not to dunk on this conclusion, but it's an insidious mindset that has become pervasive. how you spend your time, how you make your money, is one of the most important ethical and political choices you can make. convincing ourselves otherwise is arguably The Whole Problem in American society today

(1/10) How do diverse leukemia mutations converge on the same molecular program? In #RibackLab first manuscript @cp-cell.bsky.social, collaboration with @goodell-lab.bsky.social shows that disparate mutations rewire shared protein networks to form nuclear condensates called C-bodies.

pre-writing a devastating obituary for your enemy is god-tier hating of a kind you don’t often see anymore. renaissance haterism. beautiful stuff.

Scientific breakthroughs are rarely unique; someone else would’ve made them soon enough. But when prominent scientists cause harm, that harm isn’t inevitable; the world might simply have been better had the harm not been inflicted. liorpachter.wordpress.com/2018/05/18/j...

A few days after the presidential election one year ago, we went to Fordham Road in the Bronx. It was a little different last week.

As a child I ate government cheese and free school lunches. I then went on to uni thanks largely to Pell grants. I now (HAPPILY) pay taxes on an income that would not have been possible without that support. Taking care of your citizens is good actually.

EXCLUSIVE: One Saturday afternoon in October, my phone lit up with a notification. I glanced down at the message. “Anna, Lindsey Halligan here,” it began. So began my text exchange with the woman who is prosecuting the president's perceived political enemies. www.lawfaremedia.org/article/anna...

A university that signs the “compact” is one that acknowledges its own inability to compete and succeed based talent and merit. It would signal insecurity and mediocrity to current and future students and faculty. Say no. Recruit the best people, protect their freedom and support their hard work.

Second, I’m slowly getting to be in the camp that proteins don’t have functions but instead have properties. What biology does with those properties is a somewhat different matter. So maybe we need to predict properties (kcat, Kd, etc) as well

This is great. A few additions. I suspect that what we really need is a model of macromolecular thermodynamics. Prediction potential alternative conformations is nice but unless we can assign weights it’s difficult to link to biology. Same for stability etc.

If y'all don't see me at some conferences this year... it's because this has been YEARS in the making. Trans people aren't safe here. PLEASE stand up--personally and professionally (lookin' at you, academics)--for the trans people in your life.

Please apply to our tenure-track faculty position at @stanford-chemh.bsky.social! We are searching for a new colleague working at the interface between computation and molecular sciences. See post below and pls forward widely! chemh.stanford.edu/opportunitie...

happy for THE PITT but heartbroken for ANDOR, a TV show the likes of which we will never, ever see again

Over 10% of human transcription factors are oligomeric. Stoichiometry might be dialled to modulate transcription. We show CREB searches in DNA mixtures as a dimer, and suggest this might be common amongst other members of the bZIP family which fold on binding DNA. www.biorxiv.org/content/10.1...

- you clean up that banksy? - sure did, your honour, leaving a perfect, permanent outline, imbuing the work with real fuckin gravitas while making its point better than the artist did himself just like you asked

🗓️Join us for the 4th Stanford.Berkeley.UCSF Next Generation Faculty Symposium on 9/10/25! We highlight the work of 18 exceptional early-career scientists across biomedical sciences. Register and more information below: www.berkeleystanfordnextgensymposium.com/speakersalumni

Only 2 days to go! Register and join us to hear these amazing talks!

Incredibly excited for this year's iteration of the Next Generation Faculty Symposium on 9/10/25! This is a fantastic opportunity to hear 10 minute talks describing fantastic cutting-edge science from researchers preparing to launch a faculty search. Please register (link below) & forward widely :)

When reporting on these kinds of claims, the media should ask:

The “problem” with vaccines? They so effective at preventing deaths that they create generations of people that question whether disease was a problem in the first place because they have never experienced the horrors of a world without vaccines.

📢 New preprint: Aromatic Ring Flips Reveal Reshaping of Protein Dynamics in Crystals and Complexes. We addressed a long-standing question that people debated already in the 1970s - but it still remained open: Do proteins in crystals move as they do in solution? We used ring flips to find out. 1/n

Motherfucker wrote one sloppy paper in April 2020 and instead of being like oops, shit, my bad, he has kept doubling down until now he's killing most promising medical technology of the past quarter century rather than going to therapy.

Thrilled to share this manuscript from my lab where we looked at how glycopolymers that compose the glycocalyx influence protein folding and protein-protein interactions via macromolecular crowding. TLDR: The Glycocalyx stabilizes protein folding and PPIs www.biorxiv.org/content/10.1...

I listened to Bhattacharya on Steve Bannon's "War Room" podcast. If you want to know how it went, see the following email that I just sent. 1/13

I’m heartened to see this.

