@oisb-ibso.bsky.social
📤 54
📥 159
📝 18
reposted by
Journal of Cell Biology
2 months ago
Is the
#Parkinsons-associated
protein TMEM175 a proton channel: Yay or nay? Spencer Freeman and Sergio Grinstein
@sickkidsto.bsky.social
discuss new study from Riederer et al. (
rupress.org/jcb/article/...
) in Spotlight:
rupress.org/jcb/article/...
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reposted by
uOttawa
2 months ago
A look back at the installation ceremony for our President and Vice-Chancellor Marie-Eve Sylvestre 📸 Watch the replay of the ceremony at this link: bit.ly/4oudx15
#uOttawa
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reposted by
Jennifer Harr
2 months ago
🎉 New research! Microplastics don’t just pollute; they carry harmful chemicals. In
#Celegans
, this combo reduced lifespan & reproduction. This study was led almost entirely by undergraduate researchers at StMU 💙💛 🔗
www.mdpi.com/3615716
#microplastics
#NIHfunded
#science
#undergraduateresearch
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reposted by
Stirling Churchman
2 months ago
Oxidative phosphorylation complexes contain subunits encoded by both the nuclear and mitochondrial genomes. How do cells coordinate the synthesis and assembly of these complexes at the inner membrane? We teamed up with Martin Ott (
@mitolab.bsky.social
) to address this in two recent papers.
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New from M-E Harper, Luke Kennedy and Mira Cuperlovic-Culf at
@oisb-ibso.bsky.social
academic.oup.com/bib/article/...
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Computational approaches to enzymatic reaction assignment: a review of methods, validations, and future directions
Abstract. Characterizing the proteins and molecules that underpin cellular metabolism is fundamental to advancing our understanding of biological processes
https://academic.oup.com/bib/article/26/6/bbaf635/8361799
2 months ago
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reposted by
McGill Medicine and Health Sciences
2 months ago
Jean-François Cloutier appointed Associate Dean, Research, FMHS effective Jan 1, 2026! 🎉➡️
https://ow.ly/bWWm50XAXQB
~~~ Jean-François Cloutier nommé vice-doyen, Recherche, FMSS à partir du 1er janvier 2026! 🎉➡️
https://ow.ly/mCJh50XAXQJ
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reposted by
Journal of Cell Biology
2 months ago
New work by
@valthomas.bsky.social
et al. in
@sophiemartinlab.bsky.social
provides a live, 8-nm precision map of the actin fusion focus for cell-cell fusion in S.
#pombe
. This reveals
#actin
aster formation by
#myosin
Myo52-driven transport of the formin Fus1 nucleator
rupress.org/jcb/article/...
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reposted by
mara lawniczak
2 months ago
please share this postdoc job alert! come join the budding Biodiversity Cell Atlas initiative as a postdoc or senior postdoc at
@sangerinstitute.bsky.social
working closely with
@arnausebe.bsky.social
and me to make progress on what we cover in this paper
www.nature.com/articles/s41...
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The Biodiversity Cell Atlas: mapping the tree of life at cellular resolution - Nature
The Biodiversity Cell Atlas aims to create comprehensive single-cell molecular atlases across the eukaryotic tree of life, which will be phylogenetically informed, rely on high-quality genomes and use...
https://www.nature.com/articles/s41586-025-09312-4
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reposted by
Genome Journal
2 months ago
Join our wonderful #PeerReview team! We’re looking for a Scientific Editor to help uphold rigorous peer review and support our editors, reviewers, and authors. Applications are now open. Apply now 📚▶️
https://ow.ly/1ziL50XulU8
#PeerReview
#ScienceJobs
#NowHiring
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reposted by
Esther Verheyen 🇨🇦
2 months ago
Congrats Dr. Kewei Yu on your successful PhD defense!! She did a great job describing her work on a Drosophila cancer cachexia model. 🥳
@sfuscience.bsky.social
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New from Seung-Hwan Lee
@oisb-ibso.bsky.social
and collaborators at Canadian Nuclear Laboratories including Dr. Holly Laakso
www.frontiersin.org/journals/imm...
2 months ago
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New expert commentary from Dr. Mary-Ellen Harper of
@oisb-ibso.bsky.social
diabetesjournals.org/diabetes/art...
