New paper on everyone’s favourite topic, QC! We show why you should do genotype-level QC on your WGS data www.biorxiv.org/content/10.1... Very real quotes about this paper - “The most exciting, mind-blowing paper of the year!” “On a par with Fisher 1918” “I read it every night. Just so beautiful”

If you believe either that Franklin discovered the double helix, and / or Watson and Crick stole her data, ask yourself how you know this. Then take a read of this article.

I finally gave my Professorial Inaugural Lecture. A great night with friends, family, & colleagues, & sharing the stage with a good friend @cmcgettigan.bsky.social🥂 Watch: www.youtube.com/watch?v=vsTG... Bookmarks flag both my lecture and @celiaheyes.bsky.social’s (far more entertaining!) intro

Are you a UK mental health professional working with children with mental health issues - we are asking for help designing a study for social robots to complete mental health questionnaires with children aged 8 to 10 - more infor here cambridge.eu.qualtrics.com/jfe/form/SV_...

Academics in Assyria in the 7th c BC complain that admin is preventing them from doing research and teaching

The second paper (on change scores) was an explanation of why outcome change scores should not be used in observational studies. Started in 2017, it went through 2+ years of brutal peer review before being published in 2021. I'm so glad people are reading it! academic.oup.com/ije/article/...

Dear Physicists and Physics fans, I would like to encourage you to celebrate #WomenInPhysics Day this Friday, November 7th. Why November 7th? Because it is the birthday of two of the most impactful women physicists of the 1900's: Marie Curie and Lise Meitner. 🎢 ⚛️ 🧪 👩‍🔬

Practice? One of my favorite things about grad school, was the constant opportunity to talk through ideas. I search that out now. My favorite work is when I am part of a team that really takes time to talk through ideas

𝗡𝗼𝗻𝗶𝗻𝘃𝗮𝘀𝗶𝘃𝗲 𝘀𝘂𝗽𝗽𝗿𝗲𝘀𝘀𝗶𝗼𝗻 𝗼𝗳 𝗿𝗲𝘀𝗽𝗼𝗻𝘀𝗲𝘀 𝘁𝗼 𝘁𝗵𝗿𝗲𝗮𝘁 𝘂𝘀𝗶𝗻𝗴 𝗳𝗼𝗰𝘂𝘀𝗲𝗱 𝘂𝗹𝘁𝗿𝗮𝘀𝗼𝗻𝗶𝗰 𝘄𝗮𝘃𝗲𝘀 That's noninvasive! And the bed nucleus of the stria terminalis is small. Let's see what people think. doi.org/10.1523/JNEU... #neuroskyence

We’ve put up summary statistics for over 3,000 traits in the All of Us resource, and a shiny new browser alongside it! Explore your favorite gene or phenotype here: allbyall.researchallofus.org #ASHG24

🚨Do you need validated German sentences for your language experiment?🇩🇪🗯️ Check out our Munich Sentence Database (MuSe) munichsentencedatabase.franziskaknolle.com 619 sentences with cloze probabilities, entropy & recorded audio–all open access! Brilliant work by my PhD student @esterner.bsky.social 👏

My article in tomorrow's @theobserveruk.bsky.social now online. But go and buy a copy!

New from star grad student @m-meyer.bsky.social we wanted to study why delusions (and other beliefs) are so fixed. We turned to a generalization paradigm and the peak shift effect. Martin finds people with delusions over generalize causal relationships during learning: osf.io/preprints/ps...

Calling ALL health data folk: Re UK Health Data Research Service. The UK gov & Wellcome have pledged up to £600 million to create a HDRS. Myself & an ace team have been tasked by Wellcome to assess the existing health data ecosystem & identify what is needed to support the HDRS 👇. Get in touch

The cumulative effect of these improvements (and others not mentioned!) is enormous. For tough samples, like lung, incorrectly assigned signals are reduced by up to 9000-fold, and a 10- to 3000-fold improvement is common. Look at this ground truth experiment, showing wildtype vs GFP lung:

i’m pleased to have found this old post by Andrew Gelman, who is more perceptive about replications than anyone else I know statmodeling.stat.columbia.edu/2013/12/17/r...

FUNDING ALERT! The new @SSA_Addiction schemes funded by @UK_Life_Science are going live soon. All information below!! Are you an addiction researcher? There are opportunities galore!! @rcpsychAddFac @NHS_APA @addictionprofs @NPS_issed www.addiction-ssa.org/news/new-fun...

Pre-phasing long reads improves structural variant genotyping academic.oup.com/bioinformati... 🧬🖥️🧪 github.com/Zilong-Li/SV...

New pre-print "Mendelian randomization in a multi-ancestry world: reflections and practical advice" led by @amymariemason.bsky.social on - arxiv.org/abs/2510.17554

New paper from the lab: www.nature.com/articles/s41... A brief thread (1/10)

www.officeforstudents.org.uk/news-blog-an.... On visiting the USA last week several academic colleagues had got the impression that the UK was becoming increasingly illiberal. I would like to point them to this speech by arif ahmed which illustrates the UKs firm commitment to Academic freedom

Absolutely cannot wait to join Rob Delaney to discuss our books & what The Story of a Heart tells us about compassion, care, medical innovation & the NHS 🫀💗🩺 Thank you @intelligence2.bsky.social for arranging this dream conversation. Please join us! 📆 13 Nov 📍 Kiln Theatre, London ⏰ 7pm

Why are #youngpeople not equally represented in #mentalhealthresearch? In today’s article, PhD student Rachel Perowne shares findings from her systematic review, revealing why some young people remain #underrepresented and how to make research more #inclusive. www.inspirethemind.org/post/mind-th...

