🧠⚡️💊New @nature.com publication ! Mimicking opioid analgesia in cortical pain circuits We built a brain-behavior framework to decode spontaneous chronic pain in mice—and to biologically mimic morphine with a synthetic opioid gene therapy nature.com/articles/s41... @pennmedicine.bsky.social

Why do some individuals defy their polygenic score? In the largest study of its kind (402k UKB individuals; 7 continuous traits + 3 diseases), we asked: If your phenotype deviates from common-variant polygenic score prediction, what's driving that difference? www.medrxiv.org/content/10.6...

🚨 New preprint! Why do some insights from spikes translate to field potentials while others don't? In this paper we compare visual memory representations in spikes and LFPs to propose a general framework that answers this question. www.biorxiv.org/content/10.6... 🧵 (1/10) 🧠🟦 🧠💻

I've been thinking about the "virtual cell" concept and wanted to write up a few thoughts. Specifically on how I think the prior experience in GWAS informs the most likely way these models will be useful. andrewcarroll.github.io/2025/12/23/t...

🚨Call for papers: Computational markers of psychosis - From latent states to neurobiological mechanisms! Special issue in Schizophrenia Bulletin🧠 Deadline extended to April 30, 2026 We are looking forward to your papers!!

Final #neuroskyence preprint of the year! We updated our big neuroinflammation project, studying psoriasis-like inflammation in both humans and mice. Main take-home: we see impaired thalamostriatal signalling in humans and mice alongside depression / anhedonia. www.biorxiv.org/content/10.1...

Use the Eisenhower matrix to help you with deciding when/if to do stuff. Not everyone can delegate, of course, but this is where sharing work, asking for more resources can be used as a replacement for delegate.

New study out today in Nature Comms: www.nature.com/articles/s41..., in which we set out to test whether ultrasound could influence the reward-related learning computations of the nucleus accumbens, building on decades of work on dopaminergic prediction error and reinforcement learning. And it did.

fabulous resource. are you a new PI? get yourself added to the list!

this is one of my favourite observations about sample size calculations. (afaik first articulated by Miettinen in 1985)

This chart (which applies even more to social media than it did to TV) lives in my head rent free. Social media enveloping traditional media means everything and everyone is now competing in the entertainment market. Boring stuff like policy that affects millions of lives doesn’t stand a chance.

📣🔥Thrilled to announce that 2026 Computational Psychiatry Conference will take place in New Haven, CT, btw July 14-16 - www.cpconf.org @robbrutledge.bsky.social @drrickadams.bsky.social @tobiasuhauser.bsky.social @docqhuys.bsky.social @clairegillan.bsky.social Sonia Bishop More info to come soon!

Individuals with schizophrenia exhibit region-specific reductions in dendritic spine densities across cortical regions involved in visual-spatial working memory. ja.ma/48dYiTW

“GABA-glutamate corelease is functionally inhibitory or excitatory …., supporting a homeostatic role for GABA-glutamate cotransmission with broad implications for disorders of imbalanced motivation.”

Let me present the Spoon Illusion 🙂🥄 This has been in the works for over a decade when we were just goofing around testing sound localisation in my in-laws' kitchen... But we finally managed to do some reasonably controlled experiments on this. #psychscisky #neuroskyence doi.org/10.1177/0301...

1) INFO FOR RESEARCHERS: The charity ME Research UK (MERUK) has an open call for PhD-level research funding. Applicants should submit an Outline Proposal Form before Friday, 9 January 2026.

I wrote about my knee injury and recent surgery, Oliver Sacks's "A Leg to Stand On", and how a zombie Calvinism continues to distort the American health care system: open.substack.com/pub/kathrynp...

Our study aims to understand psychosis, and improve outcomes for individuals with psychosis. By intervening early, we will provide timely support and care, ultimately enhancing lives. We reached 250 participants! eim.digitrial.com @oxhealthbrc.bsky.social @cpftresearch.bsky.social

Beautifully written, funny, and important. Also ouch.

The importance of the departmental tea room where you can bump into anyone ....the importance of hearing diverse views. Today's post: The Importance of Community occamstypewriter.org/athenedonald...

For lovers of @ourworldindata.org - we have improved our search functionality! Great work by the team at the backend to improve user experience. Enjoy! ourworldindata.org/introducing-...

My review of #Crick by @matthewcobb.bsky.social has been published online by @science.org. The book is lucid, beautifully crafted, and compelling. It will instantly become the definitive guide to this extraordinary individual’s life and work.

Jonny Smallwood @themindwanders.bsky.social was a beloved friend and mentor. He was taken from us too soon. His was a beautiful mind who understood the beauty of minds. As ever before, his kind voice guides me and his work will continue. We miss you Jonny. www.cbs.mpg.de/news/obituar...

Addendum: I quickly wrote something partially about the results, and the potential for misunderstanding, but also about history's profound irony. open.substack.com/pub/arutherf...

at last. Expression of concern has appeared on BMJ stem cell paper with 44 comments pubpeer.com/publications...

That’s quite the entrance to bluesky Loic 😅!!

First time on Bsky and first big announcement! I am excited to announce that our new study explaining the missing heritability of many phenotypes using WGS data from ~347,000 UK Biobank participants has just been published in @Nature. Our manuscript is here: www.nature.com/articles/s41....

