SAVE THE DATE for the 13th Canadian Developmental Biology Conference — March 7–10, 2027 — bringing together researchers, trainees, and innovators in developmental biology from across Canada and beyond.

Why do guinea pigs have so many natural bypass arteries — and mice and humans almost none? We develop in vivo Perturb-seq for endothelial cells to ask how protective collateral arteries are built. Preprint with by Irene Fan, Ronghao Zhou, and Kristy Red-Horse: www.biorxiv.org/content/10.6...

🚨 New preprint on bioRxiv! Pericyte loss triggers hypoperfusion, BBB dysfunction, endothelial VCAM-1/type I IFN activation, venular-like transitions & delayed white matter injury linked to human SVD signatures. Congrats Dr. Dorota Stefancova & team! www.biorxiv.org/content/10.6...

🚨WE ARE HIRING🚨 Interested in regeneration? cardiac development? just like doing zebrafish research? Join us in beautiful Montreal! Check here if interested www.izfs.org/jobboard/ame... @zebrafishrock.bsky.social @isrbio.bsky.social @izfs.bsky.social

Transient Toxicity of Tamoxifen-inducible CAGG-CreER "ubiquitous CreER activation in postnatal🐭 ⏬body growth & ⏬ retinal angiogenesis" P2/4 Tmx P7 Angiogenesis⏬ 👉3-fold⏫apoptosis 👉40%⏬prolif 👉3-fold⏫P21 in Endothelial cell P21 Recovered #Angiogenesis 2026 link.springer.com/article/10.1...

This was a hard story to report. Newborns who don’t get a vitamin K shot are 81 times more likely to develop a condition where they bleed uncontrollably. But more and more families are declining the shot. And babies are dying. www.propublica.org/article/more...

Authors and Reviewers in the genAI era

Using light-activated CRISPR in zebrafish, we triggered synchronized DNA breaks and track the repair process. ⚡🐟⚡ 

 Well ... DNA repair is very different in embryos compared to tissue culture cells. Embryos repair DNA breaks incredibly fast - within minutes! www.biorxiv.org/content/10.6...

The program for the 4th Canadian Zebrafish Research Conference is now available. 📅 May 15, 2026 📍 CHU Sainte-Justine, Montreal We are excited to highlight our three Postdoc Rising Stars and to have the privilege of welcoming three invited speakers. @izfs.bsky.social @zebrafishrock.bsky.social

We are searching for a research technician to join our lab for a year 🔬🧬🐟 Please see the ad below and spread the word!! #ZebrafishRock

🚨 How do mechanical forces shape a developing organ? Our new #ScienceAdvances @science.org study, led by the amazing @cvagenapantoula.bsky.social, reveals a Piezo1-driven hydraulic mechanism, where mechanical cues control cell volume to guide cardiac formation ❤️🐟 🔗 www.science.org/doi/10.1126/...

This is wild: the authors find evidence for giant, macro-predatory octopuses in Late Cretaceous oceans that might max out at *62 feet long,* comfortably large enough to attack, kill and eat mosasaurs

How can a single cell learn without a brain? We explore this in my paper with @wallaceucsf.bsky.social! We discovered that single cells may learn using molecules similar to those that animal brains use to learn, like CaMKII. Cells can also propagate memory states to their progeny!

For those interested in endothelial junctions: our latest paper is out in iScience, and it includes a mass spectrometry based VE-cadherin interactome! Turns out that there are many more molecular intractions going on than just with the catenins… See: www.sciencedirect.com/science/arti...

"Pancreatic cancer mRNA vaccine shows lasting results in an early trial: Scientists caution that more research is needed, but nearly all of the patients who responded to the personalized vaccine are still alive six years later."

These should be fintastic! (And did they mention, it's FREE to anyone*) #ZebrafishMeeting *As long as you register 😉 🧪

Yes, they can hallucinate papers that don't exist, discuss results that seem to be imaginary, and can be confusing and inconsistent. But talking to tenured professors may still be helpful

I wrote about why every lab should have AI use guidelines, and how to do it. open.substack.com/pub/blekhman...

@tcpotts.bsky.social paper is live. Happy to share #FishNAP, a new, non-invasive way to measure #BBB permeability in 96-well format with #zebrafish www.biorxiv.org/content/10.6...

Hello, Bluesky community! ZDMS promotes the study, research & use of zebrafish disease models throughout the world while fostering diversity among the zebrafish community. We also advocate for public awareness of the importance of the field & offer informed opinions. Give us a follow, for more! 🐟👩‍🔬

I'm suing Grammarly over its paid AI feature that presented editing suggestions as if they came from me - and many other writers and journalists - without consent. State law requires consent before someone's name can be used for commercial purposes. www.wired.com/story/gramma...

Excited to share our latest work on cardiac regeneration! 🚨 Here @gulsumkayman.bsky.social identified Fibulin2 as a critical matricellular protein regulating the balance between regeneration and fibrosis. 🐟🫀 1/2 www.nature.com/articles/s44...

I just made an account and voted for this biology laboratory made of LEGO to "promote biological research and inspire more people into the world of biology". They need 10K votes. Reposting and/or voting below would be helpful. 🤗 beta.ideas.lego.com/product-idea...