Great piece by @natolambert.bsky.social on the current state of human exhaustion in the AI world. Makes this important point:

A new essay on the crazy, all or nothing approach to work happening in AI today, the looming human costs, and the lack of a finish line. I wouldn't say it's okay, but I'm not sure how to fix it. www.interconnects.ai/p/burning-out

I know that Galton called out for sharing data in 1901

Astrocytes share the same electrical properties as neurons. They spread electrical signals but don’t spike. So, while only about half the cells spike occasionally, all of them continuously transmit electrical influences. Which, then, is the tail and which is the dog?

Congrats to a legend of neuroanatomy! Her findings are foundational and her figures (or those inspired by them) are fixtures of basal ganglia talks

I am probably biased (same dept), but that you're able to treat a specific symptom with TMS (hearing voices in schizophrenia) is pretty cool I think - and a step towards precision psychiatry! And this is a proper RCT and all... www.thelancet.com/journals/lan...

1/ "Hemispherotomy leads to persistent sleep-like slow waves in the isolated cortex of awake humans" - out now in @plosbiology.org, led by Michele Colombo, Jacopo Favaro, & Marcello Massimini. 🧠

🎉 New preprint out! "Removing genetic effects on plasma proteins enhances their utility as disease biomarkers" We show that adjusting plasma proteins for genetic effects can make them stronger predictors of disease 👉 doi.org/10.1101/2025...

Roll up, roll up. Get your snake oil and miracle cures here! ✅ Precision medicine ✅ Automated causal inference ✅ Polygenic scores ✅ 1000+ outcome prediction models ✅ In sillico trials ✅ Exposomics ✅ Anything involve 'AI' ✅ Any other trend, shortcut, or bandwagon!

This was student initiated and led and I am so proud of what they have done

New paper alert! @zeinawaheed.bsky.social led this scoping review exploring models for delivery of Pharmacogenomic testing. Free access here: www.tandfonline.com/doi/full/10.... #AcademicSky 🧪

🚨 The preprint for our GWAS of Alzheimer’s disease (AD) is out Preprint: medrxiv.org/content/10.1... 🧵

Proud that the third GWAS for Alzheimer's dementia from the PGC-ALZ working group was just posted online! Huge amounts of work, and what a great collaboration! Check out our exciting findings below 👇 @pgcgenetics.bsky.social #ctglab #alzheimer #dementia #GWAS

Really interesting work by Bakhurin and colleagues challenging the reward prediction error hypothesis of dopamine: www.nature.com/articles/s41... I love this figure which both echoes and undermines the famous figure from Schultz et al. (1997).

Just in time for #ASHG2025, a new FinnGen public data release is live! This release features the first clinical laboratory value association results. Analyses cover 383 lab measurements (OMOPIDs) with data from ≥1,000 participants each. Access the results here: www.finngen.fi/en/access_re...

Nice preprint from Veronica Alvarez's group on cortically-evoked DA mediated by ACh! I We observed something quite similar in birds, and interesting to see the sensory/prefrontal distinction

🤖 If you use LinkedIn, please be aware that they automatically use your profile to train their GenAI. To turn off, go to Settings > Data Privacy > Data for Gen AI improvements.

The extremely problematic use of change scores is so poorly understood by researchers that it’s almost sickening. Most don’t even understand what is needed for the subtraction operator to work. hbiostat.org/bbr/change

Yes!! We've seen it as part of our prior study: pubmed.ncbi.nlm.nih.gov/20566748/

Why does the naked mole rat have the longest lifespan of any rodent, nearly 40 years? A 30-year long mystery unraveled @ScienceMagazine today! Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation www.science.org/doi/10.1126/...

When is work not work? What is the workiest work? gavinbuckingham.wordpress.com/2025/10/07/w...

Some good advice in here but one critical piece I always give is this: Get a hobby. Preferably a mildly social one. One that has NOTHING TO DO WITH SCIENCE. NOTHING. You need friends. Not colleagues. FRIENDS. Friends who will love you no matter your research prospects...

Michael X Cohen on why he left academia/neuroscience. mikexcohen.substack.com/p/why-i-left...

Fascinating thread about the identification of one of the first genes with a clear role in human speech and language! Extra credit for those who dig in to find out why its called a "forkhead domain" 🧪

When writing Elusive Cures, a goal was to spell out how research types connect w/ understanding brain disorders. I struggled for evolutionary approaches (ala ‘What did this evolve for?‘ instead of ‘What is it and how does it break?’ But I missed /1 www.unsiloedpodcast.com/episodes/epi...

Very useful tips…

⏳ One Week Left! Submit for the SIRS Research Fund Award by 9 October 2025. This award supports early career investigators in launching innovative projects to advance understanding, prevention, and treatment of schizophrenia. 🔗 Learn More: schizophreniaresearchsociety.org/join/researc...