Excited to share our new study characterizing spatial gene expression in the human NAc led by @prashanthi-ravi.bsky.social @svitlanabach.bsky.social @rphillips3.bsky.social in collaboration with @martinowk.bsky.social @stephaniehicks.bsky.social @alexisbattle.bsky.social @lcolladotor.bsky.social.

Thought I'd give this place a go again. I'm Kim. I'm a psychiatrist who does research on genetics and proteomics. I also do a lot of recruitment of people with psychosis for research studies. My clinical work is in a psychiatric genetics clinic in Cardiff.

New preprint: "Multivariable Mendelian randomization with weak instruments: a comparison of Bayesian and frequentist methods" led by Andrew Grant: arxiv.org/abs/2606.26638. We present a method for multivariable Mendelian randomization (MVMR): MVMR-Pony. Thread follows:

Delighted to share that the Early Intervention Mission has now surpassed 650 recruited participants — currently at 662 and counting 🎉 EIM is a UK-wide study aiming to transform early detection and intervention in mental health, helping us better understand and respond to difficulties.

They are going "all in" on zebrafish - do I have that right?

Read the introduction to my chapter, The Medical Model of Psychopathology, here: www.psychiatrymargins.com/p/the-medica...

New from our group - This longitudinal study shows 🎵 Songmaking in a group 🎵 reduces paranoia in people with schizophrenia, possibly by changing their prior beliefs about volatility osf.io/preprints/ps... huge congrats to first author Deanna Greco - a very talented graduate student - and team

100% worth your 63 seconds if you have my reading speed. sinceyouarrived.world/taken

This is the May cover of NN but it has already been debunked on biorxiv www.biorxiv.org/content/10.6... Such a clear statement about the ridiculous pace of publishing (not just NN).

Too kind, but that's not what I had in mind. Whatever you think about its author, THE DOUBLE HELIX, because it's a memoir, describes (not entirely accurately) the detailed process of discovery, what scientific work is. Is there such a book today? Or would it all be about applying for grants?

Welcome the great @john-duncan.bsky.social to Bluesky. A neuroscientist renowned for his work on the brain's "multiple-demand" system, which supports complex thinking, problem-solving, and intelligent behaviour. His research has shaped how we understand cognitive control and human intelligence.

New preprint! w/ @mheilbron.bsky.social We found that, even during simple natural scene viewing, human visual cortex predicts—hierarchically in central vision and at higher levels peripherally—reconciling classical predictive coding with recent evidence from animal models and AI (e.g. JEPA) (1/10)

Just out! Expectations modulate stimulus-evoked recurrent, but not feedforward, processing, and this is attention-dependent. NMDA-dependent feedback specifically supports perceptual integration (illusory contours), rather than mediating expectations (base rate). www.jneurosci.org/content/46/1...

An updated on Wellcome LEAP's $50 million FORM programme. deevybee.blogspot.com/2026/03/upda... #autism #microbiome

We’re pleased to announce the appointment of Professor @charlottesummers.bsky.social as our new Dean of the Faculty of Medicine. A member of our alumni, she joins us from the University of Cambridge where she leads the Victor Phillip Dahdaleh Heart & Lung Research Institute. 👉 tr.ee/wtJGHv

I build a feed for european grant funding that's updated daily and (IMO) far more transparent then the official EU fundign website: michelnivard.github.io/eu-grants-fe... (inspired by the NIH equivalent @sashagusevposts.bsky.social build yesterday)

I tracked every keyword in 22 years of Cosyne abstracts to map how computational neuroscience evolved — from Bayesian brains to neural manifolds to LLMs — and where it's heading next.

🚨🚨New work just out by the truly stellar Will Snyder - revealing rare and common genetic influences on complexity of human cortical folding !! 🚨🚨 👀 Will’s thread ⬇️ for deets, and to follow on @willsnyder.bsky.social Huge congrats to Will & thnx to fabulous collaborators who made this possible.

very enjoyable day @cpft-nhs.bsky.social at opening of our Peterborough research hub AM & teaching our residents psychopathology PM. Somewhat sore from running the Cambridge half yesterday for the excellent CPFT Head to Toe Charity - any final donations very welcome! shorturl.at/u64Rd

This recent RCT of an "AI stethoscope" claims the technology "shows promise" for diagnosing cardiovascular conditions. It does not. It is a textbook example of the risks of conducting unprincipled 'per protocol analyses'. Once again, peer review at a major medical journal has failed. 🧵 1/

Amazing. UK leading the way . Finland in silver medal position ? and I predict Switzerland could join them on the podium at some point over the next year or two

I think it's a problem for the wider public that there are so few books talking about how science is done and the lives of those who do it. occamstypewriter.org/athenedonald...

A cubic millimetre of the human brain. The whole thing is about 960,000 times this size, giving you some idea of the mind-boggling complexity we have yet to encounter. But you have to start somewhere.

OpenSAFELY is open from today! Huge thanks to all who supported this vast collaboration: whole population GP data; in a productive platform; innovative privacy protections; unprecedented support from professions, privacy campaigners; &c Now it's over to users! www.bennett.ox.ac.uk/blog/2026/02...

In this episode of the Under Review podcast, I talk to @andytattersall.bsky.social about research fraud detection, papermills, and that rat. open.spotify.com/episode/0pYD...

