FACT CHECK: Acetaminophen (Tylenol) has no credible link with autism. Tylenol is the leading option to combat dangerous fevers during pregnancy — fearmongering around tried and tested medicine puts pregnant people and children at risk. #impeachthequack

Nature research paper: Engineered prime editors with minimal genomic errors go.nature.com/4pHrRoS

🚀 Our new paper is out @natmethods.nature.com! Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells. 🔗 www.nature.com/articles/s41... 🧬 www.addgene.org/John_Ngo/

Beautiful views of the Charles from the BU MD-PhD program's annual retreat, hosted this year in @bucds.bsky.social @bumedicine.bsky.social

For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper? You got it: currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...

IT'S OFFICIAL: Connecticut, Maine, Massachusetts, New Jersey, New York State, Pennsylvania, Rhode Island and New York City have formed the Northeast Public Health Collaborative. The collaborative will issue their own vaccine recommendations and coordinate public health efforts.

Our lncRNA-in-brain review is out in @natrevneuro.nature.com ✨ The emerging roles of long noncoding RNAs in the brain We discuss 🧬 lncRNA roles in brain development, synaptic function, learning, & behavior 💡 Therapeutic potential and future directions. @unswrna.bsky.social @unswbabs.bsky.social

If you want to get started, here's a tutorial that I made: github.com/JoachimGoedh... Reach out if you have questions or want advice!!

It's been a busy time for NIH grants staff — the agency seems on track to spend its budget this fiscal year But, because of multi-year funding, fewer projects are being funded than in previous years. The number of R grants has fallen from 5,633 to 3,758 analysis by @jaspar.bsky.social

The trick to being productive is to have multiple things you're procrastinating from doing

In the August issue of µChicago, explore new research into how we remember, why we forget, and what makes certain moments, images, and fears stay with us. Read more: bit.ly/3VsiD1F

Major update: As of this morning, CVS says it's decided it can offer the vax in 13 of the 16 states IF you get a prescription. Still a big new barrier for many people, but a change from its "no vaccines at all in these states" position yesterday. The three remaining absolute-nos are MA, NV and NM.

Oh, in the Times story, here's some nuanced reporting on what has happened this week. We knew some of this already, but this clearly puts it together and adds some notes: www.nytimes.com/2025/08/27/h...

Telling it like it is 🔥 "Once again, we are seeing the federal government retaliate against our civil servants for whistleblowing—which is both illegal and a deep betrayal of the most dedicated among us." www.newsweek.com/fema-staff-l...

Some scientists haven't yet internalized the "why" behind science writing for the public - not just as a service, but for themselves. (I didn't always get it). In this piece for @natrevneuro.nature.com, I draw on the neuroscience of curiosity & decision making to unpack its value. rdcu.be/eCGr7

Michigan AG Dana Nessel comes out swinging against University of Michigan for stopping care for trans youth.

A party in my mailbox today 🥳 Thanks @nerdychristie.bsky.social @science.org for the daily newsletters and the fun free socks!! #ScienceAdviser

Last week, Boston received a letter from AG Bondi threatening to prosecute officials and withhold funds unless we cooperate with carrying out mass deportations. The US Attorney General asked for a response by today, so here it is: stop attacking our cities to hide your administration’s failures.

A fantastic thread on the terrorist attack on CDC. 👇

Sign the petition to call for the removal of RFK, Jr. www.standupforscience.net/rfk-impeachm...

This photo shows how close CDC colleagues came to being victims of a workplace mass murder A mentally ill man — radicalized by vaccine lies spread by our boss 🧠🪱— opened fire CDC shooting = domestic terrorism Call it that. Treat it as that #FireRFKJr We protect the public. Please protect us, too.

Consider joining us at Stanford as a postdoctoral fellow! If you have a published paper or a preprint, will graduate in the next period, and are excited to work in California, email me your CV and a brief statement of your research interests and trajectory by the end of August.

This dino has been through some things… and it’s only Monday.

NIH scientists say that mRNA vaccines have saved untold thousands of lives. A heroin addled nepo baby whose brain was partially eaten by a worm says mRNA vaccines are worthless and even dangerous. For busy medical patients, it can be hard to know who to trust.

The updated version of the database of PhD fellowships produced and maintained by my team can be downloaded by anyone here: research.jhu.edu/rdt/funding-... For each of the 187 fellowships, you will find a short description, deadline, $ amount, link, etc. Good luck!

Atlantic: How Many Times Can Science Funding Be Canceled?/ Whether or not Congress cuts NIH’s budget, the Trump administration has devastated its ability to operate. by Katherine J. Wu bit.ly/4fucNWT

1/2 What’s in a NOFO? PAR vs RFA vs NOSI vs NOT….what’s the difference?? NOFO: used to be called FOAs, stands for “Notice of Funding Opportunity” PA=Program announcement or Parent announcement PAS=Program announcement with set aside funds (this is rare these days) grants.nih.gov/grants/polic...

Every reputable expert I know considers mRNA vaccine technology to be one of the most revolutionary advances in medicine in our lifetimes. Its inventors won the Nobel Prize in 2023. Shutting it down now is pointless self-harm to humanity.

