Our review (with the brilliant Conor McQuaid @axelmontagne.bsky.social ) also just came out looking at glia-vascular interactions in neurodegenerative diseases - an exciting time for the field! Check it out: pharmrev.aspetjournals.org/article/S003... #glia #neurovascular #dementia #alzheimers

🔬 PhD position at Imperial College London! Uncover how pericytes, mysterious vascular cells, drive asthma inflammation. Use spatial transcriptomics, 3D imaging & transgenic models to unlock new therapies. 3-year funded PhD | Oct 2026 start 👉 www.findaphd.com/phds/project... 📧[email protected]

🚨 New preprint on bioRxiv! Pericyte loss triggers hypoperfusion, BBB dysfunction, endothelial VCAM-1/type I IFN activation, venular-like transitions & delayed white matter injury linked to human SVD signatures. Congrats Dr. Dorota Stefancova & team! www.biorxiv.org/content/10.6...

Pericyte loss precedes endothelial inflammation ⬆️VCAM1 in 👤cerebral Small Vessel Disease 11k microvessels (φ4~19 μm)🤠 in precentral gyrus grey & white matter N=20👤 Morph-O-Matic 2D cell segmentation zenodo.org/records/1735... @axelmontagne.bsky.social bioRxiv 2026 www.biorxiv.org/content/10.6...

🚨 New preprint 11,000+ human brain microvessels in cSVD. Key findings: • Early, bimodal pericyte loss • Endothelial activation comes later • Venous-like microvascular shift • Capillary density ↑ 💡 Suggests a sequential vascular pathology, not parallel. 🔗 www.biorxiv.org/content/10.6...

PhD at the University of Edinburgh exploring small vessel disease using imaging, AI and metabolic profiling to understand brain cell dysfunction and test therapies. www.dementiaresearcher.nihr.ac.uk/job/phd-meta...

Here is the FindAPhD weblink to our BHF-DRI PhD programme! Deadline: *April 14* Please spread the word!! eur02.safelinks.protection.outlook.com?url=https%3A...

🚨 PhD Programme – Vascular Dementia Research New 4-year PhD funded by BHF & UK DRI on vascular mechanisms in dementia. Training across UCL, Oxford, Leicester & Edinburgh with lab rotations. 📅 Deadline: 14 April 🎓 Start: Sept 2026 Apply: CV + statement + 2 refs → [email protected] Please share!

Development of the blood–brain barrier 👉Neural Progenitor-to-Endothelium Wnt7a/7b-RECK-GPR124-FZD Norrin-TSPAN12-LRP5/6-FZD4 👉Pericyte/Astrocyte-to-Endothelium Angiotensin II Angiopoietin 1 Shh Circumventricular organ ❎BBB◀️WIF1 #Development 2026 journals.biologists.com/dev/article/...

The BHF-UK DRI Centre for Vascular Dementia Research welcomes Dr Mohamad El Amki(University of Zurich) for the first seminar in our vascular dementia series 🗣️ Don't miss your chance to register at the link below! lnkd.in/ex5M-EZX

💫 A top highlight from last year was the official launch of our new Centre dedicated to revolutionising understanding and treatment of vascular dementia, in partnership with the British Heart Foundation ♥️ Find out more 👉 youtu.be/g8KLVN1ODfs?...

📢 PhD fellowship opportunity in Edinburgh 🏴󠁧󠁢󠁳󠁣󠁴󠁿 Deadline: Friday 9 📅 Apply now 👇🏻

🧠 An exciting fully funded 4-year PhD at the Universities of Edinburgh & Manchester with Drs. Ingo Schiessl, Audrey Chagnot, and myself! 📅 Deadline: Jan 9! 📝 Details are below 👇🏻 Please circulate this widely, thanks!

PhD opportunity in my lab, co-supervised by Karen Horsburgh and @axelmontagne.bsky.social Combining neuroimaging (MRI/PET) with spatial transcriptomic approaches to understand ageing related white matter alterations www.findaphd.com/phds/project...

🚀 Fully funded 4-yr PhD @edinburgh-uni.bsky.social & @officialuom.bsky.social on the vascular origins of Alzheimer’s (advanced imaging + proteomics) Supervisors: Drs. Axel Montagne, Ingo Schiessl, and Audrey Chagnot Join the VIDA DTC & @alzheimerssoc partnership 👉 www.findaphd.com/phds/project...

I'm hiring! Come and work with me at UCL to try and understand how the brain's blood vessels go wrong and promote dementia: www.ucl.ac.uk/work-at-ucl/...

Exciting PhD opportunity in beautiful Edinburgh: discover how ageing and vascular dementia biology maps onto neuroimaging signals. Using cutting-edge spatial transcriptomics + a new TSPO PET ligand, this project probes the immune-vascular mechanisms driving white matter decline. shorturl.at/8fMmA

New on bioRxiv! 🚨 “Pericyte and Endothelial Primary Cilia and Centrioles have Disparate Organization Across the Brain Microvasculature” This project studying #microvascular cells took an unexpected turn when we discovered that #pericytes have primary #cilia! 🔗 www.biorxiv.org/content/10.1... 🧪 🧵1/8

The #brain is often viewed as rather separate from the rest of body. One way it is separated somewhat is the BBB — the blood-brain-barrier. Fabulous primer by @axelmontagne.bsky.social and Audrey Chagnot www.cell.com/current-biol...

