🚨New preprint! ❄️🧊 How does TRPM8 sense cold/menthol? We combine cryoEM and HDX-MS to uncover the hidden dynamics that drive cold activation. A great case where thermodynamics + structures together uncover conformational landscape & function. www.biorxiv.org/content/10.1...

Ever wonder how many lives have been saved by NIH-funded research - including your own? Enter any medical condition and instantly see how your tax dollars transformed science into survival. www.ourhealthroi.com

Now published in JCIM! Thanks to reviewers and our editor for pushing us to (hopefully) clarify a few things and ensure it's clear what PENGUIN is trying to do (and what it's NOT trying to do). Also, in case you were unsure, graphic design is our passion. pubs.acs.org/doi/full/10....

New toy is unboxed

In lab’s #FIRSTPREPRINT, we present methods to measure nanometer-scale organization around & between specific proteins in condensates in live cells. We uncover unexpected heterogeneity for a liquid-like phase with local meshwork spanning 10-50nm, stemming from ribosome biogenesis in the nucleolus.

Let’s stop treating "leaving academia" as negative. Scientists train for academia, industry, or what suits them. Industry isn’t an alternative; it’s a choice. In fields like engineering, most PhDs go to industry, and no one calls it "leaving academia." We should train scientists for diverse paths.