🎉Registration is OPEN! 🎉 Abstract submissions for oral & poster talks are live for the 4th Canadian Zebrafish Research Conference! 🐟 ✈️ Travel awards will be selected from submitted abstracts, don’t miss your chance! 👉 event.fourwaves.com/4czrc/pages @izfs.bsky.social @zebrafishrock.bsky.social

Check out this review on brain 🧠capillary ion channels in health and disease… a topic that has evolved (and continues to grow) dramatically over the past decade.🗓️📅

CIHR funding rate: 13.6%. Early 2000s: 30%+. Canada’s new $1.7B Impact+ program recruits talent — but without increased Tri-Council base funding, we risk further strain on an already stretched system. We’re calling for $1B over 5 years. Support here: tinyurl.com/33c5av46

Very pleased with our newest publication! In this study, we identify the Calcineurin-NFAT-DSCR1.4 signaling pathway as a druggable driver of capillary malformations caused by the GNAQ p.R183Q mutation, which is associated with port-wine stains and Sturge-Weber syndrome. 🔗 article: rdcu.be/e2gRC

We are looking for PhD students or Postdocs with an interest in developing and using new methods for functional genetics following our recent work 👉 rdcu.be/e05Oo and academic.oup.com/nar/article/52

Our paper on TCBE-Umax is out in @natbiomedeng.nature.com! We developed these high-efficiency cytosine base editors for zebrafish, enabling rapid functional testing of disease variants. This work is led by a talented scientist, Wei Qin. www.nature.com/articles/s41...

We’re delighted to see this out today! Latest work from the lab reveals insights into the evolution of brain immunity and the developmental and evolutionary plasticity of lymphatic endothelial cells. www.nature.com/articles/s41...

Couldn't be a better way to start 2026! Excited to share our latest publication. Tremendous effort by Rouf and coauthors to investigate how the zebrafish coronary network develops and interacts with the growing cardiac muscle. journals.biologists.com/dev/article/...

I cannot stress enough that you should not do this.

Check out our latest preprint on the cellular mechanical basis of Voronoi tessellations in epithelia! This biophysics study is inspired by disordered tessellations observed in zebrafish hearts 🤓🐟💙 #SulaimaanLim #ChiuFanLeeLab arxiv.org/html/2512.13...

It's not just social media. Looks like visitors to the US from Europe and other countries that are part of the visa waiver program will have to submit an enormous amount of data about themselves and their families, including DNA, if proposed new rules are accepted

🧠 An exciting fully funded 4-year PhD at the Universities of Edinburgh & Manchester with Drs. Ingo Schiessl, Audrey Chagnot, and myself! 📅 Deadline: Jan 9! 📝 Details are below 👇🏻 Please circulate this widely, thanks!

Bat shit crazy. US plans to start checking tourists social media. It will be "mandatory" to hand over the social media info, including email addresses & phone numbers used in the last five years, as well as the names, addresses, numbers, & birthdays of family members. news.sky.com/story/us-pla...

We are actively recruiting graduate students in behavioural & systems neuroscience. Please share with any talented trainees that are looking for a position!

no idea

If you have only one thing to read today... "Universities are being retrofitted as fulfillment centers of cognitive convenience." www.currentaffairs.org/news/ai-is-d...

Applications are open for @dev-journal.bsky.social 2026 Pathway to Independence (PI) programme, supporting postdocs applying for group leader positions: Mentoring Profile raising Leadership training Network building Spread the word... www.biologists.com/grants/devel...

Exciting new #Zebrafish research from the #WeinsteinLab, led by Jong Park! “Specialized gas-exchange endothelium of the zebrafish gill” — www.biorxiv.org/content/10.6... Amazing to see red blood cells moving through the gills! Don’t forget to check out the supplemental movies ;-)

Saskatoon’s Black Fox Distillery named Worldwide Whisky Producer of the Year At least our -35 C winters produce something besides frostbite. #Canada #Whisky #Saskatchewan #Saskatoon www.ctvnews.ca/saskatoon/ar...

Interested in Zebrafish brain imaging? We released a 3D printed mold that's is super helpful for us. Check it out Customizable FDM-based zebrafish embryo mold for live imaging www.biorxiv.org/content/10.1... Work by Marcela and Jaakko in the lab

#OpenCloning is a an Open Source alternative to SnapGene/Benchling that supports automation and integration with other software ✅ Free 🔓 Open Source 🧬 More cloning methods than SnapGene 🤖 Can be automated with python 👨‍🔬 Built by a researcher — for researchers! 👉 Check it out at opencloning.org

Come join us in Heidelberg for the first German fish meeting 👩‍🔬👨‍🔬🧬🔬🐟🐠

When a larval zebrafish twitches its tail, the vascular endothelium lights up with a calcium signal, mediated by Piezo1. We used to think mechanosensing in endothelial cells was about sensing blood flow, but at least in this case it's about sensing body motion.

“By performing longitudinal live imaging of intubated adult fish we observe vascular regrowth and immune responses to [meningeal cerebrovascular injuries] over time in the same animal with unprecedented resolution” New work from #WeinsteinLab at NIH

Not sure why @lpachter.bsky.social did not post this here. But it is brilliant. Single cell genomics finally makes it to the clinic.