Very interesting paper from the Frangogiannis’s lab — #Fibroblast -Specific Loss of #TGF-β Signaling Mediates Lipomatous Metaplasia in the Infarcted #Heart (and cardiac rupture) www.ahajournals.org/doi/10.1161/... @ahajournals.bsky.social @einsteinmededu.bsky.social

A technology that played a key part in saving millions of lives during the pandemic should be celebrated. Yet in the US, research into mRNA vaccines is being cut. While sadly not unexpected, it’s irresponsible as we argue in our editorial this week 🧪 www.nature.com/articles/d41...

🚨 New preprint from the #EricAndWendySchmidtCenter! 🚨 "MORPH Predicts the Single-Cell Outcome of Genetic Perturbations Across Conditions and Data Modalities" www.biorxiv.org/content/10.1... @broadinstitute.org #SingleCell #PerturbSeq #OpticalPooledScreen #AIinBiology #ScienceNews #CompBio

#FOGBoston festivalofgenomics.com/boston

This tiny device can shrink dangerous blood clots. It’s called the ‘milli-spinner’ and its invention was partly an accident…

World Oceans Day is this weekend. 🌊⚒️🧪

Can you go from protein sequence to a generated image of protein localization? New work from the Uhler lab says yes, and it is generalizable to unseen proteins and more than one cell type. I'm excited for work moving us toward virtual cell models.

David Liu @harvard.edu beautifully articulates the criticality of basic science funding for developing revolutionary therapeutics like life-saving base editors 👏 youtu.be/8YhJM6zxYDw?...

PUPS - prediction of unseen proteins' subcellular localization - uses machine learning models to predict the localization of unseen proteins in unseen cell lines from sequence and cellular images. www.nature.com/articles/s41...

EXPOSED: Never seen before footage reveals the catastrophic impacts caused by bottom trawling ❌ @oceanauk.bsky.social www.youtube.com/watch?v=IzG9...

Exciting news...Nature Methods is hiring a new editor! This exciting and dynamic role will be shared with the Nature Research Cross-Journal Editorial Team. Apply here by June 1! springernature.wd3.myworkdayjobs.com/SpringerNatu...

Selective inhibition of stromal mechanosensing suppresses cardiac fibrosis www.nature.com/articles/s41...

David Liu receives Breakthrough Prize in Life Sciences. Liu is honored for the development of base editing and prime editing, two gene editing technologies transforming medicine. www.broadinstitute.org/news/david-l...

Thrilled that our work on coronary dominance made the cover of @cellpress.bsky.social! This beautiful image is thanks to the incredible work of @pamrc.bsky.social! 😍 #CardioSky www.cell.com/cell/fulltex...

🌟 Few hours left to submit your abstract for the Annual Meeting of the Society (3-4 July 2025, University of Surrey, Guildford). Great programme, even better people...and a murder mystery at dinner! www.microcirculation.org.uk/75th-annual-... 🌟

This week, I have the privilege of interviewing Dr. Elisabeth Bik (@elisabethbik.bsky.social) in a special two-part series. We discuss her rich professional experience and path to data sleuthing. This is part I .https://www.podbean.com/eas/pb-9p4ye-1865e2f #science #research #integrity #data

So many good suggestions in this insightful piece by Dennis J Hazelett. “The only way to give structure to your thoughts is to write them. Writing.Is.Thinking” @naturebiotech.bsky.social www.nature.com/articles/s41...

Research support for rare diseases, which cumulatively affect ~30 million Americans, is primarily derived from NIH. Such work is exemplified by Prof Anna Greka @broadinstitute.org in a new Ground Truths podcast. Open-access, w/ transcript, video, no ads erictopol.substack.com/p/anna-greka...

Francis Collins, the NIH Director for 12 years, led the Human Genome Project and other NIH efforts for 32 years, resigned today. Key words from his resignation letter www.nytimes.com/2025/03/01/u...