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Come and join us here in Cambridge! Applications open for a new faculty position, for a researcher in computational and/or theoretical biology, based jointly in Genetics and Mathematics. Happy to answer questions about research, teaching and working here. www.cam.ac.uk/jobs/faculty...

Gift link! “To reckon with Watson’s legacy, then, we propose celebrating what he wouldn’t—or couldn’t—recognize: the shared intelligence of the human race, which can produce miracles and wonders, even as each of us, individually, is so terribly fallible.“

Gift link:

Very excited to be able to finally share our latest work, "Cloud computing for equitable, data-driven dementia medicine," just published in The Lancet Digital Health! authors.elsevier.com/sd/article/S... more info in thread: 🧵

We just published a paper in PNAS, showing microstructural changes to the hippocampus in aging and presymptomatic Alzheimer's disease - in humans, in vivo. We continue to show the value of structural MRI beyond simply measuring large-scale atrophy! Read here: ow.ly/1NvV50XkXnX

New paper on everyone’s favourite topic, QC! We show why you should do genotype-level QC on your WGS data www.biorxiv.org/content/10.1... Very real quotes about this paper - “The most exciting, mind-blowing paper of the year!” “On a par with Fisher 1918” “I read it every night. Just so beautiful”

If you believe either that Franklin discovered the double helix, and / or Watson and Crick stole her data, ask yourself how you know this. Then take a read of this article.

I finally gave my Professorial Inaugural Lecture. A great night with friends, family, & colleagues, & sharing the stage with a good friend @cmcgettigan.bsky.social🥂 Watch: www.youtube.com/watch?v=vsTG... Bookmarks flag both my lecture and @celiaheyes.bsky.social’s (far more entertaining!) intro

Are you a UK mental health professional working with children with mental health issues - we are asking for help designing a study for social robots to complete mental health questionnaires with children aged 8 to 10 - more infor here cambridge.eu.qualtrics.com/jfe/form/SV_...

Academics in Assyria in the 7th c BC complain that admin is preventing them from doing research and teaching

The second paper (on change scores) was an explanation of why outcome change scores should not be used in observational studies. Started in 2017, it went through 2+ years of brutal peer review before being published in 2021. I'm so glad people are reading it! academic.oup.com/ije/article/...

Dear Physicists and Physics fans, I would like to encourage you to celebrate #WomenInPhysics Day this Friday, November 7th. Why November 7th? Because it is the birthday of two of the most impactful women physicists of the 1900's: Marie Curie and Lise Meitner. 🎢 ⚛️ 🧪 👩‍🔬

Practice? One of my favorite things about grad school, was the constant opportunity to talk through ideas. I search that out now. My favorite work is when I am part of a team that really takes time to talk through ideas

𝗡𝗼𝗻𝗶𝗻𝘃𝗮𝘀𝗶𝘃𝗲 𝘀𝘂𝗽𝗽𝗿𝗲𝘀𝘀𝗶𝗼𝗻 𝗼𝗳 𝗿𝗲𝘀𝗽𝗼𝗻𝘀𝗲𝘀 𝘁𝗼 𝘁𝗵𝗿𝗲𝗮𝘁 𝘂𝘀𝗶𝗻𝗴 𝗳𝗼𝗰𝘂𝘀𝗲𝗱 𝘂𝗹𝘁𝗿𝗮𝘀𝗼𝗻𝗶𝗰 𝘄𝗮𝘃𝗲𝘀 That's noninvasive! And the bed nucleus of the stria terminalis is small. Let's see what people think. doi.org/10.1523/JNEU... #neuroskyence

We’ve put up summary statistics for over 3,000 traits in the All of Us resource, and a shiny new browser alongside it! Explore your favorite gene or phenotype here: allbyall.researchallofus.org #ASHG24

🚨Do you need validated German sentences for your language experiment?🇩🇪🗯️ Check out our Munich Sentence Database (MuSe) munichsentencedatabase.franziskaknolle.com 619 sentences with cloze probabilities, entropy & recorded audio–all open access! Brilliant work by my PhD student @esterner.bsky.social 👏

My article in tomorrow's @theobserveruk.bsky.social now online. But go and buy a copy!

New from star grad student @m-meyer.bsky.social we wanted to study why delusions (and other beliefs) are so fixed. We turned to a generalization paradigm and the peak shift effect. Martin finds people with delusions over generalize causal relationships during learning: osf.io/preprints/ps...

Calling ALL health data folk: Re UK Health Data Research Service. The UK gov & Wellcome have pledged up to £600 million to create a HDRS. Myself & an ace team have been tasked by Wellcome to assess the existing health data ecosystem & identify what is needed to support the HDRS 👇. Get in touch

The cumulative effect of these improvements (and others not mentioned!) is enormous. For tough samples, like lung, incorrectly assigned signals are reduced by up to 9000-fold, and a 10- to 3000-fold improvement is common. Look at this ground truth experiment, showing wildtype vs GFP lung:

i’m pleased to have found this old post by Andrew Gelman, who is more perceptive about replications than anyone else I know statmodeling.stat.columbia.edu/2013/12/17/r...

FUNDING ALERT! The new @SSA_Addiction schemes funded by @UK_Life_Science are going live soon. All information below!! Are you an addiction researcher? There are opportunities galore!! @rcpsychAddFac @NHS_APA @addictionprofs @NPS_issed www.addiction-ssa.org/news/new-fun...