Excited to share our Current Biology Primer written with Dr. Audrey Chagnot in the Brain-Body Interactions special issue! We discuss how the BBB works, what happens when it breaks down, and why this matters for brain and body health. @ukdri.ac.uk @thebhf.bsky.social shorturl.at/NNc57

Interested in the heterogeneity of blood vessels in the CNS? Here we review the unique features of the spinal cord vasculature, its barrier properties and neurovascular interactions, highlighting unknown aspects and future research directions. @CRC1366 @erc.europa.eu @immunosens.bsky.social

🌟 New job opportunity 🌟 Based within the UK DRI at Edinburgh, the Rajani Lab investigates the mechanisms of white matter damage in vascular and other dementias. Find out more and apply via the link 🗓️ Apply by 22 October 2025 📌 Full details 👉 tinyurl.com/22y73642

Congratulations to Dr Maura Malpetti (UK DRI at Cambridge), who has won the 2025 European Young Researcher Award from the Fondation Recherche Alzheimer in France. 🎉👏 Read the full story 👉 tinyurl.com/243s9tuf

The Rajani Lab is hiring again! We are looking for a postdoc to join us at @ukdri.ac.uk @edinburgh-uni.bsky.social to investigate vascular-oligodendrocyte interactions in dementia. Apply here 👇 bit.ly/4nm8csZ

The Edinburgh participants at dinner at VasCog!

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✨ Preorders are OPEN ✨ My amazing wife just finished her very first children’s book, and I couldn’t be prouder 💛 📚 Preorder until Sept 7 📦 Shipped w/ tracking 🔗 www.etsy.com/shop/ElodieWho She’s poured her heart into this — every preorder, share, & boost means the world 🙌

Happy 32nd Birthday to ApoE in Dementia research🎈 On this day in 1993, Dr. Allen D. Roses (et al.) published that the presence of APOE4 genotype reliably predicts risk of early onset Alzheimer’s disease. Needless to say the AD research community was skeptical.

PhD position alert!

Serial block-face SEM of mouse Heart Capillaries #EndothelialCell #Pericyte #Telocyte There are direct physical contacts b/w CD34+/CD44+ perivascular mesenchymal cells & abluminal protrusions of EC! #Cells_MDPI 2025 www.mdpi.com/2073-4409/14...

Delighted to share our latest review in Nature Reviews Neuroscience! We examine the growing evidence that vascular dysfunction plays a key role in cognitive decline in ageing and dementia, and argue that preserving/restoring CBF should be central to future therapies. www.nature.com/articles/s41...

Just over a week left to apply for this position in our lab!

🚨 Review Alert *Walking on the tightrope: the shared roles of the bridging pericytes in the brain* Congratulations Audrey Chagnot!! 🥳 Bias aside, this feels like a really meaningful piece for the cerebrovascular field! 😊 www.frontiersin.org/journals/cel...

The Rajani Lab is hiring! We are looking for a postdoc to join us at @ukdri.ac.uk @edinburgh-uni.bsky.social to investigate neuronal activity and white matter changes in vascular dementia. Apply here 👇 bit.ly/44AFJHx

Come and join us in Manchester... We are looking for candidates interested in vascular health and neurodegeneration. This project is specifically exploring how menopause may increase Alzheimer's risk. We also have a postdoc position available: www.jobs.manchester.ac.uk/Job/JobDetai...

Amazing opportunity! specially looking for neurovascular research junior PIs!!

We're excited to welcome a new Group Leader to our vascular dementia research centre with the BHF🎉👏 Prof Susanne van Veluw's research focuses on cerebral amyloid angiopathy, where amyloid beta accumulates in the walls of the brain's blood vessels👉https://buff.ly/rNxxNRz

🧠 New paper out in Biogerontology! We reviewed evidence linking circulating immune cells to cSVD features. Thanks to all co-authors, and the journal team! 🔗 link.springer.com/article/10.1... More coming soon! #Neuroimmunology #cSVD #Biomarkers #AgingBrain #Biogerontology

Colleagues at Row Fogo Centre for Research into Ageing and the Brain (@svdresearch.bsky.social) have revealed how specific blood biomarkers may help predict the progression of cerebral small vessel disease — a major contributor to #stroke and #dementia. Read the full paper: edin.ac/4cZfM8q

Our perspective in @natrevimmunol.nature.com on new concepts in neuroimmune interactions that have challenged the old dogma that immune privilege is a result of the isolation of the nervous and immune systems. @jonykipnis.bsky.social www.nature.com/articles/s41...

Well done Dany!!! 👏🤩 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

🧠 PhD position available! Study polypathology in the medial temporal lobe at the Paris Brain Institute with @lemwisse.bsky.social , @nvillain-alz.bsky.social and myself. This exciting project combines neuroimaging, neuropathology and cognition! Please share widely 🙏

Next up: Audrey Chagnot from @ukdri.ac.uk Montagne Lab: ‘From Decline to Resilience: New Perspectives on the Roles of Pericytes at the Blood-Brain Barrier’ 🧠🧠🧠

Microglia & monocyte-derived cells were long assumed to have similar functions during remyelination. Our new paper @plosbiology.org shows non-redundant roles, with monocytes ultimately inhibiting remyelination. Team effort by Bianca Hill,Rebecca Holloway, Lindsey Forbes,Claire Davies plos.io/3RryCLF