A truly enabling new approach by @taralowensohn.bsky.social Will Cody and @sattelylab.bsky.social to probe plant genetics at scale. Single-gene-per-cell delivery coupled to an effective transcriptional selection system www.biorxiv.org/content/10.1...

Another email to Bhattacharya about his interview and his continued statements that NIH's gain of function research caused the COVID pandemic and killed millions of people. 1/8

Our research has been engulfed by an endless torrent of lab leak conspiracy theories about the origin of the pandemic - even as the evidence for zoonosis has only grown stronger. This fuels anti-science agendas and erodes public trust. Now, we respond 👇 theconversation.com/how-conspira...

Columbia University’s agreement with the Trump administration is a disaster for academic freedom, freedom of speech, & the independence of American higher education. Never in the history of our nation has an educational institution so thoroughly bent to the will of an autocrat. 1/

This is a great piece highlighting the many ways that federal investment in science benefits society.

A friend of my compared gutting of federal agencies to a wrecking a car: if you remove 30% of the parts of the car, it does not go 30% slower. It stops working.

An Evaluation of Biomolecular Energetics Learned by AlphaFold https://www.biorxiv.org/content/10.1101/2025.06.30.662466v1

People make art under hellish conditions locked up in prisons as just one example. It's because making things affirms our humanity. So yes, make art during fascism. What are we fighting for? A free society FOR ALL where we can revel in beauty, culture and all good things.

Exciting new work from Sattely lab with collaborator @pollyfordyce.bsky.social and coworkers @stanford-chemh.bsky.social, solving they biosynthesis of taxol! www.nature.com/articles/s41...

Every flashbang could instead be a meal for a poor kid. Every hotel room for a National Guardsman deployed to fire at our neighbors could house a homeless vet. Every "less-than-lethal" bullet pulled from a journalist's eye could be already needed healthcare for anyone else. All of this is a choice.

🚨New preprint! ❄️🧊 How does TRPM8 sense cold/menthol? We combine cryoEM and HDX-MS to uncover the hidden dynamics that drive cold activation. A great case where thermodynamics + structures together uncover conformational landscape & function. www.biorxiv.org/content/10.1...

Ok fine I'll listen to the Bhattacharya/Huberman interview amd share my notes

The structural basis of cold sensitivity https://www.biorxiv.org/content/10.1101/2025.06.06.658377v1

The university of California is a powerhouse of innovation, healthcare, and social mobility for California and the US.

Lots of people are keeping silent, because lots of people are scared. But my colleague Aayushi Pratap found a group of chemists at Columbia willing to talk about what's going on in the labs they lead. Her story, and Natalie Keyssar's portraits, are worth your time. cen.acs.org/policy/resea...

This story is just so sad: a postdoc's life is ruined, and so stupid: our government is disgustingly duplicitous, and the media and university are completely credulous. Needless to say, everyone must have the proper permits for your strains. More importantly, this is targeted fascism. the details:

1. Yes, that sounds like a normal aspect of any healthy intellectual field! It takes time for you to learn the nuance, the language, and the people of a new field, and then for them to learn about you. 2. Folks.... this is a statistical description of a trend, not a declaration of what you must do

If a foreign government conspired to decimate US science and technology in a manner akin to what Project 2025 architects purport to do, we would go to war. Just because they are under a cloak of self declared patriotism does not mean that they are not effectively acting as enemies of the state.

ASSIGNMENT: COMMENT ON SCHEDULE F 1 week left to comment about Schedule F, potentially making NIH institute and center director essentially political appointees. www.regulations.gov/commenton/OP... 1/n

The goal is plainly and literally to cut the number of people involved in basic science in the US by 70%

So the question then is why, right? And the answer is RFK does not care about "corruption" or "replicability" at NEJM just like Trump doesn't care about "antisemitism" at Harvard. In each case, they manufacture a narrative that is palatable to the mainstream: antisemitism, plagarism, replicability.

🚨 URGENT RESPONSE CALL 🚨 Trump’s Fool’s Gold Science EO is a dangerous sham. It gives his appointees the power to dismiss entire bodies of research and punish researchers who fail to fall in line with his agenda. We’ve launched an open letter. SIGN & SHARE NOW: actionnetwork.org/petitions/op...

Unironically they should buy up the domains for about 60 defunct local newspapers in swing states. Hire two reporters to write almost exclusively about highschool sports and new restaurants opening with every 10th article about how the local GOP is screwing over people.

The current administration is killing basic science as we know it by gutting both the NIH and the NSF. We are losing the next generation of young scientists. None of this will make America great again. And if this destruction continues, there will be no more cures coming from American science.