N End Rules
@n-end-rules.bsky.social
📤 351
📥 175
📝 16
Destabilising..
pinned post!
My first
@bsky.app
post could only be
#crossing
two accessions of
#arabidopsis
from very different 🏔️
#genetics
#plantscience
a kind of meditation.
over 1 year ago
0
20
1
reposted by
N End Rules
bioRxivpreprint
about 21 hours ago
An oxygen-sensing Polycomb-group protein encodes flooding stress memory in plants
https://www.biorxiv.org/content/10.64898/2026.05.01.722198v1
0
2
3
reposted by
N End Rules
Sjon Hartman
about 20 hours ago
So happy and proud to share our lab’s first
#plantscience
research article, revealing that angiosperms have the capacity to encode memory of flooding stress. A heroic effort by
@aidamaric.bsky.social
in collaboration with
@djgibbs.bsky.social
and others. A brief 🧵
www.biorxiv.org/content/10.6...
loading . . .
https://www.biorxiv.org/content/10.64898/2026.05.01.722198v1
6
58
33
Is this the end of science as we know it?
mikhoelias.substack.com/p/how-ai-bre...
loading . . .
How AI Breakthrough Could Shake the Scientific Publishing Process
Recent Image generation and LLM models are so good they can produce digital assets nearly undistinguishable from genuine ones.
https://mikhoelias.substack.com/p/how-ai-breakthrough-could-shake-the?triedRedirect=true
10 days ago
0
1
0
reposted by
N End Rules
Cheshire
11 days ago
For those who missed this at the other place:
open.substack.com/pub/mikhoeli...
loading . . .
How AI Breakthrough Could Shake the Scientific Publishing Process
Recent Image generation and LLM models are so good they can produce digital assets nearly undistinguishable from genuine ones.
https://open.substack.com/pub/mikhoelias/p/how-ai-breakthrough-could-shake-the
2
27
15
reposted by
N End Rules
Nottinghamshire
12 days ago
University of Nottingham set to cut 600 jobs in major cost-cutting move
#Nottinghamshire
#Notts
loading . . .
University plans 600 job cuts in major cost-cutting move
The university hopes the move will stop it from running out of cash
https://www.nottinghampost.com/news/nottingham-news/university-nottingham-set-cut-600-10933176
0
1
1
reposted by
N End Rules
Thomas Arnesen
14 days ago
N-terminal cysteine dependent proteolysis of RGS4/5 is not sensitive to physiological oxidative stress | Preprint by Ya-Min Tian, Haeun Kim, Peter Ratcliffe & Thomas Keeley
@ox.ac.uk
@ispt-proteinterm.bsky.social
#N-degron
#cysteine
www.biorxiv.org/content/10.6...
loading . . .
https://www.biorxiv.org/content/10.64898/2026.04.20.719627v1
0
8
4
reposted by
N End Rules
Plant Energy Biology Lab
13 days ago
We knew PCOs & ERFVIIs regulated plant hypoxia, but this work shows they also manage the 'reoxygenation' stress.
www.nature.com/articles/s41...
@biology.ox.ac.uk
@ox.ac.uk
@uni-muenster.de
loading . . .
H2O2 repurposes plant O2 sensing to regulate post-hypoxia responses - Nature
Experiments in Arabidopsis demonstrate that group VII ethylene response factors show differential responses to different stimuli, enabling plants in flood-prone environments to adapt to both submergen...
https://www.nature.com/articles/s41586-026-10366-1
1
31
14
reposted by
N End Rules
Kawamura Research Group
19 days ago
🎉 Thrilled - our new Nature Chemistry paper identifying H3K9acOH, a new histone PTM formed by JmjC oxygenase KDM3A - revealing an O2‑dependent PTM in chromatin regulation. Congrats to CRUK KDM team in the Kawamura & Schofield groups & thanks to our amazing collaborators! 📄
rdcu.be/fdx4f
#Epigenetics
0
9
5
reposted by
N End Rules
New Phytologist
20 days ago
Generation of Brassica napus with enhanced Sclerotinia sclerotiorum resistance through CRISPR/Cas9‐mediated inhibition of the PROTEOLYSIS6 N‐degron pathway Lin et al.
nph.onlinelibrary.wiley.com/doi/10.1111/...
1
8
6
The N-degron pathways move from basic to applied science. This pathway will prove to be of key importance for agricultural improvement. Very happy to have been a part of this work led by Chen Lin and colleagues.