2 months ago
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New from Stintzi Lab
@oisb-ibso.bsky.social
faseb.onlinelibrary.wiley.com/doi/10.1096/...
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Dystrophic Skeletal Muscle Phenotypes Can Be Horizontally Transferred via Fecal Microbiome Transplantations
We sought to determine a causal role for the microbiota in promoting dystrophic muscle characteristics by performing intra/inter-genotype fecal microbiota transplantations (FMT) between wildtype (C57....
https://faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202502999R
2 months ago
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reposted by
Can Senkal
3 months ago
We have a post-doctoral fellow position in our laboratory. Please spread the news and encourage applications. Thank you!
vcujobs.com/jobs/post-do...
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Post-Doctoral Fellow - Department of Cellular, Molecular, and Genetic Medicine - MCV Main Campus, Virginia, United States
Advertising Summary: Virginia Commonwealth University (VCU) School of Medicine is a premier academic medical center located in the heart of Richmond. Accounting for almost half of VCU’s sponsored rese...
https://vcujobs.com/jobs/post-doctoral-fellow-department-of-cellular-molecular-and-genetic-medicine-mcv-main-campus-virginia-united-states-b663b296-a3c4-4f65-805f-3c93e57d1e6b
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reposted by
PlantEvolution 🌱🌾
3 months ago
Love this Insight by
@steeltownworms.bsky.social
on a series of
@elife.bsky.social
papers on what it takes to reproduce a phenomenon of transgenerationally transmitted learned pathogen avoidance in C. elegans. Thank you, Lesley!
elifesciences.org/articles/109...
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reposted by
3 months ago
The CSMB is concerned that, despite new investments, Federal Budget 2025 weakens rather than strengthens Canada’s research ecosystem. Sustainable research funding is essential for innovation and competitiveness. Read more:
csmb-scbm.ca/csmb-stateme...
#CSMB
#Budget2025
#ResearchCanada
#Science
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New from Cameron Gibson and Idin Lantz of the Downey lab
@oisb-ibso.bsky.social
www.cell.com/trends/bioch...
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Emerging functions for nonhistone protein acetylation in budding yeast
Lysine acetylation is a post-translational modification (PTM) that is traditionally studied as a modifier of histones. In recent years, nonhistone protein acetylation has also emerged as a ubiquitous ...
https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(25)00246-4
3 months ago
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reposted by
The Ottawa Hospital
3 months ago
Big news 🎉 Dr.
@micheleardolino.bsky.social
and team just received a $3M
@terryfoxresearch.bsky.social
grant to explore how the immune system, brain and gut work together to fight cancer:
bit.ly/47XDOQi
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reposted by
4 months ago
New position available with our group related to a new research direction in cancer transcriptomics:
www.biotalent.ca/the-petridis...
@oisb-ibso.bsky.social
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Research Associate - BioTalent Canada
Research Associate Position - Russell LabDepartment of Cellular and Molecular Medicine, University of OttawaPosition Type: Full-time Research AssociateDuration: 1 year, renewable pending grant renewal/acquisitionStart Date: November 1, 2025 or laterApplication Deadline: November 15, 2025Job SummaryThe Russell Lab in the Department of Cellular and Molecular Medicine at the University of Ottawa invites applications for a Research…
https://www.biotalent.ca/the-petridish/research-associate-25108/
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The Gentile Lab at
@oisb-ibso.bsky.social
is on a roll:
www.sciencedirect.com/science/arti...
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Inhibition of nucleotide excision repair proteins associated with cancer chemotherapy
DNA repair is involved in the cellular response to alkylating agents used for the treatment of various cancers, decreasing the damages induced by the …
https://www.sciencedirect.com/science/article/pii/S0304419X25001507?via%3Dihub
4 months ago
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New from Mary-Ellen Harper's lab at
@oisb-ibso.bsky.social
:
www.sciencedirect.com/science/arti...
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Impaired xCT-mediated cystine uptake drives serine and proline metabolic reprogramming and mitochondrial fission in skeletal muscle cells
Muscle satellite cell (MuSC) proliferation is tightly regulated by redox homeostasis and nutrient availability, which are often disrupted in muscular …
https://www.sciencedirect.com/science/article/pii/S2213231725003520?via%3Dihub
4 months ago
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New from Pamenter Lab
@oisb-ibso.bsky.social
:
link.springer.com/article/10.1...
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Ca2+ Inhibits Reactive Oxygen Species Scavenging in Naked Mole-Rat Cortical Homogenates - Cellular and Molecular Neurobiology
Deleterious perturbations in reactive oxygen species (ROS) and calcium (Ca2+) handling are key initiators of cell death in hypoxia-intolerant mammalian brain. Elevated cellular Ca2+ can also inhibit R...
https://link.springer.com/article/10.1007/s10571-025-01603-8
5 months ago
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New from Golshani Lab with first author Tom Kazmirchuk
@oisb-ibso.bsky.social
ashpublications.org/bloodadvance...
5 months ago
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New work from Francesco Gentile lab at
@oisb-ibso.bsky.social
:
www.biorxiv.org/content/10.1...
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Structure-based discovery of inhibitors of Mac1 domain of nonstructural protein-3 of SARS-CoV-2 by machine learning-augmented screening of chemical space
Significant efforts have been recently dedicated to the discovery of small molecule inhibitors against the Macrodomain 1 (Mac1) of nonstructural protein 3 (NSP3) as potential antivirals for SARS-CoV-2...
https://www.biorxiv.org/content/10.1101/2025.09.05.674529v1
5 months ago
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Exciting new work from the Russell Lab
@oisb-ibso.bsky.social
rupress.org/jcb/article/...
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Identification of organelle-specific autophagy regulators from tandem CRISPR screens
Losier et al. identify distinct kinase signaling pathways that differentially regulate bulk and selective autophagy. Using kinome-wide CRISPR screening, th
https://rupress.org/jcb/article/224/10/e202405138/278221/Identification-of-organelle-specific-autophagy
5 months ago
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New from Stintzi Lab at OISB:
www.tandfonline.com/doi/full/10....
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The colonic mucosal virome in inflammatory bowel disease reveals Crassvirales depletion and disease-specific virome features
The mucosal virome is increasingly recognized for its potential role in shaping intestinal health and disease. Building on previous findings, we analyzed the mucosal virome from 51 individuals, inc...
https://www.tandfonline.com/doi/full/10.1080/19490976.2025.2539450
6 months ago
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reposted by
Dr. Julie Claycomb
7 months ago
Next we'll hear from Cian Ward from Pat O'Donaghue's lab at Western University about tRNA anticodon variants to read through ALS-causative PTCs. 🛑🏁
@trendrna.bsky.social
#TREnD2025
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reposted by
Dr. Julie Claycomb
7 months ago
Excited to hear from patients, advocates, and clinicians about RNA-related diseases at our
@rnacanada.bsky.social
patient advocacy panel. These conversations are so important to connect researchers, families, and clinicians. Thanks for sharing your stories!
@trendrna.bsky.social
#TREnD2025
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reposted by
Maitreya Dunham
7 months ago
Genome Sciences is looking for a Director of Departmental Computing. This is a rare opportunity for someone interested in leading our excellent IT team, building and maintaining computational infrastructure, and working closely with our faculty and labs
uwhires.admin.washington.edu/ENG/candidat...
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UW Human Resources
University of Washington Human Resources
https://uwhires.admin.washington.edu/ENG/candidates/default.cfm?szCategory=jobprofile&jobhistory=1&szOrderID=247721
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New from D'Amours Lab at
@oisb-ibso.bsky.social
www.pnas.org/doi/10.1073/...
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Yeast centrosomes act as organizing centers to promote Polo kinase–mediated adaptation to persistent DNA damage | PNAS
The ability of cells to overcome cell cycle arrest and adapt to the presence of unrepairable DNA damage is under the control of Polo-like kinases (...
https://www.pnas.org/doi/10.1073/pnas.2414426122?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed
7 months ago
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New work on polyphosphate biology from the Downey lab
@oisb-ibso.bsky.social
:
journals.asm.org/doi/10.1128/...
7 months ago
0
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reposted by
Graham Dellaire
8 months ago
🔥12 years in the making!🔥 So excited our paper is finally out in Cell Reports! Great collaboration with Dr. Robert Huber @ Trent U, funded by NSERC and CIHR. The evolutionarily conserved PRP4K-CHMP4B/vps32 splicing circuit regulates autophagy:
www.cell.com/cell-reports...
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The evolutionarily conserved PRP4K-CHMP4B/vps32 splicing circuit regulates autophagy
Mis-splicing of autophagy genes contributes to diverse pathologies including cancer. Mathavarajah et al. report that depletion of tumor suppressor and splicing kinase PRP4K leads to impaired autophagy...
https://www.cell.com/cell-reports/fulltext/S2211-1247%2825%2900641-2
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reposted by
Christian Landry
8 months ago
Microbes and bikes: perfect mix to get me to Montréal!
#yul
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reposted by
Genome Journal
8 months ago
@csee-scee.bsky.social members—join us for a practical webinar on peer review, hosted by the
@cdnsciencepub.com
team. Learn how to write strong reviews and get involved as a future reviewer. Check your inbox to register. 📥
#AcademicSky
#SciComm
🧪
#AcWri
#PHDSky
#ScholComms
#OpenScience
#SciPol
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reposted by
Trends in Genetics
8 months ago
"Selfish B chromosome evades genome elimination" by Cécile Courret (
@cecilecourret.bsky.social
) This Spotlight highlights recent work by Laura Ross (
@laurarossevo.bsky.social
) & colleagues in GBE (
@genomebiolevol.bsky.social
). FREE till Aug 5th with this link:
authors.elsevier.com/a/1lH50cQbJF...
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reposted by
Adrien Peyrache
8 months ago
Who wants to be my new chair?
mcgill.wd3.myworkdayjobs.com/en-US/McGill...
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Director of The Neuro (Montreal Neurological Institute-Hospital) - A joint position
Please refer to the How to Apply for a Job (for External Candidates) job aid for instructions on how to apply. If you are an active McGill employee (ie: currently in an active contract or position at ...
https://mcgill.wd3.myworkdayjobs.com/en-US/McGill_Careers/job/Montreal-Neuro/Director-of-The-Neuro--Montreal-Neurological-Institute-Hospital----A-joint-position_JR0000066888
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reposted by
8 months ago
🤔 Are you unsure what jobs you can get with your molecular biosciences degree, other than research? Then join the
@csmb-scbm.bsky.social
next Thursday, June 19, for our next webinar where we'll hear from three scientists with jobs in scientific writing! Sign up here:
zoom.us/meeting/regi...
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New work from
@oisb-ibso.bsky.social
member Francesco Gentile:
www.tandfonline.com/doi/10.1080/...
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https://www.tandfonline.com/doi/10.1080/17460441.2025.2508866?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
8 months ago
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new from Ryan Russell's Group
@oisb-ibso.bsky.social
pubmed.ncbi.nlm.nih.gov/40240354/
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Loss of VHL-mediated pRb regulation promotes clear cell renal cell carcinoma - PubMed
The von Hippel-Lindau (VHL) tumor suppressor is a substrate-defining component of E3 ubiquitin ligase complexes that target cellular substrates for proteasome-mediated degradation. VHL inactivation by...
https://pubmed.ncbi.nlm.nih.gov/40240354/
9 months ago
0
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New from SH Lee at
@oisb-ibso.bsky.social
immunenetwork.org/DOIx.php?id=...
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Cytokines in Focus: IL-2 and IL-15 in NK Adoptive Cell Cancer Immunotherapy
Marr B, et al. Immune Netw. 2025 Apr;25(2):e17. https://doi.org/10.4110/in.2025.25.e17
https://immunenetwork.org/DOIx.php?id=10.4110/in.2025.25.e17
9 months ago
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New from Rousseaux lab
@oisb-ibso.bsky.social
:
molecularneurodegeneration.biomedcentral.com/articles/10....
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A stress-dependent TDP-43 SUMOylation program preserves neuronal function - Molecular Neurodegeneration
Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) are overwhelmingly linked to TDP-43 dysfunction. Mutations in TDP-43 are rare, indicating that the progressive accumulation of exo...
https://molecularneurodegeneration.biomedcentral.com/articles/10.1186/s13024-025-00826-z
10 months ago
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