See you at Palazzo dei Normanni in Palermo for the 2026 Protein Termini Conference | Co- and post-translational modifications | Proteolytic processing and degradation pathways | Microbes, plants, animals #ProteinTermini2026 #Proteostasis #ProteinModifications #PalazzoDeiNormanni #Palermo2026

A conference about #proteostasis in a palazzo in Palermo; inclusive, affordable, and organised by the marvellous @giglionelab.bsky.social - what’s not to like? Oh, and there is a fantastic lineup of talks plus slots to spare #ProteinTermini2026

Developing leaves form a spatiotemporal oxygen gradient that is sensed through the oxygen sensing machinery and directs morphogenesis | New preprint from @daanweits.bsky.social and @syno2xis.bsky.social labs #N-degron #Cysteine #hypoxia @ispt-proteinterm.bsky.social www.biorxiv.org/content/10.1...

Two new volumes of Methods in Enzymology with 29 chapters/papers on Protein termini methods and reviews are now out! Thx to all authors!🙌 @ispt-proteinterm.bsky.social #N-degron #prenylation #myristoylation #formylation #arginylation #oxidation #acetylation www.sciencedirect.com/bookseries/m...

Protein N-terminal acetylation regulates the growth of rice plants | #NAA30 #NatC #rice #acetylation www.sciencedirect.com/science/arti...

Happy to share that our multi-omic analysis comparing two Arabidopsis accessions is now published 🌿 The first story from our @ukri.org BBSRC sLoLa #plant #proteostasis project. A great collaboration between @rothamsted.bsky.social @richardmott.bsky.social @ucl.ac.uk and Kathryn Lilley at Cambridge.

Delighted to invite applications for a PhD project in the group. Come and do some awesome biochemistry and physiology in a truly interdisciplinary team! www.findaphd.com/phds/project...

A Cell-Potent Bisubstrate Inhibitor to Probe NatD Acetyltransferase Activity | The inhibitor effectively reduced cellular Nα-acetylation on histone H4, leading to reduced migration in lung cancer cells | @acs.org ACS Chemical Biology @ispt-proteinterm.bsky.social pubs.acs.org/doi/10.1021/...

Uptake of anti-cancer drugs depends on N-terminally acetylated anion channels | @ispt-proteinterm.bsky.social www.nature.com/articles/s42...

We are advertising a PhD project investigating a cellular mechanism that ensures protein quality control during mRNA translation in plants. Please get in touch on here or via email if you are interested and I can provide further details! Lab website: sites.google.com/site/danielg...

A synthetic ERFVII-dependent circuit in yeast sheds light on the regulation of early hypoxic responses of plants | Preprint from @mikellavi.bsky.social @beagiuntoli.bsky.social @syno2xis.bsky.social #N-degron #hypoxia www.biorxiv.org/content/10.1...

Targeted degradation of pathogenic TDP-43 proteins in amyotrophic lateral sclerosis using the AUTOTAC platform | Yong Tae Kwon lab | #N-degron www.biorxiv.org/content/10.1...

Acetylhistidine in our blood can prevent kidney disease and is produced by the HisAT (NAT16) enzyme displaying a rare double-GNAT structure. Great efforts by Matti Myllykoski and the rest of the team at @unibergen.bsky.social to get this published. #acetyltransferase www.nature.com/articles/s41...

How did oxygen-sensing evolve in plants? In collaboration with @syno2xis.bsky.social Great work from @lauradc.bsky.social et. al. #plantscience @leverhulme.ac.uk “ERFVIIs as transducers of oxygen-sensing in the evolution of land plant response to hypoxia” www.cell.com/molecular-pl...

Protein acetylation as a novel post-translational modification of plant peroxisomal proteins. @ispt-proteinterm.bsky.social academic.oup.com/jxb/article-...

Two heroes of the COST ProteoCure network: Oliver Coux and Laetitia Poidevin. Many thanks from all of us! #ProteoCure2025 @costprogramme.bsky.social

actionnetwork.org/petitions/op...?

A postdoc position is available in our lab to study ADP-ribosylation and ubiquitylation signalling! We are looking for someone with experience in structural biology and biochemistry. The application deadline is June 20th. my.corehr.com/pls/uoxrecru...

Protein degradation in E. coli via N-terminal degradation signals (degrons) defined by the @kunjapur.bsky.social lab. @ispt-proteinterm.bsky.social www.biorxiv.org/content/10.1...

Oxygen sensors structurally defined. The substrate binding of N-terminal cysteine oxidases uncovered by the White lab @drmdwhite.bsky.social in @natcomms.nature.com www.nature.com/articles/s41...

Congrats to Corentin Bouvier, awardee of the FEBS Journal prize at the annual COST ProteoCure meeting. @costprogramme.bsky.social @febsj.bsky.social #ProteoCure2025

Congrats to Mónica Pozo Rodriguez, awardee of the FEBS Open Bio Poster prize at the annual COST ProteoCure meeting. @costprogramme.bsky.social @febspress.bsky.social #ProteoCure2025

Congrats to Simon Tack, awardee of the FEBS Journal Oral Presentation prize at the annual COST ProteoCure meeting. @costprogramme.bsky.social @febsj.bsky.social #ProteoCure2025

Opening of the 2025 ProteoCure #COST meeting on Crete by Rosa Farras. Looking forward to an exciting meeting.

Nobel Laureate Aaron Ciechanover gave a historic overview on the discovery of ubiquitylation and finished with some very recent data from his lab at the annual #ProteoCure meeting.

Michael Glickman presented his latest data on one of our favorite proteins UBB+1 and its role in Alzheimer's disease at the annual meeting of COST ProteoCure in Heraklion.

Starting the morning at #COST #ProteoCure2025 annual meeting with Elke Krüger talking about Proteasomopathies. @costprogramme.bsky.social

Happy to share our new study showing that the Ub E3 ligase SIAH1, known to dimerise via its C-term SBD, also dimerises via its N-term RING. When these tendencies combine, full-length SIAH1 forms multimers, which might explain its clustering in cells & preference for aggregated/multimeric substrates.

Happy to start 2025 by sharing our new preprint biorxiv.org/cgi/content/... -the first paper from our BBSRC collaborative project with @richardmott.bsky.social and Kathryn Lilley to understand what controls protein abundance in plants. 🧵 1/9

New insight into the plant #N-degronpathway from its co-discoverer, Andreas Bachmair and colleagues. The Arabidopsis N-recognin PRT6 has broader specificity than previously thought.

Job Opportunity: Assistant Engineer in N-terminomics!Join our team at I2BC, Université Paris-Saclay (20 km south of Paris)! Looking for a motivated person with expertise in mass spectrometry (N-terminal proteomics, quantitative analysis). Please share! @proteintermini #proteomics.

#TGIF-JC TMEM208 - a protein to remember amazing work from the Hegde lab showing that this long-overlooked protein helps SRP to properly release its cargo at the ER membrane, ensuring smooth translocation. especially important for multipass membrane proteins. www.science.org/doi/10.1126/...

New review on how to target lysine acetylation readers and writers from Ming-Ming Zhou and Philip Cole | p300 | CBP | PCAF | GCN5 | BrD | inhibitors www.nature.com/articles/s41...

A big thank you to @ifink-lab.bsky.social for the excellent organization of the 'Co- and Post-Translational Control in Chloroplasts' symposium in Münster. Looking forward to the second edition!

My first @bsky post to let you know that I'm joining you! Ciao a tutti!