I heard about this interesting story a couple of years ago at an AHA meeting @ahascience.bsky.social. It's great to see it published @CellSystems. Congratulations @shovalmiyara.bsky.social‬, @eldadtzahor.bsky.social @urialonlab.bsky.social et al!

Visualizing RNA in live cells using CRISPR nature.com/articles/s41...

We started writing/posting Snippets a week ago, and our third one is up now, about tissue clocks and aging, written by Katrina Woolcock with a great image by Gloria Fuentes, both colleagues at Life Science Editors. Have a look! www.lifescienceeditors.com/2025/02/13/t...

Checkout "Snippets" - the brainchild of our editor extraordinaire @sfmatheson.bsky.social www.lifescienceeditors.com/snippets/

Doing a little catch-up posting with the Let's Get Coffee series. Today I reflect on my chat with @elviraforte.bsky.social and her thought-provoking question! www.podbean.com/eas/pb-r9pgp...

A total of $12 million in grant funding is available to fund 3 investigators/investigative teams proposing novel uses of Artificial Intelligence to revolutionize cardiovascular and cerebrovascular/brain health and health care delivery. Learn more: professional.heart.org/en/research-...

#Schmidt_Center publication: Hannah Schlueter and Caroline Uhler present a method to automatically detect #gene-expression patterns related to #lineage progression from paired #single-cell data, across different biological systems: broad.io/PORCELAN @naturecomms.bsky.social @broadinstitute.org

All NIH study sections canceled indefinitely. This will halt science and devastate research budgets in universities.

Join us for an exciting two-day symposium on #BiomedicalSciences and #AI, Apr 30th/May 1st, on #MIT Campus, organized by the Eric and Wendy Schmidt Center at @broadinstitute.org. Registration is free and abstract submission is open until January 31st www.ericandwendyschmidtcenter.org/symposiums/e...

The colloquium series hosted by the Eric and Wendy Schmidt Center at the Broad Institute of MIT and Harvard and MIT EECS is restarting soon! Register at: lnkd.in/eZH_h8CV #SchmidtCenter @broadinstitute.org #MITEECS #BarbaraEngelhardt #GladstoneInstitutes #StanfordDBDS

Calling all cardiovascular scientists.... @WeinsteinConf is in Milwaukee May 14-16! Abstract submission now open. Registration portal is imminent! childrenswi.org/weinstein Are you a trainee and want to be considered for a platform talk - abstract due Feb 21!

A new large language of life model (LLLM) for the transcriptome that predicts gene expression within and across human cell types www.nature.com/articles/s41... @nature.com For more on the remarkable surge of LLLMs see erictopol.substack.com/p/learning-t...

Spatial omics of human arteries to understand what drives atherosclerosis: highlights role of the microvasculature (vasa vasorum), adventitial inflammation, migration of vascular smooth muscle cells (and more) nature.com/articles/s44...

iFlpMosaics enable the multispectral barcoding and high-throughput comparative analysis of mutant and wild-type cells www.nature.com/articles/s41... @naturemethods.bsky.social

Hello Bluesky! The Eric and Wendy Schmidt Center at @broadinstitute.org is seeking #postdocs with expertise in #MachineLearning, interested in developing novel algorithms for #biological applications. Come join us! Applications are open until December 20th. cstheory-jobs.org/2024/12/10/p...

I could not be more thrilled to announce the Nature Methods @naturemethods.bsky.social Method of the Year is Spatial Proteomics! Please see our editorial as a roadmap to the fantastic content in this special issue! www.nature.com/articles/s41...

To expedite the development of a network focussed on single-cell and spatial genomics on this platform, I started to collect accounts of scientists & groups that are broadly active in these fields. This is work in progress, DM if you want to be added or have suggestions! go.bsky.app/HZTJxbZ

Here's a starter pack focusing on cardiovascular research. I'm sure the pack is incomplete. If you'd like to be added to the list, please let me know! go.bsky.app/SgaGkv5