A discovery in mice reveals why fasting enhances a type of breast cancer treatment go.nature.com/4oUCGCk

Molecular determinants for recognition of serotonylated chromatin academic.oup.com/nar/article/...

Contrasting roles of MLL3 and MLL4 histone methyltransferases in breast cancer www.nature.com/articles/s41...

Requirements for establishment and epigenetic stability of mammalian heterochromatin. www.cell.com/molecular-ce...

Online Now: Extrachromosomal DNA associates with nuclear condensates and reorganizes chromatin structures to enhance oncogenic transcription

Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength

With the help of a technique called Massively Parallel Ribosome Profiling, researchers in Science have identified more than 4000 open reading frames—stretches of genetic material that can encode proteins—across 679 human-associated viral genomes. scim.ag/43RoAdF

Research about host-microbiome co-evolution on fungal infection in indigenous Malaysians, done by University of Malaya and NIH, on Cell. www.cell.com/cell/fulltex...

Now online! Serotonin transporter inhibits antitumor immunity through regulating the intratumoral serotonin axis

👀Preview for Lane et al: Cellular reprogramming by protein degradation: The next frontier in cancer immunotherapy by Anjana Rao @AnjanaRaoLab, Erik Ehinger @erik_ehinger at

The new issue is out! 👉 cell.com/cell/current ⁠ In this issue of Cell, Yu et al. capture evolution of KoRV-A transcriptional silencing as the virus transitions from a pathogen to a stable endogenous retrovirus. The cover features an adult koala with a joey. 📷 Credit: Currumbin Wildlife Sanctuary

Now online! Integrator loss leads to dsRNA formation that triggers the integrated stress response

Interested in the latest advancements of #epigenetics of #mammalian early embryogenesis? Then join our upcoming mini-symposium in Freiburg! 📅 April 24, 2025, 14:00-19:00 PM 📌 Max Planck Institute, Freiburg (only on-site!) 🛠️ Organized by: @iovino-lab.bsky.social Register & join free of charge.

🧑‍🔬 Summer Research Internship opportunity focus on multi-omics technologies and AI in Precision Medicine. 🧬💻🤖💊 Molecular Medicine Research Center (MMRC) at Chang Gung University, Taiwan will offer 8 internship positions for international students. teep.studyintaiwan.org/program/1178

Aspirin slow cancer metastasis by decrease platelet TXA2 and releasing T cells from suppression. www.nature.com/articles/s41...

The guide I wish I had 12 years ago: a step-by-step guide to replicate a genomics paper figure divingintogeneticsandgenomics.kit.com/32726a816b

Nature research paper: Tumour-wide RNA splicing aberrations generate actionable public neoantigens https://go.nature.com/4hTQ0UW

A two-and-a-half-year-old girl shows no signs of a rare genetic disorder, after becoming the first person to be treated for the motor-neuron condition while in the womb. https://go.nature.com/41a7Zzj

In www.biorxiv.org/content/10.1... we propose that #KRAS #dosage integrates signaling & transcription to regulate cell states, driving #heterogeneity, progression & #metastasis

If you want to learn single-cell analysis from scratch with an user friendly, hands on, approach I very strongly recommend the series of FREE workshops offered by the SAIL team at @mskcancercenter.bsky.social , lead by @ronanchaligne.bsky.social . sail.mskcc.org/computationa...

Our 🔥 brand-new PhD program IMPRS-EBM at the intersection of #Epigenetics, #Biophysics & #Metabolism is open for applications📢. Looking for a fully-funded #PhDposition at Max Planck? Here is your chance: www.ie-freiburg.mpg.de/IMPRS-PhD-Pr...

Want to apply to our next Call for Application in collaboration with Daiichi Sankyo? Join our Infosession on 14th February 2025, at 6:00 PM CET (12:00 PM EST | 9:00 AM PST) to learn everything you need to know us02web.zoom.us/webinar/regi...

✨ Excited to share my latest preprint on how H3K4 methylation promotes transcriptional memory from gametes to embryos across a transcriptionally silent window — crucial for proper zygotic genome activation and development. 🐸🧬✨ 📄 Check it out here:
doi.org/10.1101/2025... 👇 Highlights below

The role of the maternal X chromosome in brain aging www.nature.com/articles/s41... www.nature.com/articles/d41... @nature.com

🧪Wonderful study and visualization from @lucas.farnunglab.com and @jonmarkert.bsky.social, uncovering how SETD2 - an important but challenging cancer drug target - interacts with chromatin to catalyze H3K36me3. Congratulations to all involved!

How can we track age-related changes of the ovary, testes and reproductive system? A new review @natureaging.bsky.social www.nature.com/articles/s43...

So excited that our work on predicting gene expression from histone modifications using deep learning is out in NAR today. Brilliant to work with lead author @al-murphy.bsky.social and collaborators Aydan Askarova, @borislenhard.bsky.social and Nathan Skene 🧬⭐️🙏 academic.oup.com/nar/advance-...

www.biorxiv.org/content/10.1... Our study published today on #bioRxiv describe the identification of a deaminase that converts 5mC to T, enabling direct sequencing of the human methylome and genome. This achievement was made possible through a collaborative effort across all departments at #NEB.

This years keynote at the Epigenetics Meeting was very special: This morning, welcomed the President of @maxplanck.de who gave a stunning keynote on the structural biology research in his lab at @mpi-nat.bsky.social tracked with us how projects that started partly decades ago evolved over the years!

Please RS/RT. #GordonConference on "Histone and DNA Modifications" #epigenetics #chromatin 20-25. July 2025. Il Ciocco, Italy. Great speaker lineup. ➡️Register now www.grc.org/histone-and-...

We are in the middle of the first sessions at the 2024 Max Planck Freiburg Epigenetics Meeting. Find here some impressions from the welcome and warm-up. 🔥 1/X

The latest from our group, led by Megan Ostrowski and @martyyang.bsky.social, is now published in final form (www.cell.com/cell/fulltex...! Many thanks to our excellent peer reviewers for suggesting several experiments (including CAF-1 perturbation) to really improve the study =) #epigenetics

We are super excited. Tomorrow starts the 7th Max Planck Epigenetics Meeting in #Freiburg. We have an exciting line-up. Who is already in Freiburg or on its way? Raise your hands? 🙋‍♂️🙋‍♀️

The UX of LEGO Interface Panels interactionmagic.com/UX-LEGO-Inte...

Gene regulation involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. Our paper in Nature Genetics describes ChIP-DIP, a method for genome-wide mapping of hundreds of DNA-protein interactions in a single experiment. www.nature.com/articles/s41...

I have mixed feelings about the article "Behind the Graduate Mental Health Crisis in Science". It gives the impression of causality, i.e., that science is the cause of the worsening mental health crisis, but this may be a reflection of societal shift. www.nature.com/articles/s41...

The obligatory ❄️winter is here❄️-post. Winter Wonderland at the MPI-IE in Freiburg, Germany.

In this episode of the Epigenetics Podcast, we talked with Yadira Soto-Feliciano from MIT about her work on the Menin-MLL complex and the effect of small molecules on its stability in leukemia. #podcast #epigenetics #chromatin Listen here: https://buff.ly/3Ojf3nc

Our new-ish preprint: RNA Polymerase II coordinates histone deacetylation at active promoters www.biorxiv.org/content/10.1...

Our recent study in Cell Metabolism provides compelling evidence that chromatin accessibility and transcription factor network remodeling in aging reflect the predictable degrading effects of a mechanism initially driving organismal maturation. Link: doi.org/10.1016/j.cmet.2024.06.006 Thread 🧵👇1/9

Our story in PNAS today! (1) anti-AR molecules with new mechanism: induction of chromatin binding YET a disruption of transcription (2) why only ~150 genes respond to AR ligands, despite the 6,000+ AR binding sites: they need 3D clustering to matter! www.pnas.org/doi/10.1073/pnas.2406239121

Our paper on a centromere-enriched retroelement is out! link.springer.com/article/10.1... Congratulations to all the authors! Comments and reposts welcome and appreciated 🧬🔬

Reviewed this interesting paper y'day in jrl club, inhibiting IL-1beta good for stroke-induced cardiac damage

🚨Preprint alert! tinyurl.com/2zkmynsd Did you ever dream of reconstruction #spatial single-cell #enhancer activity in a multicellular organism using massively parallel enhancer-reporter assays? Then Spatial-scERA is the method for you! #spatialOMICs

Adipose tissue retains an epigenetic memory of obesity after weight loss. nature.com/articles/s41586-024-08165-7

We have 15 PhD positions available as part of the DANIO-ReCODE MSCA DN 🇪🇸🇩🇪🇸🇮🇭🇷🇦🇹🇬🇧 Great opportunity for anyone interested in developmental biology, regeneration, genomics, and computational sciences. For project descriptions and how to apply, check: euraxess.ec.europa.eu/jobs/290548