#plantscience
#nendrule
#hypoxia
nph.onlinelibrary.wiley.com/doi/10.1111/...
loading . . .
Generation of Brassica napus with enhanced Sclerotinia sclerotiorum resistance through CRISPR/Cas9‐mediated inhibition of the PROTEOLYSIS6 N‐degron pathway
Click on the article title to read more.
https://nph.onlinelibrary.wiley.com/doi/10.1111/nph.71146
20 days ago
0
5
2
reposted by
N End Rules
26 days ago
🚨 Why can’t mammals regenerate limbs like frog tadpoles or salamanders? In our new paper in
@science.org
, we show that species-specific oxygen sensing acts as a gatekeeper for initiating limb regeneration 🐭🐸 🔗
www.science.org/doi/10.1126/...
#EvoDevo
loading . . .
Species-specific oxygen sensing governs the initiation of vertebrate limb regeneration
Why mammals cannot regenerate limbs like amphibians do presents a long-standing puzzle in biology. To uncover the underlying differences, we compared amputation responses of embryonic mouse (Mus musculus) and Xenopus laevis tadpole limbs. Lowering ...
https://www.science.org/doi/10.1126/science.adw8526
21
265
122
reposted by
N End Rules
COS Heidelberg
29 days ago
New publication from Markus Wirtz and colleagues on N-terminal protein acetylation:
www.nature.com/articles/s41...
loading . . .
The ribosome-associated N-terminal acetyltransferase B coordinates global proteostasis and autophagy in plants by creating Ac/N-degrons - Nature Communications
Protein N-terminal acetylation profoundly influences protein fate. Here, the authors establish NatB as a central regulator of the interplay between ubiquitin–proteasome system and autophagy, and highl...
https://www.nature.com/articles/s41467-026-71208-2
0
15
8
reposted by
N End Rules
CRAG
about 1 month ago
🌱 CRAG launches an international call for early‑career researchers! We invite young scientists interested in starting their independent research group at CRAG 📅 Deadline - April 26 Apply now 👉
https://f.mtr.cool/jdwzombrbd
0
30
35
reposted by
N End Rules
ProteostasisUK
about 2 months ago
Proteostasis UK Logo Competition Design our new logo and win registration, UK‑based travel, and accommodation to attend the UK Proteostasis Meeting 2026, 20–21 July at The Francis Crick Institute, London. See here for more information:
proteostasisuk.co.uk/calls/proteo...
Deadline: 1st May 2026
0
8
11
reposted by
N End Rules
about 2 months ago
I am definitely where I belong! So proud of me right now 🥰 and grateful of my support system in this team 🥂!
0
3
1
reposted by
N End Rules
Mikel Lavilla-Puerta
about 2 months ago
Finally officially out!!
www.pnas.org/doi/10.1073/...
We moved the main oxygen sensing machinery from plants to yeast and we learned a few things!
loading . . .
A synthetic ERFVII-dependent circuit in yeast sheds light on the regulation of early hypoxic responses of plants | PNAS
Plants face hypoxic conditions either chronically, as particular tissues are characterized by fluctuating or stable low oxygen levels, or acutely, ...
https://www.pnas.org/doi/10.1073/pnas.2524358123
3
18
10
reposted by
N End Rules
Daan Weits
about 2 months ago
What features are required to shape hypoxic niches enclosing meristems? We
@viktoriiavoloboeva.bsky.social
in collab
@pieterverboven.bsky.social
found that a combination of cuticle barrier, densely packed tissue and metabolic activity all uniquely contribute to maintain shoot apical meristem hypoxia
3
21
16
reposted by
N End Rules
Mark Avery
2 months ago
Marsh Clubmoss rediscovered in Dunbartonshire by
@bsbiscotland.bsky.social
of
@bsbibotany.bsky.social
0
32
10
reposted by
N End Rules
The EMBO Journal
2 months ago
Asgard
#archaea
: have we found our microbial ancestors? New review (also for newcomers to the field!) by Christa Schleper and Thiago Rodrigues-Oliveira
link.springer.com/article/10.1...
1
49
27
reposted by
N End Rules
Plant Energy Biology Lab
2 months ago
Freshly online 🗞️ In Vivo Monitoring of Energy Metabolism with Genetically Encoded Fluorescent Biosensors 🌱🔋🌈🔬
@jan-oleniemeier.bsky.social
@morganlab-saarland.bsky.social
@uni-muenster.de
doi.org/10.1146/annu...
loading . . .
In Vivo Monitoring of Energy Metabolism with Genetically Encoded Fluorescent Biosensors
All organisms fuel and build themselves through their energy metabolism. While classic biochemistry conceptualizes the fluxes of energy and matter, our understanding of how energy metabolism works in ...
https://doi.org/10.1146/annurev-arplant-071425-085632
1
17
8
Back to crossing, this time with the horrible mutant nia1 nia2
#arabidopsis
#genetics
#plantscience
2 months ago
0
25
1
reposted by
N End Rules
Karolina Heyduk
2 months ago
I'd like to remind everyone that CAM has evolved as many if not more times than C4. There are entire biomes where CAM is dominant. If you like tequila, or pineapple, or your pretty orchid you got at the grocery store, you can thank CAM. Thank you for coming to my TEDtalk. Or CAMtalk as it were.
3
38
8
reposted by
N End Rules
Abiotic Stress in Plants
2 months ago
Rewiring an E3
#ligase
enhances
#cold
resilience and
#phosphate
use in
#maize
www.nature.com/articles/s41...
#PlantScience
#SciComm
@nature.com
@natcellbio.nature.com
@maizesausage.bsky.social
@plantnerd.bsky.social
@jchrispires.bsky.social
@mrillig.bsky.social
@nmouquet.bsky.social
loading . . .
Rewiring an E3 ligase enhances cold resilience and phosphate use in maize - Nature
The E3 ubiquitin ligase NLA postively regulates cold tolerance and negatively regulates phosphate uptake in maize, and a genetically engineered variant of this enzyme leads to improved cold ...
https://www.nature.com/articles/s41586-026-10142-1
0
11
7
reposted by
N End Rules
Abiotic Stress in Plants
2 months ago
Switching on and off the
#hypoxic
response in
#plants
academic.oup.com/jxb/advance-...
#PlantScience
#SciComm
@jxbotany.bsky.social
@olmiemma.bsky.social
@theplantlab.bsky.social
@isplore.bsky.social
@n-end-rules.bsky.social
@hartman-plantlab.com
@plantstress.bsky.social
@plantredox.bsky.social
loading . . .
Switching on and off the hypoxic response in plants
Abstract. Hypoxia significantly impacts plant metabolism and growth by disrupting mitochondrial respiration, and oxygen sensing plays a vital role in regul
https://academic.oup.com/jxb/advance-article/doi/10.1093/jxb/erag101/8495722?login=false
0
6
4
reposted by
N End Rules
Pierdomenico Perata
2 months ago
Switching on and off the hypoxic response in plants url:
academic.oup.com/jxb/article/...
loading . . .
Switching on and off the hypoxic response in plants
Abstract. Hypoxia significantly impacts plant metabolism and growth by disrupting mitochondrial respiration, and oxygen sensing plays a vital role in regul
https://academic.oup.com/jxb/article/doi/10.1093/jxb/erag101/8495722
0
5
3
reposted by
N End Rules
John Christie
2 months ago
Feeling blue? Find out more about the dark side of phototropin signalling 😀
academic.oup.com/plcell/advan...
loading . . .
Reversible phosphorylation of NPH3/RPT2-like proteins regulates phototropin receptor signaling
Phototropin receptor signaling requires PP2C19 and PP2C35 to dephosphorylate NPH3 and related substrates, ensuring efficient phototropism and chloroplast m
https://academic.oup.com/plcell/advance-article/doi/10.1093/plcell/koag043/8493238
0
5
3
reposted by
N End Rules
Journal of Experimental Botany
2 months ago
🔗
doi.org/10.1093/jxb/...
#PlantScience
🧪
0
1
1
reposted by
N End Rules
Yoselin Benitez-Alfonso
2 months ago
One as Head of Plant Science at Leeds The new Plant Sciences page is now live and linked to from the FBS Research and Innovation homepage - interested in joining or collaborating? Learn about the research and opportunities by visiting this website!
biologicalsciences.leeds.ac.uk/plant-sciences
loading . . .
Centre for Plant Sciences
https://biologicalsciences.leeds.ac.uk/plant-sciences
1
15
10
reposted by
N End Rules
Emma Olmi
2 months ago
Happy to see our review online in
@jxbotany.bsky.social
🌱 In this work, we provide an overview of the molecular mechanisms plants use to survive under low oxygen stress and during recovery after reoxygenation 🌊
doi.org/10.1093/jxb/...
loading . . .
