’ story on the Lacks Family website: lacksfamily.com

Now online! Molecular features of human pathological tau distinguish tauopathy-associated dementias

Our paper is (finally) out in Cell today! CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis www.cell.com/cell/fulltex... Great collaborative effort - read more from first author @asamelson.bsky.social below: