“Well I don’t like that study because it doesn't give me the result I want’

We are excited to report: Cerebral blood flow is modulated by astrocytic cAMP elevation independently of IP3R2-mediated Ca2+ signaling in mice Vittani et al. PNAS (2025) pnas.org/doi/10.1073/...

The first Master’s student with me as main supervisor graduated today! I’m proud 🥹

🐭🧠 #PrecapillarySphincters (PS) at the #arteriole–#capillary junction rapidly dilate ~30% in seconds during #SensoryStimulation—regulating #capillary #BloodFlow dynamically. Here we investigated whether they protect downstream microvessels during abrupt #BloodPressure surges 🧪🧵

Playing around with my 3yo daughter and an antique microscope. Looked at some #dandelion petals and a stamen using a Carl Zeiss P.A. 35 microscope using reflected light. 🧪

@pkpd-babe.bsky.social Can I be added to the science post? My orcID: orcid.org/0000-0002-67...

Amazing work out by Hirase Lab 🤩

Join our #PhDcourse on #openscience datasets and tools in #Neurophysiology! We'll dive into #EM, #inVivo #physiology, behavioural analysis tools, and a talk on creating animations from open data! @quorumetrix.bsky.social 📢 Free for NorDoc PhD students, but open to all! Apply now! lnkd.in/dU_fxqqu

Pass it on. #StandWithUkraine

Publications in the past week built substantially on our knowledge of the brain's waste disposal system—glymphatics—and the implications on sleep and brain aging. Featuring exceptional work by Nedergaard Lab and @jonykipnis.bsky.social erictopol.substack.com/p/our-sleep-... open-access

🤘🏻The study I have been waiting for 30 years! Only Scandinavians can pull this out let alone publish it in a Scandinavian pain journal 🤘🏻 #painscience #physio #painresearch #ignobel2025 www.degruyter.com/document/doi...

SERVICE UPDATE We normally don't ask you to "share like and subscribe" but please distribute this. You are now able to delete the link after it embeds on your post so you can get those precious extra characters, and we will catch your post mentioning research. #AcademicSky #Medsky #HigherEd

Always fascinating these links between heart and brain ilnesses academic.oup.com/brain/advanc... #HeartBrainAxis

lymphatics

🧪 E11 Bio is excited to share a major step towards brain mapping at 100x lower cost, making whole-brain connectomics at human & mouse scale feasible (🧠→🔬→💻). Critical for curing brain disorders, building human-like AI systems, and even simulating human brains. Read more: e11.bio/news/roadmap

You can generate a #podcast with two hosts discussing a research paper using notebooklm.google.com I have tried it with a couple of papers (including my own 😂), it is a nice way of getting a summary. Try it out!

🧠NON-NEUROCENTRIC STARTER PACKS FOR BRAIN RESEARCH: I this thread 🧵 I will post starter packs for fields of research not directly related to neurons: #meninges, #vasculature, #glia, #immunecells, #dementia, #headache, #microscopy, and resources to get started with #Bluesky.

Here we show how 🧠 #precapillarysphincters react to #CorticalSpreadingDepolarization which is associated with #migraine with #aura 🤕. #CSD has 3 phases: constriction, dilation, and a long lasting constriction that interrupts #bloodflow🩸 to #capillaries (Tinyurl.com/euasfses).

#Neurovasculature changes from the #arterial to the #venular end. Here I have tried to draw the #cell morphologies realistically. #Endothelialcells go from spindle shaped to rhombic shaped and #muralcells from #smoothmuscle to #pericytes. #Astrocytes same shape. www.sciencedirect.com/science/arti...

Here is a #precapillarysphincter. As #arterioles 🟢 dive into the 🧠, they branch to smaller vessels. When larger arterioles (15-25um) branch into #capillaries, they need a #sphincter (3-4um) to reduce #RBC flow⚫️ and pressure in the #capillary. The resistance is provided by #muralcell🔴 encirclement.

Here we show how #microglia contact #pericytes and #endothelialcells in the #venule end of the #capillary bed. Note also how a #primarycilium of an #interneuron invaginates the microglia. But why? 🤔 journals.sagepub.com/doi/full/10.... @gazz4science.bsky.social

Three must read papers for PhD students. #scisky #PhD #science #research #academicsky 1. The importance of stupidity in scientific research Open Access journals.biologists.com/jcs/article/...

Tell me, If you want to join the Migraine @ Headache starter pack. #Migraine #Headache #neuroscience #Neurology #pain go.bsky.app/U8U8wfW

You wanted starter packs to be searchable. Our engineers are busy keeping us online, so in the meantime, an independent developer built a new searchable library of starter packs. This is the beauty of building in the open 🦋

Here is a starter pack on the #Meninges, #CSF, and #Glymphatics. Please share and let me know if you should be on the list and I will add you! go.bsky.app/NLcabwc

Calling all #pericyte researchers! Here's a list of us to start a community on Bluesky. Please feel free to reply to get added and share with your colleagues as more join! go.bsky.app/GhVdxzC

🔬 Are you eager to dive into the world of light microscopy & learn from top-notch microscopists about its essential techniques for life science applications? If that sounds exciting, don’t miss out on this free, in-depth iBiology series! 👉 www.ibiology.org/online-biolo...

Did you know that #neuronal #processes arrange perpendicular to #vascular direction around #penetratingarterioles and arterial end #capillaries? 🤔 I have speculated that this may enhance #neurovascularcoupling. Here I show examples in the #human #brain. 🧠 vb.bioscientifica.com/view/journal...

Here is an overview of the pial #macrophages 🔵 in the #MICrONS dataset. Between an #arteriole 🔴 and a #venule 🟣 3 macrophages are hanging out on top of the #piamater #fibroblasts 🟡. The #primarycilia of each of the fibroblasts are touching a macrophage. What are they communicating? 🤔

A mapping of how Bluesky is becoming the new Scientific Twitter mikeyoungacademy.dk/bluesky-is-e...

As my first post on #Bluesky I am showing my #3Drendering of a pial #macrophage 🔵 squeezing between #fibroblast 🟡 processes next to a #penetratingarteriole. Nuclei in 🟢. Macrophages move around and help clean up waste in the #cerebrospinalfluid. www.biorxiv.org/content/10.1...