Switching on and off the hypoxic response in plants
Abstract. Hypoxia significantly impacts plant metabolism and growth by disrupting mitochondrial respiration, and oxygen sensing plays a vital role in regul
https://doi.org/10.1093/jxb/erag101
0
10
6
reposted by
N End Rules
Dan Gibbs 🌱🧬
2 months ago
My review “Co-translational control of protein stability and quality in plants” is now online at
@jxbotany.bsky.social
, in which I describe how co-translational processing and ribosome-associated quality control together establish protein stability and fate early in synthesis.
tinyurl.com/5dhhz9h6
loading . . .
Co-translational control of protein stability and quality in plants
Abstract. Proteostasis relies on the coordinated control of protein synthesis, folding, modification and degradation, and an increasingly clear picture is
https://tinyurl.com/5dhhz9h6
0
41
24
reposted by
N End Rules
2 months ago
I completely agree. However, I’ve found that several Chinese researchers publishing impactful work recently haven't responded to my invitations. If you have other recommendations—perhaps colleagues who are particularly active—please let me know!
0
1
1
reposted by
N End Rules
International Society for Protein Termini (ISPT)
3 months ago
Protein event of the year - sign up today! See you at beautiful Palazzo dei Normanni in Palermo for the FEBS 2026 Protein Termini Workshop.
#ProteinTermini
#Proteostasis
#ProteinModifications
#StructuralBiology
#PalazzoDeiNormanni
#Palermo2026
proteintermini.org/meeting/
1
8
9
reposted by
N End Rules
International Society for Protein Termini (ISPT)
2 months ago
8 days left to register | 28 invited speakers | Keynotes from F. Ulrich Hartl, Roland Beckmann and Michael Rapé |
#chaperones
#degradation
#ubiquitin
#cryoEM
#acetylation
#lipidation
#ribosomes
#proteins
proteintermini.org/meeting/
loading . . .
Protein Termini 2026 – International Society for Protein Termini (ISPT)
https://proteintermini.org/meeting/
1
4
2
reposted by
N End Rules
3 months ago
Join us in Palermo! FEBS Workshop Protein Termini 2026: the power of protein termini across bacteria, plants, and animals—from ribosome biology to proteostasis and applications. Deadline: 3 March 2026
proteintermini.org/meeting
#ProteinTermini
#Proteostasis
#FEBS
#EMBO
@iubmb.bsky.social
1
13
8
reposted by
N End Rules
Edoardo Gianni
3 months ago
How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller? Excited to share our latest work in
@science.org
on a new small polymerase. 1/n
loading . . .
A small polymerase ribozyme that can synthesize itself and its complementary strand
The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...
https://www.science.org/doi/10.1126/science.adt2760
10
501
238
Sad to say that after 14 years of service the vseed server
vseed.nottingham.ac.uk
will soon be retired. Do not despair our community resource for seed germination network analysis is still available at
netvis.ico2s.org/dev/seednet/#/
thanks to Professor Natalio Krasnogor at Newcastle University
loading . . .
http://vseed.nottingham.ac.uk
3 months ago
0
1
1
Surprisingly: "Conditional stability of HY5 through the ATE N-degron pathway regulates environmental responses in Arabidopsis thaliana". The shining bounds of N-degron pathway influence expands!
@charlene-kunaka.bsky.social
www.biorxiv.org/content/10.6...
loading . . .
https://www.biorxiv.org/content/10.64898/2026.02.10.705009v1
3 months ago
1
17
14
reposted by
N End Rules
bioRxiv Plant Bio
3 months ago
Conditional stability of HY5 through the ATE N-degron pathway regulates environmental responses in Arabidopsis thaliana
https://www.biorxiv.org/content/10.64898/2026.02.10.705009v1
0
6
4
reposted by
N End Rules
4 months ago
Are you, or do you know someone that is excited to do a PhD in plant biology. We are happy to offer a position to explore physiology, gene regulatory networks and wild species. Come join our team in a stimulating scientific environment at the University of Groningen!
werkenbij.rug.nl/vacature/phd...
loading . . .
PhD position Growth-resilience trade-offs in plants - Rijksuniversiteit Groningen
https://werkenbij.rug.nl/vacature/phd-position-growth-resilience-trade-offs-in-plants-1634/?lang=en
0
16
20
reposted by
N End Rules
Mark A. Hanson
4 months ago
We've got ISSUES. Literally. We scraped >100k special issues & over 1 million articles to bring you a PISS-poor paper. We quantify just how many excess papers are published by guest editors abusing special issues to boost their CVs. How bad is it & what can we do?
arxiv.org/abs/2601.07563
A 🧵 1/n
17
508
364
reposted by
N End Rules
New Phytologist
4 months ago
Discrete and cell-specific hypoxic responses in Arabidopsis roots resolved by single-nuclei transcriptomics Hill et al.
nph.onlinelibrary.wiley.com/doi/10.1111/...
