Ribosome hibernation in archea with HibA, with a bacterial line hpf/raiA domain rdcu.be/foDtr

Excited to share our work uncovering SNOR, a ribosome-associated factor that promotes translation restart after dormancy published in Nature!! This was, as usual, a wonderful collaborative effort between our group and the Mattei Lab @simonemattei.bsky.social @embl.org www.nature.com/articles/s41...

With Eugene Koonin, we wrote a rather comprehensive review on the origin, evolution and organization of the #virosphere. We describe all 10 viral realms and the logic behind them, and so much more. Check it out! comptes-rendus.academie-sciences.fr/biologies/ar...

Happy to share our latest paper: www.nature.com/articles/s41... Great collaboration with @ifremer.bsky.social, @cbitoulouse.bsky.social & @pasteur.fr. Studying stress in P. abyssi with near-native, minimally purified ribosomes, we identified HibA, a new hibernation factor widespread in Archaea.

Very happy to share our latest publication in Nat. Commun. www.nature.com/articles/s41... It was a great collaboration with @ifremer.bsky.social, @cbitoulouse.bsky.social and @pasteur.fr. We discovered a new hibernation factor in Archaea binding to the ribosome in three different conformations !

Our work on ribosome hibernation in archaea is out! We identified Hib, a new hibernation factor broadly distributed across archaea. Check out the preprint 👉 biorxiv.org/content/10.1101/2025.10.11.676729v1 (1/🧵)

Here we unexpectedly find that the ribosomal protein S20/L26—identified at the dawn of ribosome research but later deemed a biochemical artifact—is indeed a genuine component of the large ribosomal subunit. More on this ribosome content variation is here: www.nature.com/articles/s41...

Unique opportunity to join the CytoMorpho Lab (in Paris ❤️) as a postdoc to work on the self-organization and polarization of reconstituted networks made of microtubules, motors and actin filaments in vitro. Experience required. Please Repost 🙏 thanks !

Scrat (JEOL ARM 200) is now installed in Rennes with a Direct Electron Apollo camera. Don't hesitate to get in touch if you need nice SPA or cryo-electron tomography (single and dual axis) data 😍 biosit.univ-rennes.fr/en/tem2c #CryoEM

I think it's important to reach out to your own community and explain what the funding cuts mean in practice.

FYI: New online! Cytoplasmic mRNA decay and quality control machineries in eukaryotes

Mark your calendars! Archaea power hour is back!

New Review: DNA topoisomerase in Archaea; from Paul Villain and Tamara Basta...featured in a forthcoming special issue on Prokaryotic Chromosome Organization! #MicroSky onlinelibrary.wiley.com/doi/10.1111/...

First ribosome purification using poly-lysine beads (RAPPL, developed by @djuranoviclab.bsky.social & collaborators: www.biorxiv.org/content/10.1...). Full process—from lysis to grid prep—in just 3 hours. Look how pretty it is (even if a bit too diluted)! This is a game-changer🚀.

NSUN6 inhibitor discovery guided by its mRNA substrate bound crystal structure doi.org/10.1016/j.st... #RNA #RNAsky #RNAbiology

Voici un exemple concret des conséquences du manque de crédit dans la recherche française. Nous avons deux microscopes électroniques de pointe à Bordeaux pour la biologie structurale et cellulaire. Faute de moyens suffisants, nous devrons très probablement arrêter l'un des deux instruments…

The Institute for Integrative Biology of the Cell (I2BC) is recruiting group leaders in cell biology. Don't miss the opportunity to start your team in the vibrant environment of Paris-Saclay University. Application deadline: Feb 28, 2025 www.i2bc.paris-saclay.fr @i2bcparissaclay.bsky.social

The Asgard archaeal origins of Arf family GTPases involved in eukaryotic organelle dynamics www.nature.com/articles/s41... #jcampubs

Our paper out @CellCellPress: Structure guided discovery of viral proteins that inhibit host immunity Congrats Erez Yirmiya, Azita Leavitt, Gil Amitai, our collaborators at the Kranzusch lab, and coauthors A 🧵 1/10 www.cell.com/cell/abstrac...

Bonjour, nous avons un poste d´IE en biochimie et biologie moléculaire ouvert en mobilité interne (FSEP) au laboratoire de biologie structurale de la cellule (BIOC) située au sein de l´École polytechnique (Palaiseau) . emploi.cnrs.fr/Offres/MOBIN...

A new year, a new social network and a new article in @naturecomms.bsky.social ! It unveils how archaeal RPA orchestrates the recruitment of key players in 🧬 replication primase and polD through its WH domain, with structures of both complexes!! rdcu.be/d6GAY

New to #ubiquitin? Been with it for a while? Either way this review may be for you 🤩 Excited to share our review article in @molcell.bsky.social, diving deep into everything #ubiquitin Read here 👉: kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F... @cellpress.bsky.social @wehi-research.bsky.social

More ribosome structures solved by RAPPL (collaboration with Pavlovic Djuranovic and Hashem Labs). This one is bacterial from 2ml culture and using method described in our preprint. www.biorxiv.org/content/10.1...

Check out our recent work on CDS #m6A mediated RNA decay (CMD)! Decay relies on ribosome pausing at m6A containing codons. Great collab with the Zarnack lab & colleagues. Thank you @uniwuerzburg.bsky.social , @imbmainz.bsky.social and RMap🥳 www.cell.com/molecular-ce...

Gabriel Demo and colleagues found how a small archaeal protein (aRDF) dimerizes 30S subunits to prevent ribosome formation:

I am happy to share that the review my former PhD student Paul Villain and I wrote was published: doi.org/10.1111/mmi.... #Archaea #I2BC

Mapt mutations are found in brain disorders. Most of them are located in sequences encoding microtubule-binding domains. However, some are in the 5'UTR tau mRNAs. Understanding the effect of mutations in the amino-terminal part of tau and the role of N-truncated tau academic.oup.com/narmolmed/ar...

We are pleased to share our work on the evolution of translation initiation now published in Nature Communications. Take a look at leaderless mRNAs and eS26 in the small ribosomal subunit of Saccharolobus solfataricus. rdcu.be/d5pgg