New(ish!) paper on how within-host competition and antibiotic resistance shape the fitness of Streptococcus pneumoniae serotypes, out in August in Plos Biology. journals.plos.org/plosbiology/...

Competition & #bacterial #PopulationDynamics. @krishnaaswin77.bsky.social @sonjalehtinen.bsky.social &co show that within-host competition in #Streptococcus increases clearance & reduces establishment; #AntibioticResistance increases susceptibility to competition @plosbiology.org 🧪 plos.io/4lqcZba

Do plasmids evolve faster 🐇, slower 🐢, or just like chromosomes 🧬? In our new paper, we tackled this question using theory, simulations, bioinformatics, and experiments! 👇 Check out all the details in Paula’s thread! Hint: 🐇 (most of the time)

Two postdoc positions have been advertised in our lab at @ethzurich.bsky.social with Sebastian Bonhoeffer & Roland Regoes. If you are interested in experimental (jobs.ethz.ch/job/view/JOP...) or theoretical (jobs.ethz.ch/job/view/JOP...) epidemiology, then apply before the 2nd of June!

New paper: long-term trends in antibiotic resistance show signs of stabilisation (thread). journals.plos.org/plospathogen...

In the fight against bacterial pathogens, researchers are combining vaccination with targeted colonization of the intestine by harmless microorganisms. This approach could potentially mark a turning point in the antibiotics crisis. www.biozentrum.unibas.ch/news/detail/...

New preprint! 📢 Using a large longitudinal dataset of bacterial carriage we ask: (A) Does within-host competition between bacterial strains lower their epidemiological fitness? (B) Does this strain competition affect the fitness of Abx-resistant bugs? Answer to both = yes. More details here👇

🚨 New preprint!! How can antibiotic-resistant bacteria increase in abundance in the human gut microbiome, even without antibiotics? 🧐 We show that strain-specific ecological interactions are key to understanding resistance dynamics in microbial communities. 🧵👇 1/5 www.biorxiv.org/content/10.1...

Interesting perspective to say that probability may not exist. What I make of this is - any probability value is based on an underlying model, and all models have assumptions behind them. In that sense, probabilities are subjective estimates.

Really happy to see this paper out. Extra special for me because it marks my first research publication. Aswin has officially entered the academic world! 📈🦠🧑‍💻

New paper from our group in @pnas.org!! 🚀 Malte Mütter used our amazing liquid-handling robot to test different treatment strategies and found that combination therapy is the most effective to prevent the emergence of plasmid-mediated double resistance www.pnas.org/doi/10.1073/...

Cool paper on the effect of biotic interactions on the success of resistant strains within host!

Fun to write this review with some research friends on modelling for infection disease control. Three case studies (antigen dynamics, AMR and vaccine design) and some reflections on COVID-19 www.life-science-alliance.org/content/7/9/...