0
19
12
reposted by
N End Rules
The BanLab
5 months ago
Last X-Mas, the ribosome gave you methionine, but the very next day, MetAP took it away. This year, to save histones from tears, NatD gives you an acetyl group. ⭐️ Explore our latest paper with the Deuerling lab
@uni-konstanz.de
and Shu-ou Chan lab
@caltech.edu
!
www.science.org/doi/10.1126/...
loading . . .
Mechanism of cotranslational modification of histones H2A and H4 by MetAP1 and NatD
NAC enables cotranslational N-terminal processing of histones H2A and H4 by recruiting MetAP1 and NatD at the ribosomal tunnel.
https://tinyurl.com/ycypkzpt
0
46
17
reposted by
N End Rules
Rory Osborne
5 months ago
So happy to see this work finally online! In this Research Review, I discuss the emerging roles of H3K27me3 writers (the enzymes that lay it down) and erasers (the enzymes that remove it) in controlling plant adaptation 🌿🌡️❄️🦠
nph.onlinelibrary.wiley.com/doi/10.1111/...
loading . . .
Finding balance: the dynamic interplay between H3K27me3 writers and erasers in regulating environmental plasticity and memory
Subject to an ever-changing world, plants must respond to harmful conditions and environmental fluctuations. Their evolutionary success can be attributed to their plasticity in both perceiving and in...
https://nph.onlinelibrary.wiley.com/doi/10.1111/nph.70815
2
25
15
reposted by
N End Rules
Richard Sever
5 months ago
UKRI exploring use of AI in grant review - this will prompt debate but interested to know if people think it’d encourage novelty or the opposite?
www.chemistryworld.com/news/ukri-op...
loading . . .
UKRI opens up grant proposal data to explore using AI to smooth peer review
Surging applications has led the UK's main funder to look at ways to reduce the burden on reviewers
https://www.chemistryworld.com/news/ukri-opens-up-grant-proposal-data-to-explore-using-ai-to-smooth-peer-review/4022597.article
18
5
27
What a terrible terrible idea
add a skeleton here at some point
5 months ago
0
1
0
reposted by
N End Rules
Sjon Hartman
5 months ago
Lovely new review on H3K27me3 dynamics and potential functions in
#plantscience
by
@drosborneplantsci.bsky.social
nph.onlinelibrary.wiley.com/doi/10.1111/...
loading . . .
Finding balance: the dynamic interplay between H3K27me3 writers and erasers in regulating environmental plasticity and memory
Subject to an ever-changing world, plants must respond to harmful conditions and environmental fluctuations. Their evolutionary success can be attributed to their plasticity in both perceiving and in...
https://nph.onlinelibrary.wiley.com/doi/10.1111/nph.70815
0
19
7
reposted by
N End Rules
Dr Steve Westlake
5 months ago
This is scary. "Three of the five worst harvests on record have now occurred since 2020, leaving some farmers asking whether the growing impacts of the climate crisis are making it too financially risky to sow their crops."
www.theguardian.com/environment/...
loading . . .
UK farmers lose £800m after heat and drought cause one of worst harvests on record
Many now concerned about ability to make living in fast-changing climate after one of worst grain harvests recorded
https://www.theguardian.com/environment/2025/dec/04/record-heat-drought-2025-cost-uk-arable-farmers-estimated-800m-climate-crisis-grain-harvest?CMP=Share_AndroidApp_Other
5
108
73
reposted by
N End Rules
Peter Mabbitt
5 months ago
We’ve made some new tools to manipulate N-recognins. Check them out in our preprint.
www.biorxiv.org/content/10.1...
0
18
13
Just registered for FEBS advanced workshop Protein termini 2026 in Palermo
#proteintermini2026
(?) Looking forward to a great meeting.
@ispt-proteinterm.bsky.social
www.conferencecentral.org/webpage/view...
loading . . .
FEBS Workshop 'Protein termini 2026: From mechanisms to biological impact'
https://www.conferencecentral.org/webpage/view/45
5 months ago
0
2
4
Load more
feeds!
log in