"we recommend that advice from independent clinical experts should be sought to advise what degree of adverse BOLD fMRI signal change between scans would necessitate withdrawal from the study" - UK Medicines and Healthcare regulatory authority to RCT sponsor #Medsky 🩺🧠 #fMRI #Neuroskyence

I don’t know who needs to hear Jesse Jackson leading the kids on Sesame Street in this beautiful call-and-response reminding them that every child is somebody, but here it is

Our new meta-analysis & Mendelian randomization study shows that substance misuse, particularly cocaine, amphetamines, and cannabis, are associated with increased risk of stroke. Read more: journals.sagepub.com/doi/10.1177/... @cambridgecardio.bsky.social @camneuro.bsky.social @vpd-hlri.bsky.social

Does anyone use the Spanish version of the RBANS ("Repeatable Battery for the Assessment of Neuropsychological Status")? If you are able to send us an original form, we would be happy to compensate you for it.

Preprint alert!!! We recorded directly from the human ventral tegmental area (VTA), the principal source of cortical dopaminergic innervation, while patients performed an instrumental learning task. 🧵👇 www.biorxiv.org/content/10.6...

Hot take: one of the main benefits of running data analyses in 🐬 Docker 🐬 isn't reproducibility, but saving yourself (or your lab) hundreds or thousands of pounds in computer costs*. Here's how... #datascience #docker #rstudio #python *for a very niche set of people

Pleased to be able to offer a summer placement at the Centre for Neuropsychiatric Genetics and Genomics @cardiffuni.bsky.social through this scheme. Research Access Placements are open to undergraduates from underrepresented backgrounds @gensocuk.bsky.social

I’ve had your words tattooed on my body. I need them there. They help me. I am so grateful for all you do 🙏🙏🙏💪💪💪❤️❤️❤️

Our paper, MR-link-2 has just been published! Offering pleiotropy robust Mendelian randomization from a single region! www.nature.com/articles/s41...

With some trepidation, I'm putting this out into the world: gershmanlab.com/textbook.html It's a textbook called Computational Foundations of Cognitive Neuroscience, which I wrote for my class. My hope is that this will be a living document, continuously improved as I get feedback.

I am now hiring a PhD student in deep learning for medical images, to work at the Department of Biomedical Engineering (IMT) for our ELLIIT project on federated learning. Application deadline February 19. web103.reachmee.com/ext/I011/853...

See Jim’s comments and the whole thread.

Congrats to @torwager.bsky.social and Deanna Barch for the @nationalacademies.org Atkinson prize!! Within the umbrella of Psychological and Cognitive Sciences, they recieved it for their work in the psychiatric space (Wager: emotion/pain; Barch: Schizophrenia). www.nasonline.org/award/atkins...

𝗛𝗼𝘄 𝗱𝗼 𝗯𝗿𝗮𝗶𝗻 𝗮𝗿𝗲𝗮𝘀 𝗿𝗲𝗹𝗮𝘁𝗲𝗱 𝘁𝗼 𝗳𝘂𝗻𝗰𝘁𝗶𝗼𝗻? "High-resolution activity maps of PFC did NOT align with cytoarchitecturally defined subregions." Key tenet in neuroscience is that cytoarchitectonic boundaries correspond to functional ones. NB: study in the mouse #neuroskyence doi.org/10.1038/s415...

This is an excellent group, and look at all those videos you can find online 👀 So much stuff to learn! cls-data.github.io/CIIG/

I'm so sorry to share that Friedemann Pulvermüller, brilliant neuroscientist, has passed. He gave Embodiment ideas legs and worked tirelessly on treatments for stroke victims during his storied career. His kindness and wry humor made him sparkle.

Apply by Feb 9th to NICE to serve as professional committee member - Severe and enduring mental illness medsky #Psychiatry #Mentalhealth

🧠⚡️💊New @nature.com publication ! Mimicking opioid analgesia in cortical pain circuits We built a brain-behavior framework to decode spontaneous chronic pain in mice—and to biologically mimic morphine with a synthetic opioid gene therapy nature.com/articles/s41... @pennmedicine.bsky.social

Why do some individuals defy their polygenic score? In the largest study of its kind (402k UKB individuals; 7 continuous traits + 3 diseases), we asked: If your phenotype deviates from common-variant polygenic score prediction, what's driving that difference? www.medrxiv.org/content/10.6...

🚨 New preprint! Why do some insights from spikes translate to field potentials while others don't? In this paper we compare visual memory representations in spikes and LFPs to propose a general framework that answers this question. www.biorxiv.org/content/10.6... 🧵 (1/10) 🧠🟦 🧠💻

I've been thinking about the "virtual cell" concept and wanted to write up a few thoughts. Specifically on how I think the prior experience in GWAS informs the most likely way these models will be useful. andrewcarroll.github.io/2025/12/23/t...

🚨Call for papers: Computational markers of psychosis - From latent states to neurobiological mechanisms! Special issue in Schizophrenia Bulletin🧠 Deadline extended to April 30, 2026 We are looking forward to your papers!!

Final #neuroskyence preprint of the year! We updated our big neuroinflammation project, studying psoriasis-like inflammation in both humans and mice. Main take-home: we see impaired thalamostriatal signalling in humans and mice alongside depression / anhedonia. www.biorxiv.org/content/10.1...

Use the Eisenhower matrix to help you with deciding when/if to do stuff. Not everyone can delegate, of course, but this is where sharing work, asking for more resources can be used as a replacement for delegate.