New paper in Nature Comms with Isaac Brownell NIAMS, identifying #repurposing treatment options for the rare Merkel Cell Carcinoma (MCC). We found Aurora kinase criticality in genetic & chemogenomic screens - wonderful collaboration @gryderart.bsky.social #NCATS www.nature.com/articles/s41...

Proud of my collaborator @KidCancerLab for discovering how wound healing programs promote lung metastasis! "Aberrant activation of wound healing programs within the metastatic niche facilitates lung colonization by osteosarcoma cells" aacrjournals.org/clincancerre...

Our story in PNAS today! (1) anti-AR molecules with new mechanism: induction of chromatin binding YET a disruption of transcription (2) why only ~150 genes respond to AR ligands, despite the 6,000+ AR binding sites: they need 3D clustering to matter! www.pnas.org/doi/10.1073/pnas.2406239121