This work is finally published! 🥳🧬 Plasmids are associated with very variable fitness costs in their different bacterial hosts. But, what is the contribution of each of the plasmid-genes in these host-specific effects? Study led by @jorgesastred.bsky.social, @sanmillan.bsky.social and myself! 1/14

Can we exploit past phage infection events (prophages) to decipher the specificity of phage receptor-binding proteins such as depolymerases?🔎 Happy to share our recent work at @natcomms.nature.com 🔽 #microsky #phagesky www.nature.com/articles/s41...

Invited speaker Marco La Fortaleza starts the first session of the day talking about epigenetic diversification in bacterial multicellularity. #Multicellverse

Do restriction-modification systems shape plasmid sequence composition? A group of plasmid-aficionados, led by Liam Shaw, started to explore this during the 2023 @embo.org Workshop on Plasmids in Trieste. Happy to have contributed to this work and be part of such a great team!

Really looking forward to this!! 👇

🚨 Seminar at ETH this Thursday! 🚨 Join Dr. Jerónimo Rodríguez-Beltrán (@jerorb.bsky.social) for a talk on how plasmids shape antibiotic resistance. Plasmid evolution: a (copy) numbers game 🗓 April 3rd | 🕙 10:00–11:00 📍 CHN F42, ETH Zurich evodynamicslab.com

🚨 Excited to share that our new study, “ESKAPE pathogens rapidly develop resistance against antibiotics in development in vitro” is published in @naturemicrobiol.bsky.social. For details, see the 🧵below and read the paper here: www.nature.com/articles/s41...

🚨 Our latest research in @naturecomms.bsky.social shows a promising strategy for less resistance-prone #antibiotics. For details, see the thread below and read the paper “Exploring the principles behind antibiotics with limited resistance” here: #MEvoSky www.nature.com/articles/s41...

We kicked off this semester's #SMEE with two great talks by @dnasaur.bsky.social and @phagemuffin.bsky.social. @usyseth.bsky.social

Really glad I could contribute to this work exploring biofilm formation, mucoidy and tip adhesin diversity in #klebsiella. For those in #KLEBS2024, I provided a sneak peak of the potential relation between K3 serotype & HMV This is also my first publication since I joined @cbitoulouse.bsky.social !

Really happy to see this paper out. Extra special for me because it marks my first research publication. Aswin has officially entered the academic world! 📈🦠🧑‍💻

New paper from our group in @pnas.org!! 🚀 Malte Mütter used our amazing liquid-handling robot to test different treatment strategies and found that combination therapy is the most effective to prevent the emergence of plasmid-mediated double resistance www.pnas.org/doi/10.1073/...

Can E.coli 🦠 escape from predation by ‘living antibiotic’ 💊B.bacteriovorus, a predatory bacterium ? A first preprint from my lab for people interested in: #MicroSky, #Evolution and new ways to treat #AMR and #Bdellovibrio www.biorxiv.org/content/10.1... Some findings in the following thread:

Should I stay or should I go? 🎵 In a new opinion piece, Claudia Igler, Andrina Bernhard and I discuss how conjugative plasmids and temperate bacteriophages balance vertical and horizontal transmission: ecoevorxiv.org/repository/v... Our framework sheds light on many aspects of MGE biology (1/7)

Next in my To Read list! Surely great & thorough work from Alex Hall, led by @rleonsampedro.bsky.social Read his thread here 👇🏻👇🏻

New in Nature Comms, we show that azole-resistant Aspergillus fumigatus are more likely to evolve resistance to new antifungals due to variants in their DNA mismatch repair system rdcu.be/d3Iyc @natureportfolio.bsky.social #microsky #fungi #amr

Nora finished her paper with a sentence I like a lot "Our results show that even under extremely restrictive, competitive conditions, the simplest biological entities on Earth can still find paths to coexistence." There is a curious dichotomy in her experiments... 1/3 www.science.org/doi/10.1126/...

New preprint by the group I am doing my PhD in: “Chromosomal plasticity can drive rapid adaptation in bacteria”. This is the first chapter of Ever Vega-Cabrera's thesis and has been in the works for a long time. https://doi.org/10.1101/2024.12.11.627208 […]

Very glad to see this properly out and open access from my time with @baym.lol We've learnt so much about antibiotic resistance evolution already, and yet so many outstanding and fascinating questions remain, at all levels of selection. www.annualreviews.org/content/jour...

Possible explains our displacement papers www.sciencedirect.com/science/arti... journals.plos.org/plosbiology/...

PhD opportunity in St Andrews on plasmids, antibiotics and defence systems, in collaboration with Helen Alexander in Edinburgh. Funding via BBSRC EastBio, please share & pass on to anyone interested! #microsky🦠🧫🧬 www.findaphd.com/phds/project...

Excited to share our study led by @SakenovaNazgul! We used chemical genetics to identify and understand cross-resistance & collateral-sensitivity (CS) between antibiotics and reduced AMR development with CS drug pairs @embl.org with @camille_goemans @EPFL_en www.nature.com/articles/s41...

Interested in antibiotic cross-resistance/sensitivity? Tired of experimental evolution? Then check our new story led by brilliant @nazgulsakenova.bsky.social, now out on Nature Microbiology @naturemicrobiol.bsky.social !

🚨 New preprint!! How can antibiotic-resistant bacteria increase in abundance in the human gut microbiome, even without antibiotics? 🧐 We show that strain-specific ecological interactions are key to understanding resistance dynamics in microbial communities. 🧵👇 1/5 www.biorxiv.org/content/10.1...

Plasmids are commonly viewed as burdensome. But maybe this burden can be advantageous? Check out this new review paper from the lab that investigates this further!! onlinelibrary.wiley.com/doi/10.1002/...

I just made a starter pack on Ecology and Evolution of AMR. 🦠 ⚡ 💊 Feel free to suggest names and I’ll add them as soon as I can!! go.bsky.app/CwEzc79