Proud to share my first co-last/co-corresponding manuscript (preprint): DNA methylation shifts in tau & Aβ mice 🧬🐁 This work started during my PhD at @exeter.ac.uk (outstanding mentor: Prof Jonathan Mill) & was led forward by Szi Kay Leung, now a superstar postdoc ⭐ www.biorxiv.org/content/10.1...

Explore how the brain ages with our aging mouse brain data on the Allen Brain Cell Atlas! Explore the most comprehensive and detailed single-cell dataset of the aged and young adult mouse brain. 🧠📈 knowledge.brain-map.org/abcatlas#AQE...

Russell Vought lost! WSJ: "A Trump administration effort to block all funding that flows to outside health researchers was scrapped Tuesday evening after senior White House officials intervened." Gift link!

In 1951, Harry S. Truman laid the cornerstone of the NIH clinical center, stating, "Research to prevent disease" was a better investment for federal dollars than "providing unlimited hospitalization to treat it."

Tau PET positivity in individuals (42 cohorts worldwide, N = 12,048) with and without cognitive impairment varies with age, amyloid-β status, APOE genotype and sex @rikossenkoppele.bsky.social www.nature.com/articles/s41...

We cannot have a functional US science enterprise if NIH and other science agencies cannot be independent of the President and politics. But that’s what the corrupt Court wants; they want the President to be able to fire any civil servant and control every agency action. That’s un-American.

This morning, NASA released the #VoyagerDeclaration. This afternoon, NIH #BethesdaDeclaration signers met w/ Jay Bhattacharya. Earlier, EPA staff were terminated for their act of resistance. I made this in solidarity. @altnih4science.bsky.social @altnasa.bsky.social @alt-epa-workers.bsky.social

Partnership between David Liu, @jacksonlab.bsky.social, and rare disease group RARE Hope leads to first use of prime editing for a brain disease that reduced symptoms, extended lifespan in mice, offering hope for other rare genetic diseases. #Science #PrimeEditing

🗞️Our July issue is live!📷 This month, we're featuring work on intrinsic capacity, senescence, and more. Read it all here: www.nature.com/nataging/vol...

It is not a political statement to note the fact that science enhances our well being, expands our knowledge of the world, and drives economic growth 🧪

🚨 If you haven’t seen it yet… 📢 The NIH BioArt Source provides a library of FREE professionally designed illustrations and icons, available for anyone to use. They can be Downloaded in High Definition. Check it out at bioart.niaid.nih.gov

My postdoc work at Treutlein lab and @graycamplab.bsky.social with @jasperjanssens.bsky.social is out in @science.org ! We screen for neuron subtypes using pro-neural TFs + morphogen combinations + scRNA-seq and profiled over 700,000 cells in 480 conditions. www.science.org/doi/10.1126/...

Neuron programming! Pro-neural TFs + 480 morphogen conditions + scRNA-seq --> Diverse iN subtypes of forebrain, midbrain, hindbrain, spinal cord, and PNS. @hsiuchuanlin.bsky.social‬ @jasperjanssens.bsky.social‬ and Treutlein Lab! @science.org www.science.org/doi/10.1126/... #NGN2 #ASCL1

Hey, this is important to do. Animal testing is vital to having safe medicines. We are an extremely long way from knowing enough about how bodies function to model it all in a computer system. Animal models are needed to ensure human safety.

Summary Table of the massive defunding of biomedical research in the United States www.nytimes.com/interactive/...

Congratulations to BU’s Vickery Trinkaus-Randall, PhD, and Steven Borkan, MD, on their multi-PI T32 NIH grant to help recruit, train and inspire MD/PhD students to become clinician scientistshttps://bit.ly/44brH0e

Hot off the press! Our new paper on plasma p-tau231 in the Colombian ADAD kindred is out in Alzheimer’s & Dementia! 🧠 We found that p-tau231 begins diverging by age 19 —25 yrs before symptoms—and distinguish carriers earlier than p-tau217 or NfL alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Nazi Germany did literally ban Nature: "Articles are often published in the London weekly scientific journal Nature containing outrageous and vile attacks on German science and the national socialist state. The journal must therefore be excluded from general use in the scientific libraries."

Our colleagues at @alzassociation.bsky.social address Secretary Kennedy's disinformation campaign on research we and AA support. Thank you, Drs. Pike and Carrillo for addressing these medical inaccuracies. #geronsky #dementia

After the latest round of grading papers, I wrote about AI, ChatGPT, the death of the student essay, and what it means for the future of human cognition.

The news really sucks today. Instead of boosting a harmful Supreme Court decision, here’s something better: a practical guide on how to support the LGBTQ+ youth in your life. Because they deserve our attention, our protection, and our love. 💖🏳️‍⚧️🏳️‍🌈 www.thetrevorproject.org/resources/ar...

Why do some people who have mutations of familial Alzheimer's not get the disease? They have protective genomic variants. A first-rate review @thelancetneuro.bsky.social thelancet.com/journals/lan...